{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:50:22Z","timestamp":1792788622979,"version":"4.5.0"},"reference-count":95,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T00:00:00Z","timestamp":1465430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS071160; NS072298"],"award-info":[{"award-number":["NS071160; NS072298"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS082570; NS081243"],"award-info":[{"award-number":["NS082570; NS081243"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of California Riverside Graduate Division","award":["DYP fellowship"],"award-info":[{"award-number":["DYP fellowship"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1005643","type":"journal-article","created":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T15:17:26Z","timestamp":1465485446000},"page":"e1005643","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":155,"title":["GLT-1-Dependent Disruption of CNS Glutamate Homeostasis and Neuronal Function by the Protozoan Parasite Toxoplasma gondii"],"prefix":"10.1371","volume":"12","author":[{"given":"Cl\u00e9ment N.","family":"David","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elma S.","family":"Frias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny I.","family":"Szu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline A.","family":"Hubbard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lovelace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marena","family":"Michael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Worth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn E.","family":"McGovern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iryna M.","family":"Ethell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Glenn","family":"Stanley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Korzus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd A.","family":"Fiacco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin K.","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma H.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,6,9]]},"reference":[{"issue":"Pt 1","key":"ref1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1242\/jeb.073668","article-title":"Comparing mechanisms of host manipulation across host and parasite taxa","volume":"216","author":"KD Lafferty","year":"2013","journal-title":"J Exp Biol"},{"key":"ref2","article-title":"References: Differential Development of Toxoplasma gondii in Neural Cells","volume":"15","author":"R Fagard","year":"1999","journal-title":"Parasitology"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jalz.2008.12.001","article-title":"Alzheimer&apos;s disease and infection: do infectious agents contribute to progression of Alzheimer&apos;s disease?","volume":"5","author":"K Honjo","year":"2009","journal-title":"Alzheimers Dement"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.neurol.2009.07.004","article-title":"Chronic viral infections of the central nervous system: Aspects specific to multiple sclerosis","volume":"165","author":"P Giraudon","year":"2009","journal-title":"Rev Neurol (Paris)"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4049\/jimmunol.149.1.175","article-title":"Cheever a, Sher a. Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii","volume":"149","author":"R Gazzinelli","year":"1992","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.ijpara.2009.04.003","article-title":"Toxoplasmosis snapshots: global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis","volume":"39","author":"G Pappas","year":"2009","journal-title":"Int J Parasitol"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neulet.2010.03.057","article-title":"The probable relation between Toxoplasma gondii and Parkinson&apos;s disease","volume":"475","author":"O Miman","year":"2010","journal-title":"Neurosci Lett"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/WAD.0b013e3181f73bc2","article-title":"Could Toxoplasma gondii have any role in Alzheimer disease?","volume":"25","author":"OY Kusbeci","year":"2011","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/bdi.12123","article-title":"Antibodies to Toxoplasma gondii in individuals with mania","volume":"16","author":"F Dickerson","year":"2014","journal-title":"Bipolar Disord"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1086\/319221","article-title":"Antibodies to Toxoplasma gondii in individuals with first-episode schizophrenia","volume":"32","author":"RH Yolken","year":"2001","journal-title":"Clin Infect Dis"},{"issue":"1589","key":"ref11","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1098\/rspb.2005.3413","article-title":"Parasites as causative agents of human affective disorders? The impact of anti-psychotic, mood-stabilizer and anti-parasite medication on Toxoplasma gondii&apos;s ability to alter host behaviour","volume":"273","author":"JP Webster","year":"2006","journal-title":"Proc Biol