{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:17:42Z","timestamp":1790518662951,"version":"4.1.0"},"reference-count":90,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003006","name":"ETH Zurich","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003006","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008494","name":"Vontobel Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008494","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1005591","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T13:31:24Z","timestamp":1461331884000},"page":"e1005591","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":85,"title":["Neutrophil and Alveolar Macrophage-Mediated Innate Immune Control of Legionella pneumophila Lung Infection via TNF and ROS"],"prefix":"10.1371","volume":"12","author":[{"given":"Pascal","family":"Ziltener","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Reinheckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Oxenius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e00354","DOI":"10.1128\/mBio.00354-15","article-title":"The Legionella Kinase LegK2 Targets the ARP2\/3 Complex To Inhibit Actin Nucleation on Phagosomes and Allow Bacterial Evasion of the Late Endocytic Pathway","volume":"6","author":"C Michard","year":"2015","journal-title":"MBio"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.micinf.2013.09.007","article-title":"Molecular mimicry and original biochemical strategies for the biogenesis of a Legionella pneumophila replicative niche in phagocytic cells","volume":"15","author":"J Allombert","year":"2013","journal-title":"Microbes Infect"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrmicro1967","article-title":"The Legionella pneumophila replication vacuole: making a cosy niche inside host cells","volume":"7","author":"RR Isberg","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF03256652","article-title":"Legionnaires' disease: update on epidemiology and management options","volume":"2","author":"M Sabria","year":"2003","journal-title":"Am J Respir Med"},{"key":"ref5","article-title":"Legionellosis on the Rise: A Review of Guidelines for Prevention in the United States","author":"A Parr","year":"2014","journal-title":"J Public Health Manag Pract"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1177\/003335491513000309","article-title":"Legionnaires' disease and associated comorbid conditions as causes of death in the U.S., 2000\u20132010","volume":"130","author":"RN Wickramasekaran","year":"2015","journal-title":"Public Health Rep"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev-cellbio-100109-104034","article-title":"Modulation of host cell function by Legionella pneumophila type IV effectors","volume":"26","author":"A Hubber","year":"2010","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.scitotenv.2015.03.122","article-title":"Automobile windshield washer fluid: A potential source of transmission for Legionella","volume":"526","author":"DO Schwake","year":"2015","journal-title":"Sci Total Environ"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S1473-3099(14)70713-3","article-title":"Epidemiology and clinical management of Legionnaires' disease","volume":"14","author":"N Phin","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1128\/IAI.01891-14","article-title":"Alveolar macrophages and neutrophils are the primary reservoirs for Legionella pneumophila and mediate cytosolic surveillance of type IV secretion","volume":"82","author":"AM Copenhaver","year":"2014","journal-title":"Infect Immun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1172\/JCI111493","article-title":"Interaction between the legionnaires' disease bacterium (Legionella pneumophila) and human alveolar macrophages. Influence of antibody, lymphokines, and hydrocortisone","volume":"74","author":"TW Nash","year":"1984","journal-title":"J Clin Invest"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/cmi.12450","article-title":"Formation of a pathogen vacuole according to Legionella pneumophila: how to kill one bird with many stones","volume":"17","author":"I Finsel","year":"2015","journal-title":"Cell Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1111\/j.1462-5822.2008.01145.x","article-title":"Host cell processes that influence the intracellular survival of Legionella pneumophila","volume":"10","author":"S Shin","year":"2008","journal-title":"Cell Microbiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1084\/jem.20060766","article-title":"NF-kappaB translocation prevents host cell death after low-dose challenge by Legionella pneumophila","volume":"203","author":"VP Losick","year":"2006","journal-title":"J Exp Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1073\/pnas.1316376111","article-title":"VipD is a Rab5-activated phospholipase A1 that protects Legionella pneumophila from endosomal fusion","volume":"111","author":"AH