{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:34:41Z","timestamp":1790724881729,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006225","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000}}],"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:00:00Z","timestamp":1487289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006225","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T14:01:23Z","timestamp":1487340083000},"page":"e1006225","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":42,"title":["A high-throughput genetic screen identifies previously uncharacterized Borrelia burgdorferi genes important for resistance against reactive oxygen and nitrogen species"],"prefix":"10.1371","volume":"13","author":[{"given":"Meghan E.","family":"Ramsey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny A.","family":"Hyde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana N.","family":"Medina-Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9426-9005","authenticated-orcid":true,"given":"Tao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen E.","family":"Lundt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8378-7862","authenticated-orcid":true,"given":"Jon T.","family":"Skare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1659-5558","authenticated-orcid":true,"given":"Linden T.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,2,17]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nrmicro2714","article-title":"Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes","volume":"10","author":"JD Radolf","year":"2012","journal-title":"Nature reviews Microbiology"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1128\/IAI.63.11.4535-4539.1995","article-title":"Temperature-related differential expression of antigens in the Lyme disease spirochete, <italic>Borrelia burgdorferi<\/italic>","volume":"63","author":"B Stevenson","year":"1995","journal-title":"Infection and immunity"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1128\/IAI.72.3.1580-1586.2004","article-title":"Dissolved oxygen levels alter gene expression and antigen profiles in <italic>Borrelia burgdorferi<\/italic>","volume":"72","author":"J Seshu","year":"2004","journal-title":"Infection and immunity"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1128\/IAI.67.7.3181-3187.1999","article-title":"Effects of environmental pH on membrane proteins in <italic>Borrelia burgdorferi<\/italic>","volume":"67","author":"JA Carroll","year":"1999","journal-title":"Infection and immunity"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1128\/JB.01109-06","article-title":"<italic>Borrelia burgdorferi<\/italic> alters its gene expression and antigenic profile in response to CO<sub>2<\/sub> levels","volume":"189","author":"JA Hyde","year":"2006","journal-title":"Journal of bacteriology"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1128\/IAI.71.6.3371-3383.2003","article-title":"Global analysis of <italic>Borrelia burgdorferi<\/italic> genes regulated by mammalian host-specific signals","volume":"71","author":"CS Brooks","year":"2003","journal-title":"Infection and immunity"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1073\/pnas.032667699","article-title":"DNA microarray analysis of differential gene expression in <italic>Borrelia burgdorferi<\/italic>, the Lyme disease spirochete","volume":"99","author":"AT Revel","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"8","key":"ref8","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1128\/IAI.00507-13","article-title":"Manganese and zinc regulate virulence determinants in <italic>Borrelia burgdorferi<\/italic>","volume":"81","author":"B Troxell","year":"2013","journal-title":"Infection and immunity"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.3389\/fmicb.2016.01397","article-title":"The nucleotide excision repair pathway protects <italic>Borrelia burgdorferi<\/italic> from nitrosative stress in <italic>Ixodes scapularis<\/italic> ticks","volume":"7","author":"TJ Bourret","year":"2016","journal-title":"Front Microbiol"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"e47301","DOI":"10.1371\/journal.pone.0047301","article-title":"Early immunologic events at the tick-host interface","volume":"7","author":"DM Heinze","year":"2012","journal-title":"PloS one"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/s13071-016-1638-7","article-title":"Immunomodulatory effects of tick saliva on dermal cells exposed to <italic>Borrelia burgdorferi<\/italic>, the agent of Lyme disease","volume":"9","author":"DC Scholl","year":"2016","journal-title":"Parasit Vectors"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1365-2958.2011.07691.x","article-title":"Nitrosative damage to free and zinc-bound cysteine thiols underlies nitric oxide toxicity in wild-type <italic>Borrelia burgdorferi<\/italic>","volume":"81","author":"TJ Bourret","year":"2011","journal-title":"Molecular microbiology"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1365-2958.2008.06204.x","article-title":"<italic>Borrelia burgdorferi<\/italic> membranes