{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:03:18Z","timestamp":1787022198183,"version":"build-2736575974"},"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T00:00:00Z","timestamp":1404345600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1004245","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T14:13:45Z","timestamp":1404396825000},"page":"e1004245","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Structure of the Trehalose-6-phosphate Phosphatase from Brugia malayi Reveals Key Design Principles for Anthelmintic Drugs"],"prefix":"10.1371","volume":"10","author":[{"given":"Jeremiah D.","family":"Farelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan D.","family":"Galvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiru","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunliang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Aono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Garland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia E.","family":"Hallett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas B.","family":"Causey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alana","family":"Ali-Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Saltzberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clotilde K. S.","family":"Carlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Dunaway-Mariano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen N.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,7,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"D720","DOI":"10.1093\/nar\/gkr1194","article-title":"Nematode.net update 2011: addition of data sets and tools featuring next-generation sequencing data","volume":"40","author":"J Martin","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e317","DOI":"10.1371\/journal.pntd.0000317","article-title":"The global programme to eliminate lymphatic filariasis: health impact after 8 years","volume":"2","author":"Ea Ottesen","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"ref3","unstructured":"WHO (2009) World Health Organization Global Program to Eliminate Lymphatic Filariasis. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/lymphatic_filariasis\/disease\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/lymphatic_filariasis\/disease\/en\/<\/ext-link>. Accessed 2 June 2014."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1517\/14656566.6.2.179","article-title":"Treatment strategies underpinning the global programme to eliminate lymphatic filariasis","volume":"6","author":"JO Gyapong","year":"2005","journal-title":"Expert Opin Pharmacother"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"546","DOI":"10.4269\/ajtmh.2008.78.546","article-title":"Encephalopathy after Ivermectin Treatment in a Patient Infected with Loa Loa and Plasmodium spp","volume":"78","author":"J Kamgno","year":"2008","journal-title":"Am J Trop Med Hyg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1097\/QCO.0b013e32833fdee5","article-title":"Elimination of lymphatic filariasis: do we have the drugs to complete the job?","volume":"23","author":"MJ Bockarie","year":"2010","journal-title":"Curr Opin Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.vetpar.2005.11.019","article-title":"The detection of anthelmintic resistance in nematodes of veterinary importance","volume":"136","author":"GC Coles","year":"2006","journal-title":"Vet Parasitol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1756-3305-2-S2-S2","article-title":"Anthelmintic resistance in cyathostomin populations from horse yards in Italy, United Kingdom and Germany","volume":"2","author":"D Traversa","year":"2009","journal-title":"Parasit Vectors"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jevs.2009.04.186","article-title":"Drug Resistance in Equine Parasites: An Emerging Global Problem","volume":"29","author":"Ha Brady","year":"2009","journal-title":"J Equine Vet Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1756-3305-2-7","article-title":"Onchocerciasis Control: Vision for the Future from a Ghanian perspective","volume":"2","author":"MJ Taylor","year":"2009","journal-title":"Parasit Vectors"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1126\/science.1145406","article-title":"Draft genome of the filarial nematode parasite Brugia malayi","volume":"(80-) 317","author":"E Ghedin","year":"2007","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ng.2585","article-title":"Genomics of Loa loa, a Wolbachia-free filarial parasite of humans","volume":"45","author":"Ca Desjardins","year":"2013","journal-title":"Nat Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature10553","article-title":"Ascaris suum draft genome","volume":"479","author":"AR Jex","year":"2011","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ng.769","article-title":"The draft genome of the parasitic nematode Trichinella spiralis","volume":"43","author":"M Mitreva","year":"2011","journal-title":"Nat Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"14802","DOI":"10.1073\/pnas.0805946105","article-title":"Sequence and genetic map of Meloidogyne hapla: A compact nematode genome for plant parasitism","volume":"105","author":"CH Opperman","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/ng.227","article-title":"The Pristionchus pacificus genome provides a unique perspective on nematode lifestyle and parasitism","volume":"40","author":"C Dieterich","year":"2008","journal-title":"Nat Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1126\/science.282.5396.2012","article-title":"Genome Sequence of the Nematode C. elegans: A Platform for Investigating Biology","volume":"282","year":"1998","journal-title":"Science"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/gb-2003-4-12-238","article-title":"The draft genome sequence of the nematode Caenorhabditis briggsae, a companion to C. elegans","volume":"4","author":"BP Gupta","year":"2003","journal-title":"Genome Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"969","DOI":"10.2307\/3277515","article-title":"Development of Subperiodic Brugia malayi in the Jird, meriones unguiculatus, with notes on infections in other rodents","volume":"56","author":"LR Ash","year":"1970","journal-title":"J