{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:31:49Z","timestamp":1789587109278,"version":"build-2803163510"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006249","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000}}],"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI113134"],"award-info":[{"award-number":["AI113134"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI115834"],"award-info":[{"award-number":["AI115834"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006249","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T13:51:28Z","timestamp":1488376288000},"page":"e1006249","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":69,"title":["Chloroquine triggers Epstein-Barr virus replication through phosphorylation of KAP1\/TRIM28 in Burkitt lymphoma cells"],"prefix":"10.1371","volume":"13","author":[{"given":"Xiaofan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2432-2288","authenticated-orcid":true,"given":"Eric M.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2946-9497","authenticated-orcid":true,"given":"Sumita","family":"Bhaduri-McIntosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/275444a0","article-title":"Chloroquine enhances Epstein-Barr virus expression","volume":"275","author":"RA Karmali","year":"1978","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/282758b0","article-title":"Effect of chloroquine on Epstein-Barr virus expression","volume":"282","author":"G Lenoir","year":"1979","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrc1452","article-title":"Epstein-Barr virus: 40 years on","volume":"4","author":"LS Young","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1128\/JVI.01745-09","article-title":"Upregulation of STAT3 marks Burkitt lymphoma cells refractory to Epstein-Barr virus lytic cycle induction by HDAC inhibitors","volume":"84","author":"D Daigle","year":"2010","journal-title":"J Virol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"11438","DOI":"10.1128\/JVI.01762-13","article-title":"Signal transducer and activator of transcription 3 limits Epstein-Barr virus lytic activation in B lymphocytes","volume":"87","author":"ER Hill","year":"2013","journal-title":"J Virol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jviromet.2006.06.006","article-title":"Cells lytically infected with Epstein-Barr virus are detected and separable by immunoglobulins from EBV-seropositive individuals","volume":"137","author":"S Bhaduri-McIntosh","year":"2006","journal-title":"J Virol Methods"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"11347","DOI":"10.1128\/JVI.02008-15","article-title":"STAT3 Regulates Lytic Activation of Kaposi's Sarcoma-Associated Herpesvirus","volume":"89","author":"CA King","year":"2015","journal-title":"J Virol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"308","DOI":"10.4331\/wjbc.v5.i3.308","article-title":"KAPtain in charge of multiple missions: Emerging roles of KAP1","volume":"5","author":"CT Cheng","year":"2014","journal-title":"World J Biol Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"26267","DOI":"10.1074\/jbc.R111.252569","article-title":"KAP1 protein: an enigmatic master regulator of the genome","volume":"286","author":"S Iyengar","year":"2011","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/1541-7786.MCR-11-0134","article-title":"The ATM substrate KAP1 controls DNA repair in heterochromatin: regulation by HP1 proteins and serine 473\/824 phosphorylation","volume":"10","author":"D White","year":"2012","journal-title":"Mol Cancer Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"9169","DOI":"10.1073\/pnas.1403565111","article-title":"DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin","volume":"111","author":"MK Ayrapetov","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.molcel.2008.05.017","article-title":"ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin","volume":"31","author":"AA Goodarzi","year":"2008","journal-title":"Mol Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/ncb1446","article-title":"Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway","volume":"8","author":"Y Ziv","year":"2006","journal-title":"Nat Cell Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nbt0502-473","article-title":"Protein detection using proximity-dependent DNA ligation assays","volume":"20","author":"S Fredriksson","year":"2002","journal-title":"Nat Biotechnol"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Leuchowius KJ, Weibrecht I, Soderberg O (2011) In situ proximity ligation assay for microscopy and flow cytometry. Curr Protoc Cytom Chapter 9: Unit 9 36.","DOI":"10.1002\/0471142956.cy0936s56"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature01368","article-title":"DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation","volume":"421","author":"CJ Bakkenist","year":"2003","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1158\/1541-7786.MCR-08-0020","article-title":"DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture","volume":"6","author":"MB Kastan","year":"2008","journal-title":"Mol Cancer Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"13360","DOI":"10.1128\/JVI.01850-12","article-title":"The cellular ataxia telangiectasia-mutated kinase promotes epstein-barr virus lytic reactivation in response to multiple different types of lytic reactivation-inducing stimuli","volume":"86","author":"SR Hagemeier","year":"2012","journal-title":"J Virol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"8156","DOI":"10.1074\/jbc.M411405200","article-title":"Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment","volume":"280","author":"A Kudoh","year":"2005","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e0126088","DOI":"10.1371\/journal.pone.0126088","article-title":"DNA Damage Signaling Is Induced in the Absence of Epstein-Barr Virus (EBV) Lytic DNA Replication and in Response to Expression of ZEBRA","volume":"10","author":"R Wang'ondu","year":"2015","journal-title":"PLoS One"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"9115","DOI":"10.1128\/JVI.00909-06","article-title":"Amino acids in the basic domain of Epstein-Barr virus ZEBRA protein play distinct roles in DNA binding, activation of early lytic gene expression, and promotion of viral DNA replication","volume":"80","author":"L Heston","year":"2006","journal-title":"J Virol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5681","DOI":"10.1158\/0008-5472.CAN-08-4570","article-title":"Kruppel-associated box domain-associated protein-1 as a latency regulator for Kaposi's sarcoma-associated herpesvirus and its modulation by the viral protein kinase","volume":"69","author":"PC Chang","year":"2009","journal-title":"Cancer