Gaspar","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.immuni.2012.05.001","article-title":"Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization","volume":"37","author":"A Akhter","year":"2012","journal-title":"Immunity"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1600-065X.2011.01037.x","article-title":"Two signal models in innate immunity","volume":"243","author":"MF Fontana","year":"2011","journal-title":"Immunol Rev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.4049\/jimmunol.1003565","article-title":"Nonhematopoietic cells are key players in innate control of bacterial airway infection","volume":"186","author":"S LeibundGut-Landmann","year":"2011","journal-title":"J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"6329","DOI":"10.4049\/jimmunol.1300100","article-title":"IL-1alpha signaling initiates the inflammatory response to virulent Legionella pneumophila in vivo","volume":"190","author":"KC Barry","year":"2013","journal-title":"J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.4049\/jimmunol.166.5.3355","article-title":"Early recruitment of neutrophils determines subsequent T1\/T2 host responses in a murine model of Legionella pneumophila pneumonia","volume":"166","author":"K Tateda","year":"2001","journal-title":"J Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"7121","DOI":"10.4049\/jimmunol.181.10.7121","article-title":"A novel role for neutrophils as critical activators of NK cells","volume":"181","author":"R Sporri","year":"2008","journal-title":"J Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1128\/IAI.69.4.2017-2024.2001","article-title":"Chemokine-dependent neutrophil recruitment in a murine model of Legionella pneumonia: potential role of neutrophils as immunoregulatory cells","volume":"69","author":"K Tateda","year":"2001","journal-title":"Infect Immun"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1093\/infdis\/jiu430","article-title":"Interleukin 1 receptor-driven neutrophil recruitment accounts to MyD88-dependent pulmonary clearance of legionella pneumophila infection in vivo","volume":"211","author":"DP Mascarenhas","year":"2015","journal-title":"J Infect Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e45027","DOI":"10.1371\/journal.pone.0045027","article-title":"Dynamics of a cytokine storm","volume":"7","author":"HH Yiu","year":"2012","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature01326","article-title":"The immunopathogenesis of sepsis","volume":"420","author":"J Cohen","year":"2002","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"321s","DOI":"10.1378\/chest.112.6_Supplement.321S","article-title":"Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock","volume":"112","author":"CA Dinarello","year":"1997","journal-title":"Chest"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3389\/fmicb.2011.00126","article-title":"Immune Control of Legionella Infection: An in vivo Perspective","volume":"2","author":"R Schuelein","year":"2011","journal-title":"Front Microbiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1378\/chest.12-2820","article-title":"Incidence and risk factors of Legionella pneumophila pneumonia during anti-tumor necrosis factor therapy: a prospective French study","volume":"144","author":"F Lanternier","year":"2013","journal-title":"Chest"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1080\/00365540410019598","article-title":"A case of legionellosis during treatment with a TNFalpha antagonist","volume":"36","author":"MJ Wondergem","year":"2004","journal-title":"Scand J Infect Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.rbr.2013.04.008","article-title":"Legionella pneumonia after infliximab in a patient with rheumatoid arthritis","volume":"54","author":"S Giassi Kde","year":"2014","journal-title":"Rev Bras Reumatol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1086\/508538","article-title":"Emergence of Legionella pneumophila pneumonia in patients receiving tumor necrosis factor-alpha antagonists","volume":"43","author":"F Tubach","year":"2006","journal-title":"Clin Infect Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e1000220","DOI":"10.1371\/journal.ppat.1000220","article-title":"Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila","volume":"4","author":"S Shin","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e1001289","DOI":"10.1371\/journal.ppat.1001289","article-title":"Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila","volume":"7","author":"MF Fontana","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1128\/IAI.64.8.3236-3243.1996","article-title":"Roles for tumor necrosis factor alpha and nitric oxide in resistance of rat alveolar macrophages to Legionella pneumophila","volume":"64","author":"SJ Skerrett","year":"1996","journal-title":"Infect Immun"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1111\/j.1462-5822.2008.01180.x","article-title":"Legionella