{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:07:16Z","timestamp":1791407236533,"version":"4.3.3"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006187","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000}}],"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006187","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T19:02:23Z","timestamp":1486062143000},"page":"e1006187","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NF\u03ba\u0392 signaling by stabilizing I\u03baB\u03b1"],"prefix":"10.1371","volume":"13","author":[{"given":"Yani","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin","family":"O\u2019Boyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Auer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6868-6246","authenticated-orcid":true,"given":"Sagar","family":"Raju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuping","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Fikrig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7418-2378","authenticated-orcid":true,"given":"Richard E.","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1365-2443.2005.00837.x","article-title":"The maintenance of the endoplasmic reticulum network is regulated by p47, a cofactor of p97, through phosphorylation by cdc2 kinase","volume":"10","author":"F. Kano","year":"2005","journal-title":"Genes Cells"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/40411","article-title":"p47 is a cofactor for p97-mediated membrane fusion","volume":"388","author":"H. Kondo","year":"1997","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0014-5793(98)01232-0","article-title":"The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97","volume":"437","author":"H.H. Meyer","year":"1998","journal-title":"FEBS Lett"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1083\/jcb.200303048","article-title":"The localization and phosphorylation of p47 are important for Golgi disassembly-assembly during the cell cycle","volume":"161","author":"K. Uchiyama","year":"2003","journal-title":"J Cell Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/jb\/mvi028","article-title":"p97\/p47-Mediated biogenesis of Golgi and ER","volume":"137","author":"K. Uchiyama","year":"2005","journal-title":"J Biochem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/sj.emboj.7600152","article-title":"Structure, dynamics and interactions of p47, a major adaptor of the AAA ATPase, p97","volume":"23","author":"X. Yuan","year":"2004","journal-title":"Embo j"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"E1705","DOI":"10.1073\/pnas.1418820112","article-title":"Altered cofactor regulation with disease-associated p97\/VCP mutations","volume":"112","author":"X. Zhang","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/jmbi.2001.4864","article-title":"Solution structure and interaction surface of the C-terminal domain from p47: a major p97-cofactor involved in SNARE disassembly","volume":"311","author":"X. Yuan","year":"2001","journal-title":"J Mol Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0092-8674(01)00595-5","article-title":"Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48 (UFD1\/NPL4), a ubiquitin-selective chaperone","volume":"107","author":"M. Rape","year":"2001","journal-title":"Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bbrc.2009.03.012","article-title":"UBXD1 is a VCP-interacting protein that is involved in ER-associated degradation","volume":"382","author":"M. Nagahama","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"6679","DOI":"10.1074\/jbc.M111.284232","article-title":"The ubiquitin regulatory X (UBX) domain-containing protein TUG regulates the p97 ATPase and resides at the endoplasmic reticulum-golgi intermediate compartment","volume":"287","author":"C.M. Orme","year":"2012","journal-title":"J Biol Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/j.1365-2443.2010.01454.x","article-title":"Caenorhabditis elegans UBX cofactors for CDC-48\/p97 control spermatogenesis","volume":"15","author":"Y. Sasagawa","year":"2010","journal-title":"Genes Cells"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1007\/s00018-008-8072-8","article-title":"UBX domain proteins: major regulators of the AAA ATPase Cdc48\/p97","volume":"65","author":"C. Schuberth","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"29414","DOI":"10.1074\/jbc.M115.680686","article-title":"The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97","volume":"290","author":"F. Trusch","year":"2015","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"16082","DOI":"10.1074\/jbc.M809282200","article-title":"Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum","volume":"284","author":"S.M. Alberts","year":"2009","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0962-8924(02)02269-9","article-title":"From UBA to UBX: new words in the ubiquitin vocabulary","volume":"12","author":"A. Buchberger","year":"2002","journal-title":"Trends Cell Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.celrep.2013.02.027","article-title":"UBXN1 interferes with Rig-I-like receptor-mediated antiviral immune response by targeting MAVS","volume":"3","author":"P. Wang","year":"2013","journal-title":"Cell reports"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"10395","DOI":"10.1074\/jbc.M114.631689","article-title":"Ubiquitin-associated Domain-containing Ubiquitin Regulatory X (UBX) Protein UBXN1 Is a Negative Regulator of Nuclear Factor kappaB (NF-kappaB) Signaling","volume":"290","author":"Y.B. Wang","year":"2015","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/rmv.1708","article-title":"Innate immune interferon responses to human immunodeficiency virus-1 infection","volume":"22","author":"R. Hughes","year":"2012","journal-title":"Rev Med