Sci"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/schbul\/sbs043","article-title":"Toxoplasma gondii and other risk factors for schizophrenia: an update","volume":"38","author":"EF Torrey","year":"2012","journal-title":"Schizophrenia bulletin"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"e32489","DOI":"10.1371\/journal.pone.0032489","article-title":"Chronic Toxoplasma infection modifies the structure and the risk of host behavior","volume":"7","author":"C Afonso","year":"2012","journal-title":"PloS one"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbr.2006.11.012","article-title":"Toxoplasma gondii infection lower anxiety as measured in the plus-maze and social interaction tests in rats A behavioral analysis","volume":"177","author":"LE Gonzalez","year":"2007","journal-title":"Behavioural brain research"},{"issue":"15","key":"ref15","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1073\/pnas.0608310104","article-title":"Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors","volume":"104","author":"A Vyas","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1471-2334-9-72","article-title":"Increased incidence of traffic accidents in Toxoplasma-infected military drivers and protective effect RhD molecule revealed by a large-scale prospective cohort study","volume":"9","author":"J Flegr","year":"2009","journal-title":"BMC Infect Dis"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.pt.2013.01.007","article-title":"How and why Toxoplasma makes us crazy","volume":"29","author":"J Flegr","year":"2013","journal-title":"Trends Parasitol"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/(SICI)1097-4547(19990815)57:4<417::AID-JNR1>3.0.CO;2-N","article-title":"Astrocytes: glutamate producers for neurons","volume":"57","author":"L Hertz","year":"1999","journal-title":"J Neurosci Res"},{"issue":"12","key":"ref19","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.tins.2004.10.008","article-title":"Astrocytic control of glutamatergic activity: astrocytes as stars of the show","volume":"27","author":"L Hertz","year":"2004","journal-title":"Trends Neurosci"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","article-title":"Glutamate uptake","volume":"65","author":"NC Danbolt","year":"2001","journal-title":"Progress in neurobiology"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0896-6273(00)80086-0","article-title":"Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate","volume":"16","author":"JD Rothstein","year":"1996","journal-title":"Neuron"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ijpara.2003.12.010","article-title":"The role of astrocytes in the immunopathogenesis of toxoplasmic encephalitis","volume":"34","author":"EH Wilson","year":"2004","journal-title":"Int J Parasitol"},{"key":"ref23","first-page":"5573","article-title":"Gamma Interferon-Induced Inhibition of Toxoplasma gondii in Astrocytes Is Mediated by IGTP","volume":"69","author":"SK Halonen","year":"2001","journal-title":"Society"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s00401-001-0491-7","article-title":"Chemokines are differentially expressed by astrocytes, microglia and inflammatory leukocytes in Toxoplasma encephalitis and critically regulated by interferon-gamma","volume":"103","author":"A Strack","year":"2002","journal-title":"Acta Neuropathol"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.immuni.2008.12.013","article-title":"Behavior of parasite-specific effector CD8+ T cells in the brain and visualization of a kinesis-associated system of reticular fibers","volume":"30","author":"EH Wilson","year":"2009","journal-title":"Immunity"},{"issue":"2\u20133","key":"ref26","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.neuint.2003.12.011","article-title":"Mechanisms of glutamate release from astrocytes: gap junction &quot;hemichannels&quot;, purinergic receptors and exocytotic release","volume":"45","author":"V Parpura","year":"2004","journal-title":"Neurochemistry international"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1471-4159.2011.07289.x","article-title":"Hypo-osmotic swelling modifies glutamate-glutamine cycle in the cerebral cortex and in astrocyte cultures","volume":"118","author":"MC Hyzinski-Garcia","year":"2011","journal-title":"J Neurochem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/1742-2094-9-275","article-title":"L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the &apos;collusion&apos; hypothesis for increased extracellular L-glutamate concentration in neuroinflammation","volume":"9","author":"J Takaki","year":"2012","journal-title":"Journal of neuroinflammation"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.neuroscience.2012.10.033","article-title":"Neurotoxins released from interferon-gamma-stimulated human astrocytes","volume":"229","author":"M Lee","year":"2013","journal-title":"Neuroscience"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/jcbfm.1995.51","article-title":"Astrocytic swelling due to hypotonic