{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:49:12Z","timestamp":1779234552554,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006366","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000}}],"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI035739"],"award-info":[{"award-number":["AI035739"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006366","type":"journal-article","created":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T17:50:54Z","timestamp":1493661054000},"page":"e1006366","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Controlling transferrin receptor trafficking with GPI-valence in bloodstream stage African trypanosomes"],"prefix":"10.1371","volume":"13","author":[{"given":"Calvin","family":"Tiengwe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2201-3235","authenticated-orcid":true,"given":"Peter J.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7903-6521","authenticated-orcid":true,"given":"James D.","family":"Bangs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,5,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0968-0004(90)90195-H","article-title":"Glycolipid membrane anchoring provides clues to the mechanism of protein sorting in polarized epithelial cells","volume":"15","author":"M Lisanti","year":"1990","journal-title":"Trends Biochem Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1242\/jcs.112.17.2799","article-title":"The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research","volume":"112","author":"MAJ Ferguson","year":"1999","journal-title":"J Cell Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/j.1460-2075.1996.tb00346.x","article-title":"GPI anchor attachment is required for Gas1p transport from the endoplasmic reticulum in COP II vesicles","volume":"15","author":"TL Doering","year":"1996","journal-title":"EMBO J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0092-8674(01)00215-X","article-title":"Protein sorting upon exit from the endoplasmic reticulum","volume":"104","author":"M Mu\u00f1iz","year":"2001","journal-title":"Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.bbamem.2015.12.018","article-title":"Glycosylphosphatidylinositol-anchored proteins: Membrane organization and transport","volume":"1858","author":"C Zurzulo","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1034\/j.1600-0854.2002.030405.x","article-title":"Selective delivery of secretory cargo in Golgi-derived carriers of nonepithelial cells","volume":"3","author":"A Rustom","year":"2002","journal-title":"Traffic"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/0092-8674(92)90189-J","article-title":"Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface","volume":"68","author":"DA Brown","year":"1992","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nrm1309","article-title":"Sorting GPI-anchored proteins","volume":"5","author":"S Mayor","year":"2004","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1017\/S0031182009992034","article-title":"Bloodstream form trypanosome plasma membrane proteins: antigenic variation and invariant antigens","volume":"137","author":"A Schwede","year":"2010","journal-title":"Parasitol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1042\/bse0510047","article-title":"African trypanosomes: the genome and adaptations for immune evasion","volume":"51","author":"G Rudenko","year":"2011","journal-title":"Essays Biochem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e3527","DOI":"10.1371\/journal.pone.0003527","article-title":"Telomeric expression sites are highly conserved in <italic>Trypanosoma brucei<\/italic>","volume":"3","author":"C FLM Hertz-Fowler","year":"2008","journal-title":"PLoS One"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0166-6851(99)00060-2","article-title":"Transcription of &apos;inactive&apos; expression sites in African trypanosomes leads to expression of multiple transferrin receptor RNAs in bloodstream forms","volume":"101","author":"I Ansorge","year":"1999","journal-title":"Mol Biochem Parasitol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0092-8674(94)90574-6","article-title":"A novel heterodimeric transferrin receptor encoded by a pair of VSG expression site-associated genes in <italic>T<\/italic>. <italic>brucei<\/italic>","volume":"78","author":"D Salmon","year":"1994","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1002\/j.1460-2075.1994.tb06546.x","article-title":"Reconstitution of a surface transferrin binding complex in insect form <italic>Trypanosoma brucei<\/italic>","volume":"13","author":"MJL Ligtenberg","year":"1994","journal-title":"EMBO J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1083\/jcb.131.5.1173","article-title":"Transferrin-binding protein complex is the