{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:11:27Z","timestamp":1790363487308,"version":"4.1.0"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T00:00:00Z","timestamp":1409184000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1004327","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T18:26:27Z","timestamp":1409250387000},"page":"e1004327","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":60,"title":["Neutrophil Elastase Causes Tissue Damage That Decreases Host Tolerance to Lung Infection with Burkholderia Species"],"prefix":"10.1371","volume":"10","author":[{"given":"Manoranjan","family":"Sahoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"del Barrio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,8,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2010.02.029","article-title":"Nonresolving inflammation","volume":"140","author":"C Nathan","year":"2010","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nri2432","article-title":"Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases","volume":"8","author":"DS Schneider","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1126\/science.1214935","article-title":"Disease tolerance as a defense strategy","volume":"335","author":"R Medzhitov","year":"2012","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.chom.2013.10.013","article-title":"Inflammasome-microbiota interplay in host physiologies","volume":"14","author":"JS Ayres","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrmicro1385","article-title":"Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei","volume":"4","author":"WJ Wiersinga","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e1002452","DOI":"10.1371\/journal.ppat.1002452","article-title":"Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1beta is deleterious","volume":"7","author":"I Ceballos-Olvera","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e2500","DOI":"10.1371\/journal.pntd.0002500","article-title":"Glyburide reduces bacterial dissemination in a mouse model of melioidosis","volume":"7","author":"GC Koh","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1038\/srep03363","article-title":"Glibenclamide reduces pro-inflammatory cytokine production by neutrophils of diabetes patients in response to bacterial infection","volume":"3","author":"C Kewcharoenwong","year":"2013","journal-title":"Sci Rep"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1128\/IAI.00626-08","article-title":"Burkholderia thailandensis as a model system for the study of the virulence-associated type III secretion system of Burkholderia pseudomallei","volume":"76","author":"A Haraga","year":"2008","journal-title":"Infect Immun"},{"issue":"Pt 1","key":"ref10","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1099\/00207713-48-1-317","article-title":"Burkholderia thailandensis sp. nov., a Burkholderia pseudomallei-like species","volume":"48","author":"PJ Brett","year":"1998","journal-title":"Int J Syst Bacteriol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1128\/IAI.00080-07","article-title":"Endogenous interleukin-18 improves the early antimicrobial host response in severe melioidosis","volume":"75","author":"WJ Wiersinga","year":"2007","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-2172-12-20","article-title":"Distinct roles for nitric oxide in resistant C57BL\/6 and susceptible BALB\/c mice to control Burkholderia pseudomallei infection","volume":"12","author":"K Breitbach","year":"2011","journal-title":"BMC Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"6300","DOI":"10.1128\/IAI.00966-06","article-title":"Role of inducible nitric oxide synthase and NADPH oxidase in early control of Burkholderia pseudomallei infection in mice","volume":"74","author":"K Breitbach","year":"2006","journal-title":"Infect Immun"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1128\/IAI.65.10.4108-4113.1997","article-title":"Role of reactive nitrogen and oxygen intermediates in gamma interferon-stimulated murine macrophage bactericidal activity against Burkholderia pseudomallei","volume":"65","author":"K Miyagi","year":"1997","journal-title":"Infect Immun"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1128\/IAI.01169-09","article-title":"Importance of CXC chemokine receptor 2 in alveolar neutrophil and exudate macrophage recruitment in response to pneumococcal lung infection","volume":"78","author":"W Herbold","year":"2010","journal-title":"Infect Immun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.4049\/jimmunol.0900600","article-title":"CXCR2-dependent mucosal neutrophil influx protects against colitis-associated diarrhea caused by an attaching\/effacing lesion-forming bacterial pathogen","volume":"183","author":"ME Spehlmann","year":"2009","journal-title":"J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"6503","DOI":"10.4049\/jimmunol.167.11.6503","article-title":"CXCR2 deficiency confers impaired neutrophil recruitment and increased susceptibility during Toxoplasma gondii infection","volume":"167","author":"L Del Rio","year":"2001","journal-title":"J Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1128\/IAI.00503-08","article-title":"Human