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Casjens","year":"2000","journal-title":"Mol Microbiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e33280","DOI":"10.1371\/journal.pone.0033280","article-title":"Genome stability of Lyme disease spirochetes: comparative genomics of <italic>Borrelia burgdorferi<\/italic> plasmids","volume":"7","author":"SR Casjens","year":"2012","journal-title":"PLoS One"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/37551","article-title":"Genomic sequence of a Lyme disease spirochaete, <italic>Borrelia burgdorferi<\/italic>","volume":"390","author":"CM Fraser","year":"1997","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1128\/JB.01158-10","article-title":"Whole-genome sequences of thirteen isolates of <italic>Borrelia burgdorferi<\/italic>","volume":"193","author":"SE Schutzer","year":"2011","journal-title":"J 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Microbiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"e1000680","DOI":"10.1371\/journal.ppat.1000680","article-title":"Investigation of the genes involved in antigenic switching at the <italic>vlsE<\/italic> locus in <italic>Borrelia burgdorferi<\/italic>: an essential role for the RuvAB branch migrase","volume":"5","author":"AR Dresser","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"e1000679","DOI":"10.1371\/journal.ppat.1000679","article-title":"Central role of the Holliday junction helicase RuvAB in <italic>vlsE<\/italic> recombination and infectivity of <italic>Borrelia burgdorferi<\/italic>","volume":"5","author":"T Lin","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"e1000326","DOI":"10.1371\/journal.ppat.1000326","article-title":"A chromosomally encoded virulence factor protects the Lyme disease pathogen against host-adaptive immunity","volume":"5","author":"X Yang","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1128\/JCM.37.12.3997-4004.1999","article-title":"Human antibody responses to VlsE antigenic variation protein of Borrelia burgdorferi","volume":"37","author":"MB Lawrenz","year":"1999","journal-title":"J Clin Microbiol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0092-8674(00)80206-8","article-title":"Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes","volume":"89","author":"JR Zhang","year":"1997","journal-title":"Cell"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1128\/IAI.70.4.2139-2150.2002","article-title":"Clonal polymorphism of <italic>Borrelia burgdorferi<\/italic> strain B31 MI: implications for mutagenesis in an infectious strain background","volume":"70","author":"AF Elias","year":"2002","journal-title":"Infect Immun"},{"key":"ref71","first-page":"521","article-title":"Isolation and cultivation of Lyme disease spirochetes","volume":"57","author":"AG Barbour","year":"1984","journal-title":"Yale J Biol Med"},{"key":"ref72","unstructured":"Rosa PA, Hogan D (1992) Colony formation by <italic>Borrelia burgdorferi<\/italic> in solid medium: clonal analysis of <italic>osp<\/italic> locus variants. In: Munderloh UG, Kurtti TJ, editors. Proceeding of the First International Conference on Tick Borne Pathogens at the Host-Vector Interface. St. Paul, Minnesota: University of Minnesota."},{"key":"ref73","unstructured":"Samuels DS (1995) Electrotransformation of the spirochete <italic>Borrelia burgdorferi<\/italic>. In: Nickoloff JA, editor. Methods in Molecular Biology. Totowa, N.J.: Humana Press, Inc. pp. 253\u2013259."},{"key":"ref74","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1111\/j.1365-2958.2007.05969.x","article-title":"Genetic basis for retention of a critical virulence plasmid of <italic>Borrelia burgdorferi<\/italic>","volume":"66","author":"MW Jewett","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000073406","article-title":"New antibiotic resistance cassettes suitable for genetic studies in <italic>Borrelia burgdorferi<\/italic>","volume":"6","author":"AF Elias","year":"2003","journal-title":"J Mol Microbiol Biotechnol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"6231","DOI":"10.1128\/JB.00450-09","article-title":"GuaA and GuaB are essential for <italic>Borrelia burgdorferi<\/italic> survival in the tick-mouse infection cycle","volume":"191","author":"MW Jewett","year":"2009","journal-title":"J Bacteriol"},{"key":"ref77","article-title":"Enhanced detection of host response antibodies to <italic>Borrelia burgdorferi<\/italic> using immuno-PCR","author":"MD Halpern","year":"2013","journal-title":"Clin Vaccine Immunol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1073\/pnas.0306845101","article-title":"Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals","volume":"101","author":"D Grimm","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1128\/IAI.01193-08","article-title":"OspC-independent infection and dissemination by host-adapted <italic>Borrelia burgdorferi<\/italic>","volume":"77","author":"K Tilly","year":"2009","journal-title":"Infect Immun"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1128\/IAI.01059-09","article-title":"Use of the Cre-lox recombination system to investigate the lp54 gene requirement in the infectious cycle of <italic>Borrelia burgdorferi<\/italic>","volume":"78","author":"A Bestor","year":"2010","journal-title":"Infect Immun"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1099\/mic.0.28317-0","article-title":"Lipoprotein computational prediction in spirochaetal genomes","volume":"152","author":"JC Setubal","year":"2006","journal-title":"Microbiology"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"6723","DOI":"10.1128\/JB.185.22.6723-6727.2003","article-title":"<italic>aadA<\/italic> confers streptomycin resistance in <italic>Borrelia burgdorferi<\/italic>","volume":"185","author":"KL Frank","year":"2003","journal-title":"J Bacteriol"},{"key":"ref83","first-page":"493","article-title":"A simple method of estimating fifty percent endpoints","volume":"27","author":"LJ Reed","year":"1938","journal-title":"The American Journal of Hygiene"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1004260","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T00:00:00Z","timestamp":1403222400000}}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1003567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T20:32:26Z","timestamp":1596400346000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1003567"}},"subtitle":[],"editor":[{"given":"Jenifer","family":"Coburn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,29]]},"references-count":83,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1003567","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.ppat.1004260","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,29]]}}}