{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:27:31Z","timestamp":1791354451987,"version":"4.3.1"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T00:00:00Z","timestamp":1371081600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1003414","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T16:56:11Z","timestamp":1371142571000},"page":"e1003414","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":190,"title":["IRG and GBP Host Resistance Factors Target Aberrant, \u201cNon-self\u201d Vacuoles Characterized by the Missing of \u201cSelf\u201d IRGM Proteins"],"prefix":"10.1371","volume":"9","author":[{"given":"Arun K.","family":"Haldar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector A.","family":"Saka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony S.","family":"Piro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe Dan","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley C.","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva M.","family":"Frickel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael H.","family":"Valdivia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rn","family":"Coers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,6,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.chom.2009.05.014","article-title":"Leading a sheltered life: intracellular pathogens and maintenance of vacuolar compartments","volume":"5","author":"Y Kumar","year":"2009","journal-title":"Cell Host Microbe"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.mib.2010.11.001","article-title":"Mechanisms and consequences of bacterial targeting by the autophagy pathway","volume":"14","author":"S Shahnazari","year":"2011","journal-title":"Curr Opin Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nri3210","article-title":"Interferon-inducible effector mechanisms in cell-autonomous immunity","volume":"12","author":"JD MacMicking","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-gamma: an overview of signals, mechanisms and functions","volume":"75","author":"K Schroder","year":"2004","journal-title":"J Leukoc Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1600-065X.2008.00698.x","article-title":"Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha\/beta, IFN-gamma, and IFN-lambda in host defense","volume":"226","author":"SY Zhang","year":"2008","journal-title":"Immunol Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.mib.2011.07.002","article-title":"The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii","volume":"14","author":"JC Howard","year":"2011","journal-title":"Curr Opin Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1084\/jem.20061318","article-title":"Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages","volume":"203","author":"YM Ling","year":"2006","journal-title":"J Exp Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cell.2004.11.038","article-title":"Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages","volume":"119","author":"MG Gutierrez","year":"2004","journal-title":"Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1126\/science.1129577","article-title":"Human IRGM induces autophagy to eliminate intracellular mycobacteria","volume":"313","author":"SB Singh","year":"2006","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/ncb2119","article-title":"Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria","volume":"12","author":"SB Singh","year":"2010","journal-title":"Nat Cell Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1128\/IAI.73.6.3278-3286.2005","article-title":"p47 GTPases regulate Toxoplasma gondii survival in activated macrophages","volume":"73","author":"BA Butcher","year":"2005","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.4049\/jimmunol.173.4.2594","article-title":"Mechanisms regulating the positioning of mouse p47 resistance GTPases LRG-47 and IIGP1 on cellular membranes: retargeting to plasma membrane induced by phagocytosis","volume":"173","author":"S Martens","year":"2004","journal-title":"J Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/ni.1759","article-title":"Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria","volume":"10","author":"S Tiwari","year":"2009","journal-title":"Nat Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1128\/IAI.01288-07","article-title":"The gamma interferon (IFN-gamma)-inducible GTP-binding protein IGTP is necessary for toxoplasma vacuolar disruption and induces parasite egression in IFN-gamma-stimulated astrocytes","volume":"76","author":"T Melzer","year":"2008","journal-title":"Infect Immun"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"32143","DOI":"10.1074\/jbc.M804846200","article-title":"Inactive and active states of the interferon-inducible resistance GTPase, Irga6, in vivo","volume":"283","author":"N Papic","year":"2008","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1038\/emboj.2008.176","article-title":"Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii","volume":"27","author":"JP Hunn","year":"2008","journal-title":"EMBO J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1083\/jcb.200910105","article-title":"Automated microscopy for high-content RNAi screening","volume":"188","author":"C Conrad","year":"2010","journal-title":"J Cell Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"11984","DOI":"10.1073\/pnas.97.22.11984","article-title":"Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral","volume":"97","author":"GS Baird","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0014-5793(02)02874-0","article-title":"Oligomerization of DsRed is required for the generation of a functional red fluorescent chromophore","volume":"525","author":"A Sacchetti","year":"2002","journal-title":"FEBS Lett"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/1097-0061(20000630)16:9<785::AID-YEA550>3.0.CO;2-L","article-title":"The yeast Ty virus-like particles","volume":"16","author":"JF Roth","year":"2000","journal-title":"Yeast"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1371\/journal.pbio.0050158","article-title":"Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes","volume":"5","author":"Y Fang","year":"2007","journal-title":"PLoS Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1189\/jlb.1008599","article-title":"Balance of Irgm protein activities determines IFN-gamma-induced host defense","volume":"85","author":"SC