Res"},{"key":"ref23","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06068","article-title":"Release of human cytomegalovirus from latency by a KAP1\/TRIM28 phosphorylation switch","volume":"4","author":"B Rauwel","year":"2015","journal-title":"Elife"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"8779","DOI":"10.1128\/JVI.02976-12","article-title":"Kaposi's sarcoma-associated herpesvirus kaposin B induces unique monophosphorylation of STAT3 at serine 727 and MK2-mediated inactivation of the STAT3 transcriptional repressor TRIM28","volume":"87","author":"CA King","year":"2013","journal-title":"J Virol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1128\/JVI.00711-15","article-title":"LMP1-Induced Sumoylation Influences the Maintenance of Epstein-Barr Virus Latency through KAP1","volume":"89","author":"GL Bentz","year":"2015","journal-title":"J Virol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"7874","DOI":"10.1128\/JVI.00895-15","article-title":"Activated Nrf2 Interacts with Kaposi's Sarcoma-Associated Herpesvirus Latency Protein LANA-1 and Host Protein KAP1 To Mediate Global Lytic Gene Repression","volume":"89","author":"O Gjyshi","year":"2015","journal-title":"J Virol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"7331","DOI":"10.1128\/JVI.00596-14","article-title":"Kaposi's sarcoma-associated herpesvirus-encoded LANA interacts with host KAP1 to facilitate establishment of viral latency","volume":"88","author":"R Sun","year":"2014","journal-title":"J Virol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.antiviral.2016.08.010","article-title":"Chloroquine inhibits lytic replication of Kaposi's sarcoma-associated herpesvirus by disrupting mTOR and p38-MAPK activation","volume":"133","author":"M Yang","year":"2016","journal-title":"Antiviral Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nrmicro1089","article-title":"Endemic Burkitt's lymphoma: a polymicrobial disease?","volume":"3","author":"R Rochford","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1128\/JVI.79.2.1296-1307.2005","article-title":"Terminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivo","volume":"79","author":"LL Laichalk","year":"2005","journal-title":"J Virol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/ijc.2910310609","article-title":"A comparison of Epstein-Barr virus-specific T-cell immunity in malaria-endemic and -nonendemic regions of Papua New Guinea","volume":"31","author":"DJ Moss","year":"1983","journal-title":"Int J Cancer"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1365-2249.1990.tb05236.x","article-title":"The effects of Plasmodium falciparum malaria on immune control of B lymphocytes in Gambian children","volume":"80","author":"HC Whittle","year":"1990","journal-title":"Clin Exp Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/312449a0","article-title":"T-cell control of Epstein-Barr virus-infected B cells is lost during P. falciparum malaria","volume":"312","author":"HC Whittle","year":"1984","journal-title":"Nature"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/ijc.2910290406","article-title":"Final case reporting from the Ugandan prospective study of the relationship between EBV and Burkitt's lymphoma","volume":"29","author":"A Geser","year":"1982","journal-title":"Int J Cancer"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/0140-6736(91)92861-U","article-title":"Chromosome translocation and c-MYC activation by Epstein-Barr virus and Euphorbia tirucalli in B lymphocytes","volume":"337","author":"T Aya","year":"1991","journal-title":"Lancet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/bjc.1993.510","article-title":"Are plant factors a missing link in the evolution of endemic Burkitt's lymphoma?","volume":"68","author":"C van den Bosch","year":"1993","journal-title":"Br J Cancer"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1093\/oxfordjournals.aje.a115189","article-title":"Effect of a malaria suppression program on the incidence of African Burkitt's lymphoma","volume":"129","author":"A Geser","year":"1989","journal-title":"Am J Epidemiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1172\/JCI33700","article-title":"Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis","volume":"118","author":"KH Maclean","year":"2008","journal-title":"J Clin Invest"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1475-2875-10-116","article-title":"Patterns of chloroquine use and resistance in sub-Saharan Africa: a systematic review of household survey and molecular data","volume":"10","author":"AE Frosch","year":"2011","journal-title":"Malar J"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/978-1-62703-992-5_11","article-title":"Human B cell immortalization for monoclonal antibody production","volume":"1131","author":"J Hui-Yuen","year":"2014","journal-title":"Methods Mol Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"28122","DOI":"10.1074\/jbc.M112.368381","article-title":"Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1beta (HP1-beta) mobilization and DNA repair in heterochromatin","volume":"287","author":"E Bolderson","year":"2012","journal-title":"J Biol Chem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"7634","DOI":"10.1128\/JVI.78.14.7634-7644.2004","article-title":"Phosphorylation of Epstein-Barr virus ZEBRA protein at its casein kinase 2 sites mediates its ability to repress activation of a viral lytic cycle late gene by Rta","volume":"78","author":"AS El-Guindy","year":"2004","journal-title":"J Virol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1093\/emboj\/19.12.3080","article-title":"The Epstein-Barr virus lytic program is controlled by the co-operative functions of two transactivators","volume":"19","author":"R Feederle","year":"2000","journal-title":"Embo J"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1128\/JVI.02601-13","article-title":"B lymphocytes from patients with a hypomorphic mutation in STAT3 resist Epstein-Barr virus-driven cell proliferation","volume":"88","author":"S Koganti","year":"2014","journal-title":"J Virol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"TD Schmittgen","year":"2008","journal-title":"Nat Protoc"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006249","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T04:05:59Z","timestamp":1540353959000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006249"}},"subtitle":[],"editor":[{"given":"Paul M.","family":"Lieberman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,1]]},"references-count":45,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006249","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1006249","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,1]]}}}