{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:10:35Z","timestamp":1790809835579,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006324","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T00:00:00Z","timestamp":1492646400000}}],"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EN 305"],"award-info":[{"award-number":["EN 305"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 630 B8"],"award-info":[{"award-number":["SFB 630 B8"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006324","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T13:34:05Z","timestamp":1491831245000},"page":"e1006324","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["A quorum sensing-independent path to stumpy development in Trypanosoma brucei"],"prefix":"10.1371","volume":"13","author":[{"given":"Henriette","family":"Zimmermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2465-0599","authenticated-orcid":true,"given":"Ines","family":"Subota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Batram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian J.","family":"Janzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3384-0156","authenticated-orcid":true,"given":"Nicola G.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Engstler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,4,10]]},"reference":[{"issue":"7","key":"ref1","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/nrmicro2145","article-title":"Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens","volume":"7","author":"KW Deitsch","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1098\/rspb.1910.0035","article-title":"A case of sleeping sickness studied by precise enumerative methods: Regular periodical increase of the parasites disclosed","volume":"82","author":"D Ross","year":"1910","journal-title":"Proc R Soc London Ser B"},{"key":"ref3","first-page":"397","article-title":"\u00dcber Rezidive bei experimenteller Trypanosomiasis II","volume":"20","author":"H Ritz","year":"1916","journal-title":"Mitteilung Arch Schiffs- und Tropenhygiene"},{"issue":"3","key":"ref4","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1017\/S003118200004717X","article-title":"Identification, purification and properities of clone-specific glycoprotein antigenes constituting the surface coat of <italic>Trypanosoma brucei<\/italic>","volume":"71","author":"GA Cross","year":"1975","journal-title":"Parasitology"},{"issue":"1","key":"ref5","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1042\/bj2300195","article-title":"A new method for the rapid purification of both the membrane-bound and released forms of the variant surface glycoprotein from <italic>Trypanosoma brucei<\/italic>","volume":"230","author":"DG Jackson","year":"1985","journal-title":"Biochem J"},{"issue":"1","key":"ref6","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.molbiopara.2014.06.004","article-title":"Capturing the variant surface glycoprotein repertoire (the VSGnome) of <italic>Trypanosoma brucei<\/italic> Lister 427","volume":"195","author":"GAM Cross","year":"2014","journal-title":"Mol Biochem Parasitol. Elsevier B.V."},{"issue":"2","key":"ref7","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1126\/science.aaa4502","article-title":"The <italic>in vivo<\/italic> dynamics of antigenic variation in <italic>Trypanosoma brucei<\/italic>","volume":"2","author":"MR Mugnier","year":"2015","journal-title":"Science"},{"issue":"3","key":"ref8","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1111\/j.1365-2958.2004.04224.x","article-title":"Endocytosis, membrane recycling and sorting of GPI-anchored proteins: <italic>Trypanosoma brucei<\/italic> as a model system","volume":"53","author":"P Overath","year":"2004","journal-title":"Mol Microbiol"},{"issue":"3","key":"ref9","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1128\/EC.2.3.542-551.2003","article-title":"RNA Polymerase I Transcribes Procyclin Genes and Variant Surface Glycoprotein Gene Expression Sites in <italic>Trypanosoma brucei<\/italic>","volume":"2","author":"A G\u00fcnzl","year":"2003","journal-title":"Eukaryot Cell"},{"issue":"1","key":"ref10","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.gene.2014.09.047","article-title":"Mono-allelic VSG expression by RNA polymerase I in <italic>Trypanosoma brucei<\/italic>: expression site control from both ends?","volume":"556","author":"A G\u00fcnzl","year":"2014","journal-title":"Gene"},{"issue":"5","key":"ref11","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.chom.2016.04.020","article-title":"Epigenetic regulation of virulence gene expression in parasitic protozoa","volume":"19","author":"MT Duraisingh","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"7","key":"ref12","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1371\/journal.pbio.0060161","article-title":"A histone methyltransferase modulates antigenic variation in African trypanosomes","volume":"6","author":"LM