{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:48:07Z","timestamp":1790218087590,"version":"4.1.0"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T00:00:00Z","timestamp":1431475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1004908","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T18:06:42Z","timestamp":1431540402000},"page":"e1004908","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":71,"title":["A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome"],"prefix":"10.1371","volume":"11","author":[{"given":"Felipe H.","family":"Santiago-Tirado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard C.","family":"Hang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara L.","family":"Doering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,5,13]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.2217\/fmb.12.102","article-title":"Mechanisms of infection by the human fungal pathogen <italic>Cryptococcus neoformans<\/italic>","volume":"7","author":"W Sabiiti","year":"2012","journal-title":"Future Microbiol"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"e56269","DOI":"10.1371\/journal.pone.0056269","article-title":"Epidemiology of cryptococcal meningitis in the US: 1997\u20132009","volume":"8","author":"V Pyrgos","year":"2013","journal-title":"PLoS One"},{"key":"ref3","first-page":"61","article-title":"Cryptococcal infections in non-HIV-infected patients","volume":"124","author":"PG Pappas","year":"2013","journal-title":"Trans Am Clin Climatol Assoc"},{"issue":"8","key":"ref4","doi-asserted-by":"crossref","first-page":"e43582","DOI":"10.1371\/journal.pone.0043582","article-title":"Comparison and temporal trends of three groups with cryptococcosis: HIV-infected, solid organ transplant, and HIV-negative\/non-transplant","volume":"7","author":"EW Bratton","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1086\/368091","article-title":"The changing epidemiology of cryptococcosis: an update from population-based active surveillance in 2 large metropolitan areas, 1992\u20132000","volume":"36","author":"SA Mirza","year":"2003","journal-title":"Clin Infect Dis"},{"issue":"5\u20136","key":"ref6","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s11046-011-9505-8","article-title":"Induction of protective immunity against cryptococcosis","volume":"173","author":"KL Wozniak","year":"2012","journal-title":"Mycopathologia"},{"issue":"4","key":"ref7","first-page":"2","article-title":"Dynamics of <italic>Cryptococcus neoformans<\/italic>-macrophage interactions reveal that fungal background influences outcome during cryptococcal meningoencephalitis in humans","author":"A Alanio","year":"2011","journal-title":"MBio"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1172\/JCI72950","article-title":"Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis","volume":"124","author":"W Sabiiti","year":"2014","journal-title":"J Clin Invest"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"e22773","DOI":"10.1371\/journal.pone.0022773","article-title":"A sensitive high-throughput assay for evaluating host-pathogen interactions in <italic>Cryptococcus neoformans<\/italic> infection","volume":"6","author":"D Srikanta","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.cell.2008.07.046","article-title":"Systematic genetic analysis of virulence in the human fungal pathogen <italic>Cryptococcus neoformans<\/italic>","volume":"135","author":"OW Liu","year":"2008","journal-title":"Cell"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1042\/BST20120328","article-title":"Mechanism and function of DHHC S-acyltransferases","volume":"41","author":"ME Linder","year":"2013","journal-title":"Biochem Soc Trans"},{"issue":"43","key":"ref12","doi-asserted-by":"crossref","first-page":"41268","DOI":"10.1074\/jbc.M206573200","article-title":"Identification of a Ras palmitoyltransferase in <italic>Saccharomyces cerevisiae<\/italic>","volume":"277","author":"S Lobo","year":"2002","journal-title":"J Biol Chem"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1083\/jcb.200206120","article-title":"The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase","volume":"159","author":"AF Roth","year":"2002","journal-title":"J Cell Biol"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1042\/BST20120210","article-title":"Palmitoylation of influenza virus proteins","volume":"41","author":"M Veit","year":"2013","journal-title":"Biochem Soc Trans"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.chom.2011.06.003","article-title":"Subcellular targeting of <italic>Salmonella<\/italic> virulence proteins by host-mediated S-palmitoylation","volume":"10","author":"SW Hicks","year":"2011","journal-title":"Cell Host Microbe"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"e1003162","DOI":"10.1371\/journal.ppat.1003162","article-title":"A <italic>Toxoplasma<\/italic> palmitoyl acyl transferase and the palmitoylated armadillo repeat protein TgARO govern