{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:25:24Z","timestamp":1790108724258,"version":"4.0.1"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:00:00Z","timestamp":1424736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1004681","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T18:53:54Z","timestamp":1424804034000},"page":"e1004681","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["The Neurotrophic Receptor Ntrk2 Directs Lymphoid Tissue Neovascularization during Leishmania donovani Infection"],"prefix":"10.1371","volume":"11","author":[{"given":"Jane E.","family":"Dalton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy C.","family":"Glover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Hoodless","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eng-Kiat","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette","family":"Beattie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alun","family":"Kirby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,2,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/nri2588","article-title":"Stromal cell contributions to the homeostasis and functionality of the immune system","volume":"9","author":"SN Mueller","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"ref2","first-page":"653","article-title":"Angiogenesis in health and disease","volume":"9","author":"P Carmeliet","year":"2003","journal-title":"NatMed"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1365-2613.2009.00669.x","article-title":"Angiogenesis drives psoriasis pathogenesis","volume":"90","author":"R Heidenreich","year":"2009","journal-title":"Int J Exp Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1172\/JCI41281","article-title":"Inhibition of receptor tyrosine kinases restores immunocompetence and improves immune-dependent chemotherapy against experimental leishmaniasis in mice","volume":"120","author":"JE Dalton","year":"2010","journal-title":"J Clin Invest"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1172\/JCI45157","article-title":"Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections","volume":"121","author":"M Zeng","year":"2011","journal-title":"J Clin Invest"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e1002437","DOI":"10.1371\/journal.ppat.1002437","article-title":"Lymphoid tissue damage in HIV-1 infection depletes naive T cells and limits T cell reconstitution after antiretroviral therapy","volume":"8","author":"M Zeng","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1128\/IAI.00372-08","article-title":"Alterations of splenic architecture in malaria are induced independently of Toll-like receptors 2, 4, and 9 or MyD88 and may affect antibody affinity","volume":"76","author":"ET Cadman","year":"2008","journal-title":"Infect Immun"},{"key":"ref8","first-page":"1109","article-title":"The involvement of the spleen during chronic phase of Schistosoma mansoni infection in galectin-3-\/- mice","volume":"27","author":"C Brand","year":"2012","journal-title":"Histol Histopathol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/ni.1605","article-title":"Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone","volume":"9","author":"E Scandella","year":"2008","journal-title":"Nat Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1371\/journal.ppat.0020016","article-title":"Specific remodeling of splenic architecture by cytomegalovirus","volume":"2","author":"CA Benedict","year":"2006","journal-title":"PLoS Pathog"},{"key":"ref11","first-page":"429","article-title":"A role for tumor necrosis factor-alpha in remodeling the splenic marginal zone during Leishmania donovani infection","volume":"161","author":"CR Engwerda","year":"2002","journal-title":"AmJPathol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/S0035-9203(01)90218-4","article-title":"Leishmaniasis in Sudan. Visceral leishmaniasis","volume":"95","author":"EE Zijlstra","year":"2001","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref13","first-page":"239","article-title":"The immunopathology of experimental visceral leishmaniasis","volume":"201","author":"PM Kaye","year":"2004","journal-title":"ImmunolRev"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ajpath.2011.03.009","article-title":"Compartment-specific remodeling of splenic micro-architecture during experimental visceral leishmaniasis","volume":"179","author":"P Yurdakul","year":"2011","journal-title":"Am J Pathol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nrc1627","article-title":"Tumour vascular targeting","volume":"5","author":"D Neri","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.coph.2008.11.006","article-title":"Possible novel targets for therapeutic angiogenesis","volume":"9","author":"B Cristofaro","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.tcm.2007.03.002","article-title":"Brain-derived neurotrophic factor: a newly described mediator of angiogenesis","volume":"17","author":"P Kermani","year":"2007","journal-title":"Trends Cardiovasc Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1242\/dev.127.21.4531","article-title":"Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization","volume":"127","author":"MJ Donovan","year":"2000","journal-title":"Development"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1172\/JCI200522655","article-title":"Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors","volume":"115","author":"P Kermani","year":"2005","journal-title":"J Clin Invest"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/jlb.55.3.410","article-title":"Macrophages and angiogenesis","volume":"55","author":"C Sunderkotter","year":"1994","journal-title":"J Leukoc Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1469-7580.2003.00203.x","article-title":"Neurotrophins and the immune system","volume":"203","author":"JA Vega","year":"2003","journal-title":"J Anat"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1084\/jem.189.5.865","article-title":"Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?","volume":"189","author":"M Kerschensteiner","year":"1999","journal-title":"J Exp Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jneuroim.2014.05.003","article-title":"Neonatal Escherichia coli K1 meningitis causes learning and memory impairments in adulthood","volume":"272","author":"T Barichello","year":"2014","journal-title":"J Neuroimmunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e1003980","DOI":"10.1371\/journal.ppat.1003980","article-title":"PPARgamma agonists improve survival and neurocognitive outcomes in experimental cerebral malaria and induce neuroprotective pathways in human malaria","volume":"10","author":"L Serghides","year":"2014","journal-title":"PLoS Pathog"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ijcard.2011.02.058","article-title":"Brain-derived neurotrophic factor is up regulated in chronic Chagas disease","volume":"149","author":"PM Martinelli","year":"2011","journal-title":"Int J Cardiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1084\/jem.158.5.1522","article-title":"The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4\/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs","volume":"158","author":"DA Hume","year":"1983","journal-title":"J