{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:21:06Z","timestamp":1790695266108,"version":"4.1.0"},"reference-count":102,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T00:00:00Z","timestamp":1445558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1005241","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T20:15:20Z","timestamp":1445631320000},"page":"e1005241","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":42,"title":["Yersinia pestis Requires Host Rab1b for Survival in Macrophages"],"prefix":"10.1371","volume":"11","author":[{"given":"Michael G.","family":"Connor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda R.","family":"Pulsifer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Abu Kwaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew B.","family":"Lawrenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,10,23]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1128\/CMR.10.1.35","article-title":"<italic>Yersinia pestis<\/italic>\u2014etiologic agent of plague","volume":"10","author":"RD Perry","year":"1997","journal-title":"Clinical microbiology reviews"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"788","DOI":"10.4269\/ajtmh.13-0191","article-title":"Plague gives surprises in the first decade of the 21st century in the United States and worldwide","volume":"89","author":"T Butler","year":"2013","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"17","key":"ref3","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1001\/jama.283.17.2281","article-title":"Plague as a biological weapon: medical and public health management. Working Group on Civilian Biodefense","volume":"283","author":"TV Inglesby","year":"2000","journal-title":"Jama"},{"key":"ref4","article-title":"<italic>Yersinia pestis<\/italic> survival and replication within human neutrophil phagosomes and uptake of infected neutrophils by macrophages","author":"JL Spinner","year":"2013","journal-title":"Journal of leukocyte biology"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1128\/IAI.45.3.649-654.1984","article-title":"Growth in mouse peritoneal macrophages of <italic>Yersinia pestis<\/italic> lacking established virulence determinants","volume":"45","author":"SC Straley","year":"1984","journal-title":"Infection and immunity"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"e1004587","DOI":"10.1371\/journal.ppat.1004587","article-title":"Dissemination of a highly virulent pathogen: tracking the early events that define infection","volume":"11","author":"RJ Gonzalez","year":"2015","journal-title":"PLoS pathogens"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"7142","DOI":"10.1128\/IAI.73.11.7142-7150.2005","article-title":"Pathogenesis of <italic>Yersinia pestis<\/italic> infection in BALB\/c mice: effects on host macrophages and neutrophils","volume":"73","author":"RA Lukaszewski","year":"2005","journal-title":"Infection and immunity"},{"issue":"3870","key":"ref8","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1126\/science.163.3870.950","article-title":"Plague bacillus: survival within host phagocytes","volume":"163","author":"WA Janssen","year":"1969","journal-title":"Science"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"e1004893","DOI":"10.1371\/journal.ppat.1004893","article-title":"Circumventing Y. pestis Virulence by Early Recruitment of Neutrophils to the Lungs during Pneumonic Plague","volume":"11","author":"Y Vagima","year":"2015","journal-title":"PLoS pathogens"},{"issue":"3","key":"ref10","first-page":"286","article-title":"The basis of virulence in <italic>Pasteurella pestis<\/italic>: the development of resistance to phagocytosis in vitro","volume":"37","author":"TW Burrows","year":"1956","journal-title":"British journal of experimental pathology"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1128\/IAI.71.10.5892-5899.2003","article-title":"The ability to replicate in macrophages is conserved between <italic>Yersinia pestis<\/italic> and <italic>Yersinia pseudotuberculosis<\/italic>","volume":"71","author":"C Pujol","year":"2003","journal-title":"Infection and immunity"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1128\/IAI.00068-09","article-title":"<italic>Yersinia pestis<\/italic> can reside in autophagosomes and avoid xenophagy in murine macrophages by preventing vacuole acidification","volume":"77","author":"C Pujol","year":"2009","journal-title":"Infection and immunity"},{"issue":"7","key":"ref13","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1128\/IAI.00255-06","article-title":"Characterization