{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:25:56Z","timestamp":1791350756959,"version":"4.3.1"},"reference-count":111,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T00:00:00Z","timestamp":1467849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI100933"],"award-info":[{"award-number":["R01AI100933"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI098984"],"award-info":[{"award-number":["R01AI098984"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI090156"],"award-info":[{"award-number":["R21AI090156"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1005755","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T19:18:12Z","timestamp":1467919092000},"page":"e1005755","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["A Homolog Pentameric Complex Dictates Viral Epithelial Tropism, Pathogenicity and Congenital Infection Rate in Guinea Pig Cytomegalovirus"],"prefix":"10.1371","volume":"12","author":[{"given":"Stewart","family":"Coleman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Yeon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7667-4664","authenticated-orcid":true,"given":"Matthew","family":"Root","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"McGregor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,7,7]]},"reference":[{"issue":"Pt 5","key":"ref1","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1099\/vir.0.79888-0","article-title":"Genetic content of wild-type human cytomegalovirus","volume":"85","author":"A Dolan","year":"2004","journal-title":"J Gen Virol"},{"issue":"Suppl 4","key":"ref2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/ajt.12103","article-title":"Cytomegalovirus in solid organ transplantation","volume":"13","author":"RR Razonable","year":"2013","journal-title":". Am J Transplant"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1086\/504435","article-title":"Cytomegalovirus disease in HIV infection: twenty years of a regional population&apos;s experience","volume":"42","author":"S Kim","year":"2006","journal-title":"Clin Infect Dis"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/rmv.544","article-title":"New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection","volume":"17","author":"SC Dollard","year":"2007","journal-title":"Rev Med Virol"},{"issue":"4","key":"ref5","first-page":"240","article-title":"Immunization strategy for prevention of congenital cytomegalovirus infection","volume":"5","author":"RF Pass","year":"1996","journal-title":"Infectious agents and disease"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1053\/j.spid.2004.09.011","article-title":"Congenital cytomegalovirus infection: outcome and diagnosis","volume":"16","author":"SA Ross","year":"2005","journal-title":"Semin Pediatr Infect Dis"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/01.qco.0000168385.39390.1b","article-title":"Cytomegalovirus","volume":"18","author":"PD Griffiths","year":"2005","journal-title":"Curr Opin Infect Dis"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1128\/CMR.00062-12","article-title":"The &quot;silent&quot; global burden of congenital cytomegalovirus","volume":"26","author":"S Manicklal","year":"2013","journal-title":"Clin Microbiol Rev"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1001\/jama.289.8.1008","article-title":"Maternal immunity and prevention of congenital cytomegalovirus infection","volume":"289","author":"KB Fowler","year":"2003","journal-title":"Jama"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1471-2334-7-71","article-title":"Incidence of cytomegalovirus infection among the general population and pregnant women in the United States","volume":"7","author":"FA Colugnati","year":"2007","journal-title":"BMC Infect Dis"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1517\/17425255.2011.613824","article-title":"Cytomegalovirus antivirals and development of improved animal models","volume":"7","author":"A McGregor","year":"2011","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"6620","DOI":"10.1128\/JVI.77.12.6620-6636.2003","article-title":"Complete sequence and genomic analysis of rhesus cytomegalovirus","volume":"77","author":"SG Hansen","year":"2003","journal-title":"J Virol"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"8833","DOI":"10.1128\/JVI.70.12.8833-8849.1996","article-title":"Analysis