Henry","year":"2009","journal-title":"J Leukoc Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1371\/journal.ppat.0010024","article-title":"Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases","volume":"1","author":"S Martens","year":"2005","journal-title":"PLoS Pathog"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.1462-5822.2010.01443.x","article-title":"Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole","volume":"12","author":"A Khaminets","year":"2010","journal-title":"Cell Microbiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e4588","DOI":"10.1371\/journal.pone.0004588","article-title":"IFN-gamma-inducible Irga6 mediates host resistance against Chlamydia trachomatis via autophagy","volume":"4","author":"MA Al-Zeer","year":"2009","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.immuni.2009.06.022","article-title":"A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells","volume":"31","author":"L Bougneres","year":"2009","journal-title":"Immunity"},{"issue":"35","key":"ref27","doi-asserted-by":"crossref","first-page":"30471","DOI":"10.1074\/jbc.M111.251967","article-title":"Immunity-related gtpase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy","volume":"286","author":"MK Traver","year":"2011","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jmb.2004.09.026","article-title":"Identification of residues in the human guanylate-binding protein 1 critical for nucleotide binding and cooperative GTP hydrolysis","volume":"344","author":"GJ Praefcke","year":"2004","journal-title":"J Mol Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1126\/science.1201711","article-title":"A family of IFN-gamma-inducible 65-kD GTPases protects against bacterial infection","volume":"332","author":"BH Kim","year":"2011","journal-title":"Science"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00281-010-0220-1","article-title":"Selective degradation of p62 by autophagy","volume":"32","author":"Y Ichimura","year":"2010","journal-title":"Semin Immunopathol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4161\/auto.19496","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"8","author":"DJ Klionsky","year":"2012","journal-title":"Autophagy"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"7729","DOI":"10.4049\/jimmunol.179.11.7729","article-title":"Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense","volume":"179","author":"D Degrandi","year":"2007","journal-title":"J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e24434","DOI":"10.1371\/journal.pone.0024434","article-title":"Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it","volume":"6","author":"S Virreira Winter","year":"2011","journal-title":"PLoS One"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/319675a0","article-title":"Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy","volume":"319","author":"K Karre","year":"1986","journal-title":"Nature"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bbamem.2008.09.003","article-title":"Domain coupling in asymmetric lipid bilayers","volume":"1788","author":"V Kiessling","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e14246","DOI":"10.1371\/journal.pone.0014246","article-title":"Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner","volume":"5","author":"N Britzen-Laurent","year":"2010","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/35000617","article-title":"Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins","volume":"403","author":"B Prakash","year":"2000","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.immuni.2012.06.009","article-title":"A Cluster of Interferon-gamma-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii","volume":"37","author":"M Yamamoto","year":"2012","journal-title":"Immunity"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"6237","DOI":"10.4049\/jimmunol.180.9.6237","article-title":"Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10","volume":"180","author":"J Coers","year":"2008","journal-title":"J Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e1001346","DOI":"10.1371\/journal.ppat.1001346","article-title":"Compensatory T Cell Responses in IRG-Deficient Mice Prevent Sustained Chlamydia trachomatis Infections","volume":"7","author":"J Coers","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1111\/j.1462-5822.2007.00963.x","article-title":"Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5\/Ipaf signalling pathways","volume":"9","author":"J Coers","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e1002258","DOI":"10.1371\/journal.ppat.1002258","article-title":"Development of a transformation system for Chlamydia trachomatis: restoration of glycogen biosynthesis by acquisition of a plasmid shuttle vector","volume":"7","author":"Y Wang","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1128\/IAI.01862-06","article-title":"Bradyzoite-specific surface antigen SRS9 plays a role in maintaining Toxoplasma gondii persistence in the brain and in host control of parasite replication in the intestine","volume":"75","author":"SK Kim","year":"2007","journal-title":"Infect Immun"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"9379","DOI":"10.1073\/pnas.0712241105","article-title":"Cytoplasmic lipid droplets are translocated into the lumen of the Chlamydia trachomatis parasitophorous vacuole","volume":"105","author":"JL Cocchiaro","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"20399","DOI":"10.1074\/jbc.271.34.20399","article-title":"Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma","volume":"271","author":"GA Taylor","year":"1996","journal-title":"J Biol Chem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1046\/j.1365-2958.2001.02355.x","article-title":"Mammalian 14-3-3beta associates with the Chlamydia trachomatis inclusion membrane via its interaction with IncG","volume":"39","author":"MA Scidmore","year":"2001","journal-title":"Mol Microbiol"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1003414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T04:01:28Z","timestamp":1540353688000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1003414"}},"subtitle":[],"editor":[{"given":"Denise M.","family":"Monack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,6,13]]},"references-count":46,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1003414","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,13]]}}}