{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:22:33Z","timestamp":1790205753466,"version":"4.1.0"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T00:00:00Z","timestamp":1432771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1004873","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T18:22:13Z","timestamp":1432837333000},"page":"e1004873","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Ly6C- Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C+ Monocytes into Macrophages"],"prefix":"10.1371","volume":"11","author":[{"given":"Yannick","family":"Morias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Abels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damya","family":"Laoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Van Overmeire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Guilliams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elio","family":"Schouppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Tacke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlie J.","family":"deVries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"De Baetselier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Beschin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,5,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1126\/science.1214935","article-title":"Disease tolerance as a defense strategy","volume":"335","author":"R Medzhitov","year":"2012","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.pt.2011.05.004","article-title":"The economy of inflammation: when is less more?","volume":"27","author":"BF Sears","year":"2011","journal-title":"Trends Parasitol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/immu.200390013","article-title":"Experimental African trypanosomiasis: IFN-gamma mediates early mortality","volume":"33","author":"M Shi","year":"2003","journal-title":"Eur J Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1189\/jlb.1003500","article-title":"Trypanosoma congolense infections: antibody-mediated phagocytosis by Kupffer cells","volume":"76","author":"M Shi","year":"2004","journal-title":"J Leukoc Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1086\/503808","article-title":"Interferon-gamma and nitric oxide in combination with antibodies are key protective host immune factors during trypanosoma congolense Tc13 Infections","volume":"193","author":"S Magez","year":"2006","journal-title":"J Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1086\/520815","article-title":"Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage-derived soluble TNF are crucial for nitric oxide-mediated Trypanosoma congolense parasite killing","volume":"196","author":"S Magez","year":"2007","journal-title":"J Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1002\/eji.201041307","article-title":"IL-10 limits production of pathogenic TNF by M1 myeloid cells through induction of nuclear NF-\u03baB p50 member in Trypanosoma congolense infection-resistant C57BL\/6 mice","volume":"41","author":"T Bosschaerts","year":"2011","journal-title":"Eur J Immunol"},{"key":"ref8","first-page":"316067","article-title":"Trypanosoma congolense Infections: Induced Nitric Oxide Inhibits Parasite Growth In Vivo","volume":"2011","author":"W Lu","year":"2011","journal-title":"J Parasitol Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1126\/science.1222753","article-title":"Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host","volume":"337","author":"D Salmon","year":"2012","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"6168","DOI":"10.4049\/jimmunol.180.9.6168","article-title":"Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P","volume":"180","author":"T Bosschaerts","year":"2008","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.4049\/jimmunol.179.5.2748","article-title":"African trypanosomiasis: naturally occurring regulatory T cells favor trypanotolerance by limiting pathology associated with sustained type 1 inflammation","volume":"179","author":"M Guilliams","year":"2007","journal-title":"J Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1053\/jhep.2002.30956","article-title":"Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase","volume":"35","author":"M Bourdi","year":"2002","journal-title":"Hepatology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/hep.21498","article-title":"IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice","volume":"45","author":"A Erhardt","year":"2007","journal-title":"Hepatology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jaut.2009.08.006","article-title":"CD4 T cells in hepatic immune tolerance","volume":"34","author":"A Carambia","year":"2010","journal-title":"J Autoimmun"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.4049\/jimmunol.1102744","article-title":"CD64 expression distinguishes monocyte-derived and conventional dendritic cells and reveals their distinct role during intramuscular immunization","volume":"188","author":"C Langlet","year":"2012","journal-title":"J Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.immuni.2012.10.016","article-title":"Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen","volume":"38","author":"M Plantinga","year":"2013","journal-title":"Immunity"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","article-title":"Blood monocytes consist of two principal subsets with distinct migratory properties","volume":"19","author":"F Geissmann","year":"2003","journal-title":"Immunity"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/ni.2419","article-title":"Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages","volume":"13","author":"EL Gautier","year":"2012","journal-title":"Nat Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.immuni.2013.08.007","article-title":"Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes","volume":"39","author":"C Jakubzick","year":"2013","journal-title":"Immunity"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1182\/blood.V96.2.719","article-title":"Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages","volume":"96","author":"N