pneumophila EnhC is required for efficient replication in tumour necrosis factor alpha-stimulated macrophages","volume":"10","author":"M Liu","year":"2008","journal-title":"Cell Microbiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1111\/j.1462-5822.2007.00963.x","article-title":"Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5\/Ipaf signalling pathways","volume":"9","author":"J Coers","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.cyto.2008.08.015","article-title":"TNF receptor 1 and 2 contribute in different ways to resistance to Legionella pneumophila-induced mortality in mice","volume":"44","author":"M Fujita","year":"2008","journal-title":"Cytokine"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1086\/516530","article-title":"Antibody-mediated depletion of tumor necrosis factor-alpha impairs pulmonary host defenses to Legionella pneumophila","volume":"176","author":"SJ Skerrett","year":"1997","journal-title":"J Infect Dis"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1128\/IAI.63.9.3253-3258.1995","article-title":"In vivo regulation of replicative Legionella pneumophila lung infection by endogenous tumor necrosis factor alpha and nitric oxide","volume":"63","author":"JK Brieland","year":"1995","journal-title":"Infect Immun"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/ni.1646","article-title":"Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin","volume":"9","author":"KL Lightfield","year":"2008","journal-title":"Nat Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.molcel.2014.02.018","article-title":"Molecular basis for specific recognition of bacterial ligands by NAIP\/NLRC4 inflammasomes","volume":"54","author":"JL Tenthorey","year":"2014","journal-title":"Mol Cell"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e1000361","DOI":"10.1371\/journal.ppat.1000361","article-title":"Caspase-7 activation by the Nlrc4\/Ipaf inflammasome restricts Legionella pneumophila infection","volume":"5","author":"A Akhter","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/ni.1960","article-title":"Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria","volume":"11","author":"EA Miao","year":"2010","journal-title":"Nat Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.4049\/jimmunol.1003784","article-title":"Activation of NLRC4 by Flagellated Bacteria Triggers Caspase-1-Dependent and -Independent Responses To Restrict Legionella pneumophila Replication in Macrophages and In Vivo","volume":"187","author":"MS Pereira","year":"2011","journal-title":"J Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.micinf.2012.03.006","article-title":"The human apoptosis inhibitor NAIP induces pyroptosis in macrophages infected with Legionella pneumophila","volume":"14","author":"N Katagiri","year":"2012","journal-title":"Microbes Infect"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"6808","DOI":"10.4049\/jimmunol.180.10.6808","article-title":"NAIP and Ipaf control Legionella pneumophila replication in human cells","volume":"180","author":"M Vinzing","year":"2008","journal-title":"J Immunol"},{"key":"ref47","article-title":"Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin","author":"J Kortmann","year":"2015","journal-title":"J Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"6688","DOI":"10.1073\/pnas.1421699112","article-title":"Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens","volume":"112","author":"CN Casson","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0960-9822(02)01359-3","article-title":"Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila","volume":"13","author":"EK Wright","year":"2003","journal-title":"Curr Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ng1065","article-title":"Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila","volume":"33","author":"E Diez","year":"2003","journal-title":"Nat Genet"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"8022","DOI":"10.4049\/jimmunol.178.12.8022","article-title":"The Nod-like receptor family member Naip5\/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation","volume":"178","author":"M Lamkanfi","year":"2007","journal-title":"J Immunol"},{"key":"ref52","first-page":"93","article-title":"Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages\/neutrophils: protective and deleterious effects","volume":"22","author":"SI Grivennikov","year":"2005","journal-title":"Immunity"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1111\/j.1462-5822.2011.01646.x","article-title":"Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice","volume":"13","author":"J Lippmann","year":"2011","journal-title":"Cell Microbiol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/j.1348-0421.2007.tb04011.x","article-title":"Evasion of Legionella pneumophila from the bactericidal system by reactive oxygen species (ROS) in macrophages","volume":"51","author":"T