{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:45:24Z","timestamp":1790066724147,"version":"4.0.1"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T00:00:00Z","timestamp":1394668800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1003986","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T21:04:35Z","timestamp":1394744675000},"page":"e1003986","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":58,"title":["Caspase-1-Dependent and -Independent Cell Death Pathways in Burkholderia pseudomallei Infection of Macrophages"],"prefix":"10.1371","volume":"10","author":[{"given":"Antje","family":"Bast","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imke H. E.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matsayapan","family":"Pudla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Brakopp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Hopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Breitbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Steinmetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,3,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"K Schroder","year":"2010","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nri2725","article-title":"NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?","volume":"10","author":"J Tschopp","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.1184003","article-title":"The NLRP3 inflammasome: a sensor for metabolic danger?","volume":"327","author":"K Schroder","year":"2010","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/ni1344","article-title":"Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf","volume":"7","author":"EA Miao","year":"2006","journal-title":"Nat Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/ni1346","article-title":"Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages","volume":"7","author":"L Franchi","year":"2006","journal-title":"Nat Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"35217","DOI":"10.1074\/jbc.M604933200","article-title":"Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf","volume":"281","author":"A Amer","year":"2006","journal-title":"J Biol Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1084\/jem.20071239","article-title":"Immune recognition of Pseudomonas aeruginosa mediated by the IPAF\/NLRC4 inflammasome","volume":"204","author":"FS Sutterwala","year":"2007","journal-title":"J Exp Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1073\/pnas.0712183105","article-title":"Pseudomonas aeruginosa activates caspase 1 through Ipaf","volume":"105","author":"EA Miao","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1002\/eji.200737532","article-title":"Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation","volume":"37","author":"L Franchi","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.chom.2010.04.009","article-title":"A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system","volume":"7","author":"IE Brodsky","year":"2010","journal-title":"Cell Host Microbe"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1073\/pnas.0913087107","article-title":"Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome","volume":"107","author":"EA Miao","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e1002452","DOI":"10.1371\/journal.ppat.1002452","article-title":"Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1beta is deleterious","volume":"7","author":"I Ceballos-Olvera","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nature10510","article-title":"The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus","volume":"477","author":"Y Zhao","year":"2011","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1084\/jem.20051659","article-title":"Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection","volume":"203","author":"AB Molofsky","year":"2006","journal-title":"J Exp Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1007\/s10875-010-9386-5","article-title":"Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome","volume":"30","author":"EA Miao","year":"2010","journal-title":"J Clin Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nature10394","article-title":"Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity","volume":"477","author":"EM Kofoed","year":"2011","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.chom.2009.07.007","article-title":"The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation","volume":"6","author":"AJ Muller","year":"2009","journal-title":"Cell Host Microbe"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/ni.1960","article-title":"Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria","volume":"11","author":"EA Miao","year":"2010","journal-title":"Nat Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1600-065X.2011.01044.x","article-title":"Caspase-1-induced pyroptotic cell death","volume":"243","author":"EA Miao","year":"2011","journal-title":"Immunol Rev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1074\/mcp.M800132-MCP200","article-title":"Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes","volume":"7","author":"M Lamkanfi","year":"2008","journal-title":"Mol Cell