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Wille","year":"2013","journal-title":"J Virol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"14988","DOI":"10.1073\/pnas.0707323104","article-title":"Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1","volume":"104","author":"E Magn\u00fasd\u00f3ttir","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0092-8674(94)90321-2","article-title":"Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells","volume":"77","author":"CA Turner","year":"1994","journal-title":"Cell"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1128\/JVI.02781-14","article-title":"Cellular Differentiation Regulator BLIMP1 Induces Epstein-Barr Virus Lytic Reactivation in Epithelial and B Cells by Activating Transcription from both the R and Z Promoters","volume":"89","author":"JA Reusch","year":"2015","journal-title":"J Virol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/11926","article-title":"Klf4 is a transcription factor required for establishing the barrier function of the skin","volume":"22","author":"JA Segre","year":"1999","journal-title":"Nat Genet"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/onc.2010.474","article-title":"Mutant p53 subverts p63 control over KLF4 expression in keratinocytes","volume":"30","author":"N Cordani","year":"2011","journal-title":"Oncogene"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"11442","DOI":"10.1128\/JVI.00972-14","article-title":"Genome-Wide DNA Methylation as an Epigenetic Consequence of Epstein-Barr Virus Infection of Immortalized Keratinocytes","volume":"88","author":"CE Birdwell","year":"2014","journal-title":"J 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Factor 2 (MEF2) Family Transcription Factors to BZLF1 Expression in Epstein-Barr virus Reactivation from Latency","author":"T Murata","year":"2013","journal-title":"J Virol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"783","DOI":"10.4161\/cbt.7.5.6110","article-title":"Bad things happen in the basal layer: KLF4 and squamous cell carcinoma","volume":"7","author":"W Jiang","year":"2008","journal-title":"Cancer Biol Ther"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1099\/vir.0.038661-0","article-title":"Lytic Epstein-Barr virus infection in epithelial cells but not in B-lymphocytes is dependent on Blimp1","volume":"93","author":"M Buettner","year":"2012","journal-title":"J Gen Virol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e00726","DOI":"10.7554\/eLife.00726","article-title":"DNA methylation presents distinct binding sites for human transcription factors","volume":"2","author":"S Hu","year":"2013","journal-title":"eLife"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.cell.2013.02.004","article-title":"Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives","volume":"152","author":"CG Spruijt","year":"2013","journal-title":"Cell"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1471-2407-12-125","article-title":"Methylation profiling of Epstein-Barr virus immediate-early gene promoters, BZLF1 and BRLF1 in tumors of epithelial, NK- and B-cell origins","volume":"12","author":"L Li","year":"2012","journal-title":"BMC Cancer"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"10113","DOI":"10.1128\/JVI.00692-07","article-title":"ZEB1 and c-Jun Levels Contribute to the Establishment of Highly Lytic Epstein-Barr Virus Infection in Gastric AGS Cells","volume":"81","author":"W Feng","year":"2007","journal-title":"J 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Ther"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1349-7006.2011.01859.x","article-title":"Persistent Kr\u00fcppel-like factor 4 expression predicts progression and poor prognosis of head and neck squamous cell carcinoma","volume":"102","author":"S-K Tai","year":"2011","journal-title":"Cancer Sci"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"33994","DOI":"10.1074\/jbc.M701847200","article-title":"Kr\u00fcppel-like Factor 4 Is Acetylated by p300 and Regulates Gene Transcription via Modulation of Histone Acetylation","volume":"282","author":"PM Evans","year":"2007","journal-title":"J Biol Chem"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"28298","DOI":"10.1074\/jbc.M110.101717","article-title":"A small ubiquitin-related modifier-interacting motif functions as the transcriptional activation domain of Kr\u00fcppel-like factor 4","volume":"285","author":"JX Du","year":"2010","journal-title":"J Biol 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Cardiol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"12791","DOI":"10.1074\/jbc.M113.465443","article-title":"Sumoylation of Kr\u00fcppel-like factor 4 inhibits pluripotency induction but promotes adipocyte differentiation","volume":"288","author":"S Tahmasebi","year":"2013","journal-title":"J Biol Chem"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/intimm\/dxn024","article-title":"KLF4 is a FOXO target gene that suppresses B cell proliferation","volume":"20","author":"I Yusuf","year":"2008","journal-title":"Int Immunol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1182\/blood-2006-03-011106","article-title":"KLF4 suppresses transformation of pre-B cells by ABL oncogenes","volume":"109","author":"MG Kharas","year":"2007","journal-title":"Blood"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1182\/blood-2009-12-256446","article-title":"KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma","volume":"116","author":"H