receptor for transferrin uptake in <italic>Trypanosoma brucei<\/italic>","volume":"131","author":"D Steverding","year":"1995","journal-title":"J Cell Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5499","DOI":"10.1242\/jcs.02667","article-title":"GPI valence and the fate of secretory membrane proteins in African trypanosomes","volume":"118","author":"KJ Schwartz","year":"2005","journal-title":"J Cell Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1126\/science.3340856","article-title":"Glycosyl-phosphatidylinositol moiety that anchors <italic>Trypanosoma brucei<\/italic> variant surface glycoprotein to the membrane","volume":"239","author":"MAJ Ferguson","year":"1988","journal-title":"Science"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1091\/mbc.E09-07-0542","article-title":"Streamlined architecture and GPI-dependent trafficking in the early secretory pathway of African trypanosomes","volume":"20","author":"ES Sevova","year":"2009","journal-title":"Mol Biol Cell"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1128\/EC.2.1.76-83.2003","article-title":"Glycosylphosphatidylinositol-dependent protein trafficking in bloodstream stage <italic>Trypanosoma brucei<\/italic>","volume":"2","author":"VP Triggs","year":"2003","journal-title":"Euk Cell"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1083\/jcb.103.1.255","article-title":"Posttranslational modification and intracellular transport of a trypanosome variant surface glycoprotein","volume":"103","author":"JD Bangs","year":"1986","journal-title":"J Cell Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0166-6851(89)90132-1","article-title":"Release of the variant glycoprotein during differentiation of bloodstream to procyclic forms of <italic>Trypanosoma brucei<\/italic>","volume":"32","author":"R Bulow","year":"1989","journal-title":"Mol Biochem Parasitol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1242\/jcs.00938","article-title":"Kinetics of endocytosis and recycling of the GPI-anchored variant surface glycoprotein in <italic>Trypanosoma brucei<\/italic>","volume":"117","author":"M Engstler","year":"2004","journal-title":"J Cell Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1550-7408.1990.tb01263.x","article-title":"Degradation, recycling and shedding of <italic>Trypanosoma brucei<\/italic> variant surface glycoprotein","volume":"37","author":"A Seyfang","year":"1990","journal-title":"J Protozool"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"13318","DOI":"10.1021\/bi00211a045","article-title":"Spontaneous interlayer transfer of phospholipids: dependence on acyl chain composition","volume":"32","author":"JR Silvius","year":"1993","journal-title":"Biochem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1021\/bi00063a030","article-title":"Interbilayer transfer of phospholipid-anchored macromolecules via monomer diffusion","volume":"32","author":"JR Silvius","year":"1993","journal-title":"Biochem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1046\/j.1365-2958.2003.03245.x","article-title":"The expression level determines the surface distribution of the transferrin receptor in <italic>Trypanosoma brucei<\/italic>","volume":"47","author":"R Mussman","year":"2003","journal-title":"Mol Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"40690","DOI":"10.1074\/jbc.M404697200","article-title":"Factors affecting the level and localization of the transferrin receptor in <italic>Trypanosoma brucei<\/italic>","volume":"279","author":"R Mussman","year":"2004","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1111\/cmi.12605","article-title":"Surface proteins, ERAD and antigenic variation in <italic>Trypanosoma brucei<\/italic>","volume":"18","author":"C Tiengwe","year":"2016","journal-title":"Cell Microbiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1472-6750-5-6","article-title":"Functional complementation of RNA interference mutants in trypanosomes","volume":"5","author":"F Rusconi","year":"2005","journal-title":"BMC Biotechnol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s004360050357","article-title":"Bloodstream forms of <italic>Trypanosoma brucei<\/italic> require only small amounts of iron for growth","volume":"84","author":"D Steverding","year":"1998","journal-title":"Parasitol Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1017\/S0031182009991880","article-title":"Iron metabolism in trypanosomatids, and its crucial role in infection","volume":"137","author":"MC Taylor","year":"2010","journal-title":"Parasitol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1365-2958.2011.07842.x","article-title":"Late endosomal Rab7 regulates lysosomal trafficking of endocytic but not biosynthetic cargo in <italic>Trypanosoma brucei<\/italic>","volume":"82","author":"JS