{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:22:38Z","timestamp":1791332558777,"version":"4.3.1"},"reference-count":88,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T00:00:00Z","timestamp":1443052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1005153","type":"journal-article","created":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T17:49:39Z","timestamp":1443116979000},"page":"e1005153","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":216,"title":["Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection"],"prefix":"10.1371","volume":"11","author":[{"given":"Abderaouf","family":"Damouche","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Lazure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Avettand-F\u00e8no\u00ebl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Huot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Dejucq-Rainsford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Pascale","family":"Satie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"M\u00e9lard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludivine","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Gommet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Ghosn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Noel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Pourcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Benoist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"B\u00e9r\u00e9ziat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cosma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Favier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Vaslin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Rouzioux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Capeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"M\u00fcller-Trutwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Dereuddre-Bosquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Le Grand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Lambotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Bourgeois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,9,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1371\/journal.pmed.0050203","article-title":"Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection","volume":"5","author":"LH Kuller","year":"2008","journal-title":"PLoS Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-med-042909-093756","article-title":"HIV Infection, Inflammation, and Aging","volume":"62","author":"SG Deeks","year":"2011","journal-title":"Annu Rev Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2013.10.001","article-title":"Systemic effects of inflammation on health during chronic HIV infection","volume":"39","author":"SG Deeks","year":"2013","journal-title":"Immunity"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1086\/524143","article-title":"Relationship between T Cell Activation and CD4+ T Cell Count in HIV-Seropositive Individuals with Undetectable Plasma HIV RNA Levels in the Absence of Therapy","volume":"197","author":"PW Hunt","year":"2008","journal-title":"J Infect Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/QAD.0000000000000174","article-title":"Elevated IP10 levels are associated with immune activation and low CD4<sup>+<\/sup> T-cell counts in HIV controller patients","volume":"28","author":"N Noel","year":"2014","journal-title":"AIDS"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.immuni.2012.08.010","article-title":"Redefining the viral reservoirs that prevent HIV-1 eradication","volume":"37","author":"E Eisele","year":"2012","journal-title":"Immunity"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1097\/QAD.0b013e328352ae09","article-title":"Detection of HIV-1 RNA in seminal plasma samples from treated patients with undetectable HIV-1 RNA in blood plasma on a 2002\u20132011 survey","volume":"26","author":"S Lambert-Niclot","year":"2012","journal-title":"AIDS"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1086\/653213","article-title":"Simian immunodeficiency virus-infected macaques treated with highly active antiretroviral therapy have reduced central nervous system viral replication and inflammation but persistence of viral DNA","volume":"202","author":"MC Zink","year":"2010","journal-title":"J Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/nm1511","article-title":"Microbial translocation is a cause of systemic immune activation in chronic HIV infection","volume":"12","author":"JM Brenchley","year":"2006","journal-title":"Nat Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/path.2276","article-title":"Immune activation and inflammation in HIV-1 infection : causes and consequences","volume":"214","author":"V Appay","year":"2008","journal-title":"J Pathol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/imr.12079","article-title":"HIV-associated chronic immune activation","volume":"254","author":"M Paiardini","year":"2013","journal-title":"Immunol Rev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/mi.2012.82","article-title":"Human immunodeficiency virus and the gastrointestinal immune system: does highly active antiretroviral therapy restore gut immunity?","volume":"5","author":"CT Costiniuk","year":"2012","journal-title":"Mucosal Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1210\/jc.2004-0395","article-title":"Adipose tissue as an endocrine organ","volume":"89","author":"EE Kershaw","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"E1262","DOI":"10.1152\/ajpendo.90511.2008","article-title":"RANTES release by human adipose tissue in vivo and evidence for depot-specific differences","volume":"296","author":"R Madani","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref15","first-page":"2282","article-title":"Monocyte Chemoattractant Protein-1 Release Is Higher in Visceral than Subcutaneous Human Adipose Tissue (AT): Implication of Macrophages Resident in the AT","volume":"90","author":"JM Bruun","year":"2005"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"E656","DOI":"10.1152\/ajpendo.00127.2007","article-title":"Adipokines oversecreted by omental adipose tissue in human obesity","volume":"293","author":"E