Figueiredo","year":"2008","journal-title":"PLoS Biol"},{"issue":"7","key":"ref13","doi-asserted-by":"publisher","first-page":"3131","DOI":"10.1093\/nar\/gkv1459","article-title":"A transcription-independent epigenetic mechanism is associated with antigenic switching in <italic>Trypanosoma brucei<\/italic>","volume":"44","author":"F Aresta-Branco","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"ref14","doi-asserted-by":"publisher","first-page":"e3527","DOI":"10.1371\/journal.pone.0003527","article-title":"Telomeric expression sites are highly conserved in <italic>Trypanosoma brucei<\/italic>","volume":"3","author":"C Hertz-Fowler","year":"2008","journal-title":"PLoS One"},{"issue":"6865","key":"ref15","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/414759a","article-title":"A pol I transcriptional body associated with VSG mono-allelic expression in <italic>Trypanosoma brucei<\/italic>","volume":"414","author":"M Navarro","year":"2001","journal-title":"Nature"},{"issue":"1","key":"ref16","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1128\/EC.00282-09","article-title":"Nucleosomes are depleted at the VSG expression site transcribed by RNA polymerase I in African trypanosomes","volume":"9","author":"LM Figueiredo","year":"2010","journal-title":"Eukaryot Cell"},{"issue":"1","key":"ref17","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1128\/EC.00281-09","article-title":"Active VSG expression sites in <italic>Trypanosoma brucei<\/italic> are depleted of nucleosomes","volume":"9","author":"TM Stanne","year":"2010","journal-title":"Eukaryot Cell"},{"issue":"7","key":"ref18","doi-asserted-by":"publisher","first-page":"e1003502","DOI":"10.1371\/journal.ppat.1003502","article-title":"Mosaic VSGs and the scale of <italic>Trypanosoma brucei<\/italic> antigenic variation","volume":"9","author":"JPJ Hall","year":"2013","journal-title":"PLoS Pathog"},{"issue":"5","key":"ref19","doi-asserted-by":"publisher","first-page":"e1005994","DOI":"10.1371\/journal.pgen.1005994","article-title":"A conserved DNA repeat promotes selection of a diverse repertoire of <italic>Trypanosoma brucei<\/italic> surface antigens from the genomic archive","volume":"12","author":"G Hovel-Miner","year":"2016","journal-title":"PLoS Genet"},{"issue":"23","key":"ref20","doi-asserted-by":"publisher","first-page":"8149","DOI":"10.1093\/nar\/11.23.8149","article-title":"Telomere conversion in trypanosomes","volume":"11","author":"T de Lange","year":"1983","journal-title":"Nucleic Acids Res"},{"issue":"6028","key":"ref21","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/316562a0","article-title":"Telomeric reciprocal recombination as a possible mechanism for antigenic variation","volume":"316","author":"E Pays","year":"1985","journal-title":"Nature"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/j.1460-2075.1984.tb01975.x","article-title":"The inactivation and reactivation of an expression-linked gene copy for a variant surface glycoprotein in <italic>Trypanosoma brucei<\/italic>","volume":"3","author":"P a. M Michels","year":"1984","journal-title":"EMBO J"},{"issue":"24","key":"ref23","doi-asserted-by":"publisher","first-page":"8716","DOI":"10.1073\/pnas.0501886102","article-title":"Variant surface glycoprotein RNA interference triggers a precytokinesis cell cycle arrest in African trypanosomes","volume":"102","author":"K Sheader","year":"2005","journal-title":"Proc Natl Acad Sci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1475-9292-2-3","article-title":"Role of the long slender to short stumpy transition in the life cycle of the african trypanosomes","volume":"2","author":"JR Seed","year":"2003","journal-title":"Kinetoplastid Biol Dis"},{"issue":"1","key":"ref25","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S0166-6851(97)00160-6","article-title":"Cell density triggers slender to stumpy differentiation of <italic>Trypanosoma brucei<\/italic> bloodstream forms in culture","volume":"90","author":"B Reuner","year":"1997","journal-title":"Mol Biochem Parasitol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1242\/jcs.110.21.2661","article-title":"Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway","volume":"110","author":"E Vassella","year":"1997","journal-title":"J Cell Sci"},{"issue":"7485","key":"ref27","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/nature12864","article-title":"Genome-wide dissection of the quorum sensing signalling pathway in <italic>Trypanosoma brucei<\/italic>","volume":"505","author":"BM Mony","year":"2013","journal-title":"Nature"},{"issue":"2","key":"ref28","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/mmi.12949","article-title":"Assembling the components of the quorum sensing pathway in African trypanosomes","volume":"96","author":"BM Mony","year":"2015","journal-title":"Mol Microbiol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3389\/fcimb.2013.00078","article-title":"Bloodstream form pre-adaptation to the tsetse