or high K+ medium causes inhibition of glutamate and aspartate uptake and increases their release","volume":"15","author":"HK Kimelberg","year":"1995","journal-title":"J Cereb Blood Flow Metab"},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/glia.20423","article-title":"Anion channels in astrocytes: biophysics, pharmacology, and function","volume":"54","author":"HK Kimelberg","year":"2006","journal-title":"Glia"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/01.STR.0000124127.57946.a1","article-title":"Volume-regulated anion channels are the predominant contributors to release of excitatory amino acids in the ischemic cortical penumbra","volume":"35","author":"PJ Feustel","year":"2004","journal-title":"Stroke"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.expneurol.2007.11.027","article-title":"DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbra","volume":"210","author":"Y Zhang","year":"2008","journal-title":"Experimental neurology"},{"issue":"18","key":"ref34","doi-asserted-by":"crossref","first-page":"7176","DOI":"10.1523\/JNEUROSCI.23-18-07176.2003","article-title":"Functional changes of glial glutamate transporter GLT-1 during ischemia: an in vivo study in the hippocampal CA1 of normal mice and mutant mice lacking GLT-1","volume":"23","author":"A Mitani","year":"2003","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/bja\/aem131","article-title":"Pathophysiology of traumatic brain injury","volume":"99","author":"C Werner","year":"2007","journal-title":"Br J Anaesth"},{"issue":"10","key":"ref36","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1089\/neu.1997.14.677","article-title":"Is high extracellular glutamate the key to excitotoxicity in traumatic brain injury?","volume":"14","author":"TP Obrenovitch","year":"1997","journal-title":"Journal of neurotrauma"},{"issue":"7","key":"ref37","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1089\/ars.2009.2444","article-title":"Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis","volume":"11","author":"E Foran","year":"2009","journal-title":"Antioxid Redox Signal"},{"issue":"1\u20132","key":"ref38","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jns.2008.06.029","article-title":"Neurodegeneration in multiple sclerosis: the role of oxidative stress and excitotoxicity","volume":"274","author":"RE Gonsette","year":"2008","journal-title":"Journal of the neurological sciences"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3233\/JAD-2011-101005","article-title":"Region- and age-specific changes in glutamate transport in the AbetaPP23 mouse model for Alzheimer&apos;s disease","volume":"24","author":"A Schallier","year":"2011","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00424-010-0809-1","article-title":"Glutamate receptors, neurotoxicity and neurodegeneration","volume":"460","author":"A Lau","year":"2010","journal-title":"Pflugers Arch"},{"issue":"12","key":"ref41","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1590\/S0100-879X2010007500130","article-title":"Increased levels of glutamate in the central nervous system are associated with behavioral symptoms in experimental malaria","volume":"43","author":"AS Miranda","year":"2010","journal-title":"Braz J Med Biol Res"},{"issue":"7","key":"ref42","doi-asserted-by":"crossref","first-page":"e1000505","DOI":"10.1371\/journal.ppat.1000505","article-title":"Dynamic Imaging of CD8(+) T cells and dendritic cells during infection with Toxoplasma gondii","volume":"5","author":"B John","year":"2009","journal-title":"PLoS pathogens"},{"issue":"5","key":"ref43","first-page":"635","article-title":"Astrocyte activation correlates with cytokine production in central nervous system of Trypanosoma brucei brucei-infected mice","volume":"67","author":"CA Hunter","year":"1992","journal-title":"Lab Invest"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1073\/pnas.1220566110","article-title":"Protective role of brain water channel AQP4 in murine cerebral malaria","volume":"110","author":"D Promeneur","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"e01155","DOI":"10.1128\/mBio.01155-15","article-title":"Novel Approaches Reveal that Toxoplasma gondii Bradyzoites within Tissue Cysts Are Dynamic and Replicating Entities In Vivo","volume":"6","author":"E Watts","year":"2015","journal-title":"MBio"},{"issue":"11","key":"ref46","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.micinf.2007.06.003","article-title":"Localized recrudescence of Toxoplasma infections in the central nervous system of immunocompromised mice assessed by in vivo bioluminescence imaging","volume":"9","author":"I Dellacasa-Lindberg","year":"2007","journal-title":"Microbes Infect"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1742-2094-5-48","article-title":"Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection","volume":"5","author":"G Hermes","year":"2008","journal-title":"Journal of