{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:42:39Z","timestamp":1790700159433,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006175","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T00:00:00Z","timestamp":1485475200000}}],"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:00:00Z","timestamp":1484611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["F31AI112282"],"award-info":[{"award-number":["F31AI112282"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32AI095213"],"award-info":[{"award-number":["T32AI095213"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["RO1HL112671"],"award-info":[{"award-number":["RO1HL112671"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["RO1AI025780"],"award-info":[{"award-number":["RO1AI025780"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["RO1AI102618"],"award-info":[{"award-number":["RO1AI102618"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["RO1AI125045"],"award-info":[{"award-number":["RO1AI125045"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006175","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T14:27:48Z","timestamp":1484663268000},"page":"e1006175","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":87,"title":["Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma"],"prefix":"10.1371","volume":"13","author":[{"given":"Evelyn Santos","family":"Guerra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrono K.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Specht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhawna","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Akalin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun R.","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3799-3064","authenticated-orcid":true,"given":"Stuart M.","family":"Levitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,1,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e1003743","DOI":"10.1371\/journal.ppat.1003743","article-title":"Aspergillus fumigatus\u2014What Makes the Species a Ubiquitous Human Fungal Pathogen?","volume":"9","author":"KJ Kwon-Chung","year":"2013","journal-title":"PLoS Pathogens"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1128\/CMR.00014-09","article-title":"Innate Immunity to Aspergillus Species","volume":"22","author":"SJ Park","year":"2009","journal-title":"Clinical Microbiology Reviews"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1128\/CMR.12.2.310","article-title":"Aspergillus fumigatus and Aspergillosis","volume":"12","author":"JP Latge","year":"1999","journal-title":"Clinical Microbiology Reviews"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"165rv113","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections","volume":"4","author":"GD Brown","year":"2012","journal-title":"Science translational medicine"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e98502","DOI":"10.1371\/journal.pone.0098502","article-title":"Multi-country estimate of different manifestations of aspergillosis in cystic fibrosis","volume":"9","author":"J Armstead","year":"2014","journal-title":"PLoS ONE"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3109\/13693786.2012.738312","article-title":"Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults","volume":"51","author":"DW Denning","year":"2013","journal-title":"Medical Mycology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1183\/09031936.06.00074705","article-title":"The link between fungi and severe asthma: a summary of the evidence","volume":"27","author":"DW Denning","year":"2006","journal-title":"European Respiratory Journal"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jaci.2011.12.970","article-title":"Fungi and allergic lower respiratory tract diseases","volume":"129","author":"AP Knutsen","year":"2012","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1128\/IAI.01990-14","article-title":"Eosinophils are recruited in response to chitin exposure and enhance Th2-mediated immune pathology in Aspergillus fumigatus infection","volume":"82","author":"EM O'Dea","year":"2014","journal-title":"Infection and immunity"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1128\/IAI.01172-13","article-title":"Eosinophil Deficiency Compromises Lung Defense against Aspergillus fumigatus","volume":"82","author":"LM Lilly","year":"2014","journal-title":"Infection and Immunity"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1172\/JCI28508","article-title":"The IL-23\/IL-17 axis in inflammation","volume":"116","author":"Y Iwakura","year":"2006","journal-title":"Journal of Clinical Investigation"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.immuni.2011.02.012","article-title":"Functional Specialization of Interleukin-17 Family Members","volume":"34","author":"Y Iwakura","year":"2011","journal-title":"Immunity"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/S1473-3099(11)70217-1","article-title":"Insights into human antifungal immunity from