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mediated ectodomain shedding of EGF-like factors","volume":"24","author":"MP Sanderson","year":"2006","journal-title":"Growth Factors"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1074\/jbc.270.3.1015","article-title":"Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor\/diphtheria toxin receptor and inhibits specifically its mitogenic activity","volume":"270","author":"T Mitamura","year":"1995","journal-title":"J Biol Chem"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"8335","DOI":"10.1074\/jbc.274.12.8335","article-title":"c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function","volume":"274","author":"JS Biscardi","year":"1999","journal-title":"J Biol Chem"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.febslet.2009.10.090","article-title":"Involvement 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Gschwind","year":"2001","journal-title":"Oncogene"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"36769","DOI":"10.1074\/jbc.M007382200","article-title":"Phosphatidylinositol 3-kinase activation and interaction with focal adhesion kinase in <italic>Escherichia coli<\/italic> K1 invasion of human brain microvascular endothelial cells","volume":"275","author":"MA Reddy","year":"2000","journal-title":"J Biol Chem"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/B978-0-444-52910-7.00030-1","article-title":"Neonatal bacterial meningitis","volume":"112","author":"O Baud","year":"2013","journal-title":"Handbook of clinical neurology"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/emboj\/17.2.443","article-title":"CD66-mediated phagocytosis of Opa52 <italic>Neisseria gonorrhoeae<\/italic> requires a Src-like tyrosine kinase- and Rac1-dependent signalling pathway","volume":"17","author":"CR Hauck","year":"1998","journal-title":"EMBO J"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1002\/j.1460-2075.1996.tb00696.x","article-title":"Rho-dependent membrane folding causes Shigella entry into epithelial cells","volume":"15","author":"T Adam","year":"1996","journal-title":"EMBO J"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1002\/j.1460-2075.1995.tb07244.x","article-title":"Invasion of epithelial cells by <italic>Shigella flexneri<\/italic> induces tyrosine phosphorylation of cortactin by a pp60c-src-mediated signalling pathway","volume":"14","author":"C Dehio","year":"1995","journal-title":"EMBO J"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1083\/jcb.143.4.1003","article-title":"Interferon alpha inhibits a Src-mediated pathway necessary for Shigella-induced cytoskeletal rearrangements in epithelial cells","volume":"143","author":"G Dumenil","year":"1998","journal-title":"J Cell Biol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.bbrc.2003.08.012","article-title":"Src tyrosine kinase promotes survival and resistance to chemotherapeutics in a mouse ovarian cancer cell line","volume":"309","author":"Y Pengetnze","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nchembio806","article-title":"A clinical drug library screen identifies astemizole as an antimalarial agent","volume":"2","author":"CR Chong","year":"2006","journal-title":"Nat Chem Biol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1194\/jlr.M057539","article-title":"ORMDL\/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis","volume":"56","author":"D Siow","year":"2015","journal-title":"J Lipid Res"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1194\/jlr.M004374","article-title":"Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate","volume":"51","author":"DL Siow","year":"2010","journal-title":"J Lipid Res"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1042\/BSR20120036","article-title":"Characterization of secretory sphingomyelinase activity, lipoprotein sphingolipid content and LDL aggregation in ldlr-\/- mice fed on a high-fat diet","volume":"32","author":"GM Deevska","year":"2012","journal-title":"Bioscience reports"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1194\/jlr.M039685","article-title":"Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice","volume":"54","author":"AK Salous","year":"2013","journal-title":"J Lipid Res"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1158\/1541-7786.MCR-12-0600","article-title":"Bioactive lipids S1P and C1P are prometastatic factors in human rhabdomyosarcoma, and their tissue levels increase in response to radio\/chemotherapy","volume":"11","author":"G Schneider","year":"2013","journal-title":"Mol Cancer Res"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0021-9258(19)67936-6","article-title":"The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid","volume":"235","author":"BN Ames","year":"1960","journal-title":"J Biol Chem"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.micpath.2006.07.003","article-title":"Focal adhesion kinase is involved in type III group B streptococcal invasion of human brain microvascular endothelial cells","volume":"41","author":"S Shin","year":"2006","journal-title":"Microb Pathog"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.1232033","article-title":"RNA-guided human genome engineering via Cas9","volume":"339","author":"P Mali","year":"2013","journal-title":"Science"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.chembiol.2011.12.022","article-title":"Targeted chemical-genetic regulation of protein stability in vivo","volume":"19","author":"S Rodriguez","year":"2012","journal-title":"Chem Biol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1158\/1535-7163.MCT-07-2070","article-title":"Preclinical pharmacokinetic\/pharmacodynamic models of gefitinib and the design of equivalent dosing regimens in EGFR wild-type and mutant tumor models","volume":"7","author":"S Wang","year":"2008","journal-title":"Mol Cancer Ther"}],"container-title":["PLOS 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