Exp Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/ar.1092100311","article-title":"The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4\/80: macrophages associated with epithelia","volume":"210","author":"DA Hume","year":"1984","journal-title":"Anat Rec"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1182\/blood-2002-04-1044","article-title":"Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo","volume":"100","author":"TB Geijtenbeek","year":"2002","journal-title":"Blood"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e1000813","DOI":"10.1371\/journal.ppat.1000813","article-title":"Innate killing of Leishmania donovani by macrophages of the splenic marginal zone requires IRF-7","volume":"6","author":"R Phillips","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.chom.2013.08.004","article-title":"A transcriptomic network identified in uninfected macrophages responding to inflammation controls intracellular pathogen survival","volume":"14","author":"L Beattie","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00441-004-0876-8","article-title":"TrkB mRNA and protein in mouse spleen: structure of the spleen of functionally deficient TrkB mice","volume":"316","author":"M Perez-Perez","year":"2004","journal-title":"Cell Tissue Res"},{"key":"ref32","first-page":"309","article-title":"Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury","volume":"147","author":"MJ Donovan","year":"1995","journal-title":"Am J Pathol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1242\/dev.125.9.1591","article-title":"A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF","volume":"125","author":"LE Benjamin","year":"1998","journal-title":"Development"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1172\/JCI43992","article-title":"Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice","volume":"121","author":"M Cazorla","year":"2011","journal-title":"J Clin Invest"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1096\/fasebj.11.6.9194526","article-title":"The codependence of angiogenesis and chronic inflammation","volume":"11","author":"JR Jackson","year":"1997","journal-title":"FASEB J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1172\/JCI200422087","article-title":"An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis","volume":"114","author":"E Giraudo","year":"2004","journal-title":"J Clin Invest"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1161\/01.RES.0000057997.77714.72","article-title":"VEGFR-1-selective VEGF homologue PlGF is arteriogenic: evidence for a monocyte-mediated mechanism","volume":"92","author":"F Pipp","year":"2003","journal-title":"Circ Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1172\/JCI20465","article-title":"VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment","volume":"113","author":"C Cursiefen","year":"2004","journal-title":"J Clin Invest"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.bbrc.2008.06.036","article-title":"Modulation of ephrinB2 leads to increased angiogenesis in ischemic myocardium and endothelial cell proliferation","volume":"373","author":"A Mansson-Broberg","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1161\/ATVBAHA.108.168815","article-title":"Bone morphogenetic proteins 2 and 4 are selectively expressed by late outgrowth endothelial progenitor cells and promote neoangiogenesis","volume":"28","author":"DM Smadja","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nn.3280","article-title":"Epigenetic inheritance of a cocaine-resistance phenotype","volume":"16","author":"FM Vassoler","year":"2013","journal-title":"Nat Neurosci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1158\/1078-0432.CCR-09-1531","article-title":"Lestaurtinib enhances the antitumor efficacy of chemotherapy in murine xenograft models of neuroblastoma","volume":"16","author":"R Iyer","year":"2010","journal-title":"Clin Cancer Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1002\/dvdy.20972","article-title":"Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland","volume":"235","author":"WV Ingman","year":"2006","journal-title":"Dev Dyn"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1242\/dev.126.10.2141","article-title":"Macrophages kill capillary cells in G1 phase of the cell cycle during programmed vascular regression","volume":"126","author":"G Diez-Roux","year":"1999","journal-title":"Development"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature03928","article-title":"WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature","volume":"437","author":"IB Lobov","year":"2005","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1242\/dev.012187","article-title":"Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch","volume":"134","author":"S Rao","year":"2007","journal-title":"Development"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nri2528","article-title":"Trophic macrophages in development and disease","volume":"9","author":"JW Pollard","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1038\/emboj.2008.105","article-title":"Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells","volume":"27","author":"K Oguma","year":"2008","journal-title":"EMBO J"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1038\/sj.jid.5700827","article-title":"Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft","volume":"127","author":"S Gazzaniga","year":"2007","journal-title":"J Invest Dermatol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"5378","DOI":"10.1158\/0008-5472.CAN-04-0961","article-title":"Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice","volume":"64","author":"S Aharinejad","year":"2004","journal-title":"Cancer Res"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1158\/0008-5472.CAN-05-3523","article-title":"Colony-stimulating factor-1 antibody reverses chemoresistance in human MCF-7 breast cancer xenografts","volume":"66","author":"P Paulus","year":"2006","journal-title":"Cancer Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.2353\/ajpath.2009.080676","article-title":"High-density gene expression analysis of tumor-associated macrophages from mouse mammary tumors","volume":"174","author":"LS Ojalvo","year":"2009","journal-title":"Am J Pathol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.placenta.2010.06.008","article-title":"Placental BDNF\/TrkB signaling system is modulated by fetal growth disturbances in rat and human","volume":"31","author":"S Mayeur","year":"2010","journal-title":"Placenta"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nprot.2010.6","article-title":"In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract","volume":"5","author":"I Arnaoutova","year":"2010","journal-title":"Nat Protoc"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1004681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T16:46:09Z","timestamp":1651337169000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1004681"}},"subtitle":[],"editor":[{"given":"Ricardo T","family":"Gazzinelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,2,24]]},"references-count":54,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1004681","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,24]]}}}