polymorphonuclear neutrophil responses to Burkholderia pseudomallei in healthy and diabetic subjects","volume":"77","author":"S Chanchamroen","year":"2009","journal-title":"Infect Immun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1128\/IAI.64.12.4952-4959.1996","article-title":"Burkholderia pseudomallei activates complement and is ingested but not killed by polymorphonuclear leukocytes","volume":"64","author":"AM Egan","year":"1996","journal-title":"Infect Immun"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e2363","DOI":"10.1371\/journal.pntd.0002363","article-title":"Induction of mouse melioidosis with meningitis by CD11b+ phagocytic cells harboring intracellular B. pseudomallei as a Trojan horse","volume":"7","author":"PJ Liu","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1086\/509810","article-title":"A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei","volume":"195","author":"A Easton","year":"2007","journal-title":"J Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6261","DOI":"10.1073\/pnas.96.11.6261","article-title":"Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3","volume":"96","author":"C Coeshott","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.cell.2007.07.009","article-title":"NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta","volume":"130","author":"FR Greten","year":"2007","journal-title":"Cell"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1002\/art.24959","article-title":"Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation","volume":"60","author":"M Guma","year":"2009","journal-title":"Arthritis Rheum"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0925-4439(98)00073-8","article-title":"Structure, biologic properties, and expression of surfactant protein D (SP-D)","volume":"1408","author":"EC Crouch","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1006\/taap.2000.9000","article-title":"A characterization of amiodarone-induced pulmonary toxicity in F344 rats and identification of surfactant protein-D as a potential biomarker for the development of the toxicity","volume":"167","author":"MD Taylor","year":"2000","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1159\/000050556","article-title":"KL-6, surfactant protein A and D in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis","volume":"68","author":"R Kunitake","year":"2001","journal-title":"Respiration"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1084\/jem.20120260","article-title":"Innate Stat3-mediated induction of the antimicrobial protein Reg3gamma is required for host defense against MRSA pneumonia","volume":"210","author":"SM Choi","year":"2013","journal-title":"J Exp Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1126\/science.1148526","article-title":"Disentangling genetic variation for resistance and tolerance to infectious diseases in animals","volume":"318","author":"L Raberg","year":"2007","journal-title":"Science"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.cell.2011.03.049","article-title":"Sickle hemoglobin confers tolerance to Plasmodium infection","volume":"145","author":"A Ferreira","year":"2011","journal-title":"Cell"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1126\/science.1233632","article-title":"Role of tissue protection in lethal respiratory viral-bacterial coinfection","volume":"340","author":"AM Jamieson","year":"2013","journal-title":"Science"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.chom.2012.05.017","article-title":"Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responses","volume":"12","author":"CS Dela Cruz","year":"2012","journal-title":"Cell Host Microbe"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S1286-4579(02)01654-4","article-title":"Neutrophil elastase-mediated killing of bacteria: lessons from targeted mutagenesis","volume":"4","author":"A Belaaouaj","year":"2002","journal-title":"Microbes Infect"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/417091a","article-title":"Neutrophil elastase targets virulence factors of enterobacteria","volume":"417","author":"Y Weinrauch","year":"2002","journal-title":"Nature"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00109-010-0677-3","article-title":"Tailor-made inflammation: how neutrophil serine proteases modulate the inflammatory response","volume":"89","author":"K Kessenbrock","year":"2011","journal-title":"J Mol Med (Berl)"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nri1841","article-title":"Neutrophil serine proteases: specific regulators of inflammation","volume":"6","author":"CT Pham","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"V Brinkmann","year":"2004","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1083\/jcb.201203170","article-title":"Neutrophil extracellular traps: is immunity the second function of chromatin","volume":"198","author":"V Brinkmann","year":"2012","journal-title":"J Cell Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.4049\/jimmunol.1002471","article-title":"Neutrophil elastase mediates pathogenic effects of anthrax lethal toxin in the murine intestinal tract","volume":"185","author":"H