{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T08:35:46Z","timestamp":1794040546979,"version":"4.8.0"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T00:00:00Z","timestamp":1467676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Otis Childs Trust of the Children's Hospital of Pittsburgh","id":[{"id":"https:\/\/ror.org\/03763ep67","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["RO1 AI111871"],"award-info":[{"award-number":["RO1 AI111871"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH T32","award":["AI060525"],"award-info":[{"award-number":["AI060525"]}]},{"name":"NIH T32","award":["AI089443"],"award-info":[{"award-number":["AI089443"]}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["RO1 HL106804"],"award-info":[{"award-number":["RO1 HL106804"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Heart, Lung, and Blood Institute (US)","award":["RO1 HL110811"],"award-info":[{"award-number":["RO1 HL110811"]}],"id":[{"id":"https:\/\/ror.org\/012pb6c26","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["REU NSF EEC-1156899"],"award-info":[{"award-number":["REU NSF EEC-1156899"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012802","name":"Ragon Institute TB Initiative","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012802","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1005739","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T13:40:54Z","timestamp":1467726054000},"page":"e1005739","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":126,"title":["PET CT Identifies Reactivation Risk in Cynomolgus Macaques with Latent M. tuberculosis"],"prefix":"10.1371","volume":"12","author":[{"given":"Philana Ling","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Maiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah P.","family":"Gideon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0113-3951","authenticated-orcid":true,"given":"M. Teresa","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony M.","family":"Cadena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Rodgers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gregg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"O\u2019Malley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9308-4957","authenticated-orcid":true,"given":"Jaime","family":"Tomko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Fillmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. James","family":"Frye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Rutledge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"DiFazio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Fortune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnne L.","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,7,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nrmicro2236","article-title":"The spectrum of latent tuberculosis: rethinking the biology and intervention strategies","volume":"7","author":"CE Barry 3rd","year":"2009","journal-title":"Nature reviews Microbiology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.1128\/IAI.00592-09","article-title":"Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model","volume":"77","author":"PL Lin","year":"2009","journal-title":"Infection and immunity"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e9611","DOI":"10.1371\/journal.pone.0009611","article-title":"Reactivation of latent tuberculosis in cynomolgus macaques infected with SIV is associated with early peripheral T cell depletion and not virus load","volume":"5","author":"CR Diedrich","year":"2010","journal-title":"PloS one"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4049\/jimmunol.0903856","article-title":"Understanding latent tuberculosis: a moving target","volume":"185","author":"PL Lin","year":"2010","journal-title":"Journal of immunology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/art.27271","article-title":"Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model","volume":"62","author":"PL Lin","year":"2010","journal-title":"Arthritis and rheumatism"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1089\/aid.2012.0028","article-title":"CD4 T cell depletion exacerbates acute Mycobacterium tuberculosis while reactivation of latent infection is dependent on severity of tissue depletion in cynomolgus macaques","volume":"28","author":"PL Lin","year":"2012","journal-title":"AIDS research and human retroviruses"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.1128\/IAI.71.10.5831-5844.2003","article-title":"Experimental Mycobacterium tuberculosis infection of cynomolgus macaques closely resembles the various manifestations of human M. tuberculosis infection","volume":"71","author":"SV Capuano 3rd","year":"2003","journal-title":"Infection and immunity"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nm.3412","article-title":"Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing","volume":"20","author":"PL Lin","year":"2014","journal-title":"Nature medicine"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e1004603","DOI":"10.1371\/journal.ppat.1004603","article-title":"Variability in Tuberculosis Granuloma T Cell Responses Exists, but a Balance of Pro- and Anti-inflammatory Cytokines Is Associated with Sterilization","volume":"11","author":"HP Gideon","year":"2015","journal-title":"PLoS pathogens"},{"key":"ref10","article-title":"Radiologic responses in cynomolgous macaques