apical rhoptry tethering and reveal a critical role for the rhoptries in host cell invasion but not egress","volume":"9","author":"JR Beck","year":"2013","journal-title":"PLoS Pathog"},{"issue":"8","key":"ref17","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/tra.12081","article-title":"Global analysis of apicomplexan protein S-acyl transferases reveals an enzyme essential for invasion","volume":"14","author":"K Frenal","year":"2013","journal-title":"Traffic"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.chom.2012.06.005","article-title":"Analysis of protein palmitoylation reveals a pervasive role in <italic>Plasmodium<\/italic> development and pathogenesis","volume":"12","author":"ML Jones","year":"2012","journal-title":"Cell Host Microbe"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1128\/EC.00351-08","article-title":"Subcellular localization directs signaling specificity of the <italic>Cryptococcus neoformans<\/italic> Ras1 protein","volume":"8","author":"CB Nichols","year":"2009","journal-title":"Eukaryot Cell"},{"issue":"8","key":"ref20","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1128\/EC.00091-12","article-title":"Plasma membrane localization is required for RasA-mediated polarized morphogenesis and virulence of <italic>Aspergillus fumigatus<\/italic>","volume":"11","author":"JR Fortwendel","year":"2012","journal-title":"Eukaryot Cell"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1128\/EC.05153-11","article-title":"Roles of Ras1 membrane localization during <italic>Candida albicans<\/italic> hyphal growth and farnesol response","volume":"10","author":"AE Piispanen","year":"2011","journal-title":"Eukaryot Cell"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10156-011-0306-2","article-title":"Paradoxical roles of alveolar macrophages in the host response to <italic>Cryptococcus neoformans<\/italic>","volume":"18","author":"TJ McQuiston","year":"2012","journal-title":"J Infect Chemother"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-pathol-012513-104653","article-title":"The intracellular life of <italic>Cryptococcus neoformans<\/italic>","volume":"9","author":"C Coelho","year":"2014","journal-title":"Annu Rev Pathol"},{"issue":"1","key":"ref24","first-page":"4","article-title":"<italic>Cryptococcus neoformans<\/italic> Rim101 is associated with cell wall remodeling and evasion of the host immune responses","author":"TR O'Meara","year":"2013","journal-title":"MBio"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/j.1365-2958.2012.08134.x","article-title":"Regulated expression of cyclic AMP-dependent protein kinase A reveals an influence on cell size and the secretion of virulence factors in <italic>Cryptococcus neoformans<\/italic>","volume":"85","author":"J Choi","year":"2012","journal-title":"Mol Microbiol"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1128\/EC.00290-13","article-title":"Pbx proteins in <italic>Cryptococcus neoformans<\/italic> cell wall remodeling and capsule assembly","volume":"13","author":"P Kumar","year":"2014","journal-title":"Eukaryot Cell"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1128\/EC.00083-14","article-title":"Literature-based gene curation and proposed genetic nomenclature for <italic>Cryptococcus<\/italic>","volume":"13","author":"DO Inglis","year":"2014","journal-title":"Eukaryot Cell"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.cell.2006.03.042","article-title":"Global analysis of protein palmitoylation in yeast","volume":"125","author":"AF Roth","year":"2006","journal-title":"Cell"},{"issue":"9","key":"ref29","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1128\/IAI.71.9.4831-4841.2003","article-title":"Sexual cycle of <italic>Cryptococcus neoformans<\/italic> var. <italic>grubii<\/italic> and virulence of congenic <bold>a<\/bold> and alpha isolates","volume":"71","author":"K Nielsen","year":"2003","journal-title":"Infect Immun"},{"issue":"10","key":"ref30","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.1128\/IAI.00660-08","article-title":"<italic>Cryptococcus neoformans<\/italic> enters the endolysosomal pathway of dendritic cells and is killed by lysosomal components","volume":"76","author":"KL Wozniak","year":"2008","journal-title":"Infect Immun"},{"key":"ref31","article-title":"The fungal pathogen <italic>Cryptococcus neoformans<\/italic> manipulates macrophage phagosome maturation","author":"LM Smith","year":"2014","journal-title":"Cell Microbiol"},{"issue":"11","key":"ref32","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1128\/EC.4.11.1902-1912.2005","article-title":"A chitin synthase and its regulator protein are critical for chitosan production and growth of the fungal pathogen <italic>Cryptococcus neoformans<\/italic>","volume":"4","author":"IR Banks","year":"2005","journal-title":"Eukaryot Cell"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1111\/j.1365-2958.2006.05551.x","article-title":"Loss of cell wall