of phagosome trafficking and identification of PhoP-regulated genes important for survival of <italic>Yersinia pestis<\/italic> in macrophages","volume":"74","author":"JP Grabenstein","year":"2006","journal-title":"Infection and immunity"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1128\/IAI.45.3.655-659.1984","article-title":"<italic>Yersinia pestis<\/italic> grows within phagolysosomes in mouse peritoneal macrophages","volume":"45","author":"SC Straley","year":"1984","journal-title":"Infection and immunity"},{"issue":"9","key":"ref15","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1128\/IAI.72.9.4973-4984.2004","article-title":"The response regulator PhoP of <italic>Yersinia pseudotuberculosis<\/italic> is important for replication in macrophages and for virulence","volume":"72","author":"JP Grabenstein","year":"2004","journal-title":"Infection and immunity"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/j.1462-5822.2010.01456.x","article-title":"Autophagosomes can support <italic>Yersinia pseudotuberculosis<\/italic> replication in macrophages","volume":"12","author":"K Moreau","year":"2010","journal-title":"Cellular microbiology"},{"issue":"9","key":"ref17","doi-asserted-by":"crossref","DOI":"10.4161\/auto.29411","article-title":"Role of VAMP3 and VAMP7 in the commitment of Yersinia pseudotuberculosis to LC3-associated pathways involving single- or double-membrane vacuoles","volume":"10","author":"LA Ligeon","year":"2014","journal-title":"Autophagy"},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1371\/journal.pone.0042211","article-title":"Yersinia pestis intracellular parasitism of macrophages from hosts exhibiting high and low severity of plague","volume":"7","author":"D Ponnusamy","year":"2012","journal-title":"PloS one"},{"issue":"2","key":"ref19","first-page":"167","article-title":"Pneumonic plague in monkeys. An electron microscopic study","volume":"54","author":"MJ Finegold","year":"1969","journal-title":"The American journal of pathology"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.immuni.2014.07.013","article-title":"S1P-Dependent Trafficking of Intracellular <italic>Yersinia pestis<\/italic> through Lymph Nodes Establishes Buboes and Systemic Infection","volume":"41","author":"AL St John","year":"2014","journal-title":"Immunity"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1128\/IAI.00284-09","article-title":"Gr1+ cells control growth of YopM-negative <italic>yersinia pestis<\/italic> during systemic plague","volume":"77","author":"Z Ye","year":"2009","journal-title":"Infection and immunity"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1128\/IAI.68.6.3419-3425.2000","article-title":"The response regulator PhoP is important for survival under conditions of macrophage-induced stress and virulence in <italic>Yersinia pestis<\/italic>","volume":"68","author":"PC Oyston","year":"2000","journal-title":"Infection and immunity"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.micpath.2011.02.005","article-title":"The role of the phoPQ operon in the pathogenesis of the fully virulent CO92 strain of <italic>Yersinia pestis<\/italic> and the IP32953 strain of <italic>Yersinia pseudotuberculosis<\/italic>","volume":"50","author":"J Bozue","year":"2011","journal-title":"Microbial pathogenesis"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/infdis\/124.5.522","article-title":"The role of domestic animals in the epidemiology of plague. I. Experimental infection of dogs and cats","volume":"124","author":"JH Rust Jr.","year":"1971","journal-title":"The Journal of infectious diseases"},{"issue":"12","key":"ref25","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1111\/tra.12000","article-title":"Bacterial pathogens commandeer Rab GTPases to establish intracellular niches","volume":"13","author":"MP Stein","year":"2012","journal-title":"Traffic"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yexcr.2014.07.027","article-title":"Rab proteins: the key regulators of intracellular vesicle transport","volume":"328","author":"T Bhuin","year":"2014","journal-title":"Experimental cell research"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nrm2515","article-title":"Phagosome maturation: going through the acid test","volume":"9","author":"JM Kinchen","year":"2008","journal-title":"Nature reviews Molecular cell biology"},{"issue":"Pt 3","key":"ref28","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1042\/bj20020691","article-title":"Phagosome