{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:57:35Z","timestamp":1791205055568,"version":"4.1.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T00:00:00Z","timestamp":1421884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1004587","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T14:02:30Z","timestamp":1421935350000},"page":"e1004587","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":68,"title":["Dissemination of a Highly Virulent Pathogen: Tracking The Early Events That Define Infection"],"prefix":"10.1371","volume":"11","author":[{"given":"Rodrigo J.","family":"Gonzalez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Chelsea","family":"Lane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikki J.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric H.","family":"Weening","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,1,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0002-9440(10)62360-7","article-title":"Kinetics of disease progression and host response in a rat model of bubonic plague","volume":"166","author":"F Sebbane","year":"2005","journal-title":"Am J Pathol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/1471-2180-12-147","article-title":"Bioluminescence imaging to track bacterial dissemination of <italic>Yersinia pestis<\/italic> using different routes of infection in mice","volume":"12","author":"RJ Gonzalez","year":"2012","journal-title":"BMC Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/0-387-30746-X_14","article-title":"<italic>Yersinia pestis<\/italic> and bubonic plague","volume":"6","author":"R Brubaker","year":"2006","journal-title":"Prokaryotes"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/S0140-6736(07)60566-2","article-title":"Plague","volume":"369","author":"MB Prentice","year":"2007","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.micinf.2005.06.006","article-title":"Molecular and physiological insights into plague transmission, virulence and etiology","volume":"8","author":"D Zhou","year":"2006","journal-title":"Microbes Infect"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1128\/IAI.71.10.5892-5899.2003","article-title":"The ability to replicate in macrophages is conserved between <italic>Yersinia pestis<\/italic> and <italic>Yersinia pseudotuberculosis<\/italic>","volume":"71","author":"C Pujol","year":"2003","journal-title":"Infect Immun"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1042\/bst0310104","article-title":"<italic>Yersinia pestis<\/italic> and plague","volume":"31","author":"RW Titball","year":"2003","journal-title":"Biochem Soc Trans"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1086\/429931","article-title":"Poor vector competence of fleas and the evolution of hypervirulence in <italic>Yersinia pestis<\/italic>","volume":"191","author":"EA Lorange","year":"2005","journal-title":"J Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/0-306-48416-1_13","article-title":"A technique of intradermal injection of <italic>Yersinia<\/italic> to study <italic>Y. pestis<\/italic> physiopathology","volume":"529","author":"F Guinet","year":"2003","journal-title":"Adv Exp Med Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e00170","DOI":"10.1128\/mBio.00170-13","article-title":"<italic>Yersinia pestis<\/italic> subverts the dermal neutrophil response in a mouse model of bubonic plague","volume":"4","author":"JG Shannon","year":"2013","journal-title":"MBio"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"5526","DOI":"10.1073\/pnas.0509544103","article-title":"Role of the <italic>Yersinia pestis<\/italic> plasminogen activator in the incidence of distinct septicemic and bubonic forms of flea-borne plague","volume":"103","author":"F Sebbane","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref12","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00303-11","article-title":"Kinetics of uropathogenic <italic>Escherichia coli<\/italic> metapopulation movement during urinary tract infection","volume":"3","author":"MS Walters","year":"2012","journal-title":"MBio"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"13514","DOI":"10.1073\/pnas.0603456103","article-title":"RovA, a global regulator of <italic>Yersinia pestis<\/italic>, specifically required for bubonic plague","volume":"103","author":"JS Cathelyn","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Spinner JL, Winfree S, Starr T, Shannon JG, Nair V, et al. (2013) <italic>Yersinia pestis<\/italic> survival and replication within human neutrophil phagosomes and uptake of infected neutrophils by macrophages. J Leukoc Biol.","DOI":"10.1189\/jlb.1112551"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1189\/jlb.0407247","article-title":"Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice","volume":"83","author":"JM Daley","year":"2007","journal-title":"J Leukoc Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1128\/IAI.47.1.234-241.1985","article-title":"Survival and growth of <italic>Yersinia pestis<\/italic> within macrophages and an effect of the loss of the 47-megadalton plasmid on growth in macrophages","volume":"47","author":"WT Charnetzky","year":"1985","journal-title":"Infect