{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:15:22Z","timestamp":1791296122500,"version":"4.1.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T00:00:00Z","timestamp":1486512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Be2253\/6-3"],"award-info":[{"award-number":["Be2253\/6-3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001664","name":"Leibniz-Gemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK1459"],"award-info":[{"award-number":["GRK1459"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006172","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T18:26:05Z","timestamp":1486578365000},"page":"e1006172","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":61,"title":["Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale"],"prefix":"10.1371","volume":"13","author":[{"given":"Andr\u00e9","family":"Golldack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Henke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1869-3533","authenticated-orcid":true,"given":"B\u00e4rbel","family":"Bergmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Wiechert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5780-8703","authenticated-orcid":true,"given":"Holger","family":"Erler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Blancke Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3968-4601","authenticated-orcid":true,"given":"Tobias","family":"Spielmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5912-6626","authenticated-orcid":true,"given":"Eric","family":"Beitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,2,8]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nrd4573","article-title":"Malaria medicines: a glass half full?","volume":"14","author":"TN Wells","year":"2015","journal-title":"Nat Rev Drug Discov"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1084\/jem.84.6.569","article-title":"Studies on malarial parasites: VI. The chemistry and metabolism of normal and parasitized (<italic>P<\/italic>. <italic>knowlesi<\/italic>) monkey blood","volume":"84","author":"RW McKee","year":"1946","journal-title":"J Exp Med"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"7272","DOI":"10.1074\/jbc.274.11.7272","article-title":"Intraerythrocytic <italic>Plasmodium falciparum<\/italic> expresses a high affinity facilitative hexose transporter","volume":"274","author":"CJ Woodrow","year":"1999","journal-title":"J Biol Chem"},{"issue":"13","key":"ref4","doi-asserted-by":"crossref","first-page":"7476","DOI":"10.1073\/pnas.1330865100","article-title":"Validation of the hexose transporter of <italic>Plasmodium falciparum<\/italic> as a novel drug target","volume":"100","author":"T Joet","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1054\/drup.2000.0177","article-title":"Glycolysis as a target for the design of new anti-trypanosome drugs","volume":"4","author":"CL Verlinde","year":"2001","journal-title":"Drug Resist Updat"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1476-4598-12-152","article-title":"Tumor glycolysis as a target for cancer therapy: progress and prospects","volume":"12","author":"S Ganapathy-Kanniappan","year":"2013","journal-title":"Mol Cancer"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.1038\/ncomms7284","article-title":"Identity of a <italic>Plasmodium<\/italic> lactate\/H+ symporter structurally unrelated to human transporters","volume":"6","author":"B Wu","year":"2015","journal-title":"Nat Commun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.1038\/ncomms7721","article-title":"A lactate and formate transporter in the intraerythrocytic malaria parasite, <italic>Plasmodium falciparum<\/italic>","volume":"6","author":"RV Marchetti","year":"2015","journal-title":"Nat Commun"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1515\/hsz-2012-0339","article-title":"The formate\/nitrite transporter family of anion channels","volume":"394","author":"W L\u00fc","year":"2013","journal-title":"Biol Chem"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/iub.573","article-title":"The monocarboxylate transporter family\u2014Structure and functional characterization","volume":"64","author":"AP Halestrap","year":"2012","journal-title":"IUBMB Life"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/jcp.1041490316","article-title":"Transport of lactate in <italic>Plasmodium falciparum<\/italic>-infected human erythrocytes","volume":"149","author":"J Kanaani","year":"1991","journal-title":"J Cell Physiol"},{"issue":"25","key":"ref12","doi-asserted-by":"crossref","first-page":"15045","DOI":"10.1074\/jbc.270.25.15045","article-title":"Characterization of the enhanced transport of L- and D-lactate into human red blood cells infected with <italic>Plasmodium falciparum<\/italic> suggests the presence of a novel saturable lactate proton cotransporter","volume":"270","author":"SL Cranmer","year":"1995","journal-title":"J Biol Chem"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1042\/bj3550733","article-title":"Transport of lactate and pyruvate in the intraerythrocytic malaria parasite, <italic>Plasmodium falciparum<\/italic>","volume":"355","author":"JL Elliott","year":"2001","journal-title":"Biochem J"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1128\/AAC.36.5.1102","article-title":"Effects of cinnamic acid derivatives on in vitro growth of <italic>Plasmodium falciparum<\/italic> and on