Virol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cytogfr.2012.06.001","article-title":"HIV-1, interferon and the interferon regulatory factor system: an interplay between induction, antiviral responses and viral evasion","volume":"23","author":"G. Marsili","year":"2012","journal-title":"Cytokine & growth factor reviews"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.3390\/v3071179","article-title":"Innate antiviral response: role in HIV-1 infection","volume":"3","author":"P.M. Pitha","year":"2011","journal-title":"Viruses"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.jmb.2013.12.003","article-title":"Innate antiviral immune signaling, viral evasion and modulation by HIV-1","volume":"426","author":"A. Rustagi","year":"2014","journal-title":"J Mol Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/339070a0","article-title":"Activation of HIV gene expression during monocyte differentiation by induction of NF-kappa B","volume":"339","author":"G.E. Griffin","year":"1989","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1073\/pnas.86.7.2336","article-title":"Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B","volume":"86","author":"L. Osborn","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1128\/MMBR.59.3.481-505.1995","article-title":"Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B\/Rel transcription factors","volume":"59","author":"A. Roulston","year":"1995","journal-title":"Microbiol Rev"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Campbell, K.J., and Perkins, N.D. Regulation of NF-kappaB function. Biochemical Society symposium, 2006; 165\u2013180.","DOI":"10.1042\/bss0730165"},{"key":"ref27","first-page":"re13","article-title":"Regulation and function of IKK and IKK-related kinases","author":"H. Hacker","year":"2006","journal-title":"Science's STKE: signal transduction knowledge environment"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1146\/annurev.biochem.78.070907.102750","article-title":"The role of ubiquitin in NF-kappaB regulatory pathways","volume":"78","author":"B. Skaug","year":"2009","journal-title":"Annual review of biochemistry"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-3-540-72843-6_10","article-title":"Dynamic protein complexes regulate NF-kappaB signaling","author":"E. Wegener","year":"2008","journal-title":"Handb Exp Pharmacol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.1574-6976.2012.00335.x","article-title":"HIV latency: experimental systems and molecular models","volume":"36","author":"S. Hakre","year":"2012","journal-title":"FEMS microbiology reviews"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1089\/aid.2014.0199","article-title":"Targeting NF-kappaB signaling with protein kinase C agonists as an emerging strategy for combating HIV latency","volume":"31","author":"G. Jiang","year":"2015","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1093\/emboj\/cdg188","article-title":"HIV reproducibly establishes a latent infection after acute infection of T cells in vitro","volume":"22","author":"A. Jordan","year":"2003","journal-title":"Embo J"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1146\/annurev-med-092112-152941","article-title":"Understanding HIV latency: the road to an HIV cure","volume":"66","author":"M.S. Dahabieh","year":"2015","journal-title":"Annu Rev Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1358\/dnp.2005.18.8.944543","article-title":"Prostratin as a new therapeutic agent targeting HIV viral reservoirs","volume":"18","author":"M. Hezareh","year":"2005","journal-title":"Drug news & perspectives"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cytogfr.2012.05.003","article-title":"The development of immune-modulating compounds to disrupt HIV latency","volume":"23","author":"A.L. Remoli","year":"2012","journal-title":"Cytokine & growth factor reviews"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2174\/138945011794815266","article-title":"Activation of latent HIV-1 expression by protein kinase C agonists. A novel therapeutic approach to eradicate HIV-1 reservoirs","volume":"12","author":"G. Sanchez-Duffhues","year":"2011","journal-title":"Current drug targets"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/bies.201200170","article-title":"From reactivation of latent HIV-1 to elimination of the latent reservoir: the presence of multiple barriers to viral eradication","volume":"35","author":"L. Shan","year":"2013","journal-title":"BioEssays: news and reviews in molecular, cellular and developmental biology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"a007096","DOI":"10.1101\/cshperspect.a007096","article-title":"HIV latency","volume":"1","author":"R.F. Siliciano","year":"2011","journal-title":"Cold Spring Harbor perspectives in medicine"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tibs.2004.11.001","article-title":"A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions","volume":"30","author":"K. Heyninck","year":"2005","journal-title":"Trends Biochem Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.it.2009.05.007","article-title":"The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology","volume":"30","author":"L. Vereecke","year":"2009","journal-title":"Trends Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-0398-6_1","article-title":"A20--a bipartite ubiquitin editing enzyme with immunoregulatory potential","volume":"809","author":"I. Wertz","year":"2014","journal-title":"Adv Exp Med Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-1-4939-0398-6_2","article-title":"The biology of A20-binding inhibitors of NF-kappaB activation (ABINs)","volume":"809","author":"L. Verstrepen","year":"2014","journal-title":"Adv Exp Med Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bcp.2009.02.009","article-title":"ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling","volume":"78","author":"L. Verstrepen","year":"2009","journal-title":"Biochemical