primary immunodeficiencies","volume":"11","author":"DC Vinh","year":"2011","journal-title":"The Lancet Infectious Diseases"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.4049\/jimmunol.0804250","article-title":"Requisite Role for the Dectin-1 -Glucan Receptor in Pulmonary Defense against Aspergillus fumigatus","volume":"182","author":"JL Werner","year":"2009","journal-title":"The Journal of Immunology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/prd.12083","article-title":"Basic biology and role of interleukin-17 in immunity and inflammation","volume":"69","author":"C Zenobia","year":"2015","journal-title":"Periondotology 2000"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1128\/IAI.05529-11","article-title":"Interleukin-17 Drives Pulmonary Eosinophilia following Repeated Exposure to Aspergillus fumigatus Conidia","volume":"80","author":"BJ Murdock","year":"2012","journal-title":"Infection and Immunity"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ni.3049","article-title":"The immunology of asthma","volume":"16","author":"BN Lambrecht","year":"2014","journal-title":"Nature Immunology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.immuni.2015.10.023","article-title":"Immune Interactions with Pathogenic and Commensal Fungi: A Two-Way Street","volume":"43","author":"DM Underhill","year":"2015","journal-title":"Immunity"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ni.2797","article-title":"Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORgammat and dectin-2","volume":"15","author":"PR Taylor","year":"2014","journal-title":"Nature Immunology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"6117","DOI":"10.4049\/jimmunol.181.9.6117","article-title":"IL-17-Producing Alveolar Macrophages Mediate Allergic Lung Inflammation Related to Asthma","volume":"181","author":"C Song","year":"2008","journal-title":"The Journal of Immunology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jaci.2012.07.025","article-title":"Human versus mouse eosinophils: "That which we call an eosinophil, by any other name would stain as red"","volume":"130","author":"JJ Lee","year":"2012","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jim.2007.07.011","article-title":"Detection and quantitation of eosinophils in the murine respiratory tract by flow cytometry","volume":"327","author":"WW Stevens","year":"2007","journal-title":"Journal of Immunological Methods"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/cyto.a.20064","article-title":"Accurate and simple discrimination of mouse pulmonary dendritic cell and macrophage populations by flow cytometry: Methodology and new insights","volume":"61A","author":"K Vermaelen","year":"2004","journal-title":"Cytometry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1182\/blood.V57.6.1099.1099","article-title":"Eosinophil Autofluorescence and its Use in Isolation and Analysis of Human Eosinophils Using Flow Microfluorometry","volume":"57","author":"GJ Weil","year":"1981","journal-title":"Blood"},{"key":"ref25","article-title":"Lung-resident eosinophils represent a distinct regulatory eosinophil subset","author":"C Mesnil","year":"2016","journal-title":"The Journal of clinical investigation"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.celrep.2012.10.026","article-title":"Tracing Conidial Fate and Measuring Host Cell Antifungal Activity Using a Reporter of Microbial Viability in the Lung","volume":"2","author":"A Jhingran","year":"2012","journal-title":"Cell Reports"},{"key":"ref27","first-page":"1","article-title":"Innate IL-17-producing cells: the sentinels of the immune system","author":"DJ Cua","year":"2010","journal-title":"Nature Reviews Immunology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nri1733","article-title":"Monocyte and macrophage heterogeneity","volume":"5","author":"S Gordon","year":"2005","journal-title":"Nature Reviews Immunology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e1003940","DOI":"10.1371\/journal.ppat.1003940","article-title":"Inflammatory Monocytes Orchestrate Innate Antifungal Immunity in the Lung","volume":"10","author":"V Espinosa","year":"2014","journal-title":"PLoS Pathogens"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1128\/EC.00107-15","article-title":"Development of the CRISPR\/Cas9 System for Targeted Gene Disruption in Aspergillus fumigatus","volume":"14","author":"KK Fuller","year":"2015","journal-title":"Eukaryotic Cell"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"S261","DOI":"10.1080\/13693780802247702","article-title":"Differences in pathogenicity and clinical syndromes due to Aspergillus fumigatus and Aspergillus flavus","volume":"47","author":"AC Pasqualotto","year":"2009","journal-title":"Medical Mycology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e56651","DOI":"10.1371\/journal.pone.0056651","article-title":"Strain Dependent Variation of Immune Responses to A. fumigatus: Definition of Pathogenic