Parasitol"},{"key":"ref20","first-page":"179","article-title":"In vitro cultivation of Brugia malayi, a parasitic nematode that causes human lymphatic filariasis","volume":"12","author":"FH Falcone","year":"1995","journal-title":"ALTEX"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0166-6851(03)00092-6","article-title":"Use of RNA interference to investigate gene function in the human filarial nematode parasite Brugia malayi","volume":"129","author":"AA Aboobaker","year":"2003","journal-title":"Mol Biochem Parasitol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.molbiopara.2004.08.003","article-title":"RNA interference targeting cathepsin L and Z-like cysteine proteases of Onchocerca volvulus confirmed their essential function during L3 molting","volume":"138","author":"S Lustigman","year":"2004","journal-title":"Mol Biochem Parasitol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ijpara.2006.01.010","article-title":"RNAi mediated silencing of actin expression in adult Litomosoides sigmodontis is specific, persistent and results in a phenotype","volume":"36","author":"K Pfarr","year":"2006","journal-title":"Int J Parasitol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e1189","DOI":"10.1371\/journal.pone.0001189","article-title":"Mining predicted essential genes of Brugia malayi for nematode drug targets","volume":"2","author":"S Kumar","year":"2007","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/S0020-7519(03)00173-5","article-title":"Trehalose metabolism genes in Caenorhabditis elegans and filarial nematodes","volume":"33","author":"F Pellerone","year":"2003","journal-title":"Int J Parasitol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0020-7519(96)00151-8","article-title":"The Role of Trehalose in the Physiology of Nematodes","volume":"27","author":"C Behm","year":"1997","journal-title":"Int J Parasitol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"17R","DOI":"10.1093\/glycob\/cwg047","article-title":"New insights on trehalose: a multifunctional molecule","volume":"13","author":"AD Elbein","year":"2003","journal-title":"Glycobiology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ydbio.2005.08.027","article-title":"The C. elegans lethal gut-obstructed gob-1 gene is trehalose-6-phosphate phosphatase","volume":"287","author":"JD Kormish","year":"2005","journal-title":"Dev Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1110\/ps.062096606","article-title":"Crystal structure of trehalose-6-phosphate phosphatase \u2013 related protein: Biochemical and biological implications","volume":"15","author":"K Rao","year":"2006","journal-title":"Protein Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nature06171","article-title":"Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4","volume":"449","author":"T Obita","year":"2007","journal-title":"Nature"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1126\/science.1165322","article-title":"A Role for the ESCRT System in Cell Division in Archaea","volume":"322","author":"RY Samson","year":"2008","journal-title":"Science"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"R116","DOI":"10.1016\/j.cub.2012.01.028","article-title":"The ESCRT machinery","volume":"22","author":"O Schmidt","year":"2012","journal-title":"Curr Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"43899","DOI":"10.1074\/jbc.M112.390724","article-title":"Structural basis of molecular recognition between ESCRT-III-like protein Vps60 and AAA-ATPase regulator Vta1 in the multivesicular body pathway","volume":"287","author":"Z Yang","year":"2012","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/bies.201100191","article-title":"Moonlighting is mainstream: paradigm adjustment required","volume":"34","author":"SD Copley","year":"2012","journal-title":"BioEssays"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.sbi.2009.09.008","article-title":"Markers of fitness in a successful enzyme superfamily","volume":"19","author":"KN Allen","year":"2009","journal-title":"Curr Opin Struct Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nprot.2009.2","article-title":"Protein structure prediction on the Web: a case study using the Phyre server","volume":"4","author":"La Kelley","year":"2009","journal-title":"Nat Protoc"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1073\/pnas.0710800105","article-title":"The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state","volume":"105","author":"Z Lu","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1126\/science.1082710","article-title":"The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction","volume":"299","author":"SD Lahiri","year":"2003","journal-title":"Science"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.1021\/bi400659k","article-title":"Structural Basis for the Divergence of Substrate Speci fi city and Biological Function within HAD Phosphatases in Lipopolysaccharide and Sialic Acid Biosynthesis","volume":"52","author":"KD Daughtry","year":"2013","journal-title":"Biochemistry"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1021\/bi902019q","article-title":"Structural determinants of substrate recognition in the HAD superfamily member D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB)","volume":"49","author":"HH Nguyen","year":"2010","journal-title":"Biochemistry"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/bioinformatics\/btp036","article-title":"Fragment-based identification of druggable \u201chot spots\u201d of proteins using Fourier domain correlation techniques","volume":"25","author":"R Brenke","year":"2009","journal-title":"Bioinformatics"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"13528","DOI":"10.1073\/pnas.1101835108","article-title":"Structural conservation of druggable hot spots in protein-protein interfaces","volume":"108","author":"D Kozakov","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/jcc.20289","article-title":"Scalable Molecular Dynamics with NAMD","volume":"26","author":"JC Phillips","year":"2008","journal-title":"J Comput Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/bioinformatics\/btg137","article-title":"The DynDom database of protein domain motions","volume":"19","author":"Ra