Proteomics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e1000361","DOI":"10.1371\/journal.ppat.1000361","article-title":"Caspase-7 activation by the Nlrc4\/Ipaf inflammasome restricts Legionella pneumophila infection","volume":"5","author":"A Akhter","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1128\/CMR.18.2.383-416.2005","article-title":"Melioidosis: epidemiology, pathophysiology, and management","volume":"18","author":"AC Cheng","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrmicro1385","article-title":"Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei","volume":"4","author":"WJ Wiersinga","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4972","DOI":"10.1128\/IAI.65.12.4972-4977.1997","article-title":"Identification and characterization of a two-component regulatory system involved in invasion of eukaryotic cells and heavy-metal resistance in Burkholderia pseudomallei","volume":"65","author":"AL Jones","year":"1997","journal-title":"Infect Immun"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1128\/IAI.65.10.4108-4113.1997","article-title":"Role of reactive nitrogen and oxygen intermediates in gamma interferon-stimulated murine macrophage bactericidal activity against Burkholderia pseudomallei","volume":"65","author":"K Miyagi","year":"1997","journal-title":"Infect Immun"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"287S","DOI":"10.1042\/bst025287s","article-title":"Interferon-gamma mediates host resistance in a murine model of melioidosis","volume":"25","author":"P Santanirand","year":"1997","journal-title":"Biochem Soc Trans"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"6300","DOI":"10.1128\/IAI.00966-06","article-title":"Role of inducible nitric oxide synthase and NADPH oxidase in early control of Burkholderia pseudomallei infection in mice","volume":"74","author":"K Breitbach","year":"2006","journal-title":"Infect Immun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1111\/j.1462-5822.2005.00569.x","article-title":"Caspase-1 dependent macrophage death induced by Burkholderia pseudomallei","volume":"7","author":"GW Sun","year":"2005","journal-title":"Cell Microbiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1128\/IAI.01257-08","article-title":"Caspase-1 mediates resistance in murine melioidosis","volume":"77","author":"K Breitbach","year":"2009","journal-title":"Infect Immun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1126\/science.1230751","article-title":"Caspase-11 protects against bacteria that escape the vacuole","volume":"339","author":"Y Aachoui","year":"2013","journal-title":"Science"},{"key":"ref31","first-page":"277","article-title":"Defense Mechanisms of Hepatocytes Against Burkholderia pseudomallei","volume":"2","author":"A Bast","year":"2011","journal-title":"Front Microbiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1128\/IAI.01262-05","article-title":"Identification of Burkholderia pseudomallei genes required for the intracellular life cycle and in vivo virulence","volume":"74","author":"S Pilatz","year":"2006","journal-title":"Infect Immun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4992","DOI":"10.1128\/JB.185.16.4992-4996.2003","article-title":"A Burkholderia pseudomallei type III secreted protein, BopE, facilitates bacterial invasion of epithelial cells and exhibits guanine nucleotide exchange factor activity","volume":"185","author":"MP Stevens","year":"2003","journal-title":"J Bacteriol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1046\/j.1365-2958.2002.03190.x","article-title":"An Inv\/Mxi-Spa-like type III protein secretion system in Burkholderia pseudomallei modulates intracellular behaviour of the pathogen","volume":"46","author":"MP Stevens","year":"2002","journal-title":"Mol Microbiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e12477","DOI":"10.1371\/journal.pone.0012477","article-title":"In macrophages, caspase-1 activation by SopE and the type III secretion system-1 of S. typhimurium can proceed in the absence of flagellin","volume":"5","author":"C Hoffmann","year":"2010","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0092-8674(00)81442-7","article-title":"S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells","volume":"93","author":"WD Hardt","year":"1998","journal-title":"Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1042\/BJ20071546","article-title":"The guanine-nucleotide-exchange factor BopE from Burkholderia pseudomallei adopts a compact version of the Salmonella SopE\/SopE2 fold and undergoes a closed-to-open conformational change upon interaction with Cdc42","volume":"411","author":"A Upadhyay","year":"2008","journal-title":"Biochem J"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e1002628","DOI":"10.1371\/journal.ppat.1002628","article-title":"Membrane damage during Listeria monocytogenes infection triggers a caspase-7 dependent cytoprotective response","volume":"8","author":"SK Cassidy","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.4049\/jimmunol.1001512","article-title":"Cutting edge: proteolytic inactivation of poly(ADP-ribose) polymerase 1 by the Nlrp3 and Nlrc4 inflammasomes","volume":"185","author":"RK