Species","volume":"8","author":"L Rizzetto","year":"2013","journal-title":"PLoS ONE"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00253-011-3689-1","article-title":"Biosynthesis and function of gliotoxin in Aspergillus fumigatus","volume":"93","author":"DH Scharf","year":"2011","journal-title":"Applied Microbiology and Biotechnology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1128\/AAC.01425-07","article-title":"Assessment of Serum (1\u20133)- beta-D-Glucan Concentration as a Measure of Disease Burden in a Murine Model of Invasive Pulmonary Aspergillosis","volume":"52","author":"NP Wiederhold","year":"2008","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1164\/rccm.201405-0859PP","article-title":"IL-17 in Severe Asthma. Where Do We Stand?","volume":"190","author":"J Chesn\u00e9","year":"2014","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/mt.2009.264","article-title":"Modulation of Exaggerated-IgE Allergic Responses by Gene Transfer-mediated Antagonism of IL-13 and IL-17e","volume":"18","author":"C Mueller","year":"2009","journal-title":"Molecular Therapy"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1242\/dmm.000323","article-title":"Mouse models of allergic asthma: acute and chronic allergen challenge","volume":"1","author":"AT Nials","year":"2008","journal-title":"Disease Models and Mechanisms"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1084\/jem.20141388","article-title":"Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist","volume":"213","author":"R Sugawara","year":"2016","journal-title":"The Journal of Experimental Medicine"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/icb.2009.115","article-title":"Eosinophils and Th2 immunity: contemporary insights","volume":"88","author":"LA Spencer","year":"2010","journal-title":"Immunology and Cell Biology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nri3341","article-title":"Eosinophils: changing perspectives in health and disease","volume":"13","author":"HF Rosenberg","year":"2013","journal-title":"Nature reviews Immunology"},{"key":"ref41","first-page":"968549","article-title":"Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases","volume":"2013","author":"N Qu","year":"2013","journal-title":"Clinical & developmental immunology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1067\/mai.2001.117929","article-title":"IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines","volume":"108","author":"S Molet","year":"2001","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2014.09.004","article-title":"Potential role of myeloid cell\/eosinophil-derived IL-17 in LPS-induced endotoxin shock","volume":"453","author":"E Shimura","year":"2014","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"6350","DOI":"10.4049\/jimmunol.0902673","article-title":"Human Eosinophils Recognize Endogenous Danger Signal Crystalline Uric Acid and Produce Proinflammatory Cytokines Mediated by Autocrine ATP","volume":"184","author":"T Kobayashi","year":"2010","journal-title":"The Journal of Immunology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nri3707","article-title":"The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing","volume":"14","author":"SL Gaffen","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nm.3895","article-title":"IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases","volume":"21","author":"MWL Teng","year":"2015","journal-title":"Nat Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/cea.12358","article-title":"Re-defining the unique roles for eosinophils in allergic respiratory inflammation","volume":"44","author":"EA Jacobsen","year":"2014","journal-title":"Clinical & Experimental Allergy"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bbagen.2011.02.002","article-title":"Th17 cells in asthma and inflammation","volume":"1810","author":"SJ Aujla","year":"2011","journal-title":"Biochimica et Biophysica Acta"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/j.jaci.2014.12.1872","article-title":"Prime role of IL-17A in neutrophilia and airway smooth muscle contraction in a house dust mite-induced allergic asthma model","volume":"135","author":"J Chesn\u00e9","year":"2015","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2500\/ar.2012.3.0030","article-title":"Relationships between IL-17A and macrophages or MUC5AC in eosinophilic chronic rhinosinusitis and proposed pathological significance","volume":"3","author":"N Ono","year":"2012","journal-title":"Allergy & Rhinology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2500\/ajra.2014.28.4018","article-title":"Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodeling","volume":"28","author":"S Shimizu","year":"2014","journal-title":"American journal of rhinology & allergy"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.anai.2014.04.002","article-title":"Changing roles of eosinophils in health and disease","volume":"113","author":"GT Furuta","year":"2014","journal-title":"Annals