alpha(1\u20133) glucan affects <italic>Cryptococcus neoformans<\/italic> from ultrastructure to virulence","volume":"63","author":"AJ Reese","year":"2007","journal-title":"Mol Microbiol"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/j.1365-2958.2006.05300.x","article-title":"Investigating the caffeine effects in the yeast <italic>Saccharomyces cerevisiae<\/italic> brings new insights into the connection between TOR, PKC and Ras\/cAMP signalling pathways","volume":"61","author":"K Kuranda","year":"2006","journal-title":"Mol Microbiol"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1046\/j.1365-2958.2003.03780.x","article-title":"Cell wall alpha-1,3-glucan is required to anchor the <italic>Cryptococcus neoformans<\/italic> capsule","volume":"50","author":"AJ Reese","year":"2003","journal-title":"Mol Microbiol"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/cmi.12067","article-title":"<italic>Cryptococcus<\/italic> interactions with macrophages: evasion and manipulation of the phagosome by a fungal pathogen","volume":"15","author":"SA Johnston","year":"2013","journal-title":"Cell Microbiol"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1128\/IAI.67.2.885-890.1999","article-title":"<italic>Cryptococcus neoformans<\/italic> resides in an acidic phagolysosome of human macrophages","volume":"67","author":"SM Levitz","year":"1999","journal-title":"Infect Immun"},{"issue":"13","key":"ref38","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.1021\/ja810122f","article-title":"Robust fluorescent detection of protein fatty-acylation with chemical reporters","volume":"131","author":"G Charron","year":"2009","journal-title":"J Am Chem Soc"},{"issue":"8","key":"ref39","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nchembio.405","article-title":"Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3","volume":"6","author":"JS Yount","year":"2010","journal-title":"Nat Chem Biol"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/9780470559277.ch100225","article-title":"Visualization and Identification of Fatty Acylated Proteins Using Chemical Reporters","volume":"3","author":"JS Yount","year":"2011","journal-title":"Curr Protoc Chem Biol"},{"issue":"7","key":"ref41","doi-asserted-by":"crossref","first-page":"e1001597","DOI":"10.1371\/journal.pbio.1001597","article-title":"Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast","volume":"11","author":"MM Zhang","year":"2013","journal-title":"PLoS Biol"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1083\/jcb.200602049","article-title":"Palmitoylation by the DHHC protein Pfa4 regulates the ER exit of Chs3","volume":"174","author":"KK Lam","year":"2006","journal-title":"J Cell Biol"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"e16969","DOI":"10.1371\/journal.pone.0016969","article-title":"Specificity of transmembrane protein palmitoylation in yeast","volume":"6","author":"A Gonzalez Montoro","year":"2011","journal-title":"PLoS One"},{"issue":"14","key":"ref44","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1128\/MCB.01515-13","article-title":"Rho2 palmitoylation is required for plasma membrane localization and proper signaling to the fission yeast cell integrity mitogen- activated protein kinase pathway","volume":"34","author":"L Sanchez-Mir","year":"2014","journal-title":"Mol Cell Biol"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1128\/MCB.01248-13","article-title":"Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases","volume":"34","author":"E Young","year":"2014","journal-title":"Mol Cell Biol"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1128\/EC.00399-06","article-title":"Chitosan, the deacetylated form of chitin, is necessary for cell wall integrity in <italic>Cryptococcus neoformans<\/italic>","volume":"6","author":"LG Baker","year":"2007","journal-title":"Eukaryot Cell"},{"issue":"5","key":"ref47","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1128\/EC.3.5.1067-1075.2004","article-title":"Role of phagocytosis in the virulence of Cryptococcus neoformans","volume":"3","author":"M Del Poeta","year":"2004","journal-title":"Eukaryot Cell"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1042\/BST20120337","article-title":"Palmitoylation, pathogens and their host","volume":"41","author":"M Blanc","year":"2013","journal-title":"Biochem Soc Trans"},{"issue":"7","key":"ref49","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.pt.2014.05.003","article-title":"Acylation in trypanosomatids: an essential process and potential drug target","volume":"30","author":"AM Goldston","year":"2014","journal-title":"Trends Parasitol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/srep00739","article-title":"Mechanisms of dendritic cell lysosomal killing of <italic>Cryptococcus<\/italic>","volume":"2","author":"CR Hole","year":"2012","journal-title":"Sci Rep"},{"issue":"6","key":"ref51","doi-asserted-by":"crossref","first-page":"e1000953","DOI":"10.1371\/journal.ppat.1000953","article-title":"Cryptococcal