of the complete DNA sequence of murine cytomegalovirus","volume":"70","author":"WD Rawlinson","year":"1996","journal-title":"J Virol"},{"issue":"16","key":"ref14","doi-asserted-by":"crossref","first-page":"7656","DOI":"10.1128\/JVI.74.16.7656-7665.2000","article-title":"Complete DNA sequence of the rat cytomegalovirus genome","volume":"74","author":"C Vink","year":"2000","journal-title":"J Virol"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/1743-422X-5-139","article-title":"Analysis of the nucleotide sequence of the guinea pig cytomegalovirus (GPCMV) genome","volume":"5","author":"MR Schleiss","year":"2008","journal-title":"Virol J"},{"key":"ref16","first-page":"207","article-title":"Rhesus cytomegalovirus a nonhuman primate model for the study of human cytomegalovirus","volume":"72","author":"Y Yue","year":"2008","journal-title":"Advances in Virus Research"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/infdis\/120.4.445","article-title":"Mouse cytomegalovirus: placental infection","volume":"120","author":"KP Johnson","year":"1969","journal-title":"The Journal of infectious diseases"},{"key":"ref18","unstructured":"Kaufmann P. Guinea Pig Cavia procellus. In: Benirschke KEditorComparitive Placentation<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/medicineucsdedu\/cpa\/guinea\/htm\" xlink:type=\"simple\">http:\/\/medicineucsdedu\/cpa\/guinea\/htm<\/ext-link>. 2004."},{"issue":"Suppl A","key":"ref19","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.placenta.2006.11.002","article-title":"Animal models of human placentation\u2014a review","volume":"28","author":"AM Carter","year":"2007","journal-title":"Placenta"},{"issue":"8\u20139","key":"ref20","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.placenta.2007.02.005","article-title":"The Guinea pig placenta: model of placental growth dynamics","volume":"28","author":"A Mess","year":"2007","journal-title":"Placenta"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1128\/JVI.55.2.402-409.1985","article-title":"The placenta as a site of cytomegalovirus infection in guinea pigs","volume":"55","author":"BP Griffith","year":"1985","journal-title":"J Virol"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/infdis\/138.5.650","article-title":"Experimental congenital infection with cytomegalovirus: a guinea pig model","volume":"138","author":"ML Kumar","year":"1978","journal-title":"J Infect Dis"},{"issue":"3","key":"ref23","first-page":"32","article-title":"Guinea pig model of congenital CMV-induced hearing loss: a review","volume":"23","author":"NK Woolf","year":"1991","journal-title":"Transplant Proc"},{"issue":"2\u20133","key":"ref24","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.antiviral.2006.05.018","article-title":"Pivotal role of animal models in the development of new therapies for cytomegalovirus infections","volume":"71","author":"ER Kern","year":"2006","journal-title":"Antiviral Res"},{"key":"ref25","first-page":"88","article-title":"Cytomegaloviruses: From Molecular Pathogenesis to Intervention. II","author":"A McGregor","year":"2013"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/mgme.2000.3102","article-title":"Molecular cloning of the guinea pig cytomegalovirus (GPCMV) genome as an infectious bacterial artificial chromosome (BAC) in Escherichia coli","volume":"72","author":"A McGregor","year":"2001","journal-title":"Mol Genet Metab"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jviromet.2008.01.031","article-title":"Cloning the complete guinea pig cytomegalovirus genome as an infectious bacterial artificial chromosome with excisable origin of replication","volume":"149","author":"X Cui","year":"2008","journal-title":"J Virol Methods"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.virol.2009.05.034","article-title":"Characterization of the guinea pig cytomegalovirus genome locus that encodes homologs of human cytomegalovirus major immediate-early genes, UL128, and UL130","volume":"391","author":"S Yamada","year":"2009","journal-title":"Virology"},{"issue":"Pt 5","key":"ref29","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1099\/vir.0.027789-0","article-title":"Re-evaluation of the genome sequence of guinea pig cytomegalovirus","volume":"92","author":"K Kanai","year":"2011","journal-title":"J Gen