are the primary targets of reactive oxygen species","volume":"68","author":"JA Boylan","year":"2008","journal-title":"Molecular microbiology"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"e84625","DOI":"10.1371\/journal.pone.0084625","article-title":"Pyruvate protects pathogenic spirochetes from H<sub>2<\/sub>O<sub>2<\/sub> killing","volume":"9","author":"B Troxell","year":"2014","journal-title":"PloS one"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nrmicro3032","article-title":"The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium","volume":"11","author":"JA Imlay","year":"2013","journal-title":"Nature reviews Microbiology"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S1369-5274(99)80033-2","article-title":"Oxidative stress","volume":"2","author":"G Storz","year":"1999","journal-title":"Current opinion in microbiology"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1574-6968.2011.02226.x","article-title":"Functional analysis of <italic>Borrelia burgdorferi uvrA<\/italic> in DNA damage protection","volume":"317","author":"M Sambir","year":"2011","journal-title":"FEMS microbiology letters"},{"issue":"5471","key":"ref18","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1126\/science.288.5471.1651","article-title":"Lack of a role for iron in the Lyme disease pathogen","volume":"288","author":"JE Posey","year":"2000","journal-title":"Science (New York, NY)"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1111\/mmi.12068","article-title":"A novel iron- and copper-binding protein in the Lyme disease spirochaete","volume":"86","author":"P Wang","year":"2012","journal-title":"Molecular microbiology"},{"issue":"6660","key":"ref20","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/37551","article-title":"Genomic sequence of a Lyme disease spirochaete, <italic>Borrelia burgdorferi<\/italic>","volume":"390","author":"CM Fraser","year":"1997","journal-title":"Nature"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1365-2958.2008.06549.x","article-title":"<italic>sodA<\/italic> is essential for virulence of <italic>Borrelia burgdorferi<\/italic> in the murine model of Lyme disease","volume":"71","author":"MD Esteve-Gassent","year":"2008","journal-title":"Molecular microbiology"},{"issue":"9","key":"ref22","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1073\/pnas.0812999106","article-title":"A manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, <italic>Borrelia burgdorferi<\/italic>","volume":"106","author":"Z Ouyang","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref23","article-title":"Gene <italic>bb0318<\/italic> is critical for the oxidative stress response and infectivity of <italic>Borrelia burgdorferi<\/italic>","author":"AC Showman","year":"2016","journal-title":"Infection and immunity"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1365-2958.2005.04963.x","article-title":"<italic>Borrelia burgdorferi bb0728<\/italic> encodes a coenzyme A disulphide reductase whose function suggests a role in intracellular redox and the oxidative stress response","volume":"59","author":"JA Boylan","year":"2006","journal-title":"Molecular microbiology"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1365-2958.2011.07845.x","article-title":"The coenzyme A disulphide reductase of <italic>Borrelia burgdorferi<\/italic> is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host","volume":"82","author":"CH Eggers","year":"2011","journal-title":"Molecular microbiology"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/j.1365-2958.2009.06951.x","article-title":"The BosR regulatory protein of <italic>Borrelia burgdorferi<\/italic> interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete","volume":"74","author":"JA Hyde","year":"2009","journal-title":"Molecular microbiology"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1111\/j.1365-2958.2009.06945.x","article-title":"BosR (BB0647) governs virulence expression in <italic>Borrelia burgdorferi<\/italic>","volume":"74","author":"Z Ouyang","year":"2009","journal-title":"Molecular microbiology"},{"issue":"Pt 9","key":"ref28","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1099\/mic.0.28996-0","article-title":"Transcriptional profiling of <italic>Borrelia burgdorferi<\/italic> containing a unique <italic>bosR<\/italic> allele identifies a putative oxidative stress regulon","volume":"152","author":"JA Hyde","year":"2006","journal-title":"Microbiology (Reading, England)"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1111\/mmi.12337","article-title":"<italic>Borrelia burgdorferi<\/italic> oxidative stress regulator BosR directly represses lipoproteins primarily expressed in the tick during mammalian infection","volume":"89","author":"P Wang","year":"2013","journal-title":"Molecular microbiology"},{"issue":"10","key":"ref30","doi-asserted-by":"crossref","first-page":"e47532","DOI":"10.1371\/journal.pone.0047532","article-title":"Analysis of an ordered, comprehensive STM mutant library in infectious <italic>Borrelia burgdorferi<\/italic>: insights into the genes