{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:46:39Z","timestamp":1792730799133,"version":"4.5.0"},"reference-count":85,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1003531","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T16:49:38Z","timestamp":1375375778000},"page":"e1003531","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":112,"title":["IL-1\u03b2 Suppresses Innate IL-25 and IL-33 Production and Maintains Helminth Chronicity"],"prefix":"10.1371","volume":"9","author":[{"given":"Mario M.","family":"Zaiss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendle M.","family":"Maslowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Mosconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Guenat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Marsland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola L.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,8,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.pt.2003.10.002","article-title":"Soil-transmitted helminth infections: updating the global picture","volume":"19","author":"NR de Silva","year":"2003","journal-title":"Trends Parasitol"},{"key":"ref2","unstructured":"WHO (2010) Working to overcome the global impact of neglected tropical diseases, First WHO report on Neglected Tropical Diseases."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nri2199","article-title":"Protective immune mechanisms in helminth infection","volume":"7","author":"RM Anthony","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.it.2010.11.005","article-title":"To B or not to B: B cells and the Th2-type immune response to helminths","volume":"32","author":"N Harris","year":"2010","journal-title":"Trends Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0169-4758(92)90084-F","article-title":"Heligmosomoides polygyrus: a model for chronic gastrointestinal helminthiasis","volume":"8","author":"FG Monroy","year":"1992","journal-title":"Parasitol Today"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1002\/eji.200939721","article-title":"Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation","volume":"40","author":"M Wilson","year":"2010","journal-title":"European journal of immunology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1002\/eji.201142161","article-title":"Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrus","volume":"42","author":"H McSorley","year":"2012","journal-title":"European journal of immunology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.4049\/jimmunol.1102892","article-title":"Heligmosomoides polygyrus bakeri Induces Tolerogenic Dendritic Cells that Block Colitis and Prevent Antigen-Specific Gut T Cell Responses","volume":"189","author":"A Blum","year":"2012","journal-title":"Journal of immunology (Baltimore, Md : 1950)"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"13968","DOI":"10.1073\/pnas.0906367106","article-title":"Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function","volume":"106","author":"JC Massacand","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1084\/jem.20101074","article-title":"Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-beta pathway","volume":"207","author":"JR Grainger","year":"2010","journal-title":"J Exp Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/nm1451","article-title":"Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites","volume":"12","author":"R Anthony","year":"2006","journal-title":"Nature medicine"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.chom.2008.08.014","article-title":"Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection","volume":"4","author":"KD McCoy","year":"2008","journal-title":"Cell Host Microbe"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-3024.1979.tb00692.x","article-title":"Expulsion of Nematospiroides dubius from the intestine of mice treated with immune serum","volume":"1","author":"JM Behnke","year":"1979","journal-title":"Parasite Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: guardians of the body","volume":"27","author":"F Martinon","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"15195","DOI":"10.1016\/S0021-9258(17)36591-2","article-title":"Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity","volume":"269","author":"D Perregaux","year":"1994","journal-title":"The Journal of biological chemistry"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.1156995","article-title":"Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica","volume":"320","author":"C Dostert","year":"2008","journal-title":"Science"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1002\/1529-0131(199812)41:12<2196::AID-ART15>3.0.CO;2-2","article-title":"Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist","volume":"41","author":"B Bresnihan","year":"1998","journal-title":"Arthritis Rheum"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1369\/jhc.6A7101.2006","article-title":"Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response","volume":"55","author":"JA Kummer","year":"2007","journal-title":"J Histochem Cytochem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/MED.0b013e32833bf6dc","article-title":"Role of IL-1beta in type 2 diabetes","volume":"17","author":"CA Dinarello","year":"2010","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1186\/ar2143","article-title":"A pilot study of IL-1 inhibition by anakinra in acute gout","volume":"9","author":"A