cell morphology affects host cell interactions and pathogenicity","volume":"6","author":"LH Okagaki","year":"2010","journal-title":"PLoS Pathog"},{"issue":"1","key":"ref52","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1128\/EC.05305-11","article-title":"Role of <italic>Cryptococcus neoformans<\/italic> Rho1 GTPases in the <italic>PKC1<\/italic> signaling pathway in response to thermal stress","volume":"12","author":"WC Lam","year":"2013","journal-title":"Eukaryot Cell"},{"issue":"23","key":"ref53","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1101\/gad.11.23.3206","article-title":"<italic>Cryptococcus neoformans<\/italic> mating and virulence are regulated by the G-protein alpha subunit <italic>GPA1<\/italic> and cAMP","volume":"11","author":"JA Alspaugh","year":"1997","journal-title":"Genes Dev"},{"issue":"4","key":"ref54","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1567-1364.2006.00071.x","article-title":"The molecular basis for the immunogenicity of <italic>Cryptococcus neoformans<\/italic> mannoproteins","volume":"6","author":"SM Levitz","year":"2006","journal-title":"FEMS Yeast Res"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3389\/fcimb.2014.00106","article-title":"Mannoprotein MP84 mediates the adhesion of <italic>Cryptococcus neoformans<\/italic> to epithelial lung cells","volume":"4","author":"PA Teixeira","year":"2014","journal-title":"Front Cell Infect Microbiol"},{"issue":"41","key":"ref56","doi-asserted-by":"crossref","first-page":"35447","DOI":"10.1074\/jbc.M111.274936","article-title":"Chitosan but not chitin activates the inflammasome by a mechanism dependent upon phagocytosis","volume":"286","author":"CL Bueter","year":"2011","journal-title":"J Biol Chem"},{"issue":"12","key":"ref57","doi-asserted-by":"crossref","first-page":"5943","DOI":"10.4049\/jimmunol.1301695","article-title":"Spectrum and mechanisms of inflammasome activation by chitosan","volume":"192","author":"CL Bueter","year":"2014","journal-title":"J Immunol"},{"issue":"3","key":"ref58","doi-asserted-by":"crossref","first-page":"e00220","DOI":"10.1128\/mBio.00220-13","article-title":"Factors required for activation of urease as a virulence determinant in <italic>Cryptococcus neoformans<\/italic>","volume":"4","author":"A Singh","year":"2013","journal-title":"MBio"},{"issue":"Pt 1","key":"ref59","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1099\/mic.0.2006\/000927-0","article-title":"The iron- and cAMP-regulated gene <italic>SIT1<\/italic> influences ferrioxamine B utilization, melanization and cell wall structure in <italic>Cryptococcus neoformans<\/italic>","volume":"153","author":"KL Tangen","year":"2007","journal-title":"Microbiology"},{"key":"ref60","article-title":"A Multi-Host Approach for the Systematic Analysis of Virulence Factors in <italic>Cryptococcus neoformans<\/italic>","author":"A Desalermos","year":"2014","journal-title":"J Infect Dis"},{"issue":"3","key":"ref61","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.fgb.2005.09.007","article-title":"Split marker transformation increases homologous integration frequency in <italic>Cryptococcus neoformans<\/italic>","volume":"43","author":"J Fu","year":"2006","journal-title":"Fungal Genet Biol"},{"issue":"5","key":"ref62","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1128\/jb.175.5.1405-1411.1993","article-title":"Gene transfer in <italic>Cryptococcus neoformans<\/italic> by use of biolistic delivery of DNA","volume":"175","author":"DL Toffaletti","year":"1993","journal-title":"J Bacteriol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/978-1-61779-539-8_11","article-title":"RNA interference in <italic>Cryptococcus neoformans<\/italic>","volume":"845","author":"ML Skowyra","year":"2012","journal-title":"Methods Mol Biol"},{"issue":"2","key":"ref64","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-2958.2005.04843.x","article-title":"Cell wall integrity is dependent on the <italic>PKC1<\/italic> signal transduction pathway in <italic>Cryptococcus neoformans<\/italic>","volume":"58","author":"KJ Gerik","year":"2005","journal-title":"Mol Microbiol"},{"issue":"6","key":"ref65","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1128\/IAI.68.6.3642-3650.2000","article-title":"Antibody interactions with the capsule of <italic>Cryptococcus neoformans<\/italic>","volume":"68","author":"M Feldmesser","year":"2000","journal-title":"Infect Immun"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1004908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T04:35:43Z","timestamp":1599021343000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1004908"}},"subtitle":[],"editor":[{"given":"Damian J","family":"Krysan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,5,13]]},"references-count":65,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1004908","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,13]]}}}