required for mouse infectivity","volume":"7","author":"T Lin","year":"2012","journal-title":"PloS one"},{"issue":"10","key":"ref31","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nmeth.1377","article-title":"Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms","volume":"6","author":"T van Opijnen","year":"2009","journal-title":"Nature methods"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/mmi.13437","article-title":"Global Tn-seq analysis of carbohydrate utilization and vertebrate infectivity of <italic>Borrelia burgdorferi<\/italic>","volume":"101","author":"EB Troy","year":"2016","journal-title":"Molecular microbiology"},{"issue":"10","key":"ref33","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/nrmicro1004","article-title":"Antimicrobial reactive oxygen and nitrogen species: concepts and controversies","volume":"2","author":"FC Fang","year":"2004","journal-title":"Nature reviews Microbiology"},{"issue":"10","key":"ref34","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1128\/JB.00043-13","article-title":"The nucleotide excision repair system of <italic>Borrelia burgdorferi<\/italic> is the sole pathway involved in repair of DNA damage by UV light","volume":"195","author":"PO Hardy","year":"2013","journal-title":"Journal of bacteriology"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nprot.2015.053","article-title":"The Phyre<sup>2<\/sup> web portal for protein modeling, prediction and analysis","volume":"10","author":"LA Kelley","year":"2015","journal-title":"Nat Protoc"},{"issue":"25","key":"ref36","doi-asserted-by":"crossref","first-page":"13865","DOI":"10.1073\/pnas.97.25.13865","article-title":"Correlation between plasmid content and infectivity in <italic>Borrelia burgdorferi<\/italic>","volume":"97","author":"JE Purser","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.mimet.2011.05.004","article-title":"Multiplex PCR as a tool for validating plasmid content of <italic>Borrelia burgdorferi<\/italic>","volume":"86","author":"I Bunikis","year":"2011","journal-title":"J Microbiol Methods"},{"issue":"19","key":"ref38","doi-asserted-by":"crossref","first-page":"5544","DOI":"10.1128\/JB.183.19.5544-5553.2001","article-title":"Genetics and regulation of chitobiose utilization in <italic>Borrelia burgdorferi<\/italic>","volume":"183","author":"K Tilly","year":"2001","journal-title":"Journal of bacteriology"},{"issue":"7","key":"ref39","doi-asserted-by":"crossref","first-page":"e1002102","DOI":"10.1371\/journal.ppat.1002102","article-title":"<italic>Borrelia burgdorferi<\/italic> requires glycerol for maximum fitness during the tick phase of the enzootic cycle","volume":"7","author":"CJ Pappas","year":"2011","journal-title":"PLoS pathogens"},{"issue":"9","key":"ref40","doi-asserted-by":"crossref","first-page":"e75643","DOI":"10.1371\/journal.pone.0075643","article-title":"BB0347, from the lyme disease spirochete <italic>Borrelia burgdorferi<\/italic>, is surface exposed and interacts with the CS1 heparin-binding domain of human fibronectin","volume":"8","author":"RA Gaultney","year":"2013","journal-title":"PloS one"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1365-2958.2010.07191.x","article-title":"Analysis of a <italic>Borrelia burgdorferi<\/italic> phosphodiesterase demonstrates a role for cyclic-di-guanosine monophosphate in motility and virulence","volume":"77","author":"SZ Sultan","year":"2010","journal-title":"Molecular microbiology"},{"issue":"9","key":"ref42","doi-asserted-by":"crossref","first-page":"6169","DOI":"10.1073\/pnas.092010499","article-title":"Asymmetrical flagellar rotation in <italic>Borrelia burgdorferi<\/italic> nonchemotactic mutants","volume":"99","author":"C Li","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/j.1365-2958.2006.05550.x","article-title":"The Lyme disease agent <italic>Borrelia burgdorferi<\/italic> requires BB0690, a Dps homologue, to persist within ticks","volume":"63","author":"X Li","year":"2006","journal-title":"Molecular microbiology"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1111\/j.1365-2958.2007.05746.x","article-title":"The critical role of the linear plasmid lp36 in the infectious cycle of <italic>Borrelia burgdorferi<\/italic>","volume":"64","author":"MW Jewett","year":"2007","journal-title":"Molecular microbiology"},{"issue":"7","key":"ref45","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1128\/IAI.00266-13","article-title":"Understanding barriers to <italic>Borrelia burgdorferi<\/italic> dissemination during infection using massively parallel sequencing","volume":"81","author":"EB Troy","year":"2013","journal-title":"Infection and immunity"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1046\/j.1365-2958.2003.03452.x","article-title":"A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of <italic>Borrelia burgdorferi<\/italic> in a mammalian host","volume":"48","author":"JE Purser","year":"2003","journal-title":"Molecular microbiology"},{"issue":"8","key":"ref47","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1128\/IAI.05136-11","article-title":"The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of <italic>Borrelia burgdorferi<\/italic> in feeding <italic>Ixodes scapularis<\/italic> ticks","volume":"79","author":"MJ Caimano","year":"2011","journal-title":"Infection and immunity"},{"key":"ref48","first-page":"63","article-title":"Transposon mutagenesis as an approach to improved understanding of pathogenesis and biology","volume":"4","author":"T Lin","year":"2014","journal-title":"Frontiers in cellular and infection microbiology"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3389\/fpls.2014.00106","article-title":"Mn-euvering manganese: the role of transporter gene family members in manganese uptake and mobilization in plants","volume":"5","author":"AL Socha","year":"2014","journal-title":"Front Plant Sci"},{"issue":"28","key":"ref50","doi-asserted-by":"crossref","first-page":"11367","DOI":"10.1073\/pnas.1302515110","article-title":"Crystal structure of Ca<sup>2+<\/sup>\/H<sup>+<\/sup> antiporter protein YfkE reveals the mechanisms of Ca<sup>2+<\/sup> efflux and its pH regulation","volume":"110","author":"M Wu","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"8","key":"ref51","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00203-009-0494-7","article-title":"Characterization of <italic>Bacillus subtilis<\/italic> YfkE (ChaA): a calcium-specific Ca<sup>2+<\/sup>\/H<sup>+<\/sup> antiporter of the CaCA family","volume":"191","author":"M Fujisawa","year":"2009","journal-title":"Arch Microbiol"},{"issue":"6069","key":"ref52","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1126\/science.1215759","article-title":"Structural insight into the ion-exchange mechanism of the sodium\/calcium exchanger","volume":"335","author":"J Liao","year":"2012","journal-title":"Science (New York, NY)"},{"issue":"9","key":"ref53","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1093\/molbev\/msh177","article-title":"The cation\/Ca(2+) exchanger superfamily: phylogenetic analysis and structural implications","volume":"21","author":"X Cai","year":"2004","journal-title":"Mol Biol Evol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev.micro.60.080805.142149","article-title":"Manganese transport and the role of manganese in virulence","volume":"60","author":"KM Papp-Wallace","year":"2006","journal-title":"Annual review of microbiology"},{"issue":"9","key":"ref55","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1089\/ars.2012.5093","article-title":"Manganese complexes: diverse metabolic routes to oxidative stress resistance in prokaryotes and yeast","volume":"19","author":"VC Culotta","year":"2013","journal-title":"Antioxid Redox Signal"},{"issue":"23","key":"ref56","doi-asserted-by":"crossref","first-page":"19284","DOI":"10.1074\/jbc.M112.344903","article-title":"<italic>Borrelia burgdorferi<\/italic>, a pathogen that lacks iron, encodes manganese-dependent superoxide dismutase essential for resistance to streptonigrin","volume":"287","author":"B Troxell","year":"2012","journal-title":"The Journal of biological chemistry"},{"issue":"12","key":"ref57","doi-asserted-by":"crossref","first-page":"8468","DOI":"10.1074\/jbc.M112.433540","article-title":"A manganese-rich environment supports superoxide dismutase activity in a Lyme disease pathogen, <italic>Borrelia burgdorferi<\/italic>","volume":"288","author":"JD Aguirre","year":"2013","journal-title":"The Journal of biological chemistry"},{"issue":"1","key":"ref58","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1128\/JB.145.1.442-451.1981","article-title":"Manganese and defenses against oxygen toxicity in <italic>Lactobacillus plantarum<\/italic>","volume":"145","author":"FS Archibald","year":"1981","journal-title":"Journal of bacteriology"},{"issue":"4","key":"ref59","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1582-4934.2007.00077.x","article-title":"Physiological polyamines: simple primordial stress molecules","volume":"11","author":"HJ Rhee","year":"2007","journal-title":"J Cell Mol Med"},{"key":"ref60","article-title":"Regulation of a polyamine transporter by the conserved 3&apos; UTR-derived sRNA SorX confers resistance to singlet oxygen and organic hydroperoxides in <italic>Rhodobacter sphaeroides<\/italic>","volume":"0","author":"T Peng","year":"2016","journal-title":"RNA Biol"},{"issue":"23","key":"ref61","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1128\/JB.00277-15","article-title":"Physiological roles and adverse effects of the two cystine importers of <italic>Escherichia coli<\/italic>","volume":"197","author":"KR Chonoles Imlay","year":"2015","journal-title":"Journal of bacteriology"},{"issue":"5","key":"ref62","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1128\/JB.185.5.1572-1581.2003","article-title":"Exogenous glutathione completes the defense against oxidative stress in <italic>Haemophilus influenzae<\/italic>","volume":"185","author":"B Vergauwen","year":"2003","journal-title":"Journal of bacteriology"},{"issue":"1","key":"ref63","first-page":"e00615","article-title":"Evidence for an ABC-type riboflavin transporter system in