Silverman","year":"2011","journal-title":"Mol Microbiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/tra.12094","article-title":"Characterization of the late endosomal ESCRT machinery in <italic>Trypanosoma brucei<\/italic>","volume":"14","author":"JS Silverman","year":"2013","journal-title":"Traffic"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1242\/jcs.115.16.3253","article-title":"Developmentally regulated trafficking of the lysosomal membrane protein p67 in <italic>Trypanosoma brucei<\/italic>","volume":"115","author":"DL Alexander","year":"2002","journal-title":"J Cell Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0960-9822(00)80018-4","article-title":"<italic>N<\/italic>-linked glycans containing linear poly-<italic>N<\/italic>-acetyllactosamine as sorting signals in endocytosis in <italic>Trypanosoma brucei<\/italic>","volume":"9","author":"DP Nolan","year":"1999","journal-title":"Curr Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.cell.2015.11.051","article-title":"Extracellular vesicles from <italic>Trypanosoma brucei<\/italic> mediate virulence factor transfer and cause host anemia","volume":"164","author":"AJ Szempruch","year":"2016","journal-title":"Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e1002618","DOI":"10.1371\/journal.ppat.1002618","article-title":"Modeling of the N-glycosylated transferrin receptor suggests how transferrin binding can occur within the surface coat of <italic>Trypanosoma brucei<\/italic>","volume":"8","author":"A Mehlert","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"7272","DOI":"10.1093\/emboj\/16.24.7272","article-title":"Characterization of the ligand-binding site of the transferrin receptor in Trypanosoma brucei demonstrates a structural relationship with the N-terminal domain of the variant surface glycoprotein","volume":"16","author":"D Salmon","year":"1997","journal-title":"EMBO J"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0166-6851(96)02706-5","article-title":"Implications of conserved structural motifs in disparate trypanosome surface proteins","volume":"81","author":"M Carrington","year":"1996","journal-title":"Mol Biochem Parasitol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e1006055","DOI":"10.1371\/journal.ppat.1006055","article-title":"A receptor&apos;s tale: and eon in the life of a trypanosome receptor","volume":"13","author":"MK Higgins","year":"2017","journal-title":"PLoS Pathog"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1128\/EC.00156-09","article-title":"The role of AP-1 in developmentally regulated post-Golgi trafficking in <italic>Trypanosoma brucei<\/italic>","volume":"8","author":"NN Tazeh","year":"2009","journal-title":"Euk Cell"},{"key":"ref42","first-page":"78","article-title":"ESAG 6 and 7 products of <italic>Trypanosoma brucei<\/italic> form a transferrin binding protein complex","volume":"64","author":"D Steverding","year":"1994","journal-title":"Eur J Cell Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1074\/jbc.275.6.4072","article-title":"Characterization of a novel alanine-rich protein located in surface microdomains in Trypanosoma brucei","volume":"275","author":"DP Nolan","year":"2000","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1128\/EC.00283-06","article-title":"De novo sphingolipid synthesis is essential for viability, but not transport of glycosylphosphatidylinositol-anchored proteins in African trypanosomes","volume":"6","author":"SS Sutterwala","year":"2007","journal-title":"Euk Cell"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1365-2958.2008.06393.x","article-title":"Developmentally regulated sphingolipid synthesis in African trypanosomes","volume":"70","author":"SS Sutterwala","year":"2008","journal-title":"Mol Microbiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1126\/science.1156296","article-title":"A haptoglobin-hemoglobin receptor conveys innate immunity to <italic>Trypanosoma brucei<\/italic> in humans","volume":"320","author":"B Vanhollebeke","year":"2008","journal-title":"Science"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"e05553","DOI":"10.7554\/eLife.05553","article-title":"Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglogin receptor","volume":"3","author":"H Lane-Serff","year":"2014","journal-title":"eLIFE"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0166-6851(02)00306-7","article-title":"The origin of the serum resistance associated (<italic>SRA<\/italic>) gene and a model of the structure of the SRA polypeptide from <italic>Trypanosoma brucei rhodesiense<\/italic>","volume":"127","author":"N Campillo","year":"2003","journal-title":"Mol Biochem Parasitol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1128\/EC.05112-11","article-title":"Endosomal