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Maynard","year":"2012","journal-title":"Nature"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nri3430","article-title":"Role of the gut microbiota in immunity and inflammatory disease","volume":"13","author":"N Kamada","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.mib.2010.10.003","article-title":"Mechanisms controlling pathogen colonization of the gut","volume":"14","author":"B Stecher","year":"2011","journal-title":"Curr Opin Microbiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"a010348","DOI":"10.1101\/cshperspect.a010348","article-title":"Helicobacter and salmonella persistent infection strategies","volume":"3","author":"DM Monack","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1128\/IAI.69.3.1938-1942.2001","article-title":"Expression of cytolethal distending 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m+ for all three chromosomally located systems of DNA restriction and modification","volume":"156","author":"LR Bullas","year":"1983","journal-title":"J Bacteriol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1073\/pnas.120163297","article-title":"One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products","volume":"97","author":"KA Datsenko","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF00270447","article-title":"Phage P22-mutants with increased or decreased transduction abilities","volume":"119","author":"H Schmieger","year":"1972","journal-title":"Mol Gen Genet"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.celrep.2016.01.020","article-title":"RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer","volume":"14","author":"O Tarcic","year":"2016","journal-title":"Cell Rep"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"W305","DOI":"10.1093\/nar\/gkp427","article-title":"ToppGene Suite for gene list enrichment analysis and candidate gene prioritization","volume":"37","author":"J Chen","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"TD Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/nar\/gks808","article-title":"Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies","volume":"41","author":"A Klindworth","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2105-13-31","article-title":"PANDAseq: paired-end assembler for illumina sequences","volume":"13","author":"AP Masella","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"JG Caporaso","year":"2010","journal-title":"Nat Methods"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1093\/bioinformatics\/btq461","article-title":"Search and clustering orders of magnitude faster than BLAST","volume":"26","author":"RC 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