fly in <italic>Trypanosoma brucei<\/italic>","volume":"3","author":"E Rico","year":"2013","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"ref30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.ppat.1005439","article-title":"Quantitative proteomics uncovers novel factors involved in developmental differentiation of <italic>Trypanosoma brucei<\/italic>","volume":"12","author":"M Dejung","year":"2016","journal-title":"PLoS Pathog"},{"issue":"1387","key":"ref31","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1098\/rspb.1997.0205","article-title":"The bloodstream differentiation-division of <italic>Trypanosoma brucei<\/italic> studied using mitochondrial markers","volume":"264","author":"KM Tyler","year":"1997","journal-title":"Proc R Soc London Ser B"},{"issue":"7244","key":"ref32","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nature07997","article-title":"A surface transporter family conveys the trypanosome differentiation signal","volume":"459","author":"S Dean","year":"2009","journal-title":"Nature"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nrmicro2779","article-title":"Trypanosomal immune evasion, chronicity and transmission: an elegant balancing act","volume":"10","author":"P MacGregor","year":"2012","journal-title":"Nat Rev Microbiol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e02324","DOI":"10.7554\/eLife.02324","article-title":"Expression site attenuation mechanistically links antigenic variation and development in <italic>Trypanosoma brucei<\/italic>","volume":"3","author":"C Batram","year":"2014","journal-title":"Elife"},{"issue":"22","key":"ref35","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.1101\/gad.323404","article-title":"Cold shock and regulation of surface protein trafficking convey sensitization to inducers of stage differentiation in <italic>Trypanosoma brucei<\/italic>","volume":"18","author":"M Engstler","year":"2004","journal-title":"Genes Dev"},{"issue":"6","key":"ref36","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.mib.2007.09.014","article-title":"The cell biology of <italic>Trypanosoma brucei<\/italic> differentiation","volume":"10","author":"K Fenn","year":"2007","journal-title":"Curr Opin Microbiol"},{"issue":"16","key":"ref37","doi-asserted-by":"publisher","first-page":"7705","DOI":"10.1093\/nar\/gks533","article-title":"Identification of the regulatory elements controlling the transmission stage-specific gene expression of PAD1 in <italic>Trypanosoma brucei<\/italic>","volume":"40","author":"P MacGregor","year":"2012","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"ref38","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1111\/j.1365-2958.2003.03937.x","article-title":"Loss of the mono-allelic control of the <italic>VSG<\/italic> expression sites during the development of <italic>Trypanosoma brucei<\/italic> in the bloodstream","volume":"51","author":"A Amiguet-Vercher","year":"2004","journal-title":"Mol Microbiol"},{"issue":"4","key":"ref39","first-page":"313","article-title":"Analysis by flow cytometry of DNA synthesis during the life cycle of African trypanosomes","volume":"41","author":"SZ Shapiro","year":"1984","journal-title":"Acta Trop"},{"issue":"5","key":"ref40","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/0020-7519(73)90095-7","article-title":"Changes in oxidative metabolism and ultrastructure accompanying differentiation of the mitochondrion in <italic>Trypanosoma brucei<\/italic>","volume":"3","author":"RC Brown","year":"1973","journal-title":"Int J Parasitol"},{"issue":"12","key":"ref41","first-page":"1306","article-title":"A novel phosphatase cascade regulates differentiation in <italic>Trypanosoma brucei<\/italic> via a glycosomal signaling pathway","volume":"24","author":"B Sz\u00f6or","year":"2010","journal-title":"A novel phosphatase cascade regulates differentiation in"},{"issue":"10","key":"ref42","doi-asserted-by":"publisher","first-page":"e1003689","DOI":"10.1371\/journal.ppat.1003689","article-title":"Independent pathways can transduce the life cycle differentiation signal in <italic>Trypanosoma brucei<\/italic>","volume":"9","author":"B Sz\u00f6or","year":"2013","journal-title":"PLoS Pathog"},{"issue":"2","key":"ref43","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0166-6851(98)00046-2","article-title":"Mild acid stress as a differentiation trigger in Trypanosoma brucei","volume":"93","author":"S Rolin","year":"1998","journal-title":"Mol Biochem Parasitol"},{"issue":"5","key":"ref44","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1083\/jcb.125.5.1147","article-title":"Evidence for an interplay between cell cycle progression and the initiation of differentiation between life cycle forms of African trypanosomes","volume":"125","author":"KR Matthews","year":"1994","journal-title":"J Cell Biol"},{"issue":"2","key":"ref45","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/j.1432-1033.1990.tb19237.x","article-title":"Synchronous