So","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1136\/ard.2005.048371","article-title":"Safety of extended treatment with anakinra in patients with rheumatoid arthritis","volume":"65","author":"RM Fleischmann","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1056\/NEJMoa065213","article-title":"Interleukin-1-receptor antagonist in type 2 diabetes mellitus","volume":"356","author":"CM Larsen","year":"2007","journal-title":"N Engl J Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1136\/gut.33.9.1214","article-title":"Detection of mRNAs for macrophage products in inflammatory bowel disease by in situ hybridisation","volume":"33","author":"M Cappello","year":"1992","journal-title":"Gut"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0016-5085(93)91010-F","article-title":"Localization of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells","volume":"104","author":"KR Youngman","year":"1993","journal-title":"Gastroenterology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/gut.33.1.55","article-title":"Increased concentrations of interleukin 1 beta, interleukin-2, and soluble interleukin-2 receptors in endoscopical mucosal biopsy specimens with active inflammatory bowel disease","volume":"33","author":"J Brynskov","year":"1992","journal-title":"Gut"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1136\/gut.31.6.686","article-title":"Role of interleukin 1 in inflammatory bowel disease\u2013enhanced production during active disease","volume":"31","author":"M Ligumsky","year":"1990","journal-title":"Gut"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1084\/jem.20100257","article-title":"Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella","volume":"207","author":"P Broz","year":"2010","journal-title":"J Exp Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1073\/pnas.0913087107","article-title":"Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome","volume":"107","author":"EA Miao","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.4049\/jimmunol.1003784","article-title":"Activation of NLRC4 by flagellated bacteria triggers caspase-1-dependent and -independent responses to restrict Legionella pneumophila replication in macrophages and in vivo","volume":"187","author":"MS Pereira","year":"2011","journal-title":"J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"20459","DOI":"10.1073\/pnas.1010337107","article-title":"Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses","volume":"107","author":"M Ritter","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"5306","DOI":"10.4049\/jimmunol.175.8.5306","article-title":"Systemic dissemination and persistence of Th2 and type 2 cells in response to infection with a strictly enteric nematode parasite","volume":"175","author":"K Mohrs","year":"2005","journal-title":"Journal of immunology (Baltimore, Md : 1950)"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1182\/blood.V87.6.2095.bloodjournal8762095","article-title":"Biologic basis for interleukin-1 in disease","volume":"87","author":"CA Dinarello","year":"1996","journal-title":"Blood"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.4049\/jimmunol.162.7.4133","article-title":"B7-2 is required for the progression but not the initiation of the type 2 immune response to a gastrointestinal nematode parasite","volume":"162","author":"RJ Greenwald","year":"1999","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/0014-4894(91)90074-7","article-title":"Heligmosomoides polygyrus: CD4+ but not CD8+ T cells regulate the IgE response and protective immunity in mice","volume":"73","author":"J Urban","year":"1991","journal-title":"Experimental parasitology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"5513","DOI":"10.1073\/pnas.88.13.5513","article-title":"Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice","volume":"88","author":"J Urban","year":"1991","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","article-title":"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines","volume":"23","author":"J Schmitz","year":"2005","journal-title":"Immunity"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S1074-7613(01)00243-6","article-title":"IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo","volume":"15","author":"MM Fort","year":"2001","journal-title":"Immunity"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1084\/jem.20051496","article-title":"Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract","volume":"203","author":"AM Owyang","year":"2006","journal-title":"J Exp Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.4049\/jimmunol.180.4.2443","article-title":"IL-33, a potent inducer of adaptive immunity to intestinal nematodes","volume":"180","author":"NE Humphreys","year":"2008","journal-title":"J Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1073\/pnas.1003988107","article-title":"Systemically dispersed innate IL-13-expressing cells in type 2 immunity","volume":"107","author":"AE Price","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"6644","DOI":"10.1073\/pnas.1112268109","article-title":"Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines","volume":"109","author":"MR Hepworth","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1073\/pnas.90.2.587","article-title":"Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice","volume":"90","author":"RH Whitehead","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"31834","DOI":"10.1074\/jbc.M109.025940","article-title":"Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase Cepsilon-dependent manner","volume":"284","author":"Y Sonobe","year":"2009","journal-title":"The Journal of biological chemistry"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nri3365","article-title":"Innate lymphoid cells - a proposal for uniform nomenclature","volume":"13","author":"H Spits","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nature08900","article-title":"Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity","volume":"464","author":"DR Neill","year":"2010","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature08636","article-title":"Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells","volume":"463","author":"K Moro","year":"2009","journal-title":"Nature"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1084\/jem.20051615","article-title":"Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion","volume":"203","author":"PG Fallon","year":"2006","journal-title":"J Exp Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1073\/pnas.1201042109","article-title":"Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice","volume":"109","author":"K Yasuda","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"476","DOI":"10.4161\/gmic.21507","article-title":"Regulation of type 2 immunity to helminths by mast cells","volume":"3","author":"M Hepworth","year":"2012","journal-title":"Gut microbes"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1038\/nature08901","article-title":"IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses","volume":"464","author":"SA Saenz","year":"2010","journal-title":"Nature"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1128\/IAI.00436-12","article-title":"Type 2 innate immunity in helminth infection is induced redundantly and acts autonomously following CD11c(+) cell depletion","volume":"80","author":"K Smith","year":"2012","journal-title":"Infection and immunity"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.4049\/jimmunol.140.5.1555","article-title":"Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells","volume":"140","author":"LA Greenbaum","year":"1988","journal-title":"J Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"9699","DOI":"10.1073\/pnas.85.24.9699","article-title":"Role of interleukin 1 in the activation of T lymphocytes","volume":"85","author":"AH Lichtman","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"8181","DOI":"10.1073\/pnas.85.21.8181","article-title":"T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells","volume":"85","author":"CT Weaver","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/eji.1830230130","article-title":"Regulation of T helper cell cytokine expression: functional dichotomy of antigen-presenting cells","volume":"23","author":"J Schmitz","year":"1993","journal-title":"Eur J Immunol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"5206","DOI":"10.4049\/jimmunol.155.11.5206","article-title":"IL-4 expression in human T cells is selectively inhibited by IL-1 alpha and IL-1 beta","volume":"155","author":"CI Sandborg","year":"1995","journal-title":"J Immunol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1002\/(SICI)1521-4141(199807)28:07<2066::AID-IMMU2066>3.0.CO;2-X","article-title":"Enhanced Th2-like responses in IL-1 type 1 receptor-deficient mice","volume":"28","author":"AR Satoskar","year":"1998","journal-title":"Eur J Immunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1084\/jem.20030159","article-title":"Interleukin 1alpha promotes Th1 differentiation and inhibits disease progression in Leishmania major-susceptible BALB\/c mice","volume":"198","author":"E Von Stebut","year":"2003","journal-title":"J Exp Med"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1002\/eji.200425452","article-title":"Interleukin 1 plays a major role in the development of Th2-mediated immunity","volume":"34","author":"H Helmby","year":"2004","journal-title":"Eur J Immunol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1002\/eji.200838938","article-title":"IL-1-dependent, IL-1R1-independent resistance to gastrointestinal nematodes","volume":"39","author":"NE Humphreys","year":"2009","journal-title":"Eur J Immunol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1084\/jem.20112691","article-title":"Interleukin-1a controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33","volume":"209","author":"M Willart","year":"2012","journal-title":"The Journal of experimental medicine"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.immuni.2011.03.015","article-title":"An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma","volume":"34","author":"M Kool","year":"2011","journal-title":"Immunity"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.immuni.2012.03.021","article-title":"Epithelial Cell-Specific Act1 Adaptor Mediates Interleukin-25-Dependent Helminth Expulsion through Expansion of Lin(-)c-Kit(+) Innate Cell Population","volume":"36","author":"Z Kang","year":"2012","journal-title":"Immunity"},{"key":"ref64","first-page":"G1101","article-title":"Caco-2 cells express type I interleukin-1 receptors: ligand binding enhances proliferation","volume":"267","author":"GW Varilek","year":"1994","journal-title":"Am J Physiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"C1198","DOI":"10.1152\/ajpcell.1994.266.5.C1198","article-title":"Identification and characterization of the rat intestinal epithelial cell (IEC-18) interleukin-1 