Guan","year":"2010","journal-title":"Blood"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S1074-7613(02)00335-7","article-title":"Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program","volume":"17","author":"AL Shaffer","year":"2002","journal-title":"Immunity"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.1128\/MCB.22.13.4771-4780.2002","article-title":"Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells","volume":"22","author":"K-I Lin","year":"2002","journal-title":"Mol Cell Biol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1126\/science.276.5312.596","article-title":"Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation","volume":"276","author":"Y Lin","year":"1997","journal-title":"Science"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1101\/gad.5.5.868","article-title":"Identification and characterization of a novel repressor of beta-interferon gene expression","volume":"5","author":"AD Keller","year":"1991","journal-title":"Genes Dev"},{"key":"ref85","first-page":"476","article-title":"Abrogation of the retinoblastoma tumor suppressor checkpoint during keratinocyte immortalization is not sufficient for induction of centrosome-mediated genomic instability","volume":"63","author":"S Piboonniyom","year":"2003","journal-title":"Cancer Res"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"7004","DOI":"10.1128\/JVI.78.13.7004-7015.2004","article-title":"Production of High-Titer Epstein-Barr Virus Recombinants Derived from Akata Cells by Using a Bacterial Artificial Chromosome System","volume":"78","author":"T Kanda","year":"2004","journal-title":"J Virol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"10696","DOI":"10.1128\/JVI.01457-14","article-title":"Comprehensive high-throughput RNA sequencing analysis reveals contamination of multiple nasopharyngeal carcinoma cell lines with HeLa cell genomes","volume":"88","author":"MJ Strong","year":"2014","journal-title":"J Virol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/(SICI)1097-0215(19990924)83:1<121::AID-IJC21>3.0.CO;2-F","article-title":"Nasopharyngeal carcinoma cell line (C666-1) consistently harbouring Epstein-Barr virus","volume":"83","author":"ST Cheung","year":"1999","journal-title":"Int J Cancer J Int Cancer"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/(SICI)1097-0215(19970207)70:4<443::AID-IJC12>3.0.CO;2-G","article-title":"Establishment and characterization of human gastric carcinoma cell lines","volume":"70","author":"JG Park","year":"1997","journal-title":"Int J Cancer J Int Cancer"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.1128\/JVI.74.14.6324-6332.2000","article-title":"Epstein-Barr virus gH is essential for penetration of B cells but also plays a role in attachment of virus to epithelial cells","volume":"74","author":"SJ Molesworth","year":"2000","journal-title":"J Virol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1128\/MCB.01189-10","article-title":"A KLF4\u2013miRNA-206 Autoregulatory Feedback Loop Can Promote or Inhibit Protein Translation Depending upon Cell Context","volume":"31","author":"C-C Lin","year":"2011","journal-title":"Mol Cell Biol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.4049\/jimmunol.170.6.3125","article-title":"Identification of a Functionally Impaired Positive Regulatory Domain I Binding Factor 1 Transcription Repressor in Myeloma Cell Lines","volume":"170","author":"I Gy\u00f6ry","year":"2003","journal-title":"J Immunol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4161\/epi.1.3.3327","article-title":"Functional analysis of promoter CpG methylation using a CpG-free luciferase reporter vector","volume":"1","author":"M Klug","year":"2006","journal-title":"Epigenetics Off J DNA Methylation Soc"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"9094","DOI":"10.1128\/MCB.23.24.9094-9103.2003","article-title":"Recapitulation of the Effects of the Human Papillomavirus Type 16 E7 Oncogene on Mouse Epithelium by Somatic Rb Deletion and Detection of pRb-Independent Effects of E7 In Vivo","volume":"23","author":"SJ Balsitis","year":"2003","journal-title":"Mol Cell Biol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"7976","DOI":"10.1128\/JVI.00770-12","article-title":"An Epstein-Barr Virus (EBV) mutant with enhanced BZLF1 expression causes lymphomas with abortive lytic EBV infection in a humanized mouse model","volume":"86","author":"S-D Ma","year":"2012","journal-title":"J Virol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1128\/JVI.75.5.2388-2399.2001","article-title":"Epstein-barr virus immediate-early protein BZLF1 is SUMO-1 modified and disrupts promyelocytic leukemia bodies","volume":"75","author":"AL Adamson","year":"2001","journal-title":"J Virol"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1128\/JVI.78.10.4983-4992.2004","article-title":"The BRRF1 Early Gene of Epstein-Barr Virus Encodes a Transcription Factor That Enhances Induction of Lytic Infection by BRLF1","volume":"78","author":"GK Hong","year":"2004","journal-title":"J Virol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nmeth.3047","article-title":"Improved vectors and genome-wide libraries for CRISPR screening","volume":"11","author":"NE Sanjana","year":"2014","journal-title":"Nat 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