{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:03:20Z","timestamp":1787022200047,"version":"build-2736575974"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006385","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000}}],"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:00:00Z","timestamp":1495152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programa de Desenvolvimento Tecnol\u00f3gico em Insumos para Sa\u00fade da Funda\u00e7\u00e3o Oswaldo Cruz"},{"name":"National Institute of Science and Technology in Dengue"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37HLO44525"],"award-info":[{"award-number":["R37HLO44525"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro (BR)"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006385","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T15:21:13Z","timestamp":1495725673000},"page":"e1006385","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":99,"title":["Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9240-9978","authenticated-orcid":true,"given":"Monique Ramos de Oliveira","family":"Trugilho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio Damaceno","family":"Hottz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6414-6987","authenticated-orcid":true,"given":"Giselle Villa Flor","family":"Brunoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Teixeira-Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Costa","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Adolfo","family":"Salazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy A.","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4878-0256","authenticated-orcid":true,"given":"Fernando A.","family":"Bozza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8349-9529","authenticated-orcid":true,"given":"Patr\u00edcia T.","family":"Bozza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Perales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,5,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"S Bhatt","year":"2013","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1056\/NEJMcibr1005904","article-title":"Response to dengue fever\u2014the good, the bad, and the ugly?","volume":"363","author":"AC Schmidt","year":"2010","journal-title":"N Engl J Med"},{"key":"ref3","unstructured":"WHO (2009) Dengue: guidelines for diagnosis, treatment, prevention and control."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1086\/514048","article-title":"Dengue in the early febrile phase: viremia and antibody responses","volume":"176","author":"DW Vaughn","year":"1997","journal-title":"J Infect Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2334-8-86","article-title":"Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity","volume":"8","author":"FA Bozza","year":"2008","journal-title":"BMC Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"840","DOI":"10.4269\/ajtmh.2001.65.840","article-title":"Mechanisms of hemorrhage in dengue without circulatory collapse","volume":"65","author":"C Krishnamurti","year":"2001","journal-title":"Am J Trop Med Hyg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1080\/09537100701426604","article-title":"Thrombocytopenia in patients with dengue virus infection in the Brazilian Amazon","volume":"18","author":"MP Mourao","year":"2007","journal-title":"Platelets"},{"key":"ref8","first-page":"145","article-title":"Thrombocytopenia in dengue fever","volume":"4","author":"KI Schexneider","year":"2005","journal-title":"Curr Hematol Rep"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00281-011-0286-4","article-title":"Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum","volume":"34","author":"A Vieira-de-Abreu","year":"2012","journal-title":"Semin Immunopathol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nri2956","article-title":"Platelets and the immune continuum","volume":"11","author":"JW Semple","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.thromres.2010.10.015","article-title":"Pathogen sensing, subsequent signalling, and signalosome in human platelets","volume":"127","author":"O Garraud","year":"2011","journal-title":"Thromb Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1161\/01.CIR.0000154607.90506.45","article-title":"Dipyridamole selectively inhibits inflammatory gene expression in platelet-monocyte aggregates","volume":"111","author":"AS Weyrich","year":"2005","journal-title":"Circulation"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1172\/JCI118575","article-title":"Activated platelets signal chemokine synthesis by human monocytes","volume":"97","author":"AS Weyrich","year":"1996","journal-title":"J Clin Invest"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"916","DOI":"10.4049\/jimmunol.1200580","article-title":"Platelets present antigen in the context of MHC class I","volume":"189","author":"LM Chapman","year":"2012","journal-title":"J Immunol"},{"issue":"Suppl 1","key":"ref15","doi-asserted-by":"crossref","first-page":"E24","DOI":"10.1111\/j.1749-6632.2009.05050.x","article-title":"A re-evaluation of the mechanisms leading to dengue hemorrhagic fever","volume":"1171","author":"S Noisakran","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"ref16","first-page":"253","article-title":"Detection of dengue virus in platelets isolated from dengue patients","volume":"40","author":"S Noisakran","year":"2009","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1182\/blood-2014-09-598029","article-title":"Dengue virus binding and replication by platelets","volume":"126","author":"AY Simon","year":"2015","journal-title":"Blood"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/jth.12178","article-title":"Dengue Induces Platelet Activation, Mitochondrial Dysfunction and Cell Death through Mechanisms that Involve DC-SIGN and Caspases","volume":"11","author":"ED