receptor","volume":"266","author":"DB Sutherland","year":"1994","journal-title":"Am J Physiol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/09629359990342","article-title":"The mechanisms of action of interleukin-1 on rabbit intestinal epithelial cells","volume":"8","author":"FR Homaidan","year":"1999","journal-title":"Mediators Inflamm"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jaci.2011.09.041","article-title":"Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity","volume":"129","author":"JL Barlow","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.jaci.2009.02.026","article-title":"IL-33-activated dendritic cells induce an atypical TH2-type response","volume":"123","author":"M Rank","year":"2009","journal-title":"The Journal of allergy and clinical immunology"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4049\/jimmunol.169.1.443","article-title":"New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25","volume":"169","author":"SD Hurst","year":"2002","journal-title":"J Immunol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0300-9475.2004.01443.x","article-title":"The receptor for interleukin-17E is induced by Th2 cytokines in antigen-presenting cells","volume":"60","author":"A Gratchev","year":"2004","journal-title":"Scandinavian journal of immunology"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1084\/jem.20080698","article-title":"A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity","volume":"205","author":"A Terashima","year":"2008","journal-title":"The Journal of experimental medicine"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1182\/blood-2002-09-2817","article-title":"Mast cells produce interleukin-25 upon Fc epsilon RI-mediated activation","volume":"101","author":"K Ikeda","year":"2003","journal-title":"Blood"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1084\/jem.20070406","article-title":"IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells","volume":"204","author":"Y-H Wang","year":"2007","journal-title":"The Journal of experimental medicine"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2174\/156652411794474365","article-title":"The dual role of interleukin-25 in the control of immune-mediated pathologies","volume":"11","author":"R Caruso","year":"2010","journal-title":"Curr Mol Med"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1476-9255-8-22","article-title":"Role of IL-33 in inflammation and disease","volume":"8","author":"AM Miller","year":"2011","journal-title":"J Inflamm (Lond)"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature02664","article-title":"Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf","volume":"430","author":"S Mariathasan","year":"2004","journal-title":"Nature"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.1087262","article-title":"Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway","volume":"301","author":"M Yamamoto","year":"2003","journal-title":"Science (New York, NY)"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1074-7613(00)80596-8","article-title":"Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function","volume":"9","author":"O Adachi","year":"1998","journal-title":"Immunity"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1084\/jem.187.9.1463","article-title":"Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha\/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion","volume":"187","author":"R Horai","year":"1998","journal-title":"J Exp Med"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.4049\/jimmunol.159.5.2452","article-title":"Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice","volume":"159","author":"M Labow","year":"1997","journal-title":"Journal of immunology (Baltimore, Md : 1950)"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0092-8674(92)90030-G","article-title":"RAG-1-deficient mice have no mature B and T lymphocytes","volume":"68","author":"P Mombaerts","year":"1992","journal-title":"Cell"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1084\/jem.191.6.1069","article-title":"T1\/ST2-deficient mice demonstrate the importance of T1\/ST2 in developing primary T helper cell type 2 responses","volume":"191","author":"M Townsend","year":"2000","journal-title":"The Journal of experimental medicine"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.immuni.2011.03.021","article-title":"Intestinal bacterial colonization induces mutualistic regulatory T cell responses","volume":"34","author":"M Geuking","year":"2011","journal-title":"Immunity"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1128\/MCB.26.3.735-742.2006","article-title":"Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide","volume":"26","author":"A Didierlaurent","year":"2006","journal-title":"Mol Cell Biol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-1-61779-527-5_15","article-title":"Measuring the inflammasome","volume":"844","author":"O Gross","year":"2012","journal-title":"Methods Mol Biol"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1003531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T12:30:30Z","timestamp":1688387430000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1003531"}},"subtitle":[],"editor":[{"given":"Mark","family":"Wilson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,1]]},"references-count":85,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1003531","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,1]]}}}