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activation","volume":"22","author":"JM Curtsinger","year":"2010","journal-title":"Current Opinion in Immunology"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1002\/adma.201200446","article-title":"Engineering nano- and microparticles to tune immunity","volume":"24","author":"JJ Moon","year":"2012","journal-title":"Advanced materials"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.chom.2011.07.009","article-title":"A critical role for SOCS3 in innate resistance to Toxoplasma gondii","volume":"10","author":"RJ Whitmarsh","year":"2011","journal-title":"Cell Host Microbe"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.1128\/IAI.72.12.7240-7246.2004","article-title":"Development of a system to study CD4+-T-cell responses to transgenic ovalbumin-expressing Toxoplasma gondii during toxoplasmosis","volume":"72","author":"M Pepper","year":"2004","journal-title":"Infect Immun"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0378-1119(95)00548-K","article-title":"Stable DNA transformation of Toxoplasma gondii using phleomycin selection","volume":"165","author":"M Messina","year":"1995","journal-title":"Gene"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1016\/S0264-410X(99)00050-X","article-title":"Immunization with heat-killed Toxoplasma gondii stimulates an early IFN-gamma response and induces protection against virulent murine malaria","volume":"17","author":"A Haque","year":"1999","journal-title":"Vaccine"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.4049\/jimmunol.172.6.3686","article-title":"Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype","volume":"172","author":"PM Robben","year":"2004","journal-title":"Journal of immunology"},{"key":"ref88","first-page":"303","article-title":"Generation of macrophage cell line from fresh bone marrow cells with a myc\/raf recombinant retrovirus","volume":"10","author":"E Blasi","year":"1989","journal-title":"Cancer biochemistry biophysics"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"7747","DOI":"10.1158\/0008-5472.CAN-08-3289","article-title":"Tumor vaccines expressing flt3 ligand synergize with ctla-4 blockade to reject preimplanted tumors","volume":"69","author":"MA Curran","year":"2009","journal-title":"Cancer research"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-1-4757-9966-8_6","article-title":"Dramatic numerical increase of functionally mature dendritic cells in FLT3 ligand-treated mice","volume":"417","author":"E Maraskovsky","year":"1997","journal-title":"Advances in experimental medicine and biology"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.chom.2010.11.005","article-title":"Phosphorylation of immunity-related GTPases by a Toxoplasma 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