{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:15:28Z","timestamp":1789607728579,"version":"build-2803163510"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T00:00:00Z","timestamp":1413417600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1004401","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T21:28:29Z","timestamp":1413840509000},"page":"e1004401","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":45,"title":["A Sialic Acid Binding Site in a Human Picornavirus"],"prefix":"10.1371","volume":"10","author":[{"given":"Georg","family":"Zocher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitesh","family":"Mistry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irmgard","family":"H\u00e4hnlein-Schick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens-Ola","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Arnberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Stehle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,10,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1128\/JVI.02470-07","article-title":"Sialic acid is a cellular receptor for coxsackievirus A24 variant, an emerging virus with pandemic potential","volume":"82","author":"EC Nilsson","year":"2008","journal-title":"J Virol"},{"key":"ref2","first-page":"173","article-title":"Acute hemorrhagic conjunctivitis","volume":"45","author":"PW Wright","year":"1992","journal-title":"Am Fam Physician"},{"key":"ref3","volume":"17","unstructured":"Aubry C, Gautret P, Nougairede A, Dussouil AS, Botelho-Nevers E, <etal>et al<\/etal>.. (2012) 2012 outbreak of acute haemorrhagic conjunctivitis in Indian Ocean Islands: identification of Coxsackievirus A24 in a returned traveller. Euro Surveill <volume>17<\/volume>: : pii = 20185."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jcv.2008.07.017","article-title":"Molecular characterization of a coxsackievirus A24 variant that caused an outbreak of acute haemorrhagic conjunctivitis in Spain, 2004","volume":"43","author":"M Cabrerizo","year":"2008","journal-title":"J Clin Virol"},{"key":"ref5","first-page":"511","article-title":"An outbreak of acute haemorrhagic conjunctivitis in Melaka, Malaysia","volume":"44","author":"O Ghazali","year":"2003","journal-title":"Singapore Med J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/eye.2009.8","article-title":"Molecular and immunocytochemical identification of coxsackievirus A-24 variant from the acute haemorrhagic conjunctivitis outbreak in Taiwan in 2007","volume":"24","author":"PC Kuo","year":"2010","journal-title":"Eye (Lond)"},{"key":"ref7","first-page":"29","article-title":"An outbreak of acute hemorrhagic conjunctivitis in Yugoslavia in 1973","volume":"42","author":"M Likar","year":"1975","journal-title":"Pathol Microbiol (Basel)"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1136\/bjo.2006.098822","article-title":"Acute haemorrhagic conjunctivitis outbreak in the city of Fortaleza, northeast Brazil","volume":"90","author":"FE Moura","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1469-0691.2006.01618.x","article-title":"Molecular characterisation of a coxsackievirus A24 that caused an outbreak of acute haemorrhagic conjunctivitis, Tunisia 2003","volume":"13","author":"H Triki","year":"2007","journal-title":"Clin Microbiol Infect"},{"key":"ref10","first-page":"632","article-title":"Recent epidemic of acute haemorrhagic conjunctivitis in Calcutta","volume":"31","author":"BK Baidya","year":"1983","journal-title":"Indian J Ophthalmol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"12665","DOI":"10.1128\/JVI.00837-10","article-title":"Interaction of decay-accelerating factor with echovirus 7","volume":"84","author":"P Plevka","year":"2010","journal-title":"J Virol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"12571","DOI":"10.1128\/JVI.01592-12","article-title":"The crystal structure of a coxsackievirus B3-RD variant and a refined 9-angstrom cryo-electron microscopy reconstruction of the virus complexed with decay-accelerating factor (DAF) provide a new footprint of DAF on the virus surface","volume":"86","author":"JD Yoder","year":"2012","journal-title":"J Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.str.2005.04.011","article-title":"The crystal structure of coxsackievirus A21 and its interaction with ICAM-1","volume":"13","author":"C Xiao","year":"2005","journal-title":"Structure"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nsmb753","article-title":"X-ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein","volume":"11","author":"N Verdaguer","year":"2004","journal-title":"Nat Struct Mol Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/nsb1001-874","article-title":"Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor","volume":"8","author":"Y He","year":"2001","journal-title":"Nat Struct Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1126\/science.1553561","article-title":"Identification of the integrin VLA-2 as a receptor for echovirus 1","volume":"255","author":"JM Bergelson","year":"1992","journal-title":"Science"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1128\/JVI.69.4.2664-2666.1995","article-title":"Antibodies to the vitronectin receptor (integrin alpha V beta 3) inhibit binding and infection of foot-and-mouth disease virus to cultured cells","volume":"69","author":"A Berinstein","year":"1995","journal-title":"J Virol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"7087","DOI":"10.1128\/JVI.79.11.7087-7094.2005","article-title":"Enterovirus 70 binds to different glycoconjugates containing alpha2,3-linked sialic acid on different cell lines","volume":"79","author":"MR Nokhbeh","year":"2005","journal-title":"J Virol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"11283","DOI":"10.1128\/JVI.05597-11","article-title":"Coxsackievirus A24 variant uses sialic acid-containing O-linked glycoconjugates as cellular receptors on human ocular cells","volume":"85","author":"N Mistry","year":"2011","journal-title":"J Virol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/emboj\/18.3.543","article-title":"The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex","volume":"18","author":"EE Fry","year":"1999","journal-title":"EMBO J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1126\/science.1218713","article-title":"Crystal structure of human enterovirus 71","volume":"336","author":"P