Virol"},{"issue":"18","key":"ref30","doi-asserted-by":"crossref","first-page":"9872","DOI":"10.1128\/JVI.78.18.9872-9889.2004","article-title":"Molecular, biological, and in vivo characterization of the guinea pig cytomegalovirus (CMV) homologs of the human CMV matrix proteins pp71 (UL82) and pp65 (UL83)","volume":"78","author":"A McGregor","year":"2004","journal-title":"J Virol"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.virusres.2003.12.030","article-title":"Identification of essential and non-essential genes of the guinea pig cytomegalovirus (GPCMV) genome via transposome mutagenesis of an infectious BAC clone","volume":"101","author":"A McGregor","year":"2004","journal-title":"Virus Res"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.antiviral.2008.01.008","article-title":"Expression of the human cytomegalovirus UL97 gene in a chimeric guinea pig cytomegalovirus (GPCMV) results in viable virus with increased susceptibility to ganciclovir and maribavir","volume":"78","author":"A McGregor","year":"2008","journal-title":"Antiviral Res"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.virol.2010.10.028","article-title":"Guinea pig cytomegalovirus GP84 is a functional homolog of the human cytomegalovirus (HCMV) UL84 gene that can complement for the loss of UL84 in a chimeric HCMV","volume":"410","author":"A McGregor","year":"2011","journal-title":"Virology"},{"issue":"37\u201339","key":"ref34","doi-asserted-by":"crossref","first-page":"6175","DOI":"10.1016\/j.vaccine.2006.06.077","article-title":"Protection against congenital cytomegalovirus (CMV) disease, conferred by a replication-disabled, bacterial artificial chromosome (BAC)-based DNA vaccine","volume":"24","author":"MR Schleiss","year":"2006","journal-title":"Vaccine"},{"key":"ref35","first-page":"905","article-title":"Animal Models for the Study of Human Diseases","author":"A McGregor","year":"2013"},{"issue":"8","key":"ref36","doi-asserted-by":"crossref","first-page":"e0135567","DOI":"10.1371\/journal.pone.0135567","article-title":"Viral Glycoprotein Complex Formation, Essential Function and Immunogenicity in the Guinea Pig Model for Cytomegalovirus","volume":"10","author":"S Coleman","year":"2015","journal-title":"PLoS One"},{"issue":"5\u20136","key":"ref37","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1159\/000150510","article-title":"Human cytomegalovirus glycoproteins","volume":"39","author":"WJ Britt","year":"1996","journal-title":"Intervirology"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1128\/JVI.62.6.1956-1962.1988","article-title":"A multigene family encodes the human cytomegalovirus glycoprotein complex gcII (gp47-52 complex)","volume":"62","author":"DR Gretch","year":"1988","journal-title":"Journal of virology"},{"issue":"10","key":"ref39","doi-asserted-by":"crossref","first-page":"8191","DOI":"10.1128\/JVI.72.10.8191-8197.1998","article-title":"The human cytomegalovirus UL74 gene encodes the third component of the glycoprotein H-glycoprotein L-containing envelope complex","volume":"72","author":"MT Huber","year":"1998","journal-title":"J Virol"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1128\/JVI.62.3.875-881.1988","article-title":"Identification and characterization of three distinct families of glycoprotein complexes in the envelopes of human cytomegalovirus","volume":"62","author":"DR Gretch","year":"1988","journal-title":"J Virol"},{"issue":"12","key":"ref41","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1056\/NEJMoa0804749","article-title":"Vaccine prevention of maternal cytomegalovirus infection","volume":"360","author":"RF Pass","year":"2009","journal-title":"N Engl J Med"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/infdis\/171.1.182","article-title":"Virus-specific antibody responses to human cytomegalovirus (HCMV) in human immunodeficiency virus type 1-infected persons with HCMV retinitis","volume":"171","author":"SB Boppana","year":"1995","journal-title":"J Infect Dis"},{"issue":"9","key":"ref43","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1128\/JVI.80.9.4591-4600.2006","article-title":"Human cytomegalovirus infection elicits a glycoprotein M (gM)\/gN-specific virus-neutralizing antibody response","volume":"80","author":"M Shimamura","year":"2006","journal-title":"J