Malireddi","year":"2010","journal-title":"J Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature02664","article-title":"Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf","volume":"430","author":"S Mariathasan","year":"2004","journal-title":"Nature"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.molcel.2012.02.016","article-title":"Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-kappaB target genes","volume":"46","author":"S Erener","year":"2012","journal-title":"Mol Cell"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.immuni.2012.05.001","article-title":"Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization","volume":"37","author":"A Akhter","year":"2012","journal-title":"Immunity"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nature11419","article-title":"Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1","volume":"490","author":"P Broz","year":"2012","journal-title":"Nature"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1073\/pnas.1211521110","article-title":"Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila","volume":"110","author":"CL Case","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature10558","article-title":"Non-canonical inflammasome activation targets caspase-11","volume":"479","author":"N Kayagaki","year":"2011","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.cell.2012.07.007","article-title":"TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria","volume":"150","author":"VA Rathinam","year":"2012","journal-title":"Cell"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"e1003400","DOI":"10.1371\/journal.ppat.1003400","article-title":"Caspase-11 activation in response to bacterial secretion systems that access the host cytosol","volume":"9","author":"CN Casson","year":"2013","journal-title":"PLoS Pathog"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.chom.2010.11.007","article-title":"Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing","volume":"8","author":"P Broz","year":"2010","journal-title":"Cell Host Microbe"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1084\/jem.192.7.1035","article-title":"Salmonella-induced caspase-2 activation in macrophages: a novel mechanism in pathogen-mediated apoptosis","volume":"192","author":"V Jesenberger","year":"2000","journal-title":"J Exp Med"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nchembio.1023","article-title":"Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection","volume":"8","author":"AW Puri","year":"2012","journal-title":"Nat Chem Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1083\/jcb.200309161","article-title":"A Salmonella protein causes macrophage cell death by inducing autophagy","volume":"163","author":"LD Hernandez","year":"2003","journal-title":"J Cell Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1038\/cdd.2012.51","article-title":"AIM2\/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages","volume":"19","author":"R Pierini","year":"2012","journal-title":"Cell Death Differ"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/cdd.2013.37","article-title":"AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC","volume":"20","author":"V Sagulenko","year":"2013","journal-title":"Cell Death Differ"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1099\/0022-1317-51-7-539","article-title":"Characterisation of an acapsular mutant of Burkholderia pseudomallei identified by signature tagged mutagenesis","volume":"51","author":"T Atkins","year":"2002","journal-title":"J Med Microbiol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1128\/IAI.69.1.34-44.2001","article-title":"Detection of bacterial virulence genes by subtractive hybridization: identification of capsular polysaccharide of Burkholderia pseudomallei as a major virulence determinant","volume":"69","author":"SL Reckseidler","year":"2001","journal-title":"Infect Immun"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.femsle.2004.10.045","article-title":"Type III secretion system cluster 3 is required for maximal virulence of Burkholderia pseudomallei in a hamster infection model","volume":"242","author":"J Warawa","year":"2005","journal-title":"FEMS Microbiol Lett"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1128\/IAI.01218-10","article-title":"The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei","volume":"79","author":"MN Burtnick","year":"2011","journal-title":"Infect Immun"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"e1001068","DOI":"10.1371\/journal.ppat.1001068","article-title":"Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions","volume":"6","author":"S Schwarz","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1046\/j.1365-2958.2000.01933.x","article-title":"Identification of SopE2 from Salmonella typhimurium, a conserved guanine nucleotide exchange factor for Cdc42 of the host cell","volume":"36","author":"S Stender","year":"2000","journal-title":"Mol Microbiol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1099\/mic.0.27146-0","article-title":"Attenuated virulence and protective efficacy of a Burkholderia pseudomallei bsa type III secretion mutant in murine models of melioidosis","volume":"150","author":"MP