{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T15:19:16Z","timestamp":1773501556276,"version":"3.50.1"},"reference-count":81,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T00:00:00Z","timestamp":1417651200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1004399","type":"journal-article","created":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T20:21:04Z","timestamp":1417724464000},"page":"e1004399","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Unveiling the Intracellular Survival Gene Kit of Trypanosomatid Parasites"],"prefix":"10.1371","volume":"10","author":[{"given":"Daniella Castanheira","family":"Bartholomeu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita Marcia Cardoso","family":"de Paiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago A. O.","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanderson D.","family":"DaRocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santuza M. R.","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,12,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1051\/parasite\/2008153226","article-title":"Kinetoplastid phylogenetics, with special reference to the evolution of parasitic trypanosomes","volume":"15","author":"JR Stevens","year":"2008","journal-title":"Parasite"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/B978-0-12-385863-4.00010-1","article-title":"The genome and its implications","volume":"75","author":"SM Teixeira","year":"2011","journal-title":"Adv Parasitol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1002\/j.1460-2075.1989.tb08611.x","article-title":"Alpha-amanitin resistant transcription of protein coding genes in insect and bloodstream form Trypanosoma brucei","volume":"8","author":"G Rudenko","year":"1989","journal-title":"Embo J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1101\/gad.8.4.491","article-title":"A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes","volume":"8","author":"KR Matthews","year":"1994","journal-title":"Genes Dev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1101\/gad.7.6.996","article-title":"Coupling of poly(A) site selection and trans-splicing in Leishmania","volume":"7","author":"JH LeBowitz","year":"1993","journal-title":"Genes Dev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4161\/rna.7.2.11393","article-title":"RNA editing in kinetoplastids","volume":"7","author":"S Hajduk","year":"2010","journal-title":"RNA Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.ijpara.2007.05.015","article-title":"Comparative genomics: from genotype to disease phenotype in the leishmaniases","volume":"37","author":"DF Smith","year":"2007","journal-title":"Int J Parasitol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1146\/annurev.mi.27.100173.002023","article-title":"Biology of Trypanosoma cruzi","volume":"27","author":"Z Brener","year":"1973","journal-title":"Annu Rev Microbiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1574-6976.2012.00333.x","article-title":"Host cell invasion by Trypanosoma cruzi: a unique strategy that promotes persistence","volume":"36","author":"MC Fernandes","year":"2012","journal-title":"FEMS Microbiol Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.pt.2012.05.002","article-title":"Receptor-mediated phagocytosis of Leishmania: implications for intracellular survival","volume":"28","author":"N Ueno","year":"2012","journal-title":"Trends Parasitol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.mib.2007.09.014","article-title":"The cell biology of Trypanosoma brucei differentiation","volume":"10","author":"K Fenn","year":"2007","journal-title":"Curr Opin Microbiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.mib.2010.08.009","article-title":"Molecular mechanisms underlying the control of antigenic variation in African trypanosomes","volume":"13","author":"D Horn","year":"2010","journal-title":"Curr Opin Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1126\/science.1112642","article-title":"The genome of the African trypanosome Trypanosoma brucei","volume":"309","author":"M Berriman","year":"2005","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.1112631","article-title":"The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease","volume":"309","author":"NM El-Sayed","year":"2005","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1126\/science.1112680","article-title":"The genome of the kinetoplastid parasite, Leishmania major","volume":"309","author":"AC Ivens","year":"2005","journal-title":"Science"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/1471-2164-10-255","article-title":"Chromosome level assembly of the hybrid Trypanosoma cruzi genome","volume":"10","author":"DB Weatherly","year":"2009","journal-title":"BMC Genomics"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1126\/science.1112181","article-title":"Comparative genomics of trypanosomatid parasitic protozoa","volume":"309","author":"NM El-Sayed","year":"2005","journal-title":"Science"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"14687","DOI":"10.1073\/pnas.95.25.14687","article-title":"Double-stranded RNA induces mRNA degradation in Trypanosoma brucei","volume":"95","author":"H Ngo","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e1001161","DOI":"10.1371\/journal.ppat.1001161","article-title":"Retention and loss of RNA interference pathways in trypanosomatid protozoans","volume":"6","author":"LF Lye","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1128\/EC.05114-11","article-title":"RNA interference in protozoan parasites: achievements and challenges","volume":"10","author":"NG Kolev","year":"2011","journal-title":"Eukaryot Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.molbiopara.2003.10.005","article-title":"Tests