Virol"},{"issue":"17","key":"ref44","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1016\/j.vaccine.2007.01.011","article-title":"DNA vaccines expressing glycoprotein complex II antigens gM and gN elicited neutralizing antibodies against multiple human cytomegalovirus (HCMV) isolates","volume":"25","author":"S Shen","year":"2007","journal-title":"Vaccine"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1128\/JVI.64.3.1079-1085.1990","article-title":"Cell surface expression of human cytomegalovirus (HCMV) gp55-116 (gB): use of HCMV-recombinant vaccinia virus-infected cells in analysis of the human neutralizing antibody response","volume":"64","author":"WJ Britt","year":"1990","journal-title":"J Virol"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/infdis\/165.2.381","article-title":"Antibodies to recombinant-derived glycoprotein B after natural human cytomegalovirus infection correlate with neutralizing activity","volume":"165","author":"GS Marshall","year":"1992","journal-title":"The Journal of infectious diseases"},{"issue":"11","key":"ref47","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1086\/320714","article-title":"Modification of maternal and congenital cytomegalovirus infection by anti-glycoprotein b antibody transfer in guinea pigs","volume":"183","author":"A Chatterjee","year":"2001","journal-title":"The Journal of infectious diseases"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/viro.1994.1333","article-title":"Cloning and characterization of the guinea pig cytomegalovirus glycoprotein B gene","volume":"202","author":"MR Schleiss","year":"1994","journal-title":"Virology"},{"issue":"8","key":"ref49","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1086\/382751","article-title":"Protection against congenital cytomegalovirus infection and disease in guinea pigs, conferred by a purified recombinant glycoprotein B vaccine","volume":"189","author":"MR Schleiss","year":"2004","journal-title":"J Infect Dis"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0042-6822(92)90200-9","article-title":"Human cytomegalovirus penetrates host cells by pH-independent fusion at the cell surface","volume":"191","author":"T Compton","year":"1992","journal-title":"Virology"},{"issue":"8","key":"ref51","doi-asserted-by":"crossref","first-page":"e1002172","DOI":"10.1371\/journal.ppat.1002172","article-title":"B cell repertoire analysis identifies new antigenic domains on glycoprotein B of human cytomegalovirus which are target of neutralizing antibodies","volume":"7","author":"S Potzsch","year":"2011","journal-title":"PLoS Pathog"},{"issue":"8","key":"ref52","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1128\/JVI.01251-08","article-title":"Human cytomegalovirus glycoprotein B is required for virus entry and cell-to-cell spread but not for virion attachment, assembly, or egress","volume":"83","author":"MK Isaacson","year":"2009","journal-title":"J Virol"},{"issue":"11","key":"ref53","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1007\/s00018-008-7570-z","article-title":"Entry of herpesviruses into mammalian cells","volume":"65","author":"EE Heldwein","year":"2008","journal-title":"Cell Mol Life Sci"},{"issue":"5","key":"ref54","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nrmicro2548","article-title":"Fusing structure and function: a structural view of the herpesvirus entry machinery","volume":"9","author":"SA Connolly","year":"2011","journal-title":"Nat Rev Microbiol"},{"issue":"6","key":"ref55","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1073\/pnas.1424818112","article-title":"Structural and biochemical studies of HCMV gH\/gL\/gO and Pentamer reveal mutually exclusive cell entry complexes","volume":"112","author":"C Ciferri","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ref56","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1128\/JVI.01875-15","article-title":"Scanning Mutagenesis of Human Cytomegalovirus Glycoprotein gH\/gL","volume":"90","author":"EP Schultz","year":"2016","journal-title":"J Virol"},{"issue":"17","key":"ref57","doi-asserted-by":"crossref","first-page":"8999","DOI":"10.1128\/JVI.01325-15","article-title":"Human Cytomegalovirus gH\/gL\/gO Promotes the Fusion Step of Entry into All Cell Types, whereas gH\/gL\/UL128-131 Broadens Virus Tropism through a Distinct Mechanism","volume":"89","author":"M