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New York: Palgrave Macmillan."},{"key":"ref2","unstructured":"World Health Organization (2012) World malaria report: 2012. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/malaria\/publications\/world_malaria_report_2012\/en\/index.html\" xlink:type=\"simple\">http:\/\/www.who.int\/malaria\/publications\/world_malaria_report_2012\/en\/index.html<\/ext-link>. Accessed 19 March 2013."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1056\/NEJMoa0807381","article-title":"Efficacy of RTS,S\/AS01E vaccine against malaria in children 5 to 17 months of age","volume":"359","author":"P Bejon","year":"2008","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1056\/NEJMoa1102287","article-title":"First results of phase 3 trial of RTS,S\/AS01 malaria vaccine in African children","volume":"365","year":"2011","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/S0140-6736(08)61655-4","article-title":"Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, Kenya","volume":"372","author":"WP O'Meara","year":"2008","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/415673a","article-title":"The pathogenic basis of malaria","volume":"415","author":"LH Miller","year":"2002","journal-title":"Nature"},{"key":"ref7","unstructured":"Amaratunga C, Lopera-Mesa TM, Tse JG, Mita-Mendoza NK, Fairhurst RM (2010) In:Kaufmann S, Rouse B, Sacks D, editor. Immunology of infectious diseases. Washington, DC: American Society of Microbiology Press."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S1473-3099(12)70055-5","article-title":"Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta-analysis","volume":"12","author":"SM Taylor","year":"2012","journal-title":"Lancet Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1601-5223.1949.tb03339.x","article-title":"The rate of mutation of human genes","volume":"35","author":"JB Haldane","year":"1949","journal-title":"Hereditas"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0140-6736(00)02073-0","article-title":"Red cells I: inherited anaemias","volume":"355","author":"DJ Weatherall","year":"2000","journal-title":"Lancet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","article-title":"Human malaria parasites in continuous 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Ifediba","year":"1985","journal-title":"Blood"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1182\/blood.V100.4.1172.h81602001172_1172_1176","article-title":"Hemoglobin E: a balanced polymorphism protective against high parasitemias and thus severe P falciparum malaria","volume":"100","author":"K Chotivanich","year":"2002","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1128\/JCM.25.1.56-60.1987","article-title":"Thalassemic erythrocytes inhibit in vitro growth of Plasmodium falciparum","volume":"25","author":"CR Brockelman","year":"1987","journal-title":"J Clin Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/274701a0","article-title":"Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malaria","volume":"274","author":"G Pasvol","year":"1978","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0035-9203(80)90182-0","article-title":"The interaction between sickle haemoglobin and the malarial parasite Plasmodium falciparum","volume":"74","author":"G Pasvol","year":"1980","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"777","DOI":"10.4269\/ajtmh.1979.28.777","article-title":"The role of hemoglobins C, S, and Nbalt in the inhibition of malaria parasite development in vitro","volume":"28","author":"MJ Friedman","year":"1979","journal-title":"Am J Trop Med Hyg"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1182\/blood.V67.4.997.997","article-title":"Synchronized cultures of P falciparum in abnormal red cells: the mechanism of the inhibition of growth in HbCC cells","volume":"67","author":"JA Olson","year":"1986","journal-title":"Blood"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1182\/blood-2002-10-3105","article-title":"Aberrant development of Plasmodium falciparum in hemoglobin CC red cells: implications for the malaria protective effect of the homozygous state","volume":"101","author":"RM Fairhurst","year":"2003","journal-title":"Blood"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1172\/JCI110248","article-title":"Impairment of the growth of Plasmodium falciparum in HbEE erythrocytes","volume":"68","author":"RL Nagel","year":"1981","journal-title":"J Clin Invest"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0140-6736(76)91738-4","article-title":"Fetal haemoglobin and malaria","volume":"1","author":"G Pasvol","year":"1976","journal-title":"Lancet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/280245a0","article-title":"Oxidant damage mediates 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Luzzatto","year":"1970","journal-title":"Lancet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1126\/science.360396","article-title":"Sickling rates of human AS red cells infected in vitro with Plasmodium falciparum malaria","volume":"202","author":"EF Roth Jr","year":"1978","journal-title":"Science"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1073\/pnas.75.4.1994","article-title":"Erythrocytic mechanism of sickle cell resistance to malaria","volume":"75","author":"MJ Friedman","year":"1978","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e2360","DOI":"10.1371\/journal.pone.0002360","article-title":"The genomic analysis of erythrocyte microRNA expression in sickle cell diseases","volume":"3","author":"SY Chen","year":"2008","journal-title":"PLoS 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Baruch","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/0140-6736(90)93174-N","article-title":"Human cerebral malaria: association with erythrocyte rosetting and lack of anti-rosetting antibodies","volume":"336","author":"J Carlson","year":"1990","journal-title":"Lancet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1182\/blood.V78.3.812.812","article-title":"Rosetting of Plasmodium falciparum-infected red blood cells with uninfected red blood cells enhances microvascular obstruction under flow conditions","volume":"78","author":"DK Kaul","year":"1991","journal-title":"Blood"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0092-8674(95)90055-1","article-title":"The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes","volume":"82","author":"XZ 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Raventos-Suarez","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1126\/science.272.5267.1502","article-title":"Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta","volume":"272","author":"M