{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:31:06Z","timestamp":1791235866580,"version":"4.1.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T00:00:00Z","timestamp":1427932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1004789","type":"journal-article","created":{"date-parts":[[2015,4,3]],"date-time":"2015-04-03T11:51:53Z","timestamp":1428061913000},"page":"e1004789","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":79,"title":["Selection and Spread of Artemisinin-Resistant Alleles in Thailand Prior to the Global Artemisinin Resistance Containment Campaign"],"prefix":"10.1371","volume":"11","author":[{"given":"Eldin","family":"Talundzic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila Akinyi","family":"Okoth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanungnit","family":"Congpuong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz M.","family":"Plucinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira F.","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick S.","family":"Kachur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chansuda","family":"Wongsrichanalai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wichai","family":"Satimai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Barnwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatachalam","family":"Udhayakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,4,2]]},"reference":[{"issue":"24","key":"ref1","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1056\/NEJMc0805011","article-title":"Evidence of artemisinin-resistant malaria in western Cambodia","volume":"359","author":"H. Noedl","year":"2008","journal-title":"N Engl J Med"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1365-3156.2005.01557.x","article-title":"In vivo sensitivity monitoring of mefloquine monotherapy and artesunate-mefloquine combinations for the treatment of uncomplicated falciparum malaria in Thailand in 2003","volume":"11","author":"S. Vijaykadga","year":"2006","journal-title":"Trop Med Int Health"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1473-3099(02)00239-6","article-title":"Epidemiology of drug-resistant malaria","volume":"2","author":"C. Wongsrichanalai","year":"2002","journal-title":"Lancet Infect Dis"},{"issue":"6895","key":"ref4","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nature00813","article-title":"Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum","volume":"418","author":"J.C. Wootton","year":"2002","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/1475-2875-11-300","article-title":"Artemisinin resistance containment project in Thailand. II: Responses to mefloquine-artesunate combination therapy among falciparum malaria patients in provinces bordering Cambodia","volume":"11","author":"W. Satimai","year":"2012","journal-title":"Malar J"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"641","DOI":"10.4269\/ajtmh.2007.76.641","article-title":"Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border","volume":"76","author":"A.P. Alker","year":"2007","journal-title":"Am J Trop Med Hyg"},{"issue":"9830","key":"ref7","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/S0140-6736(12)60484-X","article-title":"Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study","volume":"379","author":"A.P. Phyo","year":"2012","journal-title":"Lancet"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","article-title":"Artemisinin resistance in Plasmodium falciparum malaria","volume":"361","author":"A.M. Dondorp","year":"2009","journal-title":"N Engl J Med"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S1473-3099(12)70181-0","article-title":"Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study","volume":"12","author":"C. Amaratunga","year":"2012","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"e1001398","DOI":"10.1371\/journal.pmed.1001398","article-title":"Malaria burden and artemisinin resistance in the mobile and migrant population on the Thai-Myanmar border, 1999\u20132011: an observational study","volume":"10","author":"V.I. Carrara","year":"2013","journal-title":"PLoS Med"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"e57689","DOI":"10.1371\/journal.pone.0057689","article-title":"Reduced susceptibility of Plasmodium falciparum to artesunate in southern Myanmar","volume":"8","author":"M.P. Kyaw","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1073\/pnas.1211205110","article-title":"Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia","volume":"110","author":"S. Takala-Harrison","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/infdis\/jiu491","article-title":"Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia","volume":"211","author":"S. Takala-Harrison","year":"2014","journal-title":"J Infect Dis"},{"key":"ref14","article-title":"Strategic Plan to Strengthen Malaria Control and Elimination in the Greater Mekong Sub region: 2010\u20132014","year":"2010"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/1475-2875-11-247","article-title":"Artemisinin resistance containment project in Thailand. (I): Implementation of