maturation: aging gracefully","volume":"366","author":"OV Vieira","year":"2002","journal-title":"The Biochemical journal"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.chom.2012.01.010","article-title":"Yersinia entry into host cells requires Rab5-dependent dephosphorylation of PI(4,5)P(2) and membrane scission","volume":"11","author":"H Sarantis","year":"2012","journal-title":"Cell host & microbe"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1042\/BST0381413","article-title":"Endosome-lysosome fusion","volume":"38","author":"JP Luzio","year":"2010","journal-title":"Biochemical Society transactions"},{"issue":"8","key":"ref31","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/nrm2217","article-title":"Lysosomes: fusion and function","volume":"8","author":"JP Luzio","year":"2007","journal-title":"Nature reviews Molecular cell biology"},{"issue":"72","key":"ref32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1042\/bss0720077","article-title":"Membrane traffic to and from lysosomes","author":"JP Luzio","year":"2005","journal-title":"Biochemical Society symposium"},{"issue":"24","key":"ref33","doi-asserted-by":"crossref","first-page":"6960","DOI":"10.1002\/j.1460-2075.1996.tb01088.x","article-title":"<italic>Mycobacterium<\/italic>-containing phagosomes are accessible to early endosomes and reflect a transitional state in normal phagosome biogenesis","volume":"15","author":"S Sturgill-Koszycki","year":"1996","journal-title":"The EMBO journal"},{"issue":"20","key":"ref34","doi-asserted-by":"crossref","first-page":"13326","DOI":"10.1074\/jbc.272.20.13326","article-title":"Arrest of mycobacterial phagosome maturation is caused by a block in vesicle fusion between stages controlled by rab5 and rab7","volume":"272","author":"LE Via","year":"1997","journal-title":"The Journal of biological chemistry"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1083\/jcb.200106049","article-title":"Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest","volume":"154","author":"RA Fratti","year":"2001","journal-title":"The Journal of cell biology"},{"issue":"9","key":"ref36","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1073\/pnas.0737613100","article-title":"<italic>Mycobacterium tuberculosis<\/italic> glycosylated phosphatidylinositol causes phagosome maturation arrest","volume":"100","author":"RA Fratti","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.bbrc.2009.06.152","article-title":"Dissection of Rab7 localization on <italic>Mycobacterium tuberculosis<\/italic> phagosome","volume":"387","author":"S Seto","year":"2009","journal-title":"Biochemical and biophysical research communications"},{"issue":"7","key":"ref38","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1083\/jcb.200603026","article-title":"Higher order Rab programming in phagolysosome biogenesis","volume":"174","author":"EA Roberts","year":"2006","journal-title":"The Journal of cell biology"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1128\/IAI.00688-10","article-title":"The early secretory pathway contributes to the growth of the <italic>Coxiella<\/italic>-replicative niche","volume":"79","author":"EM Campoy","year":"2011","journal-title":"Infection and immunity"},{"issue":"5","key":"ref40","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1128\/IAI.72.5.3048-3053.2004","article-title":"<italic>Legionella pneumophila<\/italic> replication vacuole formation involves rapid recruitment of proteins of the early secretory system","volume":"72","author":"I Derre","year":"2004","journal-title":"Infection and immunity"},{"issue":"5","key":"ref41","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.cell.2012.06.050","article-title":"Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses","volume":"150","author":"N Dong","year":"2012","journal-title":"Cell"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"e01035","DOI":"10.1128\/mBio.01035-13","article-title":"AMPylation is critical for Rab1 localization to vacuoles containing Legionella pneumophila","volume":"5","author":"CA Hardiman","year":"2014","journal-title":"MBio"},{"issue":"9","key":"ref43","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/j.1462-5822.2010.01468.x","article-title":"The <italic>Anaplasma phagocytophilum<\/italic>-occupied vacuole selectively recruits Rab-GTPases that are predominantly associated with recycling endosomes","volume":"12","author":"B Huang","year":"2010","journal-title":"Cellular