Lee","year":"2003","journal-title":"Bioinformatics"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1093\/bioinformatics\/bti420","article-title":"A comprehensive and non-redundant database of protein domain movements","volume":"21","author":"G Qi","year":"2005","journal-title":"Bioinformatics"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0081224","article-title":"Classification of Domain Movements in Proteins Using Dynamic Contact Graphs","volume":"8","author":"D Taylor","year":"2013","journal-title":"PLoS One"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"W545","DOI":"10.1093\/nar\/gkq366","article-title":"Dali server: conservation mapping in 3D","volume":"38","author":"L Holm","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1105\/tpc.105.031229","article-title":"The Structure of a Cyanobacterial Sucrose-Phosphatase Reveals the Sugar Tongs That Release Free Sucrose in the Cell","volume":"17","author":"S Fieulaine","year":"2005","journal-title":"Plant Cell"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1104\/pp.010898","article-title":"Evolution of Sucrose Synthesis [w]","volume":"128","author":"JE Lunn","year":"2002","journal-title":"Plant Physiol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1023\/A:1006130802706","article-title":"Cloning and expression of a prokaryotic sucrose-phosphate synthase gene from the cyanobacterium Synechocystis sp. PCC 6803","volume":"40","author":"JE Lunn","year":"1999","journal-title":"Plant Mol Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1111\/febs.12481","article-title":"Viewing serine\/threonine protein phosphatases through the eyes of drug designers","volume":"280","author":"M Zhang","year":"2013","journal-title":"FEBS J"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1126\/science.1095920","article-title":"Protein kinase inhibitors: insights into drug design from structure","volume":"303","author":"MEM Noble","year":"2004","journal-title":"Science"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.2174\/138161212800672697","article-title":"Recent advances in designing substrate-competitive protein kinase inhibitors","volume":"18","author":"K-C Han","year":"2012","journal-title":"Curr Pharm Des"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"9361","DOI":"10.1073\/pnas.1105687108","article-title":"Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognition","volume":"108","author":"V Chaptal","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1042\/BJ20040892","article-title":"Carbohydrate-binding modules: fine-tuning polysaccharide recognition","volume":"382","author":"AB Boraston","year":"2004","journal-title":"Biochem J"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jmb.2009.06.074","article-title":"Structural insights into antibody recognition of mycobacterial polysaccharides","volume":"392","author":"T Murase","year":"2009","journal-title":"J Mol Biol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1021\/ar300024d","article-title":"Carbohydrate-aromatic interactions","volume":"46","author":"JL Asensio","year":"2013","journal-title":"Acc Chem Res"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/jmbi.2000.4042","article-title":"T-Coffee: A novel method for fast and accurate multiple sequence alignment","author":"C Notredame","year":"2000","journal-title":"J Mol Biol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1093\/nar\/gkg556","article-title":"ESPript\/ENDscript: extracting and rendering sequence and 3D information from atomic structures of proteins","volume":"31","author":"P Gouet","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0168-1656(94)00143-Z","article-title":"Simple fed-batch technique for high cell density cultivation of Escherichia coli","volume":"39","author":"U Rinas","year":"1995","journal-title":"J Biotechnol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1107\/S0907444906019949","article-title":"HKL-3000: the integration of data reduction and structure solution\u2013from diffraction images to an initial model in minutes","volume":"62","author":"W Minor","year":"2006","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"PD Adams","year":"2010","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"P Emsley","year":"2004","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1107\/S0907444909042073","article-title":"MolProbity: all-atom structure validation for macromolecular crystallography","volume":"66","author":"VB Chen","year":"2010","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1107\/S0907444904026460","article-title":"Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions","volume":"60","author":"E Krissinel","year":"2004","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0091-679X(08)61384-9","article-title":"Genetic mapping with polymorphic sequence-tagged sites","volume":"48","author":"BD Williams","year":"1995","journal-title":"Methods Cell Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0378-1119(00)00579-5","article-title":"Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans","volume":"263","author":"L Timmons","year":"2001","journal-title":"Gene"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2013a visualization system for exploratory research and analysis","volume":"25","author":"EF Pettersen","year":"2004","journal-title":"J Comput Chem"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/jcc.21287","article-title":"CHARMM: The Biomolecular Simulation Program","volume":"30","author":"BR Brooks","year":"2009","journal-title":"J Comput Chem"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1021\/jp984440c","article-title":"Development of a Generalized Born Model Parametrization for Proteins and Nucleic Acids","volume":"103","author":"BN Dominy","year":"1999","journal-title":"J Phys Chem B"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1004245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T07:21:52Z","timestamp":1565594512000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1004245"}},"subtitle":[],"editor":[{"given":"David L.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,3]]},"references-count":70,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1004245","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,3]]}}}