Plevka","year":"2012","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0966-842X(02)02383-1","article-title":"Picornavirus-receptor interactions","volume":"10","author":"MG Rossmann","year":"2002","journal-title":"Trends Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0968-0004(00)89105-7","article-title":"Dali: a network tool for protein structure comparison","volume":"20","author":"L Holm","year":"1995","journal-title":"Trends Biochem Sci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.sbi.2011.08.009","article-title":"Viruses and sialic acids: rules of engagement","volume":"21","author":"U Neu","year":"2011","journal-title":"Curr Opin Struct Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"9609","DOI":"10.1021\/bi00155a013","article-title":"Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography","volume":"31","author":"NK Sauter","year":"1992","journal-title":"Biochemistry"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1128\/JVI.03070-13","article-title":"Antigenic and receptor binding properties of enterovirus 68","volume":"88","author":"T Imamura","year":"2014","journal-title":"J Virol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0008-6215(91)84084-R","article-title":"Conformational analysis of sialyloligosaccharides","volume":"218","author":"S Sabesan","year":"1991","journal-title":"Carbohydr Res"},{"key":"ref28","first-page":"14587","article-title":"The canyon hypothesis. Hiding the host cell receptor attachment site on a viral surface from immune surveillance","volume":"264","author":"MG Rossmann","year":"1989","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1128\/JVI.74.3.1477-1485.2000","article-title":"Sialylation of the host receptor may modulate entry of demyelinating persistent Theiler&apos;s virus","volume":"74","author":"L Zhou","year":"2000","journal-title":"J Virol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1099\/vir.0.80730-0","article-title":"Structure of Foot-and-mouth disease virus serotype A10 61 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation","volume":"86","author":"EE Fry","year":"2005","journal-title":"J Gen Virol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S1542-0124(12)70213-6","article-title":"Structure and biological roles of mucin-type O-glycans at the ocular surface","volume":"8","author":"A Guzman-Aranguez","year":"2010","journal-title":"Ocul Surf"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nm.2267","article-title":"The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis","volume":"17","author":"EC Nilsson","year":"2011","journal-title":"Nat Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"6519","DOI":"10.1002\/anie.201101559","article-title":"A potent trivalent sialic acid inhibitor of adenovirus type 37 infection of human corneal cells","volume":"50","author":"S Spjut","year":"2011","journal-title":"Angew Chem Int Ed Engl"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/35001095","article-title":"Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands","volume":"403","author":"PI Kitov","year":"2000","journal-title":"Nature"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1167\/iovs.03-0560","article-title":"Characterization of a spontaneously immortalized cell line (IOBA-NHC) from normal human conjunctiva","volume":"44","author":"Y Diebold","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1107\/S0907444909047337","article-title":"Xds","volume":"66","author":"W Kabsch","year":"2010","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1107\/S0907444994003112","article-title":"The CCP4 suite: programs for protein crystallography","volume":"50","year":"1994","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref38","unstructured":"Schrodinger LLC (2010) The PyMOL Molecular Graphics System, Version 1.3r1."},{"key":"ref39","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","article-title":"Refinement of macromolecular structures by the maximum-likelihood method","volume":"53","author":"GN Murshudov","year":"1997","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"PD Adams","year":"2010","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"P Emsley","year":"2010","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1073\/pnas.181342398","article-title":"Electrostatics of nanosystems: application to microtubules and the ribosome","volume":"98","author":"NA Baker","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"8293","DOI":"10.1021\/ja00179a012","article-title":"A molecular mechanics force field (MM3) for alcohols and ethers","volume":"112","author":"NL Allinger","year":"1990","journal-title":"Journal of the American Chemical Society"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B","article-title":"Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function","volume":"19","author":"GM Morris","year":"1998","journal-title":"Journal of Computational Chemistry"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/prot.20251","article-title":"Making optimal use of empirical energy functions: Force-field parameterization in crystal space","volume":"57","author":"E Krieger","year":"2004","journal-title":"Proteins: Structure, Function, and Bioinformatics"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1002\/jcc.10349","article-title":"A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations","volume":"24","author":"Y Duan","year":"2003","journal-title":"Journal of Computational Chemistry"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3832","DOI":"10.1021\/j100011a061","article-title":"Molecular Mechanical and Molecular Dynamic Simulations of Glycoproteins and Oligosaccharides. 1. GLYCAM_93 Parameter Development","volume":"99","author":"RJ Woods","year":"1995","journal-title":"The Journal of Physical Chemistry"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/bioinformatics\/15.4.305","article-title":"ESPript: analysis of multiple sequence alignments in PostScript","volume":"15","author":"P Gouet","year":"1999","journal-title":"Bioinformatics"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1004401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:03:14Z","timestamp":1598400194000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1004401"}},"subtitle":[],"editor":[{"given":"F\u00e9lix A.","family":"Rey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,16]]},"references-count":48,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1004401","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,16]]}}}