of cytoplasmic RNA interference (RNAi) and construction of a tetracycline-inducible T7 promoter system in Trypanosoma cruzi","volume":"133","author":"WD DaRocha","year":"2004","journal-title":"Mol Biochem Parasitol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/1469-0691.12095","article-title":"The therapeutic potential of immune cross-talk in leishmaniasis","volume":"19","author":"MA Hartley","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S1415-47572012005000008","article-title":"Trypanosomatid comparative genomics: Contributions to the study of parasite biology and different parasitic diseases","volume":"35","author":"SM Teixeira","year":"2012","journal-title":"Genet Mol Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.pt.2014.05.001","article-title":"Determinants of disease phenotype in trypanosomatid parasites","volume":"30","author":"LI McCall","year":"2014","journal-title":"Trends Parasitol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.4049\/jimmunol.172.8.4902","article-title":"A leucine-rich repeat motif of Leishmania parasite surface antigen 2 binds to macrophages through the complement receptor 3","volume":"172","author":"L Kedzierski","year":"2004","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.molbiopara.2004.05.004","article-title":"Genetic complementation of Leishmania deficient in PSA (GP46) restores their resistance to lysis by complement","volume":"137","author":"LM Lincoln","year":"2004","journal-title":"Mol Biochem Parasitol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s004300100076","article-title":"Leishmania infection and virulence","volume":"190","author":"G Matlashewski","year":"2001","journal-title":"Med Microbiol Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0166-6851(99)00236-4","article-title":"Analysis of antisense and double stranded RNA downregulation of A2 protein expression in Leishmania donovani","volume":"107","author":"WW Zhang","year":"2000","journal-title":"Mol Biochem Parasitol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"35508","DOI":"10.1074\/jbc.M305030200","article-title":"Comparison of the A2 gene locus in Leishmania donovani and Leishmania major and its control over cutaneous infection","volume":"278","author":"WW Zhang","year":"2003","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00436-011-2325-4","article-title":"Effect of A2 gene on infectivity of the nonpathogenic parasite Leishmania tarentolae","volume":"109","author":"A Mizbani","year":"2011","journal-title":"Parasitol Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"20509","DOI":"10.1016\/S0021-9258(17)32022-7","article-title":"A differentially expressed gene family encoding \u201camastin,\u201d a surface protein of Trypanosoma cruzi amastigotes","volume":"269","author":"SM Teixeira","year":"1994","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.molbiopara.2005.01.006","article-title":"Characterization and developmental gene regulation of a large gene family encoding amastin surface proteins in Leishmania spp","volume":"140","author":"A Rochette","year":"2005","journal-title":"Mol Biochem Parasitol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/molbev\/msp214","article-title":"The evolution of amastin surface glycoproteins in trypanosomatid parasites","volume":"27","author":"AP Jackson","year":"2010","journal-title":"Mol Biol Evol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e60209","DOI":"10.1371\/journal.pone.0060209","article-title":"Predicting the proteins of Angomonas deanei, Strigomonas culicis and their respective endosymbionts reveals new aspects of the trypanosomatidae family","volume":"8","author":"MC Motta","year":"2013","journal-title":"PLoS ONE"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e51804","DOI":"10.1371\/journal.pone.0051804","article-title":"Trypanosoma cruzi: role of delta-amastin on extracellular amastigote cell invasion and differentiation","volume":"7","author":"MC Cruz","year":"2012","journal-title":"PLoS ONE"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1111\/j.1462-5822.2012.01831.x","article-title":"T rypanosoma cruzi trans-sialidase as a multifunctional enzyme in Chagas&apos; disease","volume":"14","author":"SS Dc-Rubin","year":"2012","journal-title":"Cell Microbiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1046\/j.1432-1033.2002.02968.x","article-title":"The trans-sialidase from the african trypanosome Trypanosoma brucei","volume":"269","author":"G Montagna","year":"2002","journal-title":"Eur J Biochem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1515\/BC.2003.133","article-title":"Trans-sialidase-like sequences from Trypanosoma congolense conserve most of the critical active site residues found in other trans-sialidases","volume":"384","author":"E Tiralongo","year":"2003","journal-title":"Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jprot.2013.02.011","article-title":"The Trypanosoma rangeli trypomastigote surfaceome reveals novel proteins and targets for specific diagnosis","volume":"82","author":"G Wagner","year":"2013","journal-title":"J Proteomics"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1111\/j.1462-5822.2006.00755.x","article-title":"Expression of trypomastigote trans-sialidase in metacyclic forms of Trypanosoma cruzi increases parasite escape from its parasitophorous vacuole","volume":"8","author":"SS Rubin-de-Celis","year":"2006","journal-title":"Cell Microbiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1590\/S0001-37652006000100010","article-title":"Molecular basis of mammalian cell invasion by Trypanosoma cruzi","volume":"78","author":"N