{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:57:41Z","timestamp":1790470661378,"version":"4.1.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001664","name":"Leibniz-Gemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00fcr Infektionsforschung","doi-asserted-by":"publisher","award":["Ebokon"],"award-info":[{"award-number":["Ebokon"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004431","name":"Directorate-General for Research and Innovation","doi-asserted-by":"publisher","award":["653316"],"award-info":[{"award-number":["653316"]}],"id":[{"id":"10.13039\/100004431","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1005656","type":"journal-article","created":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T17:46:06Z","timestamp":1463593566000},"page":"e1005656","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Chimeric Mice with Competent Hematopoietic Immunity Reproduce Key Features of Severe Lassa Fever"],"prefix":"10.1371","volume":"12","author":[{"given":"Lisa","family":"Oestereich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"L\u00fcdtke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Ruibal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Pallasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romy","family":"Kerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Rieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Wurr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Bockholt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 V.","family":"P\u00e9rez-Gir\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Krasemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"G\u00fcnther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Mu\u00f1oz-Fontela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,5,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.3201\/eid1212.060812","article-title":"Mastomys natalensis and Lassa fever, West Africa","volume":"12","author":"E Lecompte","year":"2006","journal-title":"Emerging Infect Dis"},{"key":"ref2","first-page":"1","article-title":"Lassa fever in West African sub-region: an overview","volume":"44","author":"O Ogbu","year":"2007","journal-title":"J Vector Borne Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.3390\/v4102031","article-title":"Pathogenesis of Lassa fever","volume":"4","author":"NE Yun","year":"2012","journal-title":"Viruses"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"9192","DOI":"10.1128\/JVI.00555-06","article-title":"Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus","volume":"80","author":"L Mart\u00ednez-Sobrido","year":"2006","journal-title":"J Virol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1128\/JVI.01362-09","article-title":"Z proteins of New World arenaviruses bind RIG-I and interfere with type I interferon induction","volume":"84","author":"L Fan","year":"2010","journal-title":"J Virol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.3390\/v2112443","article-title":"Inhibition of the Type I Interferon Antiviral Response During Arenavirus Infection","volume":"2","author":"P Borrow","year":"2010","journal-title":"Viruses"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.4049\/jimmunol.170.6.2797","article-title":"Cutting edge: impairment of dendritic cells and adaptive immunity by Ebola and Lassa viruses","volume":"170","author":"S Mahanty","year":"2003","journal-title":"J Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e1000836","DOI":"10.1371\/journal.ppat.1000836","article-title":"T cell-dependence of Lassa fever pathogenesis","volume":"6","author":"L Flatz","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.3390\/v4112766","article-title":"Immune Responses and Lassa Virus Infection","volume":"4","author":"M Russier","year":"2012","journal-title":"Viruses"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/0035-9203(85)90388-8","article-title":"Endemic Lassa fever in Liberia. IV. Selection of optimally effective plasma for treatment by passive immunization","volume":"79","author":"PB Jahrling","year":"1985","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.3390\/v4091802","article-title":"Animal models, prophylaxis, and therapeutics for arenavirus infections","volume":"4","author":"E Vela","year":"2012","journal-title":"Viruses"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1128\/JVI.74.5.2186-2192.2000","article-title":"Characterization of human CD4+ T-cell clones recognizing conserved and variable epitopes of the Lassa virus nucleoprotein","volume":"74","author":"J Meulen ter","year":"2000","journal-title":"J Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"5890","DOI":"10.1128\/JVI.01948-08","article-title":"Early and strong immune responses are associated with control of viral replication and recovery in Lassa virus-infected cynomolgus monkeys","volume":"83","author":"S Baize","year":"2009","journal-title":"J Virol"},{"key":"ref14","first-page":"83","article-title":"Biology