Fried","year":"1996","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1046\/j.1365-2958.2003.03570.x","article-title":"Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria","volume":"49","author":"A Salanti","year":"2003","journal-title":"Mol Microbiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/40888","article-title":"P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1","volume":"388","author":"JA Rowe","year":"1997","journal-title":"Nature"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1084\/jem.176.5.1311","article-title":"Plasmodium falciparum erythrocyte rosetting is mediated by promiscuous lectin-like interactions","volume":"176","author":"J Carlson","year":"1992","journal-title":"J Exp Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1084\/jem.187.1.15","article-title":"Identification of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) as the rosetting ligand of the malaria parasite P. falciparum","volume":"187","author":"Q Chen","year":"1998","journal-title":"J Exp Med"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1084\/jem.177.1.145","article-title":"Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites","volume":"177","author":"L Schofield","year":"1993","journal-title":"J Exp Med"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e46424","DOI":"10.1371\/journal.pone.0046424","article-title":"Plasma Uric Acid Levels Correlate with Inflammation and Disease Severity in Malian Children with Plasmodium falciparum Malaria","volume":"7","author":"TM Lopera-Mesa","year":"2012","journal-title":"PLoS One"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.chom.2007.06.012","article-title":"Plasmodium falciparum erythrocyte membrane protein-1 specifically suppresses early production of host interferon-gamma","volume":"2","author":"MC D'Ombrain","year":"2007","journal-title":"Cell Host Microbe"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1182\/blood.V82.12.3752.3752","article-title":"Alteration in cytoadherence and rosetting of Plasmodium falciparum-infected thalassemic red blood cells","volume":"82","author":"R Udomsangpetch","year":"1993","journal-title":"Blood"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nature03631","article-title":"Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria","volume":"435","author":"RM Fairhurst","year":"2005","journal-title":"Nature"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1073\/pnas.0711401105","article-title":"Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin","volume":"105","author":"R Cholera","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e14798","DOI":"10.1371\/journal.pone.0014798","article-title":"A role for fetal hemoglobin and maternal immune IgG in infant resistance to Plasmodium falciparum malaria","volume":"6","author":"C Amaratunga","year":"2011","journal-title":"PLoS 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Cyrklaff","year":"2011","journal-title":"Science"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nri1686","article-title":"Immunological processes in malaria pathogenesis","volume":"5","author":"L Schofield","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1128\/CMR.17.3.509-539.2004","article-title":"Pathogenesis of malaria and clinically similar conditions","volume":"17","author":"IA Clark","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1471-4906(03)00229-1","article-title":"Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria","volume":"24","author":"NH Hunt","year":"2003","journal-title":"Trends Immunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1586\/eri.10.90","article-title":"Adjunctive therapy for cerebral malaria and other severe forms 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Opin Infect Dis"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"O Takeuchi","year":"2010","journal-title":"Cell"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1084\/jem.20021067","article-title":"Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis","volume":"198","author":"P Villa","year":"2003","journal-title":"J Exp Med"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1073\/pnas.051606598","article-title":"Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress","volume":"98","author":"AL Siren","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1182\/blood.V98.6.1802","article-title":"Heme is a potent 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but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9","volume":"104","author":"P Parroche","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.4049\/jimmunol.172.5.3101","article-title":"Hemozoin-inducible proinflammatory events in vivo: potential role in malaria infection","volume":"172","author":"M Jaramillo","year":"2004","journal-title":"J Immunol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1182\/blood-2009-06-226415","article-title":"Plasmodium falciparum-infected erythrocytes induce NF-kappaB regulated inflammatory pathways in human cerebral endothelium","volume":"114","author":"AK Tripathi","year":"2009","journal-title":"Blood"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.4049\/jimmunol.139.10.3493","article-title":"Inhibition of murine malaria (Plasmodium chabaudi) in vivo by recombinant 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A"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/nm.2601","article-title":"Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization","volume":"18","author":"AJ Cunnington","year":"2012","journal-title":"Nat Med"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.cell.2011.03.049","article-title":"Sickle hemoglobin confers tolerance to Plasmodium infection","volume":"145","author":"A Ferreira","year":"2011","journal-title":"Cell"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"e1002579","DOI":"10.1371\/journal.ppat.1002579","article-title":"HMOX1 gene promoter alleles and high HO-1 levels are associated with severe malaria in Gambian children","volume":"8","author":"M Walther","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0140-6736(03)12564-0","article-title":"Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production","volume":"361","author":"BK Lopansri","year":"2003","journal-title":"Lancet"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1084\/jem.20070819","article-title":"Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria","volume":"204","author":"TW Yeo","year":"2007","journal-title":"J