pathogenic spirochetes","volume":"4","author":"RK Deka","year":"2013","journal-title":"MBio"},{"issue":"8","key":"ref64","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1128\/IAI.00315-15","article-title":"Cyclic di-GMP modulates gene expression in Lyme disease spirochetes at the tick-mammal interface to promote spirochete survival during the blood meal and tick-to-mammal transmission","volume":"83","author":"MJ Caimano","year":"2015","journal-title":"Infection and immunity"},{"issue":"12","key":"ref65","doi-asserted-by":"crossref","first-page":"7147","DOI":"10.1128\/IAI.72.12.7147-7154.2004","article-title":"BBE02 disruption mutants of <italic>Borrelia burgdorferi<\/italic> B31 have a highly transformable, infectious phenotype","volume":"72","author":"H Kawabata","year":"2004","journal-title":"Infection and immunity"},{"issue":"3","key":"ref66","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1128\/IAI.00917-15","article-title":"Phosphoenolpyruvate phosphotransferase system components modulate gene transcription and virulence of <italic>Borrelia burgdorferi<\/italic>","volume":"84","author":"BK Khajanchi","year":"2015","journal-title":"Infection and immunity"},{"issue":"8","key":"ref67","doi-asserted-by":"crossref","first-page":"e0136707","DOI":"10.1371\/journal.pone.0136707","article-title":"Absence of <italic>sodA<\/italic> increases the levels of oxidation of key metabolic determinants of <italic>Borrelia burgdorferi<\/italic>","volume":"10","author":"MD Esteve-Gassent","year":"2015","journal-title":"PloS one"},{"issue":"3","key":"ref68","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0002-9440(10)62050-0","article-title":"Bb2Bb3 regulation of murine Lyme arthritis is distinct from Ncf1 and independent of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase","volume":"167","author":"H Crandall","year":"2005","journal-title":"The American journal of pathology"},{"key":"ref69","doi-asserted-by":"crossref","DOI":"10.1002\/9780471729259.mc12c04s20","article-title":"Genetic transformation of <italic>Borrelia burgdorferi<\/italic>","author":"JA Hyde","year":"2011","journal-title":"Current protocols in microbiology"},{"key":"ref70","first-page":"253","article-title":"Electrotransformation of the spirochete <italic>Borrelia burgdorferi<\/italic>","volume":"47","author":"DS Samuels","year":"1995","journal-title":"Methods in molecular biology (Clifton, NJ)"},{"issue":"1","key":"ref71","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1128\/IAI.69.1.446-455.2001","article-title":"Decreased infectivity in <italic>Borrelia burgdorferi<\/italic> strain B31 is associated with loss of linear plasmid 25 or 28\u20131","volume":"69","author":"M Labandeira-Rey","year":"2001","journal-title":"Infection and immunity"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1186\/1471-2164-13-578","article-title":"Identification of essential genes of the periodontal pathogen <italic>Porphyromonas gingivalis<\/italic>","volume":"13","author":"BA Klein","year":"2012","journal-title":"BMC genomics"},{"key":"ref73","article-title":"The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2016 update","author":"E Afgan","year":"2016","journal-title":"Nucleic acids research"},{"issue":"3","key":"ref74","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1128\/JCM.35.3.685-690.1997","article-title":"An optimized PCR leads to rapid and highly sensitive detection of <italic>Borrelia burgdorferi<\/italic> in patients with Lyme borreliosis","volume":"35","author":"S Priem","year":"1997","journal-title":"J Clin Microbiol"},{"issue":"2","key":"ref75","doi-asserted-by":"crossref","first-page":"e17414","DOI":"10.1371\/journal.pone.0017414","article-title":"Nod2 suppresses <italic>Borrelia burgdorferi<\/italic> mediated murine Lyme arthritis and carditis through the induction of tolerance","volume":"6","author":"T Petnicki-Ocwieja","year":"2011","journal-title":"PloS one"},{"issue":"10","key":"ref76","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1089\/vbz.2012.1189","article-title":"Assessment of transcriptional activity of <italic>Borrelia burgdorferi<\/italic> and host cytokine genes during early and late infection in a mouse model","volume":"13","author":"E Hodzic","year":"2013","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"Web Server issue","key":"ref77","doi-asserted-by":"crossref","first-page":"W320","DOI":"10.1093\/nar\/gku316","article-title":"Deciphering key features in protein structures with the new ENDscript server","volume":"42","author":"X Robert","year":"2014","journal-title":"Nucleic acids research"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006225","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T11:04:50Z","timestamp":1719054290000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006225"}},"subtitle":[],"editor":[{"given":"Denise M.","family":"Monack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,17]]},"references-count":77,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006225","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,17]]}}}