Maury","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref17","first-page":"4196","article-title":"Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo","volume":"82","author":"V Mohamed-Ali","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"ref18","first-page":"847","article-title":"Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid","volume":"83","author":"SK Fried","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"ref19","first-page":"157","article-title":"Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity","volume":"43","author":"A Stofkova","year":"2009","journal-title":"Endocr Regul"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2174\/157436209787048711","article-title":"Leptin signaling: A key pathway in immune responses","volume":"4","author":"C Procaccini","year":"2009","journal-title":"Curr Signal Transduct Ther"},{"key":"ref21","first-page":"85","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"N Ouchi","year":"2011","journal-title":"Nat Publ Gr"},{"key":"ref22","article-title":"Inflammation and metabolic disorders","volume":"444","author":"GS Hotamisligil","year":"2006"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nri2922","article-title":"Immunometabolism: an emerging frontier","volume":"11","author":"D Mathis","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"ref24","article-title":"Obesity induces a phenotypic switch in adipose tissue macrophage polarization","volume":"117","author":"CN Lumeng","year":"2007"},{"key":"ref25","first-page":"315","article-title":"Previews A New \u201c\u2018 Immunological \u2018\u201d Role for Adipocytes in Obesity","volume":"17","author":"Z Hruskova","year":"2013","journal-title":"CMET"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"SP Weisberg","year":"2003","journal-title":"J Clin Invest"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nm.1964","article-title":"CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity","volume":"15","author":"S Nishimura","year":"2009","journal-title":"Nat Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1161\/ATVBAHA.109.192583","article-title":"Interplay between human adipocytes and T lymphocytes in obesity: CCL20 as an adipochemokine and T lymphocytes as lipogenic modulators","volume":"29","author":"C Duffaut","year":"2009","journal-title":"Arter Thromb Vasc Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nm.2002","article-title":"Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters","volume":"15","author":"M Feuerer","year":"2009","journal-title":"Nat Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.cmet.2013.02.009","article-title":"Article Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation","volume":"17","author":"T Deng","year":"2013","journal-title":"Cell Metab"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrm2391","article-title":"Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes","volume":"9","author":"A Guilherme","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1161\/01.ATV.0000183883.72263.13","article-title":"A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha","volume":"25","author":"T Suganami","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1177\/135965350601100610","article-title":"HIV-1 infection alters gene expression in adipose tissue, which contributes to HIV- 1\/HAART-associated lipodystrophy","volume":"11","author":"M Giralt","year":"2006","journal-title":"Antivir Ther"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.beem.2010.12.001","article-title":"Adipose tissue biology and HIV-infection","volume":"25","author":"M Giralt","year":"2011","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3851\/IMP1988","article-title":"Effects of ritonavir-boosted darunavir, atazanavir and lopinavir on adipose functions and insulin sensitivity in murine and human adipocytes","volume":"17","author":"E Capel","year":"2012","journal-title":"Antivir Ther"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.molmed.2010.03.002","article-title":"HIV-associated lipodystrophy: from fat injury to premature aging","volume":"16","author":"M Caron-Debarle","year":"2010","journal-title":"Trends Mol Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3851\/IMP2021","article-title":"HIV-1 Tat protein impairs adipogenesis and induces the expression and secretion of proinflammatory cytokines in human SGBS adipocytes","volume":"17","author":"J D\u00edaz-Delf\u00edn","year":"2012","journal-title":"Antivir Ther"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1128\/AAC.00104-12","article-title":"Effects of rilpivirine on human adipocyte differentiation, gene expression, and release of adipokines and cytokines","volume":"56","author":"J D\u00edaz-Delf\u00edn","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1097\/00002030-200409240-00013","article-title":"Adipose tissue expression of IL-18 and HIV-associated lipodystrophy","volume":"18","author":"B Lindegaard","year":"2004","journal-title":"AIDS"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1177\/135965350400900412","article-title":"Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic patients","volume":"9","author":"V Jan","year":"2004","journal-title":"Antivir Ther"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"E261","DOI":"10.1152\/ajpendo.00056.2003","article-title":"Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy","volume":"286","author":"JA Johnson","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/QAI.0b013e31829bdb67","article-title":"Differentially altered molecular signature of visceral adipose tissue in HIV-1-associated lipodystrophy","volume":"64","author":"JM Gallego-Escuredo","year":"2013","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/01.qai.0000435599.27727.6c","article-title":"The role of HIV and monocytes\/macrophages in adipose tissue biology","volume":"65","author":"CM Shikuma","year":"2014","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1097\/00002030-200212060-00006","article-title":"HIV and antiretroviral drug distribution in plasma and fat tissue of HIV-infected patients with lipodystrophy","volume":"16","author":"N Dupin","year":"2002","journal-title":"AIDS"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1096\/fj.01-0947fje","article-title":"Human adipose cells