Zhou","year":"2015","journal-title":"Journal of virology"},{"issue":"3","key":"ref58","doi-asserted-by":"crossref","first-page":"e00332","DOI":"10.1128\/mBio.00332-13","article-title":"Human cytomegalovirus (HCMV) glycoprotein gB promotes virus entry in trans acting as the viral fusion protein rather than as a receptor-binding protein","volume":"4","author":"PT Wille","year":"2013","journal-title":"MBio"},{"issue":"20","key":"ref59","doi-asserted-by":"crossref","first-page":"10960","DOI":"10.1128\/JVI.78.20.10960-10966.2004","article-title":"Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome","volume":"78","author":"S Varnum","year":"2004","journal-title":"Journal of virology"},{"issue":"18","key":"ref60","doi-asserted-by":"crossref","first-page":"10023","DOI":"10.1128\/JVI.78.18.10023-10033.2004","article-title":"Human cytomegalovirus UL131-128 genes are indispensable for virus growth in endothelial cells and virus transfer to leukocytes","volume":"78","author":"G Hahn","year":"2004","journal-title":"Journal of virology"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1128\/JVI.80.2.710-722.2006","article-title":"Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion","volume":"80","author":"BJ Ryckman","year":"2006","journal-title":"Journal of virology"},{"issue":"1","key":"ref62","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1128\/JVI.01910-07","article-title":"Characterization of the human cytomegalovirus gH\/gL\/UL128-131 complex that mediates entry into epithelial and endothelial cells","volume":"82","author":"BJ Ryckman","year":"2008","journal-title":"J Virol"},{"issue":"50","key":"ref63","doi-asserted-by":"crossref","first-page":"18153","DOI":"10.1073\/pnas.0509201102","article-title":"Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropism","volume":"102","author":"D Wang","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"16","key":"ref64","doi-asserted-by":"crossref","first-page":"10330","DOI":"10.1128\/JVI.79.16.10330-10338.2005","article-title":"Human cytomegalovirus UL131 open reading frame is required for epithelial cell tropism","volume":"79","author":"D Wang","year":"2005","journal-title":"J Virol"},{"issue":"13","key":"ref65","doi-asserted-by":"crossref","first-page":"8361","DOI":"10.1128\/JVI.79.13.8361-8373.2005","article-title":"Human cytomegalovirus UL130 protein promotes endothelial cell infection through a producer cell modification of the virion","volume":"79","author":"M Patrone","year":"2005","journal-title":"Journal of virology"},{"issue":"7","key":"ref66","doi-asserted-by":"crossref","first-page":"e1003463","DOI":"10.1371\/journal.ppat.1003463","article-title":"The HCMV gH\/gL\/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytes","volume":"9","author":"M Nogalski","year":"2013","journal-title":"PLoS Pathogens"},{"issue":"5","key":"ref67","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1128\/JVI.02249-09","article-title":"A human cytomegalovirus gO-null mutant fails to incorporate gH\/gL into the virion envelope and is unable to enter fibroblasts and epithelial and endothelial cells","volume":"84","author":"PT Wille","year":"2010","journal-title":"J Virol"},{"issue":"1","key":"ref68","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.coviro.2012.01.001","article-title":". Human cytomegalovirus entry into cells","volume":"2","author":"AL Vanarsdall","year":"2012","journal-title":"Curr Opin Virol"},{"issue":"4","key":"ref69","doi-asserted-by":"crossref","first-page":"e34795","DOI":"10.1371\/journal.pone.0034795","article-title":"Human cytomegalovirus entry into dendritic cells occurs via a macropinocytosis-like pathway in a pH-independent and cholesterol-dependent manner","volume":"7","author":"F Haspot","year":"2012","journal-title":"PLoS One"},{"key":"ref70","article-title":"HCMV induces macropinocytosis for host cell entry in fibroblasts","author":"S Hetzenecker","year":"2015","journal-title":"Traffic"},{"issue":"Pt 6","key":"ref71","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1099\/vir.0.018994-0","article-title":"Sequential mutations associated with adaptation of human cytomegalovirus to growth in cell culture","volume":"91","author":"DJ Dargan","year":"2010","journal-title":"J Gen Virol"},{"issue":"Pt 9","key":"ref72","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1099\/vir.0.81921-0","article-title":"Role