neuroinflammation"},{"issue":"6","key":"ref48","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/BF00932696","article-title":"A morphological study of chronic cerebral toxoplasmosis in mice: comparison of four different strains of Toxoplasma gondii","volume":"80","author":"DJ Ferguson","year":"1994","journal-title":"Parasitol Res"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF00734512","article-title":"The host-parasite relationship of Toxoplasma gondii in the brains of chronically infected mice","volume":"411","author":"DJ Ferguson","year":"1987","journal-title":"Virchows Arch A Pathol Anat Histopathol"},{"issue":"12","key":"ref50","doi-asserted-by":"crossref","first-page":"e28925","DOI":"10.1371\/journal.pone.0028925","article-title":"The distribution of Toxoplasma gondii cysts in the brain of a mouse with latent toxoplasmosis: implications for the behavioral manipulation hypothesis","volume":"6","author":"M Berenreiterova","year":"2011","journal-title":"PloS one"},{"issue":"4","key":"ref51","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0166-2236(00)01576-9","article-title":"Actin and the agile spine: how and why do dendritic spines dance?","volume":"23","author":"S Halpain","year":"2000","journal-title":"Trends Neurosci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"e623","DOI":"10.1038\/tp.2015.115","article-title":"Schizophrenia: a tale of two critical periods for prefrontal cortical development","volume":"5","author":"LD Selemon","year":"2015","journal-title":"Transl Psychiatry"},{"issue":"3","key":"ref53","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.pneurobio.2005.02.003","article-title":"Molecular mechanisms of dendritic spine development and remodeling","volume":"75","author":"IM Ethell","year":"2005","journal-title":"Progress in neurobiology"},{"issue":"8861","key":"ref54","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/0140-6736(93)90754-5","article-title":"Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain","volume":"341","author":"MJ During","year":"1993","journal-title":"Lancet"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neuint.2011.10.017","article-title":"Riluzole elevates GLT-1 activity and levels in striatal astrocytes","volume":"60","author":"M Carbone","year":"2012","journal-title":"Neurochemistry international"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.pbb.2014.10.001","article-title":"GLT-1 transporter: an effective pharmacological target for various neurological disorders","volume":"127","author":"N Soni","year":"2014","journal-title":"Pharmacol Biochem Behav"},{"issue":"3","key":"ref57","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1084\/jem.20140413","article-title":"Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer&apos;s disease","volume":"212","author":"K Takahashi","year":"2015","journal-title":"The Journal of experimental medicine"},{"issue":"7021","key":"ref58","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nature03180","article-title":"Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression","volume":"433","author":"JD Rothstein","year":"2005","journal-title":"Nature"},{"issue":"2","key":"ref59","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.neuroscience.2007.02.003","article-title":"Neuroprotective potential of ceftriaxone in in vitro models of stroke","volume":"146","author":"J Lipski","year":"2007","journal-title":"Neuroscience"},{"issue":"1\u20133","key":"ref60","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejphar.2010.04.021","article-title":"Pharmacological evaluation of glutamate transporter 1 (GLT-1) mediated neuroprotection following cerebral ischemia\/reperfusion injury","volume":"638","author":"R Verma","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"ref61","article-title":"Neuroprotective Effects of the Glutamate Transporter Activator (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline (MS-153) following Traumatic Brain Injury in the Adult Rat","author":"AC Fontana","year":"2015","journal-title":"Journal of neurotrauma"},{"issue":"3","key":"ref62","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/TA.0b013e31825133c0","article-title":"The beta-lactam antibiotic, ceftriaxone, provides neuroprotective potential via anti-excitotoxicity and anti-inflammation response in a rat model of traumatic brain injury","volume":"73","author":"J Wei","year":"2012","journal-title":"J Trauma Acute Care Surg"},{"issue":"4","key":"ref63","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1093\/alcalc\/agu019","article-title":"Effects of ceftriaxone on systemic and central expression of anti- and pro-inflammatory cytokines in alcohol-preferring (P) rats exposed to ethanol","volume":"49","author":"PS Rao","year":"2014","journal-title":"Alcohol and alcoholism (Oxford, Oxfordshire)"},{"issue":"1","key":"ref64","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2174\/1874467210801010068","article-title":"Immunomodulatory properties of antibiotics","volume":"1","author":"SC