Faust","year":"2000","journal-title":"Blood"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"e1001045","DOI":"10.1371\/journal.ppat.1001045","article-title":"Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2\/CCR2, IFN-gamma and MyD88 signaling","volume":"6","author":"T Bosschaerts","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1182\/blood-2005-04-1485","article-title":"Identification of a common gene signature for type II cytokine-associated myeloid cells elicited in vivo in different pathologic conditions","volume":"108","author":"GH Ghassabeh","year":"2006","journal-title":"Blood"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/ni.2063","article-title":"The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- monocytes","volume":"12","author":"RN Hanna","year":"2011","journal-title":"Nat Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1161\/CIRCRESAHA.111.253377","article-title":"NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis","volume":"110","author":"RN Hanna","year":"2012","journal-title":"Circ Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1002\/eji.200636012","article-title":"Interleukin-10 derived from macrophages and\/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA","volume":"36","author":"L Siewe","year":"2006","journal-title":"Eur J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s12016-008-8091-0","article-title":"Inflammatory pathways in liver homeostasis and liver injury","volume":"36","author":"F Tacke","year":"2009","journal-title":"Clin Rev Allergy Immunol"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"e1003096","DOI":"10.1371\/journal.ppat.1003096","article-title":"TNF\u03b1-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection","volume":"9","author":"E Helk","year":"2013","journal-title":"PLoS Pathog"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3109\/08941939.2011.568594","article-title":"Tumor necrosis factor-\u03b1 in liver ischemia\/reperfusion injury","volume":"24","author":"BC Perry","year":"2011","journal-title":"J Invest Surg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1365-3024.2006.00925.x","article-title":"Trypanosoma congolense infections: MHC class II-restricted immune responses mediate either protection or disease, depending on IL-10 function","volume":"29","author":"MQ Shi","year":"2007","journal-title":"Parasite Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1161\/CIRCRESAHA.113.300890","article-title":"Monocyte and macrophage heterogeneity in the heart","volume":"112","author":"M Nahrendorf","year":"2013","journal-title":"Circ Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1084\/jem.20070075","article-title":"Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis","volume":"204","author":"L Arnold","year":"2007","journal-title":"J Exp Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.immuni.2013.02.012","article-title":"Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus","volume":"38","author":"R Shechter","year":"2013","journal-title":"Immunity"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"E3186","DOI":"10.1073\/pnas.1119964109","article-title":"Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis","volume":"109","author":"P Ramachandran","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1161\/CIRCRESAHA.111.260760","article-title":"Bone marrow-specific deficiency of nuclear receptor Nur77 enhances atherosclerosis","volume":"110","author":"AA Hamers","year":"2012","journal-title":"Circ Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1172\/JCI28549","article-title":"Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques","volume":"117","author":"F Tacke","year":"2007","journal-title":"J Clin Invest"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1126\/science.1178331","article-title":"Development of monocytes, macrophages, and dendritic cells","volume":"327","author":"F Geissmann","year":"2010","journal-title":"Science"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1126\/science.1175202","article-title":"Identification of splenic reservoir monocytes and their deployment to inflammatory sites","volume":"325","author":"FK Swirski","year":"2009","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.cell.2013.03.010","article-title":"Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposal","volume":"153","author":"LM Carlin","year":"2013","journal-title":"Cell"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1126\/science.1142883","article-title":"Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior","volume":"317","author":"C Auffray","year":"2007","journal-title":"Science"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1002\/art.21365","article-title":"Selective expansion of a monocyte subset expressing the CD11c dendritic cell marker in the Yaa model of systemic lupus erythematosus","volume":"52","author":"H Amano","year":"2005","journal-title":"Arthritis Rheum"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.celrep.2014.09.032","article-title":"Nonclassical Ly6C(-) Monocytes Drive the Development of Inflammatory Arthritis in Mice","volume":"9","author":"AV Misharin","year":"2014","journal-title":"Cell Rep"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2012.12.001","article-title":"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis","volume":"38","author":"S Yona","year":"2013","journal-title":"Immunity"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.immuni.2012.08.026","article-title":"Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells","volume":"37","author":"E Zigmond","year":"2012","journal-title":"Immunity"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nri3671","article-title":"Monocytes and macrophages: developmental pathways and tissue homeostasis","volume":"14","author":"F Ginhoux","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.4049\/jimmunol.172.7.4410","article-title":"Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response","volume":"172","author":"C