differentiation of <italic>Trypanosoma brucei<\/italic> from bloodstream to procyclic forms <italic>in vitro<\/italic>","volume":"192","author":"K Ziegelbauer","year":"1990","journal-title":"Eur J Biochem"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/BF00941941","article-title":"Stimulating effect of citrate and <italic>cis<\/italic>-aconitate on the transformation of <italic>Trypanosoma brucei<\/italic> bloodstream forms to procyclic forms <italic>in vitro<\/italic>","volume":"66","author":"R Brun","year":"1981","journal-title":"Zeitschrift f\u00fcr Parasitenkd"},{"issue":"1","key":"ref47","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/j.1432-1033.1986.tb09955.x","article-title":"The effect of citrate\/<italic>cis<\/italic>-aconitate on oxidative metabolism during transformation of <italic>Trypanosoma brucei<\/italic>","volume":"160","author":"P Overath","year":"1986","journal-title":"Eur J Biochem"},{"issue":"Pt 6","key":"ref48","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1242\/jcs.108.6.2231","article-title":"Mitochondrial genome repositioning during the differentiation of the African trypanosome between life cycle forms is microtubule mediated","volume":"108","author":"KR Matthews","year":"1995","journal-title":"J Cell Sci"},{"issue":"11","key":"ref49","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.pt.2009.08.001","article-title":"The heart of darkness: growth and form of <italic>Trypanosoma brucei<\/italic> in the tsetse fly","volume":"25","author":"R Sharma","year":"2009","journal-title":"Trends Parasitol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3389\/fcimb.2013.00053","article-title":"Through the dark continent: African trypanosome development in the tsetse fly","volume":"3","author":"B Rotureau","year":"2013","journal-title":"Front Cell Infect Microbiol"},{"issue":"3","key":"ref51","first-page":"53","article-title":"Transformation of monomorphic and pleomorphic <italic>Trypanosoma brucei<\/italic>","volume":"262","author":"R McCulloch","year":"2004","journal-title":"Methods Mol Biol"},{"issue":"4","key":"ref52","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.chom.2011.03.013","article-title":"Transmission stages dominate trypanosome within-host dynamics during chronic infections","volume":"9","author":"P MacGregor","year":"2011","journal-title":"Cell Host Microbe"},{"issue":"17","key":"ref53","doi-asserted-by":"publisher","first-page":"4846","DOI":"10.1093\/emboj\/18.17.4846","article-title":"Control of variant surface glycoprotein gene-expression sites in <italic>Trypanosoma brucei<\/italic>","volume":"18","author":"I Chaves","year":"1999","journal-title":"EMBO J"},{"issue":"1","key":"ref54","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0166-6851(01)00243-2","article-title":"Control of VSG gene expression sites","volume":"114","author":"P Borst","year":"2001","journal-title":"Mol Biochem Parasitol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/030098587200901s01","article-title":"Review of pathology of diseases in domestic and laboratory animals caused by <italic>Trypanosoma congolense<\/italic>, <italic>T<\/italic>. <italic>vivax<\/italic>, <italic>T<\/italic>. <italic>brucei<\/italic>, <italic>T<\/italic>. <italic>rhodesiense<\/italic> and <italic>T<\/italic>. <italic>gambiense<\/italic>","volume":"9","author":"GJ Losos","year":"1972","journal-title":"Vet Pathol"},{"issue":"6","key":"ref56","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/0035-9203(70)90096-9","article-title":"The pathology of African trypanosomiasis","volume":"64","author":"LG Goodwin","year":"1970","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"5","key":"ref57","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/0035-9203(86)90395-0","article-title":"Similarity in variable antigen type composition of <italic>Trypanosoma brucei rhodesiense<\/italic> populations in different sites within the mouse host","volume":"80","author":"CMR Turner","year":"1986","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"6","key":"ref58","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.chom.2016.05.002","article-title":"<italic>Trypanosoma brucei<\/italic> parasites occupy and functionally adapt to the adipose tissue in mice","volume":"19","author":"S Trindade","year":"2016","journal-title":"Cell Host Microbe"},{"key":"ref59","first-page":"109","article-title":"Trypanosomiasis and leishmaniasis: biology and control","author":"P Borst","year":"1997"},{"issue":"6666","key":"ref60","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/35166","article-title":"The role of transferrin-receptor variation in the host range of <italic>Trypanosoma brucei<\/italic>","volume":"391","author":"W Bitter","year":"1998","journal-title":"Nature"},{"issue":"1","key":"ref61","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/j.1365-2958.2005.04831.x","article-title":"Trypanosomes change their transferrin receptor expression to