electronic-based malaria information system for early case detection and individual case management in provinces along the Thai-Cambodian border","volume":"11","author":"A. Khamsiriwatchara","year":"2012","journal-title":"Malar J"},{"key":"ref16","year":"2008"},{"key":"ref17","year":"2010"},{"issue":"6077","key":"ref18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1126\/science.1215966","article-title":"A major genome region underlying artemisinin resistance in malaria","volume":"336","author":"I.H. Cheeseman","year":"2012","journal-title":"Science"},{"issue":"7481","key":"ref19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature12876","article-title":"A molecular marker of artemisinin-resistant Plasmodium falciparum malaria","volume":"505","author":"F. Ariey","year":"2014","journal-title":"Nature"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1314981","article-title":"Spread of artemisinin resistance in Plasmodium falciparum malaria","volume":"371","author":"E.A. Ashley","year":"2014","journal-title":"N Engl J Med"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ng.3189","article-title":"Genetic architecture of artemisinin-resistant Plasmodium falciparum","volume":"47","author":"O. Miotto","year":"2015","journal-title":"Nat Genet"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ng.2624","article-title":"Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia","volume":"45","author":"O. Miotto","year":"2013","journal-title":"Nat Genet"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Nyunt, M.H., et al., Molecular Assessment of Artemisinin Resistance Markers, Polymorphisms in the K13 Propeller, and a Multidrug-Resistance Gene in the Eastern and Western Border Areas of Myanmar. Clin Infect Dis, 2014. pii: ciu1160. [Epub ahead of print]","DOI":"10.1093\/cid\/ciu1160"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Tun, K.M., et al., Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker. Lancet Infect Dis, 2015. pii: S1473-3099(15)70032-0.","DOI":"10.1016\/S1473-3099(15)70032-0"},{"issue":"6220","key":"ref25","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1126\/science.1260867","article-title":"Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates","volume":"347","author":"J. Straimer","year":"2015","journal-title":"Science"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/1475-2875-8-155","article-title":"Genetic diversity and population structure of Plasmodium falciparum in Thailand, a low transmission country","volume":"8","author":"T. Pumpaibool","year":"2009","journal-title":"Malar J"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.actatropica.2005.04.010","article-title":"The origins and spread of antimalarial drug resistance: lessons for policy makers","volume":"94","author":"T.J. Anderson","year":"2005","journal-title":"Acta Trop"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1128\/AAC.00691-10","article-title":"Tracking origins and spread of sulfadoxine-resistant Plasmodium falciparum dhps alleles in Thailand","volume":"55","author":"M.T. Alam","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"ref29","year":"2008"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/infdis\/jiq038","article-title":"Selective sweeps and genetic lineages of Plasmodium falciparum drug-resistant alleles in Ghana","volume":"203","author":"M.T. Alam","year":"2011","journal-title":"J Infect Dis"},{"issue":"5443","key":"ref31","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1126\/science.286.5443.1351","article-title":"A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum","volume":"286","author":"X. Su","year":"1999","journal-title":"Science"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1755-0998.2011.02985.x","article-title":"POLYSAT: an R package for polyploid microsatellite analysis","volume":"11","author":"L.V. Clark","year":"2011","journal-title":"Mol Ecol Resour"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"W573","DOI":"10.1093\/nar\/gks485","article-title":"T-REX: a web server for inferring, validating and visualizing phylogenetic trees and networks","volume":"40","author":"A. Boc","year":"2012","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"e1000209","DOI":"10.1371\/journal.pmed.1000209","article-title":"Developing global maps of the dominant anopheles vectors of human malaria","volume":"7","author":"S.I. Hay","year":"2010","journal-title":"PLoS Med"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1004862","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T00:00:00Z","timestamp":1429660800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1004789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:31:41Z","timestamp":1588969901000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1004789"}},"subtitle":[],"editor":[{"given":"Rick M.","family":"Fairhurst","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,2]]},"references-count":34,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1004789","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.ppat.1004862","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,2]]}}}