{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:42:50Z","timestamp":1791297770011,"version":"4.1.0"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T00:00:00Z","timestamp":1395878400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1004008","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T17:10:13Z","timestamp":1395940213000},"page":"e1004008","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":45,"title":["Broadly Reactive Human CD8 T Cells that Recognize an Epitope Conserved between VZV, HSV and EBV"],"prefix":"10.1371","volume":"10","author":[{"given":"Christopher","family":"Chiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"McCausland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Sidney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuh-Mei","family":"Duh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Rouphael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneesh","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Mulligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Carrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Wieland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron J.","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bali","family":"Pulendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjoern","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafi","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,3,27]]},"reference":[{"key":"ref1","unstructured":"Fields BN, Knipe DM, Howley PM, editors (2007) Fields' Virology. London: Wolters Kluwer\/Lippincott Williams & Wilkins. 2664 p."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/infdis\/165.1.119","article-title":"Subclinical Varicella-Zoster Virus Viremia, Herpes Zoster, and T Lymphocyte Immunity to Varicella-Zoster Viral Antigens after Bone Marrow Transplantation","volume":"165","author":"A Wilson","year":"1992","journal-title":"J Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/jmv.10555","article-title":"Stress-induced subclinical reactivation of varicella zoster virus in astronauts","volume":"72","author":"SK Mehta","year":"2004","journal-title":"Journal of Medical Virology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"E245","DOI":"10.1111\/1469-0691.12131","article-title":"Subclinical VZV reactivation in immunocompetent children hospitalized in the ICU associated with prolonged fever duration","volume":"19","author":"V Papaevangelou","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"ref5","first-page":"341","article-title":"VZV T cell-mediated immunity","volume":"342","author":"A Weinberg","year":"2010","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0891-5520(05)70312-3","article-title":"Immune responses to varicella-zoster virus","volume":"10","author":"AM Arvin","year":"1996","journal-title":"Infect Dis Clin North Am"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1542\/peds.18.1.109","article-title":"Disturbances in gamma globulin synthesis as experiments of nature","volume":"18","author":"RA Good","year":"1956","journal-title":"Pediatrics"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"7087","DOI":"10.1016\/j.vaccine.2007.07.051","article-title":"Phenotypic and functional characterization of ex vivo T cell responses to the live attenuated herpes zoster vaccine","volume":"25","author":"J Patterson-Bartlett","year":"2007","journal-title":"Vaccine"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1086\/653605","article-title":"Zoster Vaccine: Current Status and Future Prospects","volume":"51","author":"MN Oxman","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"636","DOI":"10.4049\/jimmunol.142.2.636","article-title":"T lymphocyte cytotoxicity with natural varicella-zoster virus infection and after immunization with live attenuated varicella vaccine","volume":"142","author":"PS Diaz","year":"1989","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/infdis\/166.2.253","article-title":"Immune Response of Elderly Individuals to a Live Attenuated Varicella Vaccine","volume":"166","author":"MJ Levin","year":"1992","journal-title":"J Infect Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/infdis\/170.3.522","article-title":"Immune Responses Of Elderly Persons 4 Years After Receiving A Live Attenuated Varicella Vaccine","volume":"170","author":"MJ Levin","year":"1994","journal-title":"J Infect Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1056\/NEJMoa051016","article-title":"A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults","volume":"352","author":"MN Oxman","year":"2005","journal-title":"New England Journal of Medicine"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1086\/375828","article-title":"Identification of CD8+ T Cell Epitopes in the Immediate Early 62 Protein (IE62) of Varicella-Zoster Virus, and Evaluation of Frequency of CD8+ T Cell Response to IE62, by Use of IE62 Peptides after Varicella Vaccination","volume":"188","author":"CR Frey","year":"2003","journal-title":"J Infect Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1128\/JVI.02528-08","article-title":"Distinct Profiles of Cytotoxic Granules in Memory CD8 T Cells Correlate with Function, Differentiation Stage, and Antigen Exposure","volume":"83","author":"A Harari","year":"2009","journal-title":"J Virol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/COH.0b013e32834ddcf2","article-title":"Acquired transcriptional programming in functional and exhausted virus-specific CD8 T cells","volume":"7","author":"B Youngblood","year":"2011","journal-title":"Curr Opin HIV AIDS"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature05115","article-title":"PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression","volume":"443","author":"CL Day","year":"2006","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0042-6822(89)90244-4","article-title":"A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells","volume":"173","author":"JG Jacobson","year":"1989","journal-title":"Virology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1128\/JVI.68.5.3317-3323.1994","article-title":"Deletion of the varicella-zoster virus large subunit of ribonucleotide reductase impairs growth of virus in vitro","volume":"68","author":"TC Heineman","year":"1994","journal-title":"Journal of Virology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2249.2011.04502.x","article-title":"Immunology in the Clinic Review Series; focus on host responses: T cell responses to herpes simplex viruses","volume":"167","author":"KJ Laing","year":"2012","journal-title":"Clinical & Experimental Immunology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1172\/JCI60556","article-title":"Cross-presentation and genome-wide screening reveal candidate T cells antigens for a herpes simplex virus type 1 vaccine","volume":"122","author":"L Jing","year":"2012","journal-title":"Journal of Clinical Investigation"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.4049\/jimmunol.170.8.4380","article-title":"T Cell Immunity to Herpes Simplex Viruses in Seronegative Subjects: Silent Infection or Acquired Immunity?","volume":"170","author":"CM Posavad","year":"2003","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.semcancer.2008.10.008","article-title":"Epstein-Barr virus evasion of CD8+ and CD4+ T cell immunity via concerted actions of multiple gene products","volume":"18","author":"ME Ressing","year":"2008","journal-title":"Seminars in Cancer Biology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/nm.3103","article-title":"Rapid host immune response and viral dynamics in herpes simplex virus-2 infection","volume":"19","author":"JT Schiffer","year":"2013","journal-title":"Nat Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1084\/jem.188.12.2205","article-title":"Viral immune evasion due to persistence of activated T cells without effector function","volume":"188","author":"AJ Zajac","year":"1998","journal-title":"J Exp Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nature04444","article-title":"Restoring function in exhausted CD8 T cells during chronic viral infection","volume":"439","author":"DL Barber","year":"2006","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"831","DOI":"10.4049\/jimmunol.177.2.831","article-title":"Stimulation History Dictates Memory CD8 T Cell Phenotype: Implications for Prime-Boost Vaccination","volume":"177","author":"D Masopust","year":"2006","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1586\/erv.11.93","article-title":"Molecular studies of the Oka varicella vaccine","volume":"10","author":"M Quinlivan","year":"2011","journal-title":"Expert Review of Vaccines"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/375411a0","article-title":"Herpes simplex virus turns off the TAP to evade host immunity","volume":"375","author":"A Hill","year":"1995","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1084\/jem.20070256","article-title":"A CD8+ T cell immune evasion protein specific to Epstein-Barr virus and its close relatives in Old World primates","volume":"204","author":"AD Hislop","year":"2007","journal-title":"J Exp Med"},{"key":"ref31","first-page":"155","article-title":"Varicella Zoster Virus Immune Evasion Strategies","volume":"342","author":"A Abendroth","year":"2010","journal-title":"Curr Top Microbiol Immunol"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1004008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T11:33:09Z","timestamp":1689075189000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1004008"}},"subtitle":[],"editor":[{"given":"Frank","family":"Carbone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,27]]},"references-count":31,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1004008","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,27]]}}}