of Allergy, Asthma & Immunology"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/MCP.0000000000000225","article-title":"Asthma phenotypes and endotypes","volume":"22","author":"GS Skloot","year":"2016","journal-title":"Current Opinion in Pulmonary Medicine"},{"key":"ref54","first-page":"37","article-title":"Optimal Management of Severe\/Refractory Asthma","volume":"5","author":"S Pakhale","year":"2011","journal-title":"Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1440-1843.2006.00784.x","article-title":"Inflammatory subtypes in asthma: assessment and identification using induced sputum","volume":"11","author":"JL Simpson","year":"2006","journal-title":"Respirology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/mi.2015.2","article-title":"Eosinophils in mucosal immune responses","volume":"8","author":"J Travers","year":"2015","journal-title":"Mucosal Immunology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/infdis\/154.3.483","article-title":"In vitro killing of spores and hyphae of Aspergillus fumigatus and Rhizopus oryzae by rabbit neutrophil cationic peptides and bronchoalveolar macrophages","volume":"154","author":"SM Levitz","year":"1986","journal-title":"The Journal of infectious diseases"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nrmicro732","article-title":"The damage-response framework of microbial pathogenesis","volume":"1","author":"A Casadevall","year":"2003","journal-title":"Nature reviews Microbiology"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"e1004643","DOI":"10.1371\/journal.ppat.1004643","article-title":"Recognition of Aspergillus fumigatus hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular traps","volume":"11","author":"FV Loures","year":"2015","journal-title":"PLoS Pathogens"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.chom.2011.04.007","article-title":"A nonredundant role for plasmacytoid dendritic cells in host defense against the human fungal pathogen Aspergillus fumigatus","volume":"9","author":"ZG Ramirez-Ortiz","year":"2011","journal-title":"Cell host & microbe"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"e1004378","DOI":"10.1371\/journal.ppat.1004378","article-title":"Myeloid Derived Hypoxia Inducible Factor 1-alpha Is Required for Protection against Pulmonary Aspergillus fumigatus Infection","volume":"10","author":"KM Shepardson","year":"2014","journal-title":"PLoS Pathogens"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"e26232","DOI":"10.1371\/journal.pone.0026232","article-title":"Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with Cryptococcus neoformans","volume":"6","author":"JP Wang","year":"2011","journal-title":"PloS one"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"e01905","DOI":"10.1128\/mBio.01905-15","article-title":"Protection against Experimental Cryptococcosis following Vaccination with Glucan Particles Containing Cryptococcus Alkaline Extracts","volume":"6","author":"CA Specht","year":"2015","journal-title":"mBio"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.4049\/jimmunol.181.6.4004","article-title":"Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrow","volume":"181","author":"KD Dyer","year":"2008","journal-title":"Journal of immunology"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"e1004589","DOI":"10.1371\/journal.ppat.1004589","article-title":"Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection","volume":"11","author":"A Jhingran","year":"2015","journal-title":"PLoS Pathogens"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1084\/jem.20101850","article-title":"Antiviral CD8+ T cell effector activities in situ are regulated by target cell type","volume":"208","author":"MM Hufford","year":"2011","journal-title":"Journal of Experimental Medicine"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"e1004701","DOI":"10.1371\/journal.ppat.1004701","article-title":"Chitin Recognition via Chitotriosidase Promotes Pathologic Type-2 Helper T Cell Responses to Cryptococcal Infection","volume":"11","author":"DL Wiesner","year":"2015","journal-title":"PLoS Pathogens"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/ni0706-681","article-title":"Interpreting flow cytometry data: a guide for the perplexed","volume":"7","author":"LA Herzenberg","year":"2006","journal-title":"Nature Immunology"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006175","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T00:00:00Z","timestamp":1485475200000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T23:04:02Z","timestamp":1601334242000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006175"}},"subtitle":[],"editor":[{"given":"Amariliz","family":"Rivera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1,17]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006175","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727215437.793532091","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,17]]}}}