microbiology"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4161\/auto.7.1.13840","article-title":"Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase","volume":"7","author":"J Huang","year":"2011","journal-title":"Autophagy"},{"issue":"7168","key":"ref45","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nature06336","article-title":"<italic>Legionella pneumophila<\/italic> proteins that regulate Rab1 membrane cycling","volume":"450","author":"A Ingmundson","year":"2007","journal-title":"Nature"},{"issue":"9","key":"ref46","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1084\/jem.20031706","article-title":"<italic>Legionella<\/italic> subvert the functions of Rab1 and Sec22b to create a replicative organelle","volume":"199","author":"JC Kagan","year":"2004","journal-title":"The Journal of experimental medicine"},{"issue":"6041","key":"ref47","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1126\/science.1207193","article-title":"De-AMPylation of the small GTPase Rab1 by the pathogen <italic>Legionella pneumophila<\/italic>","volume":"333","author":"MR Neunuebel","year":"2011","journal-title":"Science"},{"issue":"10","key":"ref48","doi-asserted-by":"crossref","first-page":"5855","DOI":"10.1128\/IAI.71.10.5855-5870.2003","article-title":"Rab GTPases are recruited to chlamydial inclusions in both a species-dependent and species-independent manner","volume":"71","author":"KA Rzomp","year":"2003","journal-title":"Infection and immunity"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1042\/BST20120167","article-title":"The role of Rab GTPases in the transport of vacuoles containing <italic>Legionella pneumophila<\/italic> and <italic>Coxiella burnetii<\/italic>","volume":"40","author":"CA Hardiman","year":"2012","journal-title":"Biochemical Society transactions"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1083\/jcb.119.4.749","article-title":"GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex","volume":"119","author":"EJ Tisdale","year":"1992","journal-title":"The Journal of cell biology"},{"issue":"1\u20132","key":"ref51","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0014-5793(89)81722-3","article-title":"Biochemical properties of the YPT-related rab1B protein. Comparison with rab1A","volume":"256","author":"N Touchot","year":"1989","journal-title":"FEBS letters"},{"issue":"1","key":"ref52","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1083\/jcb.115.1.31","article-title":"Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments","volume":"115","author":"H Plutner","year":"1991","journal-title":"The Journal of cell biology"},{"issue":"3","key":"ref53","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/cdd.2013.187","article-title":"Regulation of autophagy by the Rab GTPase network","volume":"21","author":"X Ao","year":"2014","journal-title":"Cell Death Differ"},{"key":"ref54","article-title":"Bacteria-autophagy interplay: a battle for survival","author":"J Huang","year":"2014","journal-title":"Nature reviews Microbiology"},{"issue":"5","key":"ref55","doi-asserted-by":"crossref","first-page":"G412","DOI":"10.1152\/ajpgi.00118.2013","article-title":"Rab1a regulates sorting of early endocytic vesicles","volume":"306","author":"A Mukhopadhyay","year":"2014","journal-title":"American journal of physiology Gastrointestinal and liver physiology"},{"issue":"Pt 5","key":"ref56","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1242\/jcs.079020","article-title":"Proteomic analysis of endocytic vesicles: Rab1a regulates motility of early endocytic vesicles","volume":"124","author":"A Mukhopadhyay","year":"2011","journal-title":"Journal of cell science"},{"issue":"1","key":"ref57","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.chom.2011.11.009","article-title":"The <italic>Legionella pneumophila<\/italic> effector DrrA is sufficient to stimulate SNARE-dependent membrane fusion","volume":"11","author":"K Arasaki","year":"2012","journal-title":"Cell host & microbe"},{"issue":"2","key":"ref58","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/embor.2012.211","article-title":"Mechanism of Rab1b deactivation by the <italic>Legionella pneumophila<\/italic> GAP LepB","volume":"14","author":"E Mihai Gazdag","year":"2013","journal-title":"EMBO reports"},{"issue":"5994","key":"ref59","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1126\/science.1192276","article-title":"The <italic>Legionella<\/italic> effector protein DrrA AMPylates the membrane traffic regulator Rab1b","volume":"329","author":"MP