localization of the serum resistance-associated protein in African trypanosomes confers human infectivity","volume":"10","author":"NA Stephens","year":"2011","journal-title":"Euk Cell"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0166-6851(99)00002-X","article-title":"A tightly regulated inducible expression system for conditional gene knockouts and dominant-negative genetics in <italic>Trypanosoma brucei<\/italic>","volume":"99","author":"E Wirtz","year":"1999","journal-title":"Mol Biochem Parasitol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0169-4758(94)90402-2","article-title":"Axenic culture of African trypanosome bloodstream forms","volume":"10","author":"H Hirumi","year":"1994","journal-title":"Parasitol Today"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0166-6851(02)00092-0","article-title":"The architecture of variant surface glycoprotein gene expression sites in <italic>Trypanosoma brucei<\/italic>","volume":"122","author":"M Berriman","year":"2002","journal-title":"Mol Biochem Parasitol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0014-4894(91)90012-L","article-title":"<italic>Trypanosoma brucei<\/italic>: analysis of codon usage and nucleotide composition of nuclear genes","volume":"73","author":"M Parsons","year":"1991","journal-title":"Exp Parasitol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2164-9-2","article-title":"Codon usage suggests that translational selection has a mahor impact on protein expression in trypanosomatids","volume":"9","author":"D Horn","year":"2008","journal-title":"BMC Genomics"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/j.1600-0854.2007.00588.x","article-title":"Multiple signals regulate trafficking of the lysosomal membrane protein p67 in African trypanosomes","volume":"8","author":"NN Tazeh","year":"2007","journal-title":"Traffic"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/j.1365-2958.2008.06195.x","article-title":"The LAMP-like protein p67 plays an essential role in the lysosome of African trypanosomes","volume":"68","author":"RF Peck","year":"2008","journal-title":"Mol Microbiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1128\/IAI.24.3.617-627.1979","article-title":"Inactivation or elimination of potentially trypanolytic, complement-activating immune complexes by pathogenic trypanosomes","volume":"24","author":"AE Balber","year":"1979","journal-title":"Infect Immun"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/bs.mcb.2014.12.011","article-title":"Scanning and three-dimensional electron microscopy methods for the study of Trypanosoma brucei and Leishmania mexicana flagella","volume":"127","author":"E Gluenz","year":"2015","journal-title":"Methods Cell Biol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0014-5793(85)81223-0","article-title":"Synthesis of a hydrolase for the membrane-form variant surface glycoprotein is repressed during transformation of <italic>Trypanosoma brucei<\/italic>","volume":"187","author":"R Bulow","year":"1985","journal-title":"FEBS Lett"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"13813","DOI":"10.1016\/S0021-9258(18)67092-9","article-title":"A phospholipase C from <italic>Trypanosoma brucei<\/italic> which selectively cleaves the glycolipid on the variant surface glycoprotein","volume":"261","author":"D Hereld","year":"1986","journal-title":"J Biol Chem"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/302349a0","article-title":"The membrane form of variant surface glycoproteins of <italic>Trypanosoma brucei<\/italic>","volume":"302","author":"ML Cardoso de Almeida","year":"1983","journal-title":"Nature"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1073\/pnas.75.4.1989","article-title":"Crossreacting determinants in variant-specific surface antigens of African trypanosomes","volume":"75","author":"AF Barbet","year":"1978","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1073\/pnas.82.10.3207","article-title":"Rapid processing of the carboxyl terminus of a trypanosome variant surface glycoprotein","volume":"82","author":"JD Bangs","year":"1985","journal-title":"Proc Natl Acad Sci USA"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006366","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T02:52:45Z","timestamp":1658976765000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006366"}},"subtitle":[],"editor":[{"given":"Kent L.","family":"Hill","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,5,1]]},"references-count":63,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,5,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006366","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1006366","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,1]]}}}