Tauber","year":"2008","journal-title":"Curr Mol Pharmacol"},{"issue":"2","key":"ref65","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The use of the elevated plus maze as an assay of anxiety-related behavior in rodents","volume":"2","author":"AA Walf","year":"2007","journal-title":"Nat Protoc"},{"issue":"Pt 1","key":"ref66","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/brain\/awu312","article-title":"System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice","volume":"138","author":"P Mesci","year":"2015","journal-title":"Brain"},{"issue":"10","key":"ref67","doi-asserted-by":"crossref","first-page":"6549","DOI":"10.4049\/jimmunol.178.10.6549","article-title":"System xc- and glutamate transporter inhibition mediates microglial toxicity to oligodendrocytes","volume":"178","author":"M Domercq","year":"2007","journal-title":"J Immunol"},{"issue":"5","key":"ref68","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/j.1471-4159.2007.04487.x","article-title":"Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation","volume":"101","author":"SW Barger","year":"2007","journal-title":"J Neurochem"},{"issue":"7","key":"ref69","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.4049\/jimmunol.152.7.3578","article-title":"Involvement of the cystine transport system xc- in the macrophage-induced glutamate-dependent cytotoxicity to neurons","volume":"152","author":"D Piani","year":"1994","journal-title":"J Immunol"},{"issue":"8","key":"ref70","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1128\/IAI.00605-15","article-title":"Reproducing increased dopamine with infection to evaluate the role of parasite-encoded tyrosine hydroxylase activity","volume":"83","author":"GA McConkey","year":"2015","journal-title":"Infect Immun"},{"issue":"3","key":"ref71","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1128\/IAI.02465-14","article-title":"Reassessment of the role of aromatic amino acid hydroxylases and the effect of infection by Toxoplasma gondii on host dopamine","volume":"83","author":"ZT Wang","year":"2015","journal-title":"Infect Immun"},{"issue":"8","key":"ref72","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1128\/IAI.00642-15","article-title":"Reply to &quot;reproducing increased dopamine with infection to evaluate the role of parasite-encoded tyrosine hydroxylase activity&quot;","volume":"83","author":"ZT Wang","year":"2015","journal-title":"Infect Immun"},{"issue":"6","key":"ref73","doi-asserted-by":"crossref","first-page":"e01428","DOI":"10.1128\/mBio.01428-15","article-title":"Toxoplasma gondii Infections Alter GABAergic Synapses and Signaling in the Central Nervous System","volume":"6","author":"JM Brooks","year":"2015","journal-title":"MBio"},{"issue":"1","key":"ref74","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/clinids\/18.1.38","article-title":"Early and longitudinal evaluations of treated infants and children and untreated historical patients with congenital toxoplasmosis: the Chicago Collaborative Treatment Trial","volume":"18","author":"J McAuley","year":"1994","journal-title":"Clin Infect Dis"},{"issue":"12","key":"ref75","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.jpsychires.2013.09.009","article-title":"Resting state EEG power and coherence abnormalities in bipolar disorder and schizophrenia","volume":"47","author":"JW Kam","year":"2013","journal-title":"J Psychiatr Res"},{"issue":"2","key":"ref76","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0028-3932(94)90001-9","article-title":"EEG power spectra in Huntington&apos;s disease: clinical and neuropsychological correlates","volume":"32","author":"FW Bylsma","year":"1994","journal-title":"Neuropsychologia"},{"key":"ref77","article-title":"Brain neural synchronization and functional coupling in Alzheimer&apos;s disease as revealed by resting state EEG rhythms","author":"C Babiloni","year":"2015","journal-title":"Int J Psychophysiol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.nbd.2013.05.012","article-title":"Mouse models of gene-environment interactions in schizophrenia","volume":"57","author":"G Kannan","year":"2013","journal-title":"Neurobiol Dis"},{"issue":"9","key":"ref79","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1017\/S0031182015000505","article-title":"Toxoplasma gondii seropositivity and cognitive functions in school-aged children","volume":"142","author":"A Mendy","year":"2015","journal-title":"Parasitology"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.bbi.2014.12.006","article-title":"Immediate rather than delayed memory impairment in older adults with latent toxoplasmosis","volume":"45","author":"A Mendy","year":"2015","journal-title":"Brain, behavior, and immunity"},{"issue":"4","key":"ref81","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1017\/S0031182014001577","article-title":"Association between latent toxoplasmosis and cognition in adults: a cross-sectional study","volume":"142","author":"SD