of human cytomegalovirus UL131A in cell type-specific virus entry and release","volume":"87","author":"B Adler","year":"2006","journal-title":"The Journal of general virology"},{"key":"ref73","first-page":"63","article-title":"Cytomegalovirus cell tropism","volume":"325","author":"C Sinzger","year":"2008","journal-title":"Current topics in microbiology and immunology"},{"issue":"17","key":"ref74","doi-asserted-by":"crossref","first-page":"9680","DOI":"10.1128\/JVI.01167-13","article-title":"Comparative analysis of gO isoforms reveals that strains of human cytomegalovirus differ in the ratio of gH\/gL\/gO and gH\/gL\/UL128-131 in the virion envelope","volume":"87","author":"M Zhou","year":"2013","journal-title":"J Virol"},{"issue":"2","key":"ref75","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1128\/JVI.01500-15","article-title":"Viral Regulation of Cell Tropism in Human Cytomegalovirus","volume":"90","author":"G Li","year":"2015","journal-title":"Journal of virology"},{"issue":"2","key":"ref76","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1128\/JVI.01809-09","article-title":"Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH\/gL\/UL128-131A complex","volume":"84","author":"A Macagno","year":"2010","journal-title":"Journal of virology"},{"issue":"23","key":"ref77","doi-asserted-by":"crossref","first-page":"11884","DOI":"10.1128\/JVI.01701-15","article-title":"Vaccine-Derived Neutralizing Antibodies to the Human Cytomegalovirus gH\/gL Pentamer Potently Block Primary Cytotrophoblast Infection","volume":"89","author":"F Chiuppesi","year":"2015","journal-title":"Journal of virology"},{"issue":"13","key":"ref78","doi-asserted-by":"crossref","first-page":"7444","DOI":"10.1128\/JVI.00467-12","article-title":"Antibodies against the gH\/gL\/UL128\/UL130\/UL131 complex comprise the majority of the anti-cytomegalovirus (anti-CMV) neutralizing antibody response in CMV hyperimmune globulin","volume":"86","author":"AE Fouts","year":"2012","journal-title":"J Virol"},{"issue":"4","key":"ref79","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.2353\/ajpath.2006.050482","article-title":"Maternal antibodies enhance or prevent cytomegalovirus infection in the placenta by neonatal Fc receptor-mediated transcytosis","volume":"168","author":"E Maidji","year":"2006","journal-title":"Am J Pathol"},{"issue":"24","key":"ref80","doi-asserted-by":"crossref","first-page":"13301","DOI":"10.1128\/JVI.77.24.13301-13314.2003","article-title":"Human cytomegalovirus transmission from the uterus to the placenta correlates with the presence of pathogenic bacteria and maternal immunity","volume":"77","author":"L Pereira","year":"2003","journal-title":"J Virol"},{"issue":"3","key":"ref81","doi-asserted-by":"crossref","first-page":"e59863","DOI":"10.1371\/journal.pone.0059863","article-title":"Fetal human cytomegalovirus transmission correlates with delayed maternal antibodies to gH\/gL\/pUL128-130-131 complex during primary infection","volume":"8","author":"D Lilleri","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"ref82","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1086\/315022","article-title":"A subunit cytomegalovirus vaccine based on recombinant envelope glycoprotein B and a new adjuvant","volume":"180","author":"RF Pass","year":"1999","journal-title":"The Journal of infectious diseases"},{"issue":"45","key":"ref83","doi-asserted-by":"crossref","first-page":"5760","DOI":"10.1016\/j.vaccine.2008.07.092","article-title":"Cytomegalovirus vaccines fail to induce epithelial entry neutralizing antibodies comparable to natural infection","volume":"26","author":"X Cui","year":"2008","journal-title":"Vaccine"},{"issue":"5","key":"ref84","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1111\/j.1600-6143.2009.02616.x","article-title":"Preemptive therapy for systemic and pulmonary human cytomegalovirus infection in lung transplant recipients","volume":"9","author":"G Gerna","year":"2009","journal-title":"American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"},{"issue":"5","key":"ref85","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1093\/infdis\/172.5.1212","article-title":"Reduced congenital cytomegalovirus (CMV) infection after maternal immunization with a guinea pig CMV glycoprotein before