Hottz","year":"2013","journal-title":"J Thromb Haemost"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1182\/blood-2013-05-504449","article-title":"Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation","volume":"122","author":"ED Hottz","year":"2013","journal-title":"Blood"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.4049\/jimmunol.1400091","article-title":"Platelet activation and apoptosis modulate monocyte inflammatory responses in dengue","volume":"193","author":"ED Hottz","year":"2014","journal-title":"J Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jprot.2015.01.011","article-title":"Proteomic profiling of nipple aspirate fluid (NAF): Exploring the complementarity of different peptide fractionation strategies","volume":"117","author":"GV Brunoro","year":"2015","journal-title":"J Proteomics"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1002\/elps.201000401","article-title":"Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS\/MS","volume":"31","author":"Y Zhang","year":"2010","journal-title":"Electrophoresis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1182\/blood-2011-03-339705","article-title":"Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes","volume":"118","author":"JW Rowley","year":"2011","journal-title":"Blood"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1111\/jth.13493","article-title":"Histones link inflammation and thrombosis through the induction of Weibel-Palade body exocytosis","volume":"14","author":"A Michels","year":"2016","journal-title":"J Thromb Haemost"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1182\/blood-2011-03-343061","article-title":"Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4","volume":"118","author":"F Semeraro","year":"2011","journal-title":"Blood"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1182\/blood-2011-01-332676","article-title":"Histones induce rapid and profound thrombocytopenia in mice","volume":"118","author":"TA Fuchs","year":"2011","journal-title":"Blood"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e75961","DOI":"10.1371\/journal.pone.0075961","article-title":"Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism","volume":"8","author":"M Nakahara","year":"2013","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.thromres.2015.10.012","article-title":"Extracellular histones induce tissue factor expression in vascular endothelial cells via TLR and activation of NF-kappaB and AP-1","volume":"137","author":"X Yang","year":"2016","journal-title":"Thromb Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1186\/s13054-014-0543-8","article-title":"Impact of plasma histones in human sepsis and their contribution to cellular injury and inflammation","volume":"18","author":"ML Ekaney","year":"2014","journal-title":"Crit Care"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"638","DOI":"10.4269\/ajtmh.2009.08-0008","article-title":"Hemostatic changes in Vietnamese children with mild dengue correlate with the severity of vascular leakage rather than bleeding","volume":"81","author":"B Wills","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1160\/TH14-01-0056","article-title":"Platelet function alterations in dengue are associated with plasma leakage","volume":"112","author":"M Michels","year":"2014","journal-title":"Thromb Haemost"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0092-8674(89)90292-4","article-title":"PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes","volume":"59","author":"E Larsen","year":"1989","journal-title":"Cell"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1159\/000322904","article-title":"Frequency alterations in key innate immune cell components in the peripheral blood of dengue patients detected by FACS analysis","volume":"3","author":"JJ Tsai","year":"2011","journal-title":"J Innate Immun"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1186\/s12879-015-1271-7","article-title":"Differential proteomic analysis of virus-enriched fractions obtained from plasma pools of patients with dengue fever or severe dengue","volume":"15","author":"R Fragnoud","year":"2015","journal-title":"BMC Infect Dis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e93968","DOI":"10.1371\/journal.pone.0093968","article-title":"PKCdelta regulates force signaling during VEGF\/CXCL4 induced dissociation of endothelial tubes","volume":"9","author":"J Jamison","year":"2014","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/jmicro\/dfn007","article-title":"Imaging the interaction between dengue 2 virus and human blood platelets using atomic force and electron microscopy","volume":"57","author":"K Ghosh","year":"2008","journal-title":"J Electron Microsc (Tokyo)"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.4049\/jimmunol.181.5.3495","article-title":"Lipopolysaccharide is a direct agonist for platelet RNA splicing","volume":"181","author":"PN Shashkin","year":"2008","journal-title":"J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1002\/art.20267","article-title":"Chromatin breakdown during necrosis by serum Dnase1 and the plasminogen system","volume":"50","author":"M Napirei","year":"2004","journal-title":"Arthritis Rheum"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/art.38265","article-title":"Cooperation of factor VII-activating protease and serum DNase I in the release of nucleosomes from necrotic cells","volume":"66","author":"F Stephan","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1681\/ASN.2014070673","article-title":"Neutrophil Extracellular Trap-Related Extracellular Histones Cause Vascular Necrosis in Severe GN","volume":"26","author":"SV Kumar","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1172\/JCI83873","article-title":"Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation","volume":"126","author":"CC