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In: Arvin A, Campadelli-Fiume G, Mocarski E, Moore PS, Roizman B <etal>et al<\/etal>.., editors. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge.","DOI":"10.1017\/CBO9780511545313.027"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1073\/pnas.0730835100","article-title":"Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase","volume":"100","author":"R Bransteitter","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"13578","DOI":"10.1128\/JVI.01663-07","article-title":"X box binding protein XBP-1s transactivates the Kaposi&apos;s sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency","volume":"81","author":"SJ Wilson","year":"2007","journal-title":"J Virol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1128\/JVI.01306-09","article-title":"Blimp-1-dependent plasma cell differentiation is required for efficient maintenance of murine gammaherpesvirus latency and 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Zhang","year":"2001","journal-title":"Int Immunol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/embor.2010.132","article-title":"MicroRNAs encoded by Kaposi&apos;s sarcoma-associated herpesvirus regulate viral life cycle","volume":"11","author":"CC Lu","year":"2010","journal-title":"EMBO Rep"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1128\/JVI.01997-09","article-title":"Epigenetic regulation of Kaposi&apos;s sarcoma-associated herpesvirus latency by virus-encoded microRNAs that target Rta and the cellular Rbl2-DNMT pathway","volume":"84","author":"F Lu","year":"2010","journal-title":"J Virol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.chom.2009.11.008","article-title":"Regulation of KSHV lytic switch protein expression by a virus-encoded microRNA: an evolutionary adaptation that fine-tunes lytic reactivation","volume":"6","author":"P Bellare","year":"2009","journal-title":"Cell 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