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Turell","year":"1992","journal-title":"Am J Trop Med Hyg"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"426","DOI":"10.4269\/ajtmh.1997.57.426","article-title":"Delayed migration of Plasmodium sporozoites from the mosquito bite site to the blood","volume":"57","author":"S Sidjanski","year":"1997","journal-title":"Am J Trop Med Hyg"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1128\/JVI.01630-10","article-title":"Dengue virus infection of mast cells triggers endothelial cell activation","volume":"85","author":"MG Brown","year":"2011","journal-title":"J Virol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3389\/fimmu.2015.00238","article-title":"Mast cells and influenza a virus: association with allergic responses and beyond","volume":"6","author":"AC Graham","year":"2015","journal-title":"Front 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I. Infection enhancement by non-neutralizing antibody","volume":"146","author":"SB Halstead","year":"1977","journal-title":"J Exp Med"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1743-422X-10-127","article-title":"Development of a transmission model for dengue virus","volume":"10","author":"RC Christofferson","year":"2013","journal-title":"Virol J"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1128\/JVI.74.11.4957-4966.2000","article-title":"Modulation of dengue virus infection in human cells by alpha, beta, and gamma interferons","volume":"74","author":"MS Diamond","year":"2000","journal-title":"J Virol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.immuni.2013.10.004","article-title":"Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin","volume":"39","author":"S 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primary or secondary dengue infection by using the TaqMan automated amplification system","volume":"37","author":"T Laue","year":"1999","journal-title":"J Clin Microbiol"},{"key":"ref84","unstructured":"Schmid MA, Glasner DR, Shah S, Michlmayr D, Kramer LD, and Harris E (2016). Data from: Mosquito saliva increases endothelial permeability in the skin, immune cell migration, and dengue pathogenesis during antibody-dependent enhancement. Dryad Digital Repository. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.5061\/dryad.4rd14\" xlink:type=\"simple\">http:\/\/dx.doi.org\/10.5061\/dryad.4rd14<\/ext-link>."}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1005676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T07:08:49Z","timestamp":1600758529000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1005676"}},"subtitle":[],"editor":[{"given":"Mark T.","family":"Heise","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,6,16]]},"references-count":84,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1005676","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726427992.793523536","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,16]]}}}