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in human CD34+ progenitors impairs the differentiation of an early T\/NK cell precursor","volume":"377","author":"C Dorival","year":"2008","journal-title":"Virology"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/gene.2011.65","article-title":"The role of SNPs in the \u03b1-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART","volume":"13","author":"R Rajasuriar","year":"2012","journal-title":"Genes and immunity"},{"issue":"2","key":"ref79","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2174\/157016212799937209","article-title":"Identification of IL7RA risk alleles for rapid progression during HIV-1 infection: a comprehensive study in the GRIV cohort","volume":"10","author":"S Limou","year":"2012","journal-title":"Current HIV research"},{"issue":"3","key":"ref80","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.molcel.2012.08.022","article-title":"NOTCH1 nuclear 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receptor","volume":"109","author":"C Delarasse","year":"2009","journal-title":"Journal of neurochemistry"},{"issue":"7","key":"ref84","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1634\/stemcells.2006-0669","article-title":"ATP modulates cell proliferation and elicits two different electrophysiological responses in human mesenchymal stem cells","volume":"25","author":"E Coppi","year":"2007","journal-title":"Stem Cells"},{"issue":"4","key":"ref85","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11302-007-9085-8","article-title":"The role of ATP and adenosine in the brain under normoxic and ischemic conditions","volume":"3","author":"F Pedata","year":"2007","journal-title":"Purinergic Signal"},{"issue":"6173","key":"ref86","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/333571a0","article-title":"Stimulation of B-cell progenitors by cloned murine interleukin-7","volume":"333","author":"AE Namen","year":"1988","journal-title":"Nature"},{"issue":"4","key":"ref87","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/3877","article-title":"Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency","volume":"20","author":"A Puel","year":"1998","journal-title":"Nature genetics"},{"issue":"8","key":"ref88","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1182\/blood.V96.8.2803","article-title":"A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency","volume":"96","author":"CM Roifman","year":"2000","journal-title":"Blood"},{"issue":"6","key":"ref89","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.4049\/jimmunol.1203547","article-title":"IL-7 modulates in vitro and in vivo human memory T regulatory cell functions through the CD39\/ATP axis","volume":"191","author":"M Younas","year":"2013","journal-title":"J Immunol"},{"issue":"8","key":"ref90","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1515\/hsz-2013-0114","article-title":"p0071\/PKP4, a multifunctional protein coordinating cell adhesion with cytoskeletal organization","volume":"394","author":"R Keil","year":"2013","journal-title":"Biological chemistry"},{"issue":"1\u20133","key":"ref91","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.febslet.2004.05.030","article-title":"Biochemical and cell biological characterization of a mammalian septin, Sept11","volume":"568","author":"N Hanai","year":"2004","journal-title":"FEBS letters"},{"issue":"2","key":"ref92","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.lungcan.2008.05.010","article-title":"Down-regulation of PKCzeta expression inhibits chemotaxis signal transduction in human lung cancer cells","volume":"63","author":"Y Liu","year":"2009","journal-title":"Lung cancer (Amsterdam, Netherlands)"},{"issue":"1","key":"ref93","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4049\/jimmunol.1201685","article-title":"SLAT regulates CD8+ T cell clonal expansion in a Cdc42- and NFAT1-dependent manner","volume":"190","author":"S Feau","year":"2013","journal-title":"J Immunol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-1-4614-8289-5_6","article-title":"The role of the Gadd45 family in the nervous system: a focus on neurodevelopment, neuronal injury, and cognitive neuroepigenetics","volume":"793","author":"FA Sultan","year":"2013","journal-title":"Advances in experimental medicine and biology"},{"issue":"6\u20137","key":"ref95","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.biochi.2007.02.006","article-title":"Diverse functions of RNase L and implications in pathology","volume":"89","author":"C 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