Muller","year":"2010","journal-title":"Science"},{"issue":"44","key":"ref60","doi-asserted-by":"crossref","first-page":"17945","DOI":"10.1073\/pnas.1113133108","article-title":"Protein LidA from <italic>Legionella<\/italic> is a Rab GTPase supereffector","volume":"108","author":"S Schoebel","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"ref61","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1600-0854.2010.01050.x","article-title":"<italic>Legionella pneumophila<\/italic> promotes functional interactions between plasma membrane syntaxins and Sec22b","volume":"11","author":"K Arasaki","year":"2010","journal-title":"Traffic"},{"issue":"33","key":"ref62","doi-asserted-by":"crossref","first-page":"24000","DOI":"10.1074\/jbc.M113.470625","article-title":"The <italic>Legionella pneumophila<\/italic> GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism","volume":"288","author":"AK Mishra","year":"2013","journal-title":"The Journal of biological chemistry"},{"issue":"10","key":"ref63","doi-asserted-by":"crossref","first-page":"e47123","DOI":"10.1371\/journal.pone.0047123","article-title":"Development of bioluminescent bioreporters for in vitro and in vivo tracking of <italic>Yersinia pestis<\/italic>","volume":"7","author":"Y Sun","year":"2012","journal-title":"PloS one"},{"issue":"5738","key":"ref64","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1126\/science.1116008","article-title":"Genome-wide RNAi screen for host factors required for intracellular bacterial infection","volume":"309","author":"H Agaisse","year":"2005","journal-title":"Science"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/msb.2011.7","article-title":"RNAi screen of <italic>Salmonella<\/italic> invasion shows role of COPI in membrane targeting of cholesterol and Cdc42","volume":"7","author":"B Misselwitz","year":"2011","journal-title":"Molecular systems biology"},{"issue":"12","key":"ref66","doi-asserted-by":"crossref","first-page":"6424","DOI":"10.1128\/IAI.67.12.6424-6433.1999","article-title":"Optimization of plasmid maintenance in the attenuated live vector vaccine strain <italic>Salmonella<\/italic> typhi CVD 908-htrA","volume":"67","author":"JE Galen","year":"1999","journal-title":"Infection and immunity"},{"issue":"12","key":"ref67","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/ncb883","article-title":"<italic>Legionella<\/italic> phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites","volume":"4","author":"JC Kagan","year":"2002","journal-title":"Nature cell biology"},{"issue":"9","key":"ref68","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/j.1365-2443.2006.00997.x","article-title":"Screening for target Rabs of TBC (Tre-2\/Bub2\/Cdc16) domain-containing proteins based on their Rab-binding activity","volume":"11","author":"T Itoh","year":"2006","journal-title":"Genes to cells: devoted to molecular & cellular mechanisms"},{"issue":"3","key":"ref69","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1034\/j.1600-0854.2003.00103.x","article-title":"Golgin-84 is a rab1 binding partner involved in Golgi structure","volume":"4","author":"A Satoh","year":"2003","journal-title":"Traffic"},{"issue":"1\u20132","key":"ref70","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0167-4889(98)00050-0","article-title":"Rab proteins","volume":"1404","author":"O Martinez","year":"1998","journal-title":"Biochimica et biophysica acta"},{"issue":"6","key":"ref71","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1083\/jcb.99.6.1936","article-title":"<italic>Legionella pneumophila<\/italic> inhibits acidification of its phagosome in human monocytes","volume":"99","author":"MA Horwitz","year":"1984","journal-title":"The Journal of cell biology"},{"issue":"9","key":"ref72","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1084\/jem.192.9.1261","article-title":"<italic>Legionella pneumophila<\/italic> replication vacuoles mature into acidic, endocytic organelles","volume":"192","author":"S Sturgill-Koszycki","year":"2000","journal-title":"The Journal of experimental medicine"},{"issue":"4","key":"ref73","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1128\/MMBR.00023-07","article-title":"Manipulation of rab GTPase function by intracellular bacterial pathogens","volume":"71","author":"JH Brumell","year":"2007","journal-title":"Microbiology and molecular biology reviews: MMBR"},{"issue":"6","key":"ref74","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1042\/BST20120158","article-title":"Rab proteins of the endoplasmic reticulum: functions and interactors","volume":"40","author":"C Ortiz Sandoval","year":"2012","journal-title":"Biochemical Society transactions"},{"issue":"24","key":"ref75","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.1007\/s00018-012-1021-6","article-title":"Are Rab proteins the link between Golgi organization and membrane trafficking?","volume":"69","author":"S Liu","year":"2012","journal-title":"Cellular and molecular life sciences: CMLS"},{"issue":"6","key":"ref76","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1371\/journal.pone.0038097","article-title":"Human genome-wide RNAi screen for host factors that modulate intracellular Salmonella growth","volume":"7","author":"JM Thornbrough","year":"2012","journal-title":"PloS one"},{"issue":"7","key":"ref77","doi-asserted-by":"crossref","first-page":"e1000110","DOI":"10.1371\/journal.ppat.1000110","article-title":"RNAi screen of endoplasmic reticulum-associated host factors reveals a role for IRE1alpha in supporting Brucella replication","volume":"4","author":"QM Qin","year":"2008","journal-title":"PLoS pathogens"},{"issue":"7","key":"ref78","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1462-5822.2005.00527.x","article-title":"Autophagy induction favours the generation and maturation of the <italic>Coxiella<\/italic>-replicative vacuoles","volume":"7","author":"MG Gutierrez","year":"2005","journal-title":"Cellular microbiology"},{"issue":"3","key":"ref79","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1462-5822.2007.01068.x","article-title":"Subversion of cellular autophagy by <italic>Anaplasma phagocytophilum<\/italic>","volume":"10","author":"H Niu","year":"2008","journal-title":"Cellular microbiology"},{"issue":"1","key":"ref80","doi-asserted-by":"crossref","first-page":"e54566","DOI":"10.1371\/journal.pone.0054566","article-title":"Effector protein translocation by the Coxiella burnetii Dot\/Icm type IV secretion system requires endocytic maturation of the pathogen-occupied vacuole","volume":"8","author":"HJ Newton","year":"2013","journal-title":"PloS one"},{"issue":"9","key":"ref81","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1086\/382894","article-title":"Phagosomal acidification is not a prerequisite for intracellular multiplication of <italic>Legionella pneumophila<\/italic> in human monocytes","volume":"189","author":"H Wieland","year":"2004","journal-title":"The Journal of infectious diseases"},{"issue":"1","key":"ref82","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.critrevonc.2008.02.008","article-title":"Cathepsin D\u2014many functions of one aspartic protease","volume":"68","author":"P Benes","year":"2008","journal-title":"Crit Rev Oncol Hematol"},{"issue":"9","key":"ref83","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrm2745","article-title":"Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function","volume":"10","author":"P Saftig","year":"2009","journal-title":"Nature reviews Molecular cell biology"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev-physiol-021014-071649","article-title":"Lysosomal Physiology","volume":"77","author":"H Xu","year":"2015","journal-title":"Annual review of physiology"},{"issue":"5","key":"ref85","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/tra.12158","article-title":"<italic>Legionella pneumophila<\/italic> subversion of host vesicular transport by SidC effector proteins","volume":"15","author":"FA Horenkamp","year":"2014","journal-title":"Traffic"},{"issue":"1","key":"ref86","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.devcel.2006.05.013","article-title":"Targeting of host Rab GTPase function by the intravacuolar pathogen <italic>Legionella pneumophila<\/italic>","volume":"11","author":"MP Machner","year":"2006","journal-title":"Developmental cell"},{"issue":"9","key":"ref87","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/ncb1463","article-title":"The <italic>Legionella pneumophila<\/italic> effector protein DrrA is a Rab1 guanine nucleotide-exchange factor","volume":"8","author":"T Murata","year":"2006","journal-title":"Nature cell biology"},{"issue":"5852","key":"ref88","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.1149121","article-title":"A bifunctional bacterial protein links GDI displacement to Rab1 activation","volume":"318","author":"MP Machner","year":"2007","journal-title":"Science"},{"issue":"52","key":"ref89","doi-asserted-by":"crossref","first-page":"21212","DOI":"10.1073\/pnas.1114023109","article-title":"<italic>Legionella