Harada","year":"2007","journal-title":"Microbiol Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1128\/IAI.01187-10","article-title":"Differential requirements for NAIP5 in activation of the NLRC4 inflammasome","volume":"79","author":"KL Lightfield","year":"2011","journal-title":"Infect Immun"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature10558","article-title":"Non-canonical inflammasome activation targets caspase-11","volume":"479","author":"N Kayagaki","year":"2011","journal-title":"Nature"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1128\/IAI.73.5.3166-3171.2005","article-title":"Maturation of the Legionella pneumophila-containing phagosome into a phagolysosome within gamma interferon-activated macrophages","volume":"73","author":"M Santic","year":"2005","journal-title":"Infect Immun"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"18479","DOI":"10.1038\/srep18479","article-title":"Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance","volume":"5","author":"K Caution","year":"2015","journal-title":"Sci Rep"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/sj.cdd.4402044","article-title":"Broad-spectrum caspase inhibitors: from myth to reality?","volume":"14","author":"D Chauvier","year":"2007","journal-title":"Cell Death Differ"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/sj.cdd.4401247","article-title":"Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity","volume":"10","author":"J Rozman-Pungercar","year":"2003","journal-title":"Cell Death Differ"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1515\/hsz-2012-0213","article-title":"Cysteine cathepsins are not critical for TRAIL- and CD95-induced apoptosis in several human cancer cell lines","volume":"393","author":"A Spes","year":"2012","journal-title":"Biol Chem"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1042\/bj3590335","article-title":"Sphingosine-induced apoptosis is dependent on lysosomal proteases","volume":"359","author":"K Kagedal","year":"2001","journal-title":"Biochem J"},{"key":"ref63","first-page":"1816","article-title":"Cytochrome c release and endoplasmic reticulum stress are involved in caspase-dependent apoptosis induced by G418","volume":"61","author":"QH Jin","year":"2004","journal-title":"Cell Mol Life Sci"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/cdd.2009.214","article-title":"Lysosomal membrane permeabilization and cathepsin release is a Bax\/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes","volume":"17","author":"C Oberle","year":"2010","journal-title":"Cell Death Differ"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.diagmicrobio.2009.11.001","article-title":"Sequential changes of Legionella antigens and bacterial load in the lungs and urines of a mouse model of pneumonia","volume":"66","author":"Y Chen","year":"2010","journal-title":"Diagn Microbiol Infect Dis"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1007\/s00134-008-1063-2","article-title":"In vivo effect of adhesion inhibitor heparin on Legionella pneumophila pathogenesis in a murine pneumonia model","volume":"34","author":"F Ader","year":"2008","journal-title":"Intensive Care Med"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"7557","DOI":"10.1073\/pnas.1501289112","article-title":"IL-1R signaling enables bystander cells to overcome bacterial blockade of host protein synthesis","volume":"112","author":"AM Copenhaver","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1462-5822.2005.00629.x","article-title":"Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides","volume":"8","author":"N Lapaque","year":"2006","journal-title":"Cell Microbiol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1172\/JCI7124","article-title":"Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia","volume":"104","author":"K Kurahashi","year":"1999","journal-title":"J Clin Invest"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0046-8177(81)80021-4","article-title":"The pathology of the Legionella pneumonias. A review of 74 cases and the literature","volume":"12","author":"WC Winn Jr.","year":"1981","journal-title":"Hum Pathol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.2169\/internalmedicine.48.2647","article-title":"Lung abscess caused by Legionella species: implication of the immune status of hosts","volume":"48","author":"H Yu","year":"2009","journal-title":"Intern Med"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.celrep.2014.06.028","article-title":"The neutrophil NLRC4 inflammasome selectively promotes IL-1beta maturation without pyroptosis during acute Salmonella challenge","volume":"8","author":"KW Chen","year":"2014","journal-title":"Cell Rep"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"e1000822","DOI":"10.1371\/journal.ppat.1000822","article-title":"Inhibition of host vacuolar H+-ATPase activity by a Legionella pneumophila effector","volume":"6","author":"L