express CD4, CXCR4, and CCR5 [corrected] receptors: a new target cell type for the immunodeficiency virus-1?","volume":"16","author":"U Hazan","year":"2002","journal-title":"FASEB J"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1097\/00002030-200311210-00019","article-title":"In vitro infection of human primary adipose cells with HIV-1: a reassessment","volume":"17","author":"S Munier","year":"2003","journal-title":"AIDS"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.yexcr.2004.12.003","article-title":"Tumor necrosis factor-alpha stimulates HIV-1 production in primary culture of human adipocytes","volume":"304","author":"T Maurin","year":"2005","journal-title":"Exp Cell Res"},{"key":"ref48","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3007148","article-title":"HIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR\/GR co-regulation","volume":"5","author":"N Agarwal","year":"2013","journal-title":"Sci Transl Med"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/00002030-200401230-00007","article-title":"HIV-1 Nef protein in the nucleus influences adipogenesis as well as viral transcription through the peroxisome proliferator-activated receptors","volume":"18","author":"K Otake","year":"2004","journal-title":"AIDS"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1096\/fj.13-246876","article-title":"HIV protein Nef causes dyslipidemia and formation of foam cells in mouse models of atherosclerosis","volume":"28","author":"HL Cui","year":"2014","journal-title":"FASEB J"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.it.2010.08.001","article-title":"Adaptive immunity and adipose tissue biology","volume":"31","author":"DA Kaminski","year":"2010","journal-title":"Trends Immunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1467-789X.2009.00623.x","article-title":"Subcutaneous and visceral adipose tissue: structural and functional differences","volume":"11","author":"MM Ibrahim","year":"2010","journal-title":"Obes Rev"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1600-0684.1997.tb00315.x","article-title":"Chemoattractant factors (IP-10, MIP-1alpha, IL-16) mRNA expression in mononuclear cells from different tissues during acute SIVmac251 infection of macaques","volume":"26","author":"A Ch\u00e9ret","year":"1997","journal-title":"J Med Primatol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/viro.1998.9558","article-title":"RANTES, IFN-gamma, CCR1, and CCR5 mRNA expression in peripheral blood, lymph node, and bronchoalveolar lavage mononuclear cells during primary simian immunodeficiency virus infection of macaques","volume":"255","author":"A Ch\u00e9ret","year":"1999","journal-title":"Virology"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"e1003810","DOI":"10.1371\/journal.ppat.1003810","article-title":"Semen CD4+ T cells and macrophages are productively infected at all stages of SIV infection in macaques","volume":"9","author":"S Bernard-Stoecklin","year":"2013","journal-title":"PLoS Pathog"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.4049\/jimmunol.0902626","article-title":"Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses","volume":"185","author":"A Leone","year":"2010","journal-title":"J Immunol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.immuni.2012.09.020","article-title":"Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets","volume":"38","author":"T Sathaliyawala","year":"2013","journal-title":"Immunity"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/ni.1718","article-title":"Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus","volume":"10","author":"T Gebhardt","year":"2009","journal-title":"Nat Immunol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.it.2011.04.008","article-title":"Defining macrophage phenotype and function in adipose tissue","volume":"32","author":"E Dalmas","year":"2011","journal-title":"Trends Immunol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/QAI.0b013e31825c3a68","article-title":"Adipogenic\/lipid, inflammatory, and mitochondrial parameters in subcutaneous adipose tissue of untreated HIV-1-infected long-term nonprogressors: significant alterations despite low viral burden","volume":"61","author":"F Vidal","year":"2012","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"Suppl 1","key":"ref61","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/sj.cdd.4401583","article-title":"Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism","volume":"12","author":"K Muthumani","year":"2005","journal-title":"Cell Death Differ"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1210\/me.2007-0124","article-title":"Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor {gamma} and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy","volume":"22","author":"S Shrivastav","year":"2008","journal-title":"Mol Endocrinol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4252\/wjsc.v3.i4.25","article-title":"Adipose-derived stromal cells: Their identity and uses in clinical trials, an update","volume":"3","author":"L Casteilla","year":"2011","journal-title":"World J Stem Cells"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Baglioni S, Francalanci M, Squecco R, Lombardi A, Cantini G, Angeli R, et al. Characterization of human adult stem-cell populations isolated from visceral and subcutaneous adipose tissue. <comment>doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1096\/fj.08-126946\" xlink:type=\"simple\">10.1096\/fj.08-126946<\/ext-link><\/comment>","DOI":"10.1096\/fj.08-126946"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1742-4690-8-3","article-title":"Mesenchymal stem cell derived hematopoietic cells are permissive to HIV-1 infection","volume":"8","author":"TZ Nazari-Shafti","year":"2011","journal-title":"Retrovirology"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/1742-4690-6-106","article-title":"Dynamics of viral replication in blood and lymphoid tissues during SIVmac251 infection of macaques","volume":"6","author":"A Mannioui","year":"2009","journal-title":"Retrovirology"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"e37348","DOI":"10.1371\/journal.pone.0037348","article-title":"Impact of short-term HAART initiated during the chronic stage or shortly