gestational primary CMV infection in the guinea pig model","volume":"172","author":"CJ Harrison","year":"1995","journal-title":"J Infect Dis"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1386-6532(02)00100-2","article-title":"Animal models of congenital cytomegalovirus infection: an overview of progress in the characterization of guinea pig cytomegalovirus (GPCMV)","author":"MR Schleiss","year":"2002","journal-title":"J Clin Virol"},{"issue":"1","key":"ref87","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.virol.2008.06.018","article-title":"Identification of a 1.6 kb genome locus of guinea pig cytomegalovirus required for efficient viral growth in animals but not in cell culture","volume":"379","author":"N Nozawa","year":"2008","journal-title":"Virology"},{"issue":"5","key":"ref88","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1093\/infdis\/142.5.732","article-title":"Vaccination for the prevention of maternal and fetal infection with guinea pig cytomegalovirus","volume":"142","author":"FJ Bia","year":"1980","journal-title":"J Infect Dis"},{"issue":"3","key":"ref89","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/infdis\/149.3.355","article-title":"Vaccination against transplacental cytomegalovirus transmission: vaccine reactivation and efficacy in guinea pigs","volume":"149","author":"FJ Bia","year":"1984","journal-title":"The Journal of infectious diseases"},{"issue":"1","key":"ref90","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.virol.2013.03.008","article-title":"Characterization of the guinea pig CMV gH\/gL\/GP129\/GP131\/GP133 complex in infection and spread","volume":"441","author":"M Auerbach","year":"2013","journal-title":"Virology"},{"issue":"19","key":"ref91","doi-asserted-by":"crossref","first-page":"10489","DOI":"10.1128\/JVI.01546-13","article-title":"Impact of sequence variation in the UL128 locus on production of human cytomegalovirus in fibroblast and epithelial cells","volume":"87","author":"I Murrell","year":"2013","journal-title":"J Virol"},{"issue":"2","key":"ref92","doi-asserted-by":"crossref","first-page":"e0005413","DOI":"10.1128\/genomeA.00054-13","article-title":"Complete genome sequence of pathogenic Guinea pig cytomegalovirus from salivary gland homogenates of infected animals","volume":"1","author":"D Yang","year":"2013","journal-title":"Genome announcements"},{"issue":"6","key":"ref93","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1099\/vir.0.064527-0","article-title":"Guinea pig cytomegalovirus GP129\/131\/133, homologues of human cytomegalovirus UL128\/130\/131A, are necessary for infection of monocytes and macrophages","volume":"95","author":"S Yamada","year":"2014","journal-title":"Journal of general virology"},{"issue":"2","key":"ref94","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3390\/v6020448","article-title":"Molecular and biological characterization of a new isolate of guinea pig cytomegalovirus","volume":"6","author":"MR Schleiss","year":"2014","journal-title":"Viruses"},{"issue":"5","key":"ref95","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00928-14","article-title":"Complete genome sequence of cell culture-attenuated Guinea pig cytomegalovirus cloned as an infectious bacterial artificial chromosome","volume":"2","author":"D Yang","year":"2014","journal-title":"Genome announcements"},{"issue":"1","key":"ref96","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.virol.2008.12.030","article-title":"The impact of genome length on replication and genome stability of the herpesvirus guinea pig cytomegalovirus","volume":"386","author":"X Cui","year":"2009","journal-title":"Virology"},{"issue":"21","key":"ref97","doi-asserted-by":"crossref","first-page":"7972","DOI":"10.1073\/pnas.85.21.7972","article-title":"Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells","volume":"85","author":"EJ Bowman","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref98","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.virusres.2012.05.024","article-title":"Acid-dependent viral entry","volume":"167","author":"A Vazquez-Calvo","year":"2012","journal-title":"Virus Res"},{"issue":"11\u201312","key":"ref99","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.placenta.2007.08.003","article-title":"Caviomorph placentation as a model for trophoblast