Immun"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1128\/IAI.00385-08","article-title":"<italic>Yersinia pestis<\/italic> type III secretion system-dependent inhibition of human polymorphonuclear leukocyte function","volume":"76","author":"JL Spinner","year":"2008","journal-title":"Infect Immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1128\/IAI.01246-07","article-title":"Human dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin (CD209) is a receptor for <italic>Yersinia pestis<\/italic> that promotes phagocytosis by dendritic cells","volume":"76","author":"P Zhang","year":"2008","journal-title":"Infect Immun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fimmu.2013.00286","article-title":"Lights, camera, and action: vertebrate skin sets the stage for immune cell interaction with arthropod-vectored pathogens","volume":"4","author":"SZ Chong","year":"2013","journal-title":"Front Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e1000484","DOI":"10.1371\/journal.ppat.1000484","article-title":"Vector transmission of <italic>Leishmania<\/italic> abrogates vaccine-induced protective immunity","volume":"5","author":"NC Peters","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e3196","DOI":"10.1371\/journal.pntd.0003196","article-title":"Evaluation of the murine immune response to <italic>Xenopsylla cheopis<\/italic> flea saliva and its effect on transmission of <italic>Yersinia pestis<\/italic>","volume":"8","author":"CF Bosio","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref22","first-page":"197","article-title":"The evolution of flea-borne transmission in <italic>Yersinia pestis<\/italic>","volume":"7","author":"BJ Hinnebusch","year":"2005","journal-title":"Current issues in molecular biology"},{"key":"ref23","first-page":"2145","article-title":"Intradermal injection, as opposed to subcutaneous injection, enhances immunogenicity and suppresses tumorigenicity of tumor cells","volume":"63","author":"B Bonnotte","year":"2003","journal-title":"Cancer Research"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"811","DOI":"10.4161\/hv.7.8.16274","article-title":"Transcutaneous and intradermal vaccination","volume":"7","author":"B Combadiere","year":"2011","journal-title":"Hum Vaccin"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1128\/IAI.00606-12","article-title":"Kinetics of innate immune response to <italic>Yersinia pestis<\/italic> after intradermal infection in a mouse model","volume":"80","author":"CF Bosio","year":"2012","journal-title":"Infect Immun"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1128\/IAI.06061-11","article-title":"Updating perspectives on the initiation of <italic>Bacillus anthracis<\/italic> growth and dissemination through its host","volume":"80","author":"ZP Weiner","year":"2012","journal-title":"Infect Immun"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1189\/jlb.0605288","article-title":"Migratory monocytes and granulocytes are major lymphatic carriers of <italic>Salmonella<\/italic> from tissue to draining lymph node","volume":"79","author":"M Bonneau","year":"2006","journal-title":"J Leukoc Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/35097083","article-title":"Genome sequence of <italic>Yersinia pestis<\/italic>, the causative agent of plague","volume":"413","author":"J Parkhill","year":"2001","journal-title":"Nature"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nmeth765","article-title":"A Tn7-based broad-range bacterial cloning and expression system","volume":"2","author":"K-H Choi","year":"2005","journal-title":"Nat Methods"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"17786","DOI":"10.1073\/pnas.0506840102","article-title":"Progression of primary pneumonic plague: a mouse model of infection, pathology, and bacterial transcriptional activity","volume":"102","author":"WW Lathem","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e45261","DOI":"10.1371\/journal.pone.0045261","article-title":"Characteristics of multi-organ lymphangiectasia resulting from temporal deletion of calcitonin receptor-like receptor in adult mice","volume":"7","author":"SL Hoopes","year":"2012","journal-title":"PLoS ONE"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1073\/pnas.1112729109","article-title":"Pulmonary infection by <italic>Yersinia pestis<\/italic> rapidly establishes a permissive environment for microbial proliferation","volume":"109","author":"PA Price","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"J Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.immuni.2008.07.012","article-title":"Dynamics of neutrophil migration in lymph nodes during infection","volume":"29","author":"T Chtanova","year":"2008","journal-title":"Immunity"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1004587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T02:52:36Z","timestamp":1598669556000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1004587"}},"subtitle":[],"editor":[{"given":"Raphael H.","family":"Valdivia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,1,22]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1004587","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725321978.793562343","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,22]]}}}