for assessing tuberculosis chemotherapy regimens","author":"PL Lin","year":"2013","journal-title":"Antimicrobial agents and chemotherapy"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"14188","DOI":"10.1073\/pnas.1121497109","article-title":"Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques","volume":"109","author":"PL Lin","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"265ra167","DOI":"10.1126\/scitranslmed.3009500","article-title":"PET\/CT imaging reveals a therapeutic response to oxazolidinones in macaques and humans with tuberculosis","volume":"6","author":"MT Coleman","year":"2014","journal-title":"Science translational medicine"},{"key":"ref13","article-title":"The Tubercle Bacillus","author":"G Canetti","year":"1955"},{"key":"ref14","first-page":"37","article-title":"Some clinical features of tuberculosis","volume":"33","author":"A Poulsen","year":"1957","journal-title":"Acta Tuberc Scand"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1164\/rccm.201311-1976LE","article-title":"Increased cellular activity in thoracic lymph nodes in early human latent tuberculosis infection","volume":"189","author":"N Ghesani","year":"2014","journal-title":"American journal of respiratory and critical care medicine"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s40336-016-0164-0","article-title":"PET\/CT imaging of infection","volume":"4","author":"AO Ankrah","year":"2016","journal-title":"Clin Transl Imaging"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e2912","DOI":"10.1097\/MD.0000000000002912","article-title":"A Case Report: Systemic Lymph Node Tuberculosis Mimicking Lymphoma on 18F-FDG PET\/CT","volume":"95","author":"Q Wang","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1016\/j.ejrad.2011.09.002","article-title":"Patterns of pulmonary tuberculosis on FDG-PET\/CT","volume":"81","author":"M Soussan","year":"2012","journal-title":"Eur J Radiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S1473-3099(13)70253-6","article-title":"Is tuberculosis a lymphatic disease with a pulmonary portal?","volume":"14","author":"MA Behr","year":"2014","journal-title":"The Lancet Infectious diseases"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1172\/JCI46252","article-title":"The multistage vaccine H56 boosts the effects of BCG to protect cynomolgus macaques against active tuberculosis and reactivation of latent Mycobacterium tuberculosis infection","volume":"122","author":"PL Lin","year":"2012","journal-title":"The Journal of clinical investigation"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1093\/infdis\/jis381","article-title":"Extrapulmonary locations of mycobacterium tuberculosis DNA during latent infection","volume":"206","author":"J Barrios-Payan","year":"2012","journal-title":"J Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1155\/2005\/287460","article-title":"The risk of tuberculosis transmission in solid organ transplantation: Is it more than a theoretical concern?","volume":"16","author":"G Rose","year":"2005","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3346\/jkms.2014.29.3.386","article-title":"(18)F-FDG positron-emission tomography\/computed tomography findings of radiographic lesions suggesting old healed tuberculosis","volume":"29","author":"YJ Jeong","year":"2014","journal-title":"J Korean Med Sci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.5603\/NMR.2014.0027","article-title":"Multiple hepatic lesions in a case of isolated hepatic tuberculosis simulating metastases on 18F-FDG PET\/CT imaging","volume":"17","author":"S Karunanithi","year":"2014","journal-title":"Nucl Med Rev Cent East Eur"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/j.1754-9485.2011.02309.x","article-title":"Imaging characteristics of extrapulmonary tuberculosis lesions on dual time point imaging (DTPI) of FDG PET\/CT","volume":"55","author":"HR Razak","year":"2011","journal-title":"J Med Imaging Radiat Oncol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1128\/IAI.00064-06","article-title":"Early events in Mycobacterium tuberculosis infection in cynomolgus macaques","volume":"74","author":"PL Lin","year":"2006","journal-title":"Infection and immunity"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1128\/IAI.01599-13","article-title":"Early Changes by (18)Fluorodeoxyglucose positron emission tomography coregistered with computed tomography predict outcome after Mycobacterium tuberculosis infection in cynomolgus macaques","volume":"82","author":"MT Coleman","year":"2014","journal-title":"Infection and immunity"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e1004804","DOI":"10.1371\/journal.pcbi.1004804","article-title":"Computational and Empirical Studies Predict Mycobacterium tuberculosis-Specific T Cells as a Biomarker for Infection Outcome","volume":"12","author":"S Marino","year":"2016","journal-title":"PLoS Comput Biol"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1005739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T23:37:04Z","timestamp":1718667424000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1005739"}},"subtitle":[],"editor":[{"given":"Marcel A.","family":"Behr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,7,5]]},"references-count":28,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,7,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1005739","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,5]]}}}