and pathogenesis of lymphocytic choriomeningitis virus infection","volume":"263","author":"MBA Oldstone","year":"2002","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"8925","DOI":"10.1073\/pnas.1408148111","article-title":"Type I interferon is a therapeutic target for virus-induced lethal vascular damage","volume":"111","author":"R Baccala","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2334-4-1","article-title":"Stampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virus","volume":"4","author":"FM Uckun","year":"2004","journal-title":"BMC Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e72290","DOI":"10.1371\/journal.pone.0072290","article-title":"Infection of type I interferon receptor-deficient mice with various old world arenaviruses: a model for studying virulence and host species barriers","volume":"8","author":"T Rieger","year":"2013","journal-title":"PLoS ONE"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"10908","DOI":"10.1128\/JVI.01433-13","article-title":"Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus","volume":"87","author":"NE Yun","year":"2013","journal-title":"J Virol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e2804","DOI":"10.1371\/journal.pntd.0002804","article-title":"Evaluation of antiviral efficacy of ribavirin, arbidol, and T-705 (favipiravir) in a mouse model for Crimean-Congo hemorrhagic fever","volume":"8","author":"L Oestereich","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.4049\/jimmunol.1400222","article-title":"Mucosal Polyinosinic-Polycytidylic Acid Improves Protection Elicited by Replicating Influenza Vaccines via Enhanced Dendritic Cell Function and T Cell Immunity","volume":"193","author":"JV P\u00e9rez-Gir\u00f3n","year":"2014","journal-title":"J Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/ni1101","article-title":"Circulating hematopoietic progenitors with T lineage potential","volume":"5","author":"BA Schwarz","year":"2004","journal-title":"Nat. Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.3201\/eid1512.090864","article-title":"Mopeia virus-related arenavirus in natal multimammate mice, Morogoro, Tanzania","volume":"15","author":"S G\u00fcnther","year":"2009","journal-title":"Emerging Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.4049\/jimmunol.154.11.6013","article-title":"Recruitment and proliferation of CD8+ T cells in respiratory virus infections","volume":"154","author":"RA Tripp","year":"1995","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"6428","DOI":"10.4049\/jimmunol.1101459","article-title":"p53 Serves as a Host Antiviral Factor That Enhances Innate and Adaptive Immune Responses to Influenza A Virus","volume":"187","author":"C Munoz-Fontela","year":"2011","journal-title":"J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.4049\/jimmunol.180.4.2562","article-title":"CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality","volume":"180","author":"KL Lin","year":"2008","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1172\/JCI200522675","article-title":"Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair","volume":"115","author":"JS Duffield","year":"2005","journal-title":"J Clin Invest"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1074-7613(02)00365-5","article-title":"In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens","volume":"17","author":"S Jung","year":"2002","journal-title":"Immunity"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/jmv.1890260204","article-title":"Hematologic dysfunction in Lassa fever","volume":"26","author":"S Fisher-Hoch","year":"1988","journal-title":"J Med Virol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e1004528","DOI":"10.1371\/journal.ppat.1004528","article-title":"Experimental cerebral malaria pathogenesis\u2014hemodynamics at the blood brain barrier","volume":"10","author":"A Nacer","year":"2014","journal-title":"PLoS Pathog"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"7341","DOI":"10.1128\/IAI.69.12.7341-7348.2001","article-title":"CD8(+)-T-cell depletion ameliorates circulatory shock in Plasmodium berghei-infected mice","volume":"69","author":"WL Chang","year":"2001","journal-title":"Infect Immun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1084\/jem.20121015","article-title":"Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice","volume":"209","author":"H Frebel","year":"2012","journal-title":"J Exp Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1586\/erv.12.139","article-title":"The search for animal models for Lassa fever vaccine development","volume":"12","author":"IS Lukashevich","year":"2013","journal-title":"Expert Rev Vaccines"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1128\/JVI.06284-11","article-title":"Functional interferon system is required for clearance of lassa virus","volume":"86","author":"NE Yun","year":"2012","journal-title":"J