pharmacology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.cellbio.15.1.435","article-title":"SCF and Cullin\/Ring H2-based ubiquitin ligases","volume":"15","author":"R.J. Deshaies","year":"1999","journal-title":"Annual review of cell and developmental biology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S1097-2765(02)00538-5","article-title":"The SCF ubiquitin ligase: an extended look","volume":"9","author":"P.K. Jackson","year":"2002","journal-title":"Mol Cell"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0300-9084(01)01237-8","article-title":"Control of IkappaBalpha proteolysis by the ubiquitin-proteasome pathway","volume":"83","author":"K. Tanaka","year":"2001","journal-title":"Biochimie"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0092-8674(03)00722-0","article-title":"COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases","volume":"114","author":"G.A. Cope","year":"2003","journal-title":"Cell"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/embo-reports\/kvf028","article-title":"An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells","volume":"3","author":"M. Ohh","year":"2002","journal-title":"EMBO Rep"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e1000280","DOI":"10.1371\/journal.ppat.1000280","article-title":"Rotavirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of beta-TrCP: a novel mechanism of IFN antagonism","volume":"5","author":"J.W. Graff","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2091-13-7","article-title":"The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-kappaB activity by blocking ubiquitination mediated proteasomal degradation of IkappaBalpha in human hepatoma cells","volume":"13","author":"M. Surjit","year":"2012","journal-title":"BMC biochemistry"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nrm1471","article-title":"The SCF ubiquitin ligase: insights into a molecular machine","volume":"5","author":"T. Cardozo","year":"2004","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s11373-005-9058-2","article-title":"F-box proteins: the key to protein degradation","volume":"13","author":"M.S. Ho","year":"2006","journal-title":"Journal of biomedical science"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/sj.mt.6300370","article-title":"Titers of HIV-based vectors encoding shRNAs are reduced by a dicer-dependent mechanism","volume":"16","author":"A. Poluri","year":"2008","journal-title":"Mol Ther"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1021\/bi802198q","article-title":"Isolation of mammalian 26S proteasomes and p97\/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins","volume":"48","author":"H.C. Besche","year":"2009","journal-title":"Biochemistry"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/jb\/mvi074","article-title":"A novel protein specifically interacting with Homer2 regulates ubiquitin-proteasome systems","volume":"137","author":"T. Ishibashi","year":"2005","journal-title":"J Biochem"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1074\/jbc.M110.158030","article-title":"The UBX protein SAKS1 negatively regulates endoplasmic reticulum-associated degradation and p97-dependent degradation","volume":"286","author":"D.P. LaLonde","year":"2011","journal-title":"J Biol Chem"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1128\/MCB.01056-09","article-title":"The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function","volume":"30","author":"F. Wu-Baer","year":"2010","journal-title":"Mol Cell Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nrmicro2223","article-title":"Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs","volume":"7","author":"M. Coiras","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1126\/science.278.5341.1295","article-title":"Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy [see comments]","volume":"278","author":"D. Finzi","year":"1997","journal-title":"Science"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s11908-014-0392-2","article-title":"How Might We Cure HIV?","volume":"16","author":"D.M. Margolis","year":"2014","journal-title":"Current infectious disease reports"},{"key":"ref61","first-page":"104","article-title":"What do we need to do to cure HIV infection","volume":"18","author":"R.F. Siliciano","year":"2010","journal-title":"Top HIV Med"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2174\/1566524013363816","article-title":"Role of the NF-kappaB pathway in the pathogenesis of human disease states","volume":"1","author":"Y. Yamamoto","year":"2001","journal-title":"Current molecular medicine"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"12053","DOI":"10.1128\/JVI.01970-12","article-title":"Human CRM1 Augments Production of Infectious Human and Feline Immunodeficiency Viruses from Murine Cells","volume":"86","author":"H. Elinav","year":"2012","journal-title":"J Virol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"D. Kim","year":"2013","journal-title":"Genome Biol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nbt.2450","article-title":"Differential analysis of gene regulation at transcript resolution with RNA-seq","volume":"31","author":"C. Trapnell","year":"2013","journal-title":"Nat Biotechnol"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006187","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T16:09:53Z","timestamp":1601568593000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006187"}},"subtitle":[],"editor":[{"given":"Bryan R.","family":"Cullen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,2]]},"references-count":65,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006187","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1006187","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,2]]}}}