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Epidemiol"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/clinids\/22.1.91","article-title":"Recurrence of urinary tract infection in a primary care setting: analysis of a 1-year follow-up of 179 women","volume":"22","author":"R Ikaheimo","year":"1996","journal-title":"Clin Infect Dis"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.disamonth.2014.12.002","article-title":"Urinary tract infections","volume":"61","author":"S Kumar","year":"2015","journal-title":"Dis Mon"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1128\/IAI.57.11.3383-3388.1989","article-title":"Interleukin-6 induced at mucosal surfaces by gram-negative bacterial infection","volume":"57","author":"P de Man","year":"1989","journal-title":"Infect Immun"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s002400050043","article-title":"Evaluation of urinary IL-1alpha and IL-1beta in gravid females and patients with bacterial cystitis and microscopic hematuria","volume":"26","author":"JV Candela","year":"1998","journal-title":"Urol Res"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1523-1755.2005.00381.x","article-title":"Chemokine response to febrile urinary tract infection","volume":"68","author":"G Otto","year":"2005","journal-title":"Kidney Int"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1172\/JCI116650","article-title":"IL-8 and the neutrophil response to mucosal Gram negative infection","volume":"92","author":"W Agace","year":"1993","journal-title":"J Clin Invest"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.1365-2958.2001.02361.x","article-title":"Escherichia coli P fimbriae utilize the Toll-like receptor 4 pathway for cell activation","volume":"40","author":"B Frendeus","year":"2001","journal-title":"Mol Microbiol"},{"issue":"Suppl 2","key":"ref15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1365-2362.2008.02004.x","article-title":"TLR- and CXCR1-dependent innate immunity: insights into the genetics of urinary tract infections","volume":"38","author":"B Ragnarsdottir","year":"2008","journal-title":"Eur J Clin Invest"},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1699-0463.1990.tb05034.x","article-title":"Bacterial Adherence as a Virulence Factor in Urinary-Tract Infection","volume":"98","author":"P de Man","year":"1990","journal-title":"APMIS"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nri2782","article-title":"Mast cell-orchestrated immunity to pathogens","volume":"10","author":"SN Abraham","year":"2010","journal-title":"Nat Rev 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Schaale","year":"2016","journal-title":"Mucosal Immunol"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.juro.2010.03.024","article-title":"Escherichia coli 83972 bacteriuria protects against recurrent lower urinary tract infections in patients with incomplete bladder emptying","volume":"184","author":"F Sunden","year":"2010","journal-title":"J Urol"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1172\/JCI66451","article-title":"Bacterial control of host gene expression through RNA polymerase II","volume":"123","author":"N Lutay","year":"2013","journal-title":"J Clin Invest"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/QCO.0000000000000019","article-title":"Asymptomatic bacteriuria","volume":"27","author":"LE Nicolle","year":"2014","journal-title":"Curr Opin Infect 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At Molecular UTI Conference (Urinary Tract Infection; molecular advances and novel therapies); 2014; Malm\u00f6, Sweden."},{"key":"ref27","unstructured":"Ambite I, The molecular basis of acute cystitis; IL-1b and inflammasome dysregulation. At the 17th International Congress of Mucosal Immunology (ICMI 2015) 2015; Berlin, Germany."},{"issue":"23","key":"ref28","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1056\/NEJMe0811014","article-title":"Interleukin-1beta and the autoinflammatory diseases","volume":"360","author":"CA Dinarello","year":"2009","journal-title":"N Engl J Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family","volume":"27","author":"CA Dinarello","year":"2009","journal-title":"Annu Rev Immunol"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.4049\/jimmunol.179.3.1913","article-title":"Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages","volume":"179","author":"Y Qu","year":"2007","journal-title":"J Immunol"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1128\/IAI.34.3.920-929.1981","article-title":"Glycolipid receptors for uropathogenic Escherichia coli on human erythrocytes and uroepithelial cells","volume":"34","author":"H Leffler","year":"1981","journal-title":"Infect Immun"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1128\/IAI.49.2.407-413.1985","article-title":"Genetic diversity in relation to serotype in Escherichia coli","volume":"49","author":"DA Caugant","year":"1985","journal-title":"Infect Immun"},{"issue":"2","key":"ref33","first-page":"194","article-title":"Asymptomatic bacteriuria in schoolgirls. VIII. Clinical course during a 3-year follow-up","volume":"92","author":"U Lindberg","year":"1978","journal-title":"J Pediatr"},{"issue":"7081","key":"ref34","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature04515","article-title":"Cryopyrin activates the inflammasome in response to toxins and ATP","volume":"440","author":"S Mariathasan","year":"2006","journal-title":"Nature"},{"issue":"6996","key":"ref35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature02664","article-title":"Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf","volume":"430","author":"S Mariathasan","year":"2004","journal-title":"Nature"},{"issue":"9","key":"ref36","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1084\/jem.187.9.1463","article-title":"Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha\/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion","volume":"187","author":"R Horai","year":"1998","journal-title":"J Exp Med"},{"issue":"5206","key":"ref37","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1126\/science.7535475","article-title":"Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme","volume":"267","author":"K Kuida","year":"1995","journal-title":"Science"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/3001534","article-title":"The assumptions underlying the analysis of variance","volume":"3","author":"C Eisenhart","year":"1947","journal-title":"Biometrics"},{"issue":"41","key":"ref39","doi-asserted-by":"crossref","first-page":"27924","DOI":"10.1074\/jbc.M109.035147","article-title":"Control of promatrilysin (MMP7) activation and substrate-specific activity by sulfated glycosaminoglycans","volume":"284","author":"HJ Ra","year":"2009","journal-title":"J Biol 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