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Teles","year":"2013","journal-title":"Science"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1039\/b800520f","article-title":"Stress-related and spontaneous stage differentiation of Toxoplasma gondii","volume":"4","author":"F Ferreira da Silva Mda","year":"2008","journal-title":"Mol Biosyst"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1128\/IAI.51.1.147-156.1986","article-title":"In vitro cultivation of Toxoplasma gondii cysts in astrocytes in the presence of gamma interferon","volume":"51","author":"TC Jones","year":"1986","journal-title":"Infect Immun"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.chom.2013.03.002","article-title":"Host cell subversion by Toxoplasma GRA16, an exported dense granule protein that targets the host cell nucleus and alters gene expression","volume":"13","author":"A Bougdour","year":"2013","journal-title":"Cell Host 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Physiol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"C Trapnell","year":"2012","journal-title":"Nat Protoc"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"W133","DOI":"10.1093\/nar\/gkn300","article-title":"DiRE: identifying distant regulatory elements of co-expressed genes","volume":"36","author":"V Gotea","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"A Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1084\/jem.20061845","article-title":"The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis","volume":"204","author":"ZJ Roberts","year":"2007","journal-title":"J Exp Med"},{"key":"ref83","unstructured":"Korber B (2000) HIV Signature and sequence variation analysis. . In: Rodrigo AG, Learn GH, editors. Computational analysis of HIV molecular sequences. Dordrecht, Netherlands: Kluwer Academic Publishers. pp. 55\u201372."}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1003779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T16:34:27Z","timestamp":1597250067000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1003779"}},"subtitle":[],"editor":[{"given":"David L.","family":"Sacks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,19]]},"references-count":83,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1003779","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,19]]}}}