pneumophila<\/italic> regulates the small GTPase Rab1 activity by reversible phosphorylcholination","volume":"108","author":"Y Tan","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"7357","key":"ref90","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nature10307","article-title":"<italic>Legionella pneumophila<\/italic> SidD is a deAMPylase that modifies Rab1","volume":"475","author":"Y Tan","year":"2011","journal-title":"Nature"},{"issue":"7362","key":"ref91","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature10335","article-title":"Modulation of Rab GTPase function by a protein phosphocholine transferase","volume":"477","author":"S Mukherjee","year":"2011","journal-title":"Nature"},{"issue":"5","key":"ref92","doi-asserted-by":"crossref","first-page":"e1003382","DOI":"10.1371\/journal.ppat.1003382","article-title":"Structural basis for Rab1 de-AMPylation by the Legionella pneumophila effector SidD","volume":"9","author":"Y Chen","year":"2013","journal-title":"PLoS pathogens"},{"issue":"10","key":"ref93","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1038\/emboj.2013.82","article-title":"Structure of the <italic>Legionella<\/italic> effector AnkX reveals the mechanism of phosphocholine transfer by the FIC domain","volume":"32","author":"V Campanacci","year":"2013","journal-title":"The EMBO journal"},{"issue":"1","key":"ref94","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4269\/ajtmh.1994.51.109","article-title":"Cat-transmitted fatal pneumonic plague in a person who traveled from Colorado to Arizona","volume":"51","author":"JM Doll","year":"1994","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"4","key":"ref95","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1128\/IAI.61.4.1320-1329.1993","article-title":"Phenotypic modulation by <italic>Legionella pneumophila<\/italic> upon infection of macrophages","volume":"61","author":"Y Abu Kwaik","year":"1993","journal-title":"Infection and immunity"},{"issue":"4","key":"ref96","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1111\/j.1365-2958.2008.06453.x","article-title":"A Dot\/Icm-translocated ankyrin protein of <italic>Legionella pneumophila<\/italic> is required for intracellular proliferation within human macrophages and protozoa","volume":"70","author":"S Al-Khodor","year":"2008","journal-title":"Molecular microbiology"},{"issue":"4","key":"ref97","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1128\/IAI.69.4.2569-2579.2001","article-title":"HtrA homologue of <italic>Legionella pneumophila<\/italic>: an indispensable element for intracellular infection of mammalian but not protozoan cells","volume":"69","author":"LL Pedersen","year":"2001","journal-title":"Infection and immunity"},{"issue":"5","key":"ref98","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nmeth.1318","article-title":"Enzymatic assembly of DNA molecules up to several hundred kilobases","volume":"6","author":"DG Gibson","year":"2009","journal-title":"Nature methods"},{"issue":"4","key":"ref99","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1600-0854.2011.01165.x","article-title":"Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes","volume":"12","author":"S Seto","year":"2011","journal-title":"Traffic"},{"issue":"4","key":"ref100","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods (San Diego, Calif)"},{"issue":"1\u20132","key":"ref101","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0378-1119(93)90478-L","article-title":"Cloning of the YenI restriction endonuclease and methyltransferase from <italic>Yersinia enterocolitica<\/italic> serotype O8 and construction of a transformable R-M+ mutant","volume":"136","author":"SA Kinder","year":"1993","journal-title":"Gene"},{"issue":"38","key":"ref102","doi-asserted-by":"crossref","first-page":"13826","DOI":"10.1073\/pnas.0404012101","article-title":"Insights into the evolution of <italic>Yersinia pestis<\/italic> through whole-genome comparison with <italic>Yersinia pseudotuberculosis<\/italic>","volume":"101","author":"PS Chain","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1005241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T23:34:02Z","timestamp":1718148842000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1005241"}},"subtitle":[],"editor":[{"given":"Denise M.","family":"Monack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,10,23]]},"references-count":102,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1005241","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,23]]}}}