Yoshida","year":"2006","journal-title":"An Acad Bras Cienc"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0166-6851(01)00245-6","article-title":"The mucin-like glycoprotein super-family of Trypanosoma cruzi: structure and biological roles","volume":"114","author":"A Acosta-Serrano","year":"2001","journal-title":"Mol Biochem Parasitol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1093\/nar\/gkp172","article-title":"Genomic organization and expression profile of the mucin-associated surface protein (masp) family of the human pathogen Trypanosoma cruzi","volume":"37","author":"DC Bartholomeu","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e1779","DOI":"10.1371\/journal.pntd.0001779","article-title":"The MASP family of Trypanosoma cruzi: changes in gene expression and antigenic profile during the acute phase of experimental infection","volume":"6","author":"SL dos Santos","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e3176","DOI":"10.1371\/journal.pntd.0003176","article-title":"Genome of the Avirulent Human-infective Trypanosome \u2013 Trypanosoma rangeli","volume":"8","author":"PH Stoco","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/ng2053","article-title":"Comparative genomic analysis of three Leishmania species that cause diverse human disease","volume":"39","author":"CS Peacock","year":"2007","journal-title":"Nat Genet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1101\/gr.122945.111","article-title":"Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania","volume":"21","author":"MB Rogers","year":"2011","journal-title":"Genome Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/dnares\/dst031","article-title":"The Genome Sequence of Leishmania (Leishmania) amazonensis: Functional Annotation and Extended Analysis of Gene Models","volume":"20","author":"F Real","year":"2013","journal-title":"DNA Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1093\/nar\/gkr834","article-title":"Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species","volume":"40","author":"F Raymond","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e984","DOI":"10.1371\/journal.pntd.0000984","article-title":"Shotgun sequencing analysis of Trypanosoma cruzi I Sylvio X10\/1 and comparison with T. cruzi VI CL Brener","volume":"5","author":"O Franzen","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1186\/1471-2164-13-531","article-title":"Comparative genomic analysis of human infective Trypanosoma cruzi lineages with the bat-restricted subspecies T. cruzi marinkellei","volume":"13","author":"O Franzen","year":"2012","journal-title":"BMC Genomics"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1084\/jem.20030635","article-title":"Surface sialic acids taken from the host allow trypanosome survival in tsetse fly vectors","volume":"199","author":"K Nagamune","year":"2004","journal-title":"J Exp Med"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/molbev\/mst001","article-title":"Repeat-enriched proteins are related to host cell invasion and immune evasion in parasitic protozoa","volume":"30","author":"TA Mendes","year":"2013","journal-title":"Mol Biol Evol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s00239-004-2645-4","article-title":"The evolution of amino acid repeat arrays in Plasmodium and other organisms","volume":"59","author":"AL Hughes","year":"2004","journal-title":"J Mol Evol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.micinf.2008.03.005","article-title":"Molecular characterization of ribonucleoproteic antigens containing repeated amino acid sequences from Trypanosoma cruzi","volume":"10","author":"FS Pais","year":"2008","journal-title":"Microbes Infect"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1128\/IAI.01102-09","article-title":"Upregulated expression of B-cell antigen family tandem repeat proteins by Leishmania amastigotes","volume":"78","author":"Y Goto","year":"2010","journal-title":"Infect Immun"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3389\/fimmu.2012.00361","article-title":"Cell signaling during Trypanosoma cruzi invasion","volume":"3","author":"FY Maeda","year":"2012","journal-title":"Front Immunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"e2676","DOI":"10.1371\/journal.pntd.0002676","article-title":"A cytoplasmic new catalytic subunit of Calcineurin in Trypanosoma cruzi and its molecular and functional characterization","volume":"8","author":"PR Orrego","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1128\/AAC.48.8.3033-3042.2004","article-title":"Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity","volume":"48","author":"KM Grant","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"36257","DOI":"10.1074\/jbc.M606256200","article-title":"Identification and characterization of a protein-tyrosine phosphatase in Leishmania: Involvement in virulence","volume":"281","author":"M Nascimento","year":"2006","journal-title":"J Biol Chem"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"40757","DOI":"10.1074\/jbc.M307660200","article-title":"Evidence that intracellular beta1-2 mannan is a virulence factor in Leishmania parasites","volume":"278","author":"JE Ralton","year":"2003","journal-title":"J Biol Chem"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"8168","DOI":"10.1128\/MCB.21.23.8168-8183.2001","article-title":"Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dolicholphosphate-mannose synthase gene deletion mutants","volume":"21","author":"A Garami","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1110289","article-title":"The Trypanosoma cruzi proteome","volume":"309","author":"JA Atwood 