Virol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature13989","article-title":"Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors","volume":"518","author":"E Gomez Perdiguero","year":"2015","journal-title":"Nature"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1128\/JVI.77.3.1727-1737.2003","article-title":"Arenavirus-mediated liver pathology: acute lymphocytic choriomeningitis virus infection of rhesus macaques is characterized by high-level interleukin-6 expression and hepatocyte proliferation","volume":"77","author":"IS Lukashevich","year":"2003","journal-title":"J Virol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.immuni.2015.10.013","article-title":"Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage","volume":"43","author":"A Bhattacharya","year":"2015","journal-title":"Immunity"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fimmu.2016.00025","article-title":"Balancing Immune Protection and Immune Pathology by CD8(+) T-Cell Responses to Influenza Infection","volume":"7","author":"S Duan","year":"2016","journal-title":"Front Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nri3916","article-title":"New insights into the immunopathology and control of dengue virus infection","volume":"15","author":"G Screaton","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.3390\/v3071059","article-title":"T cells and pathogenesis of hantavirus cardiopulmonary syndrome and hemorrhagic fever with renal syndrome","volume":"3","author":"M Terajima","year":"2011","journal-title":"Viruses"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nri3166","article-title":"Regulating the adaptive immune response to respiratory virus infection","volume":"12","author":"TJ Braciale","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1084\/jem.20131556","article-title":"Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection","volume":"211","author":"S Srivastava","year":"2014","journal-title":"J Exp Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.4049\/jimmunol.164.8.4220","article-title":"Type I IFN modulates innate and specific antiviral immunity","volume":"164","author":"JE Durbin","year":"2001","journal-title":"J Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e1001304","DOI":"10.1371\/journal.ppat.1001304","article-title":"Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice","volume":"7","author":"S-U Seo","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.4049\/jimmunol.166.2.1097","article-title":"Bystander activation of CD8+ T cells contributes to the rapid production of IFN-gamma in response to bacterial pathogens","volume":"166","author":"G Lertmemongkolchai","year":"2001","journal-title":"J Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"7474","DOI":"10.1128\/JVI.00658-14","article-title":"Anti-inflammatory cytokines directly inhibit innate but not adaptive CD8+ T cell functions","volume":"88","author":"BE Freeman","year":"2014","journal-title":"J Virol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1002\/1521-4141(2002010)32:10<2807::AID-IMMU2807>3.0.CO;2-0","article-title":"Contribution of CD8+ T cells to innate immunity: IFN-\u03b3 secretion induced by IL-12 and IL-18","volume":"32","author":"RE Berg","year":"2002","journal-title":"Eur J Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1128\/JVI.02948-15","article-title":"Animal model of sensorineural hearing loss associated with Lassa virus infection","volume":"90","author":"NE Yun","year":"2015","journal-title":"J Virol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"7673","DOI":"10.1073\/pnas.93.15.7673","article-title":"Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma","volume":"93","author":"JF Bromberg","year":"1996","journal-title":"PNAS"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1182\/blood-2005-07-2834","article-title":"Modulation of STAT1 protein levels: a mechanism shaping CD8 T-cell responses in vivo","volume":"107","author":"MP Gil","year":"2006","journal-title":"Blood"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"408","DOI":"10.4269\/ajtmh.1987.36.408","article-title":"Pediatric Lassa fever: a review of 33 Liberian cases","volume":"36","author":"MH Monson","year":"1987","journal-title":"Am J Trop Med Hyg"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e3233","DOI":"10.1371\/journal.pntd.0003233","article-title":"Clinical features and patient management of Lujo hemorrhagic fever","volume":"8","author":"NH Sewlall","year":"2014","journal-title":"PLoS Negl Trop Dis"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1005656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T07:49:26Z","timestamp":1692344966000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1005656"}},"subtitle":[],"editor":[{"given":"Ana","family":"Fernandez-Sesma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,5,18]]},"references-count":51,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1005656","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,18]]}}}