invasion","volume":"28","author":"A Mess","year":"2007","journal-title":"Placenta"},{"issue":"3","key":"ref100","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/76985","article-title":"The labyrinthine placenta","volume":"25","author":"J Rinkenberger","year":"2000","journal-title":"Nat Genet"},{"issue":"1","key":"ref101","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0022-5320(67)80233-8","article-title":"Light and electron microscopic studies of the guinea pig cytomegalovirus","volume":"18","author":"JN Middelkamp","year":"1967","journal-title":"Journal of ultrastructure research"},{"issue":"17","key":"ref102","doi-asserted-by":"crossref","first-page":"7720","DOI":"10.1128\/JVI.74.17.7720-7729.2000","article-title":"Fast screening procedures for random transposon libraries of cloned herpesvirus genomes: mutational analysis of human cytomegalovirus envelope glycoprotein genes","volume":"74","author":"U Hobom","year":"2000","journal-title":"J Virol"},{"key":"ref103","unstructured":"Choi KY, Horvat D, McGregor A. Live vaccine strategies demonstrate the potential importance of humoral responses to the pentameric complex in the guinea pig congenital CMV model. 5th International Congenital CMV Conference and 15th International CMV\/Beta herpes virus workshop; April 20\u201324, 2015; Brisbane Australia2015. p. 44."},{"issue":"3","key":"ref104","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/rmv.645","article-title":". Human cytomegalovirus tropism for endothelial\/epithelial cells: scientific background and clinical implications","volume":"20","author":"MG Revello","year":"2010","journal-title":"Reviews in medical virology"},{"issue":"3","key":"ref105","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0049-3848(86)90153-2","article-title":"Identification of receptors for fibrinogen and von Willebrand factor mediating aggregation in guinea pig platelets","volume":"43","author":"JM Kupinski","year":"1986","journal-title":"Thromb Res"},{"key":"ref106","unstructured":"Cardin R, Bravo F, Wang M, Bernstein DI, editors. Characterization of New Guinea Pig Cytomegalovirus Isolates: Differences in Tissue Tropism, Transplacental Transmission, and Cochlear Infection. Combined meetings of 4th Congenital Cytomegalovirus Conference and 14th International CMV\/Betaherpesvirus Workshop; 2012; San Francisco, CA."},{"issue":"14","key":"ref107","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1073\/pnas.1419875112","article-title":"A viral regulator of glycoprotein complexes contributes to human cytomegalovirus cell tropism","volume":"112","author":"G Li","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref108","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.tibs.2009.10.001","article-title":"N-glycan structures: recognition and processing in the ER","volume":"35","author":"M Aebi","year":"2010","journal-title":"Trends in biochemical sciences"},{"issue":"3","key":"ref109","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1023\/A:1008136714136","article-title":"Molecular characterization of the guinea pig cytomegalovirus UL83 (pp65) protein homolog","volume":"19","author":"MR Schleiss","year":"1999","journal-title":"Virus Genes"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/978-1-62703-125-7_20","article-title":"Isolation, growth, and characterization of human renal epithelial cells using traditional and 3D methods","volume":"945","author":"JJ Gildea","year":"2013","journal-title":"Methods in molecular biology"},{"issue":"2","key":"ref111","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1128\/JVI.52.2.436-447.1984","article-title":"Characterization of the guinea pig cytomegalovirus genome by molecular cloning and physical mapping","volume":"52","author":"M Gao","year":"1984","journal-title":"J Virol"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1005755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T16:09:38Z","timestamp":1600877378000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1005755"}},"subtitle":[],"editor":[{"given":"Peter A","family":"Barry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,7,7]]},"references-count":111,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,7,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1005755","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,7]]}}}