Fang","year":"2010","journal-title":"J Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e28149","DOI":"10.1371\/journal.pone.0028149","article-title":"Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense","volume":"6","author":"RR Vethanayagam","year":"2011","journal-title":"PLoS One"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"S195","DOI":"10.1097\/01.CCM.0000057843.47705.E8","article-title":"Neutrophils and acute lung injury","volume":"31","author":"E Abraham","year":"2003","journal-title":"Crit Care Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1165\/rcmb.2008-0348TR","article-title":"Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury","volume":"40","author":"RL Zemans","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/01.moh.0000190113.31027.d5","article-title":"Neutrophil granule contents in the pathogenesis of lung injury","volume":"13","author":"TJ Moraes","year":"2006","journal-title":"Curr Opin Hematol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2119\/molmed.2010.00138","article-title":"Contribution of neutrophils to acute lung injury","volume":"17","author":"J Grommes","year":"2011","journal-title":"Mol Med"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e64689","DOI":"10.1371\/journal.pone.0064689","article-title":"Human neutrophil elastase degrades SPLUNC1 and impairs airway epithelial defense against bacteria","volume":"8","author":"D Jiang","year":"2013","journal-title":"PLoS One"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1128\/IAI.01252-10","article-title":"Serine proteases degrade airway mucins in cystic fibrosis","volume":"79","author":"MO Henke","year":"2011","journal-title":"Infect Immun"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00408-003-1008-z","article-title":"Proteolysis of surfactant protein D by cystic fibrosis relevant proteases","volume":"181","author":"C von Bredow","year":"2003","journal-title":"Lung"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"33224","DOI":"10.1074\/jbc.273.50.33224","article-title":"A novel mechanism for bradykinin production at inflammatory sites. Diverse effects of a mixture of neutrophil elastase and mast cell tryptase versus tissue and plasma kallikreins on native and oxidized kininogens","volume":"273","author":"A Kozik","year":"1998","journal-title":"J Biol Chem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1348-0421.1996.tb01088.x","article-title":"Bradykinin generation triggered by Pseudomonas proteases facilitates invasion of the systemic circulation by Pseudomonas aeruginosa","volume":"40","author":"Y Sakata","year":"1996","journal-title":"Microbiol Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00109-009-0564-y","article-title":"Contact system activation in severe infectious diseases","volume":"88","author":"S Oehmcke","year":"2010","journal-title":"J Mol Med (Berl)"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1165\/rcmb.2003-0253OC","article-title":"Deficiency in neutrophil elastase does not impair neutrophil recruitment to inflamed sites","volume":"30","author":"TO Hirche","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/ni.1960","article-title":"Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria","volume":"11","author":"EA Miao","year":"2010","journal-title":"Nat Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/nm1140","article-title":"Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis","volume":"10","author":"T Wang","year":"2004","journal-title":"Nat Med"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1371\/journal.ppat.0020053","article-title":"Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia","volume":"2","author":"R Le Goffic","year":"2006","journal-title":"PLoS Pathog"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1128\/MMBR.57.4.823-837.1993","article-title":"Bacterial extracellular zinc-containing metalloproteases","volume":"57","author":"CC Hase","year":"1993","journal-title":"Microbiol Rev"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1042\/BST0391450","article-title":"Therapeutic potential of human elafin","volume":"39","author":"L Shaw","year":"2011","journal-title":"Biochem Soc Trans"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"158ra144","DOI":"10.1126\/scitranslmed.3004212","article-title":"Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis","volume":"4","author":"JP Motta","year":"2012","journal-title":"Sci Transl Med"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2210-2-1","article-title":"In vivo models of lung neutrophil activation. Comparison of mice and hamsters","volume":"2","author":"R Corteling","year":"2002","journal-title":"BMC Pharmacol"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1004327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T20:57:27Z","timestamp":1598216247000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1004327"}},"subtitle":[],"editor":[{"given":"David","family":"Weiss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,8,28]]},"references-count":58,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,8,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1004327","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,28]]}}}