Gale","year":"2015","journal-title":"Parasitology"},{"issue":"24","key":"ref82","doi-asserted-by":"crossref","first-page":"6114","DOI":"10.1111\/mec.12888","article-title":"Toxoplasma gondii infection reduces predator aversion in rats through epigenetic modulation in the host medial amygdala","volume":"23","author":"SA Hari Dass","year":"2014","journal-title":"Molecular ecology"},{"issue":"4","key":"ref83","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1242\/dmm.014183","article-title":"Chronic murine toxoplasmosis is defined by subtle changes in neuronal connectivity","volume":"7","author":"A Parlog","year":"2014","journal-title":"Dis Model Mech"},{"issue":"1","key":"ref84","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF03033364","article-title":"Behavioral characterization of GLT1 (+\/-) mice as a model of mild glutamatergic hyperfunction","volume":"13","author":"A Kiryk","year":"2008","journal-title":"Neurotox Res"},{"issue":"1","key":"ref85","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11064-005-9077-4","article-title":"Nitric oxide produced during sublethal ischemia is crucial for the preconditioning-induced down-regulation of glutamate transporter GLT-1 in neuron\/astrocyte co-cultures","volume":"31","author":"T Yamada","year":"2006","journal-title":"Neurochemical research"},{"issue":"384","key":"ref86","doi-asserted-by":"crossref","first-page":"ra68","DOI":"10.1126\/scisignal.aaa4312","article-title":"Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation","volume":"8","author":"K Raju","year":"2015","journal-title":"Sci Signal"},{"issue":"13","key":"ref87","first-page":"5260","article-title":"Differential regulation of two isoforms of the glial glutamate transporter EAAT2 by DLG1 and CaMKII. The Journal of neuroscience: the official journal of the","volume":"35","author":"SM Underhill","year":"2015","journal-title":"Society for Neuroscience"},{"issue":"4","key":"ref88","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/ana.20003","article-title":"Altered expression of the glutamate transporter EAAT2b in neurological disease","volume":"55","author":"NJ Maragakis","year":"2004","journal-title":"Ann Neurol"},{"issue":"25","key":"ref89","doi-asserted-by":"crossref","first-page":"9159","DOI":"10.1523\/JNEUROSCI.0302-11.2011","article-title":"Nuclear factor-kappaB contributes to neuron-dependent induction of glutamate transporter-1 expression in astrocytes","volume":"31","author":"M Ghosh","year":"2011","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"12","key":"ref90","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1002\/glia.22566","article-title":"Upregulation of glutamate transporter GLT-1 by mTOR-Akt-NF-small ka, CyrillicB cascade in astrocytic oxygen-glucose deprivation","volume":"61","author":"YF Ji","year":"2013","journal-title":"Glia"},{"issue":"1","key":"ref91","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s11064-013-1200-3","article-title":"Differential regulation of GLT-1\/EAAT2 gene expression by NF-kappaB and N-myc in male mouse brain during postnatal development","volume":"39","author":"RK Gupta","year":"2014","journal-title":"Neurochemical research"},{"issue":"2","key":"ref92","doi-asserted-by":"crossref","first-page":"e1005447","DOI":"10.1371\/journal.ppat.1005447","article-title":"Neurons are the Primary Target Cell for the Brain-Tropic Intracellular Parasite Toxoplasma gondii","volume":"12","author":"CM Cabral","year":"2016","journal-title":"PLoS pathogens"},{"issue":"10","key":"ref93","doi-asserted-by":"crossref","first-page":"7105","DOI":"10.1074\/jbc.M112.410944","article-title":"Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1","volume":"288","author":"L Morel","year":"2013","journal-title":"The Journal of biological chemistry"},{"issue":"6","key":"ref94","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1046\/j.1471-4159.1997.69062612.x","article-title":"Neuronal soluble factors differentially regulate the expression of the GLT1 and GLAST glutamate transporters in cultured astroglia","volume":"69","author":"G Gegelashvili","year":"1997","journal-title":"J Neurochem"},{"issue":"1\u20132","key":"ref95","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jneuroim.2005.04.018","article-title":"A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis","volume":"165","author":"EH Wilson","year":"2005","journal-title":"Journal of neuroimmunology"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1005643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T16:43:19Z","timestamp":1692376999000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1005643"}},"subtitle":[],"editor":[{"given":"Mikhail","family":"Pletnikov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,6,9]]},"references-count":95,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1005643","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726408855.793519494","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,9]]}}}