the permeability of the membrane of malaria-infected erythrocytes","volume":"36","author":"J Kanaani","year":"1992","journal-title":"Antimicrob Agents Chemother"},{"issue":"4717","key":"ref15","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1126\/science.3839598","article-title":"Sequence and structure of a human glucose transporter","volume":"229","author":"M Mueckler","year":"1985","journal-title":"Science"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"e62906","DOI":"10.1371\/journal.pone.0062906","article-title":"The open access malaria box: a drug discovery catalyst for neglected diseases","volume":"8","author":"T Spangenberg","year":"2013","journal-title":"PLoS One"},{"issue":"5\u20136","key":"ref17","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1080\/09687680701342669","article-title":"The conserved sequence NXX[S\/T]HX[S\/T]QDXXXT of the lactate\/pyruvate:H<sup>+<\/sup> symporter subfamily defines the function of the substrate translocation pathway","volume":"24","author":"I Soares-Silva","year":"2007","journal-title":"Mol Membr Biol"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/0092-8674(94)90361-1","article-title":"Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle","volume":"76","author":"CK Garcia","year":"1994","journal-title":"Cell"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrd3410","article-title":"The resurgence of covalent drugs","volume":"10","author":"J Singh","year":"2011","journal-title":"Nat Rev Drug Discov"},{"issue":"7272","key":"ref20","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nature08610","article-title":"Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel","volume":"462","author":"Y Wang","year":"2009","journal-title":"Nature"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/bioinformatics\/16.2.135","article-title":"TeXshade: shading and labeling of multiple sequence alignments using LaTeX2e","volume":"16","author":"E Beitz","year":"2000","journal-title":"Bioinformatics"},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1371\/journal.ppat.0030148","article-title":"Genome sequence of <italic>Babesia bovis<\/italic> and comparative analysis of apicomplexan hemoprotozoa","volume":"3","author":"KA Brayton","year":"2007","journal-title":"PLoS Pathog"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nrd4683","article-title":"Hit and lead criteria in drug discovery for infectious diseases of the developing world","volume":"14","author":"K Katsuno","year":"2015","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.chembiol.2015.11.008","article-title":"The power of sophisticated phenotypic screening and modern mechanism-of-action methods","volume":"23","author":"BK Wagner","year":"2016","journal-title":"Cell Chem Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fphar.2015.00091","article-title":"How do antimalarial drugs reach their intracellular targets?","volume":"6","author":"K Basore","year":"2015","journal-title":"Front Pharmacol"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.tube.2013.09.003","article-title":"Why are membrane targets discovered by phenotypic screens and genome sequencing in <italic>Mycobacterium tuberculosis<\/italic>?","volume":"93","author":"RC Goldman","year":"2013","journal-title":"Tuberculosis (Edinb)"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1473-3099(13)70328-1","article-title":"New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects","volume":"14","author":"AI Zumla","year":"2014","journal-title":"Lancet Infect Dis"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nrd.2015.18","article-title":"The drug-target residence time model: a 10-year retrospective","volume":"15","author":"RA Copeland","year":"2016","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2007.13","article-title":"High-efficiency yeast transformation using the LiAc\/SS carrier DNA\/PEG method","volume":"2","author":"RD Gietz","year":"2007","journal-title":"Nat Protoc"},{"issue":"4254","key":"ref30","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","article-title":"Human malaria parasites in continuous culture","volume":"193","author":"W Tr\u00e4ger","year":"1976","journal-title":"Science"},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1023\/A:1020908831426","article-title":"2-Polyfluoroalkylchromones: Synthesis of regioisomeric 3-(2-hydroxyaryl)-5-polyfluoroalkyl- and 5-(2-hydroxyaryl)-3-polyfluoroalkylisoxazoles and determination of their structures by <sup>1<\/sup>H, <sup>19<\/sup>F, and <sup>13<\/sup>C NMR spectroscopy","volume":"51","author":"VY Sosnovskikh","year":"2002","journal-title":"Russ Chem Bull Int Ed"},{"issue":"19","key":"ref32","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1016\/S0040-4020(01)98182-7","article-title":"Reactivity of ambident anions\u2014II: Kinetics of alkylation of \u03b2-ketoester alkaline enolates by ethyl tosylate in hexamethylphosphotriamide","volume":"27","author":"AL Kurts","year":"1971","journal-title":"Tetrahedron"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T03:36:11Z","timestamp":1601609771000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006172"}},"subtitle":[],"editor":[{"given":"Margaret A","family":"Phillips","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,8]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006172","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,8]]}}}