Sunderk\u00f6tter","year":"2004","journal-title":"J Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1084\/jem.20061011","article-title":"Monocytes give rise to mucosal, but not splenic, conventional dendritic cells","volume":"204","author":"C Varol","year":"2007","journal-title":"J Exp Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.celrep.2013.10.010","article-title":"Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta","volume":"5","author":"JP Michaud","year":"2013","journal-title":"Cell Rep"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.4049\/jimmunol.182.2.1107","article-title":"IL-10 dampens TNF\/inducible nitric oxide synthase-producing dendritic cell-mediated pathogenicity during parasitic infection","volume":"182","author":"M Guilliams","year":"2009","journal-title":"J Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/B978-0-12-394590-7.00003-8","article-title":"Monocyte-mediated immune defense against murine Listeria monocytogenes infection","volume":"113","author":"NV Serbina","year":"2012","journal-title":"Adv Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/hep.22950","article-title":"Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis","volume":"50","author":"KR Karlmark","year":"2009","journal-title":"Hepatology"},{"issue":"Suppl 1","key":"ref51","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1186\/1755-1536-5-S1-S27","article-title":"Functional role of intrahepatic monocyte subsets for the progression of liver inflammation and liver fibrosis in vivo","volume":"5","author":"F Tacke","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"11761","DOI":"10.1074\/jbc.M112.446575","article-title":"Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease","volume":"288","author":"RH McMahan","year":"2013","journal-title":"J Biol Chem"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.4049\/jimmunol.0803172","article-title":"Ly6C(low) monocytes differentiate into dendritic cells and cross-tolerize T cells through PDL-1","volume":"182","author":"Y Peng","year":"2009","journal-title":"J Immunol"},{"issue":"9","key":"ref54","doi-asserted-by":"crossref","first-page":"e107533","DOI":"10.1371\/journal.pone.0107533","article-title":"Imbalance of circulating monocyte subsets and PD-1 dysregulation in Q fever endocarditis: the role of IL-10 in PD-1 modulation","volume":"9","author":"MB Ka","year":"2014","journal-title":"PLoS One"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/82763","article-title":"IL-6 switches the differentiation of monocytes from dendritic cells to macrophages","volume":"1","author":"P Chomarat","year":"2000","journal-title":"Nat Immunol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.4049\/jimmunol.1100889","article-title":"M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells","volume":"187","author":"M Heusinkveld","year":"2011","journal-title":"J Immunol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000353243","article-title":"The mucosal factors retinoic acid and TGF-\u03b21 induce phenotypically and functionally distinct dendritic cell types","volume":"162","author":"G den Hartog","year":"2013","journal-title":"Int Arch Allergy Immunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.it.2011.12.001","article-title":"Differential macrophage programming in the tumor microenvironment","volume":"33","author":"B Ruffell","year":"2012","journal-title":"Trends Immunol"},{"issue":"8","key":"ref59","doi-asserted-by":"crossref","first-page":"e1004282","DOI":"10.1371\/journal.ppat.1004282","article-title":"Ly6Chi monocyte recruitment is responsible for Th2 associated host-protective macrophage accumulation in liver inflammation due to schistosomiasis","volume":"10","author":"M Nascimento","year":"2014","journal-title":"PLoS Pathog"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1182\/blood.V77.6.1131.1131","article-title":"Molecular physiology of granulocyte-macrophage colony-stimulating factor","volume":"77","author":"JC Gasson","year":"1991","journal-title":"Blood"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"TA Wynn","year":"2013","journal-title":"Nature"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.immuni.2013.04.004","article-title":"Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes","volume":"38","author":"D Hashimoto","year":"2013","journal-title":"Immunity"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1084\/jem.20120340","article-title":"Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages","volume":"209","author":"G Hoeffel","year":"2012","journal-title":"J Exp Med"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1126\/science.1219179","article-title":"A lineage of myeloid cells independent of Myb and hematopoietic stem cells","volume":"336","author":"C Schulz","year":"2012","journal-title":"Science"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1038\/ncomms2877","article-title":"Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation","volume":"4","author":"LC Davies","year":"2013","journal-title":"Nat Commun"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1126\/science.1204351","article-title":"Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation","volume":"332","author":"SJ Jenkins","year":"2011","journal-title":"Science"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/nm.3258","article-title":"Local proliferation dominates lesional macrophage accumulation in atherosclerosis","volume":"19","author":"CS Robbins","year":"2013","journal-title":"Nat Med"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1004873","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T07:34:29Z","timestamp":1717918469000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1004873"}},"subtitle":[],"editor":[{"given":"P'ng","family":"Loke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,5,28]]},"references-count":67,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1004873","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,28]]}}}