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Stevenaert","year":"2005","journal-title":"Blood"},{"issue":"5","key":"ref53","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.4049\/jimmunol.174.5.2612","article-title":"Natural killer dendritic cells have both antigen presenting and lytic function and in response to CpG produce IFN-gamma via autocrine IL-12","volume":"174","author":"VG Pillarisetty","year":"2005","journal-title":"J Immunol"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.immuni.2011.11.016","article-title":"The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation","volume":"36","author":"SM Gordon","year":"2012","journal-title":"Immunity"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1365-3024.1991.tb00295.x","article-title":"Susceptibility of N&apos;Dama and Boran cattle to sequential challenges with tsetse-transmitted clones of Trypanosoma 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Poggi","year":"2006","journal-title":"Clin Dev Immunol"},{"issue":"7381","key":"ref59","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nature10624","article-title":"Natural killer cells act as rheostats modulating antiviral T cells","volume":"481","author":"SN Waggoner","year":"2012","journal-title":"Nature"},{"issue":"1","key":"ref60","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.virol.2012.10.005","article-title":"NK cells controlling virus-specific T cells: Rheostats for acute vs. persistent infections","volume":"435","author":"RM Welsh","year":"2013","journal-title":"Virology"},{"issue":"4","key":"ref61","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/eji.201242620","article-title":"NK cells exacerbate the pathology of influenza virus infection in mice","volume":"43","author":"G Zhou","year":"2013","journal-title":"Eur J 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Biol"},{"issue":"6","key":"ref83","doi-asserted-by":"crossref","first-page":"e1004964","DOI":"10.1371\/journal.ppat.1004964","article-title":"NK-, NKT- and CD8-Derived IFNgamma Drives Myeloid Cell Activation and Erythrophagocytosis, Resulting in Trypanosomosis-Associated Acute Anemia","volume":"11","author":"J Cnops","year":"2015","journal-title":"PLoS Pathog"},{"issue":"8","key":"ref84","doi-asserted-by":"crossref","first-page":"e1001045","DOI":"10.1371\/journal.ppat.1001045","article-title":"Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2\/CCR2, IFN-gamma and MyD88 signaling","volume":"6","author":"T Bosschaerts","year":"2010","journal-title":"PLoS Pathog"},{"issue":"9","key":"ref85","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/pim.12208","article-title":"IFN-gamma mediates early B-cell loss in experimental African trypanosomosis","volume":"37","author":"J Cnops","year":"2015","journal-title":"Parasite 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journal"},{"issue":"5148","key":"ref89","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/2181273a0","article-title":"Separation of trypanosomes from the blood of infected rats and mice by anion-exchangers","volume":"218","author":"SM Lanham","year":"1968","journal-title":"Nature"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1005733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T05:50:05Z","timestamp":1692424205000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1005733"}},"subtitle":[],"editor":[{"given":"Jude 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