Xu","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1084\/jem.192.9.1261","article-title":"Legionella pneumophila replication vacuoles mature into acidic, endocytic organelles","volume":"192","author":"S Sturgill-Koszycki","year":"2000","journal-title":"J Exp Med"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.it.2012.09.005","article-title":"Caspases and immunity in a deadly grip","volume":"34","author":"IG Rodrigue-Gervais","year":"2013","journal-title":"Trends Immunol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"e1002628","DOI":"10.1371\/journal.ppat.1002628","article-title":"Membrane damage during Listeria monocytogenes infection triggers a caspase-7 dependent cytoprotective response","volume":"8","author":"SK Cassidy","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.4049\/jimmunol.176.8.4520","article-title":"Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA","volume":"176","author":"K Takahashi","year":"2006","journal-title":"J Immunol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1158\/0008-5472.CAN-05-4183","article-title":"Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions","volume":"66","author":"B Helfer","year":"2006","journal-title":"Cancer Res"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"5578","DOI":"10.1242\/jcs.130633","article-title":"Lysosomal exocytosis and caspase-8-mediated apoptosis in UVA-irradiated keratinocytes","volume":"126","author":"H Appelqvist","year":"2013","journal-title":"J Cell Sci"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/sj.cdd.4401264","article-title":"Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin","volume":"10","author":"H Hentze","year":"2003","journal-title":"Cell Death Differ"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1016\/j.biocel.2009.07.010","article-title":"Calpain activates caspase-8 in neuron-like differentiated PC12 cells via the amyloid-beta-peptide and CD95 pathways","volume":"41","author":"T Vaisid","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"ref82","article-title":"Francisella tularensis Modulates a Distinct Subset of Regulatory Factors and Sustains Mitochondrial Integrity to Impair Human Neutrophil Apoptosis","author":"JM McCracken","year":"2016","journal-title":"J Innate Immun"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1083\/jcb.150.4.887","article-title":"Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis","volume":"150","author":"T Nakagawa","year":"2000","journal-title":"J Cell Biol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"e31469","DOI":"10.1371\/journal.pone.0031469","article-title":"Membrane-bound TNF induces protective immune responses to M. bovis BCG infection: regulation of memTNF and TNF receptors comparing two memTNF molecules","volume":"7","author":"ML Olleros","year":"2012","journal-title":"PLoS One"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1128\/IAI.61.12.5361-5373.1993","article-title":"Identification of Legionella pneumophila genes required for growth within and killing of human macrophages","volume":"61","author":"AB Sadosky","year":"1993","journal-title":"Infect Immun"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"841","DOI":"10.4049\/jimmunol.1200794","article-title":"Identification of protective B cell antigens of Legionella pneumophila","volume":"189","author":"SS Weber","year":"2012","journal-title":"J Immunol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1111\/j.1462-5822.2007.01005.x","article-title":"The Legionella pneumophila response regulator LqsR promotes host cell interactions as an element of the virulence regulatory network controlled by RpoS and LetA","volume":"9","author":"A Tiaden","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1046\/j.1365-2958.2001.02645.x","article-title":"Icm\/dot-dependent upregulation of phagocytosis by Legionella pneumophila","volume":"42","author":"H Hilbi","year":"2001","journal-title":"Mol Microbiol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1073\/pnas.95.4.1669","article-title":"Host cell killing and bacterial conjugation require overlapping sets of genes within a 22-kb region of the Legionella pneumophila genome","volume":"95","author":"G Segal","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/978-1-62703-161-5_31","article-title":"Assessment of legionella-specific immunity in mice","volume":"954","author":"SS Weber","year":"2013","journal-title":"Methods Mol Biol"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1005591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T21:05:04Z","timestamp":1600463104000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1005591"}},"subtitle":[],"editor":[{"given":"Zhao-Qing","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,4,22]]},"references-count":90,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1005591","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,22]]}}}