allow effective uptake of host transferrin","volume":"58","author":"HGAM Van Luenen","year":"2005","journal-title":"Mol Microbiol"},{"issue":"2","key":"ref62","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/0166-6851(93)90200-H","article-title":"Control of G1 to S cell cycle progression of <italic>Trypanosoma brucei<\/italic> S427cl1 organisms under axenic conditions","volume":"57","author":"GA Morgan","year":"1993","journal-title":"Mol Biochem Parasitol"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0166-6851(96)02625-4","article-title":"The requirements for G1 checkpoint progression of <italic>Trypanosoma brucei<\/italic> S 427 clone 1","volume":"78","author":"GA Morgan","year":"1996","journal-title":"Mol Biochem Parasitolchemical Parasitol"},{"issue":"Pt 1","key":"ref64","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1017\/S0031182003004256","article-title":"Mathematical and statistical analysis of the <italic>Trypanosoma brucei<\/italic> slender to stumpy transition","volume":"128","author":"NJ Savill","year":"2004","journal-title":"Parasitology"},{"issue":"1","key":"ref65","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/0166-6851(93)90163-R","article-title":"Abrupt RNA changes precede the first cell division during the differentiation of <italic>Trypanosoma brucei<\/italic> bloodstream forms into procyclic forms <italic>in vitro<\/italic>","volume":"61","author":"E Pays","year":"1993","journal-title":"Mol Biochem Parasitol"},{"issue":"4","key":"ref66","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/j.1460-2075.1985.tb03728.x","article-title":"Inactivation and reactivation of a variant-specific antigen gene in cyclically transmitted <italic>Trypanosoma brucei<\/italic>","volume":"4","author":"MF Delauw","year":"1985","journal-title":"EMBO J"},{"issue":"6","key":"ref67","doi-asserted-by":"publisher","first-page":"985","DOI":"10.2307\/3282883","article-title":"Continuous cultivation of <italic>Trypanosoma brucei<\/italic> blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers","volume":"75","author":"H Hirumi","year":"1989","journal-title":"J Parasitol"},{"issue":"1","key":"ref68","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1046\/j.1365-2958.2001.02471.x","article-title":"Deletion of a novel protein kinase with PX and FYVE-related domains increases the rate of differentiation of <italic>Trypanosoma brucei<\/italic>","volume":"41","author":"E Vassella","year":"2001","journal-title":"Mol Microbiol"},{"issue":"5","key":"ref69","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1111\/j.1462-5822.2010.01566.x","article-title":"Molecular bases of cytoskeleton plasticity during the <italic>Trypanosoma brucei<\/italic> parasite cycle","volume":"13","author":"B Rotureau","year":"2011","journal-title":"Cell Microbiol"},{"issue":"3","key":"ref70","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1111\/j.1365-2958.2011.07721.x","article-title":"Lipoamide dehydrogenase is essential for both bloodstream and procyclic <italic>Trypanosoma brucei<\/italic>","volume":"81","author":"A Roldan","year":"2011","journal-title":"Mol Microbiol"},{"issue":"20","key":"ref71","doi-asserted-by":"publisher","first-page":"10302","DOI":"10.1093\/nar\/gks801","article-title":"DOT1A-dependent H3K76 methylation is required for replication regulation in <italic>Trypanosoma brucei<\/italic>","volume":"40","author":"A Gassen","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"5313","DOI":"10.1038\/ncomms6313","article-title":"Structure-guided mutational analysis reveals the functional requirements for product specificity of DOT1 enzymes","volume":"5","author":"G Dindar","year":"2014","journal-title":"Nat Commun"},{"issue":"2","key":"ref73","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/j.1550-7408.1999.tb04592.x","article-title":"Assembly of the paraflagellar rod and the flagellum attachment zone complex during the <italic>Trypanosoma brucei<\/italic> cell cycle","volume":"46","author":"L Kohl","year":"1999","journal-title":"J Eukaryot Microbiol"},{"key":"ref74","unstructured":"Okabe M, Ito K. How to make figures and presentations that are friendly to color blind people.pdf. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/Jfly.Iam.U-Tokyo.Ac.Jp\/Color\/Index.Html\" xlink:type=\"simple\">http:\/\/Jfly.Iam.U-Tokyo.Ac.Jp\/Color\/Index.Html<\/ext-link>. 2002. p. 1\u20134."}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006324","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T00:00:00Z","timestamp":1492646400000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T06:52:12Z","timestamp":1658904732000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006324"}},"subtitle":[],"editor":[{"given":"Samuel James","family":"Black","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,4,10]]},"references-count":74,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006324","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,10]]}}}