Exp Med"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/S0140-6736(02)11474-7","article-title":"A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children","volume":"360","author":"MR Hobbs","year":"2002","journal-title":"Lancet"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1128\/IAI.59.9.3280-3283.1991","article-title":"Killing of Plasmodium falciparum in vitro by nitric oxide derivatives","volume":"59","author":"KA Rockett","year":"1991","journal-title":"Infect Immun"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1365-3024.1994.tb00346.x","article-title":"Possible role of nitric oxide in malarial immunosuppression","volume":"16","author":"KA Rockett","year":"1994","journal-title":"Parasite Immunol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1172\/JCI118074","article-title":"Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines","volume":"96","author":"R De Caterina","year":"1995","journal-title":"J Clin Invest"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/S0002-9440(10)64299-X","article-title":"Anti-adhesive effect of nitric oxide on Plasmodium falciparum cytoadherence under flow","volume":"162","author":"S Serirom","year":"2003","journal-title":"Am J Pathol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"e128","DOI":"10.1371\/journal.pmed.0020128","article-title":"An immune basis for malaria protection by the sickle cell trait","volume":"2","author":"TN Williams","year":"2005","journal-title":"PLoS Med"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1182\/blood-2011-08-371062","article-title":"Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait","volume":"119","author":"L Gong","year":"2012","journal-title":"Blood"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/192733a0","article-title":"Gamma-globulin and acquired immunity to human malaria","volume":"192","author":"S Cohen","year":"1961","journal-title":"Nature"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/00034983.1979.11687244","article-title":"Abnormal haemoglobins in the Sudan savanna of Nigeria. II. Immunological response to malaria in normals and subjects with sickle cell trait","volume":"73","author":"R Cornille-Brogger","year":"1979","journal-title":"Ann Trop Med Parasitol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/0035-9203(92)90083-O","article-title":"Morbidity from malaria and immune responses to defined Plasmodium falciparum antigens in children with sickle cell trait in The Gambia","volume":"86","author":"SJ Allen","year":"1992","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/ije\/28.4.793","article-title":"Longitudinal study of Plasmodium falciparum infection and immune responses in infants with or without the sickle cell trait","volume":"28","author":"JY Le Hesran","year":"1999","journal-title":"Int J Epidemiol"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"566","DOI":"10.4269\/ajtmh.2000.62.566","article-title":"Antibody responses to Plasmodium falciparum: evolution according to the severity of a prior clinical episode and association with subsequent reinfection","volume":"62","author":"AJ Luty","year":"2000","journal-title":"Am J Trop Med Hyg"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1086\/429832","article-title":"The sickle cell trait is associated with enhanced immunoglobulin G antibody responses to Plasmodium falciparum variant surface antigens","volume":"191","author":"G Cabrera","year":"2005","journal-title":"J Infect Dis"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"e978","DOI":"10.1371\/journal.pone.0000978","article-title":"Haemoglobin C and S role in acquired immunity against Plasmodium falciparum malaria","volume":"2","author":"F Verra","year":"2007","journal-title":"PLoS One"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1093\/infdis\/jir638","article-title":"Hemoglobin S and C heterozygosity enhances neither the magnitude nor breadth of antibody responses to a diverse array of Plasmodium falciparum antigens","volume":"204","author":"X Tan","year":"2011","journal-title":"J Infect Dis"},{"key":"ref104","first-page":"635","article-title":"Opsonic activity of human immune serum on in vitro phagocytosis of Plasmodium falciparum infected red blood cells by monocytes","volume":"47","author":"A Celada","year":"1982","journal-title":"Clin Exp Immunol"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1084\/jem.173.4.785","article-title":"Surface antigen expression on Plasmodium falciparum-infected erythrocytes is modified in alpha- and beta-thalassemia","volume":"173","author":"GA Luzzi","year":"1991","journal-title":"J Exp Med"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1046\/j.1365-2141.2002.03610.x","article-title":"The membrane characteristics of Plasmodium falciparum-infected and -uninfected heterozygous alpha(0)thalassaemic erythrocytes","volume":"118","author":"TN Williams","year":"2002","journal-title":"Br J Haematol"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1182\/blood-2003-11-3820","article-title":"Enhanced phagocytosis of ring-parasitized mutant erythrocytes: a common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia trait","volume":"104","author":"K Ayi","year":"2004","journal-title":"Blood"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/ni.f.205","article-title":"Immunity to malaria: more questions than answers","volume":"9","author":"J Langhorne","year":"2008","journal-title":"Nature Immunol"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1182\/blood.V98.9.2859","article-title":"Peripheral blood dendritic cells in children with acute Plasmodium falciparum malaria","volume":"98","author":"BC Urban","year":"2001","journal-title":"Blood"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1084\/jem.20011174","article-title":"The mechanism and significance of deletion of parasite-specific CD4(+) T cells in malaria infection","volume":"195","author":"H Xu","year":"2002","journal-title":"J Exp Med"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"E2117","DOI":"10.1073\/pnas.1206573109","article-title":"A Plasmodium-encoded cytokine suppresses T-cell immunity during malaria","volume":"109","author":"T Sun","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.4049\/jimmunol.175.4.2510","article-title":"Plasmodium yoelii can ablate vaccine-induced long-term protection in mice","volume":"175","author":"MN Wykes","year":"2005","journal-title":"J Immunol"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/21900","article-title":"Plasmodium 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