3rd","year":"2005","journal-title":"Science"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2307\/3282136","article-title":"Uptake, distribution, and oxidation of fatty acids by Leishmania mexicana amastigotes","volume":"73","author":"JD Berman","year":"1987","journal-title":"J Parasitol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/0092-8674(91)90008-M","article-title":"A novel cell surface trans-sialidase of Trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells","volume":"65","author":"S Schenkman","year":"1991","journal-title":"Cell"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1128\/IAI.61.9.3636-3641.1993","article-title":"Involvement of the stage-specific 82-kilodalton adhesion molecule of Trypanosoma cruzi metacyclic trypomastigotes in host cell invasion","volume":"61","author":"MI Ramirez","year":"1993","journal-title":"Infect Immun"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.yexcr.2006.10.008","article-title":"A conserved domain of the gp85\/trans-sialidase family activates host cell extracellular signal-regulated kinase and facilitates Trypanosoma cruzi infection","volume":"313","author":"MH Magdesian","year":"2007","journal-title":"Exp Cell Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1128\/IAI.57.6.1663-1667.1989","article-title":"Metacyclic neutralizing effect of monoclonal antibody 10D8 directed to the 35- and 50-kilodalton surface glycoconjugates of Trypanosoma cruzi","volume":"57","author":"N Yoshida","year":"1989","journal-title":"Infect Immun"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1128\/IAI.01542-08","article-title":"Trypanosoma cruzi GP63 proteins undergo stage-specific differential posttranslational modification and are important for host cell infection","volume":"77","author":"MM Kulkarni","year":"2009","journal-title":"Infect Immun"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"47078","DOI":"10.1074\/jbc.M106017200","article-title":"Trypanosoma cruzi prolyl oligopeptidase Tc80 is involved in nonphagocytic mammalian cell invasion by trypomastigotes","volume":"276","author":"P Grellier","year":"2001","journal-title":"J Biol Chem"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0166-6851(92)90050-T","article-title":"Inhibitors of the major cysteinyl proteinase (GP57\/51) impair host cell invasion and arrest the intracellular development of Trypanosoma cruzi in vitro","volume":"52","author":"MN Meirelles","year":"1992","journal-title":"Mol Biochem Parasitol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1093\/emboj\/17.17.4975","article-title":"Oligopeptidase B-dependent signaling mediates host cell invasion by Trypanosoma cruzi","volume":"17","author":"EV Caler","year":"1998","journal-title":"Embo j"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.1128\/IAI.69.6.3916-3923.2001","article-title":"LYT1 protein is required for efficient in vitro infection by Trypanosoma cruzi","volume":"69","author":"R Manning-Cela","year":"2001","journal-title":"Infect Immun"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"6627","DOI":"10.1074\/jbc.M110.167247","article-title":"Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity","volume":"286","author":"MN Alvarez","year":"2011","journal-title":"J Biol Chem"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.4049\/jimmunol.155.6.3102","article-title":"Role of the Leishmania surface protease gp63 in complement fixation, cell adhesion, and resistance to complement-mediated lysis","volume":"155","author":"A Brittingham","year":"1995","journal-title":"J Immunol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"9258","DOI":"10.1073\/pnas.160257897","article-title":"Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major","volume":"97","author":"GF Spath","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1099\/mic.0.050252-0","article-title":"Exclusion of synaptotagmin V at the phagocytic cup by Leishmania donovani lipophosphoglycan results in decreased promastigote internalization","volume":"157","author":"AF Vinet","year":"2011","journal-title":"Microbiology"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1084\/jem.20060559","article-title":"A Leishmania amazonensis ZIP family iron transporter is essential for parasite replication within macrophage phagolysosomes","volume":"203","author":"C Huynh","year":"2006","journal-title":"J Exp Med"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1128\/IAI.00687-13","article-title":"Heme uptake mediated by LHR1 is essential for Leishmania amazonensis virulence","volume":"81","author":"DC Miguel","year":"2013","journal-title":"Infect Immun"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"411","DOI":"10.4049\/jimmunol.1002175","article-title":"Leishmania inhibitor of serine peptidase 2 prevents TLR4 activation by neutrophil elastase promoting parasite survival in murine macrophages","volume":"186","author":"MS Faria","year":"2011","journal-title":"J Immunol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1128\/EC.00198-09","article-title":"Overexpression of mitochondrial Leishmania major ascorbate peroxidase enhances tolerance to oxidative stress-induced programmed cell death and protein damage","volume":"8","author":"S Dolai","year":"2009","journal-title":"Eukaryot Cell"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1004399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T13:00:04Z","timestamp":1690722004000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1004399"}},"subtitle":[],"editor":[{"given":"Marc-Jan","family":"Gubbels","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,12,4]]},"references-count":81,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1004399","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,4]]}}}