post-exposure on SIV infection of male genital organs","volume":"7","author":"M Moreau","year":"2012","journal-title":"PLoS One"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1172\/JCI64314","article-title":"Expansion of HIV-specific T follicular helper cells in chronic HIV infection","volume":"122","author":"M Lindqvist","year":"2012","journal-title":"J Clin Invest"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/nm.3781","article-title":"B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers","volume":"21","author":"Y Fukazawa","year":"2015","journal-title":"Nat Med"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"e40351","DOI":"10.1371\/journal.pone.0040351","article-title":"Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms","volume":"7","author":"S Lucas","year":"2012","journal-title":"PLoS One"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1038\/oby.2011.68","article-title":"Role of the gut in visceral fat inflammation and metabolic disorders","volume":"19","author":"YY Lam","year":"2011","journal-title":"Obesity (Silver Spring)"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","article-title":"Inflammatory Mechanisms in Obesity","volume":"29","author":"MF Gregor","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/QAD.0000000000000599","article-title":"Human adipose tissue as a reservoir for memory CD4+ T cells and HIV","volume":"29","author":"J Couturier","year":"2015","journal-title":"AIDS"},{"key":"ref74","first-page":"1608","article-title":"Interplay Between Human Adipocytes and T Lymphocytes","author":"C Duffaut","year":"2009"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1074\/jbc.M408687200","article-title":"Human immunodeficiency virus protease inhibitors accumulate into cultured human adipocytes and alter expression of adipocytokines","volume":"280","author":"C Vernochet","year":"2005","journal-title":"J Biol Chem"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1097\/QAD.0b013e328347c083","article-title":"Downregulation of CD38 activation markers by atorvastatin in HIV patients with undetectable viral load","volume":"25","author":"S De Wit","year":"2011","journal-title":"AIDS"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1310\/hct1303-153","article-title":"Statin therapy decreases serum levels of high-sensitivity C-reactive protein and tumor necrosis factor-\u03b1 in HIV-infected patients treated with ritonavir-boosted protease inhibitors","volume":"13","author":"L Calza","journal-title":"HIV Clin Trials"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"128","DOI":"10.4161\/adip.24075","article-title":"Sex differences in adipose tissue: It is not only a question of quantity and distribution","volume":"2","author":"E Fuente-Mart\u00edn","year":"2013","journal-title":"Adipocyte"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1089\/08892220050117014","article-title":"Sensitive and robust one-tube real-time reverse transcriptase-polymerase chain reaction to quantify SIV RNA load: comparison of one- versus two-enzyme systems","volume":"16","author":"R Hofmann-Lehmann","year":"2000","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1172\/JCI23006","article-title":"Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS","volume":"115","author":"C Kornfeld","year":"2005","journal-title":"J Clin Invest"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"13456","DOI":"10.1128\/JVI.01619-07","article-title":"Dynamics of T-cell responses and memory T cells during primary simian immunodeficiency virus infection in cynomolgus macaques","volume":"81","author":"I Karlsson","year":"2007","journal-title":"J Virol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1097\/QAD.0b013e32830fbdbc","article-title":"HIV-DNA in rectal cells is well correlated with HIV-DNA in blood in different groups of patients, including long-term non-progressors","volume":"22","author":"V Avettand-Fenoel","year":"2008","journal-title":"AIDS"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/jmv.21390","article-title":"LTR real-time PCR for HIV-1 DNA quantitation in blood cells for early diagnosis in infants born to seropositive mothers treated in HAART area (ANRS CO 01)","volume":"81","author":"V Avettand-F\u00e8no\u00ebl","year":"2009","journal-title":"J Med Virol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"e64219","DOI":"10.1371\/journal.pone.0064219","article-title":"A single HIV-1 cluster and a skewed immune homeostasis drive the early spread of HIV among resting CD4+ cell subsets within one month post-infection","volume":"8","author":"C Bacchus","year":"2013","journal-title":"PLoS One"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1681\/ASN.2013050564","article-title":"The kidney as a reservoir for HIV-1 after renal transplantation","volume":"25","author":"G Canaud","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"ref86","first-page":"149","article-title":"Orchitis and human immunodeficiency virus type 1 infected cells in reproductive tissues from men with the acquired immune deficiency syndrome","volume":"139","author":"J Pudney","year":"1991","journal-title":"Am J Pathol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1742-4690-5-119","article-title":"Human prostate supports more efficient replication of HIV-1 R5 than X4 strains ex vivo","volume":"5","author":"A Le Tortorec","year":"2008","journal-title":"Retrovirology"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.1128\/JVI.03628-14","article-title":"Detection of Simian Immunodeficiency Virus in Semen, Urethra, and Male Reproductive Organs during Efficient Highly Active Antiretroviral Therapy","volume":"89","author":"G Matusali","year":"2015","journal-title":"J Virol"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1005153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T06:30:04Z","timestamp":1653201004000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1005153"}},"subtitle":[],"editor":[{"given":"Guido","family":"Silvestri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,9,24]]},"references-count":88,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,9,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1005153","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,24]]}}}