Stevens","year":"2004","journal-title":"Microbiology"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.tim.2010.09.002","article-title":"Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei","volume":"18","author":"GW Sun","year":"2010","journal-title":"Trends Microbiol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1128\/IAI.71.4.1622-1629.2003","article-title":"Flagella are virulence determinants of Burkholderia pseudomallei","volume":"71","author":"KL Chua","year":"2003","journal-title":"Infect Immun"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"S140","DOI":"10.1016\/S0035-9203(08)70031-2","article-title":"A role of Burkholderia pseudomallei flagella as a virulent factor","volume":"102 Suppl 1","author":"T Chuaygud","year":"2008","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1574-695X.2009.00574.x","article-title":"Comparative in vivo and in vitro analyses of putative virulence factors of Burkholderia pseudomallei using lipopolysaccharide, capsule and flagellin mutants","volume":"56","author":"C Wikraiphat","year":"2009","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1128\/jb.179.7.2116-2125.1997","article-title":"Mutagenesis of Burkholderia pseudomallei with Tn5-OT182: isolation of motility mutants and molecular characterization of the flagellin structural gene","volume":"179","author":"D DeShazer","year":"1997","journal-title":"J Bacteriol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1128\/IAI.00263-08","article-title":"Burkholderia pseudomallei type III secretion system mutants exhibit delayed vacuolar escape phenotypes in RAW 264.7 murine macrophages","volume":"76","author":"MN Burtnick","year":"2008","journal-title":"Infect Immun"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nature04822","article-title":"Assembly of the inner rod determines needle length in the type III secretion injectisome","volume":"441","author":"TC Marlovits","year":"2006","journal-title":"Nature"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1128\/JB.00328-08","article-title":"YscP and YscU switch the substrate specificity of the Yersinia type III secretion system by regulating export of the inner rod protein YscI","volume":"190","author":"SE Wood","year":"2008","journal-title":"J Bacteriol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"25303","DOI":"10.1074\/jbc.M112.381574","article-title":"The Salmonella type III secretion system inner rod protein PrgJ is partially folded","volume":"287","author":"D Zhong","year":"2012","journal-title":"J Biol Chem"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1042\/BJ20111620","article-title":"EscI: a crucial component of the type III secretion system forms the inner rod structure in enteropathogenic Escherichia coli","volume":"442","author":"N Sal-Man","year":"2012","journal-title":"Biochem J"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jim.2008.11.011","article-title":"Generation of murine bone marrow derived macrophages in a standardised serum-free cell culture system","volume":"342","author":"K Eske","year":"2009","journal-title":"J Immunol Methods"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.1128\/AEM.01669-09","article-title":"Versatile dual-technology system for markerless allele replacement in Burkholderia pseudomallei","volume":"75","author":"CM Lopez","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1099\/mic.0.049163-0","article-title":"A novel FK-506-binding-like protein that lacks peptidyl-prolyl isomerase activity is involved in intracellular infection and in vivo virulence of Burkholderia pseudomallei","volume":"157","author":"IH Norville","year":"2011","journal-title":"Microbiology"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1465-9921-8-47","article-title":"Phenotypic alterations in type II alveolar epithelial cells in CD4+ T cell mediated lung inflammation","volume":"8","author":"M Gereke","year":"2007","journal-title":"Respir Res"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1086\/498983","article-title":"Role of T cells in innate and adaptive immunity against murine Burkholderia pseudomallei infection","volume":"193","author":"A Haque","year":"2006","journal-title":"J Infect Dis"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1038\/nprot.2006.435","article-title":"Isolation of CD4+ T cells from murine lungs: a method to analyze ongoing immune responses in the lung","volume":"1","author":"KA Sauer","year":"2006","journal-title":"Nat Protoc"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1465-9921-13-94","article-title":"Heterogeneity of respiratory dendritic cell subsets and lymphocyte populations in inbred mouse strains","volume":"13","author":"H Hackstein","year":"2012","journal-title":"Respir Res"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1003986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T08:49:46Z","timestamp":1597567786000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1003986"}},"subtitle":[],"editor":[{"given":"Patrick","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,13]]},"references-count":77,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1003986","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,13]]}}}