Yost","year":"2016","journal-title":"J Clin Invest"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e25969","DOI":"10.1371\/journal.pone.0025969","article-title":"Elevated levels of cell-free circulating DNA in patients with acute dengue virus infection","volume":"6","author":"TT Ha","year":"2011","journal-title":"PLoS One"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/nm.2053","article-title":"Extracellular histones are major mediators of death in sepsis","volume":"15","author":"J Xu","year":"2009","journal-title":"Nat Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/0953710031000092802","article-title":"Human platelet 20S proteasome: inhibition of its chymotrypsin-like activity and identification of the proteasome activator PA28. A preliminary report","volume":"14","author":"H Ostrowska","year":"2003","journal-title":"Platelets"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nri3084","article-title":"Towards a systems understanding of MHC class I and MHC class II antigen presentation","volume":"11","author":"J Neefjes","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1158\/0008-5472.CAN-11-1872","article-title":"Platelet-derived MHC class I confers a pseudonormal phenotype to cancer cells that subverts the antitumor reactivity of natural killer immune cells","volume":"72","author":"T Placke","year":"2012","journal-title":"Cancer Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.coi.2003.11.004","article-title":"Proteasome and peptidase function in MHC-class-I-mediated antigen presentation","volume":"16","author":"PM Kloetzel","year":"2004","journal-title":"Curr Opin Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nri2575","article-title":"MHC class I antigen presentation: learning from viral evasion strategies","volume":"9","author":"TH Hansen","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1074\/mcp.M113.031757","article-title":"Global proteome analysis identifies active immunoproteasome subunits in human platelets","volume":"13","author":"C Klockenbusch","year":"2015","journal-title":"Mol Cell Proteomics"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/nm921","article-title":"T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura","volume":"9","author":"B Olsson","year":"2003","journal-title":"Nat Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1182\/blood-2009-09-244772","article-title":"A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy","volume":"115","author":"L Chow","year":"2010","journal-title":"Blood"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1182\/blood-2013-08-523308","article-title":"Allogeneic platelet transfusions prevent murine T-cell-mediated immune thrombocytopenia","volume":"123","author":"L Guo","year":"2014","journal-title":"Blood"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1182\/blood-2015-10-673426","article-title":"CD8+ T cells mediate antibody-independent platelet clearance in mice","volume":"127","author":"CM Arthur","year":"2016","journal-title":"Blood"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/sj.icb.7100008","article-title":"Of cascades and perfect storms: the immunopathogenesis of dengue haemorrhagic fever-dengue shock syndrome (DHF\/DSS)","volume":"85","author":"T Pang","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cell.2005.06.015","article-title":"Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets","volume":"122","author":"MM Denis","year":"2005","journal-title":"Cell"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"e52902","DOI":"10.1371\/journal.pone.0052902","article-title":"Multiploid CD61+ cells are the pre-dominant cell lineage infected during acute dengue virus infection in bone marrow","volume":"7","author":"KB Clark","year":"2012","journal-title":"PLoS One"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.exphem.2011.11.011","article-title":"Infection of bone marrow cells by dengue virus in vivo","volume":"40","author":"S Noisakran","year":"2012","journal-title":"Exp Hematol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"435783","DOI":"10.1155\/2015\/435783","article-title":"Inflammasome in platelets: allying coagulation and inflammation in infectious and sterile diseases?","volume":"2015","author":"ED Hottz","year":"2015","journal-title":"Mediators Inflamm"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1128\/JCM.30.3.545-551.1992","article-title":"Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction","volume":"30","author":"RS Lanciotti","year":"1992","journal-title":"J Clin Microbiol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1089\/vbz.2005.5.137","article-title":"West Nile virus infection and serologic response among persons previously vaccinated against yellow fever and Japanese encephalitis viruses","volume":"5","author":"BW Johnson","year":"2005","journal-title":"Vector Borne Zoonotic Dis"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1128\/CVI.00105-06","article-title":"Altered enzyme-linked immunosorbent assay immunoglobulin M (IgM)\/IgG optical density ratios can correctly classify all primary or secondary dengue virus infections 1 day after the onset of symptoms, when all of the viruses can be isolated","volume":"13","author":"AK Falconar","year":"2006","journal-title":"Clin Vaccine Immunol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0166-0934(91)90011-N","article-title":"An ELISA procedure for the diagnosis of dengue infections","volume":"33","author":"G Kuno","year":"1991","journal-title":"J Virol Methods"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1128\/CDLI.10.4.622-630.2003","article-title":"Comparison of capture immunoglobulin M (IgM) and IgG enzyme-linked immunosorbent assay (ELISA) and nonstructural protein NS1 serotype-specific IgG ELISA for differentiation of primary and secondary dengue virus infections","volume":"10","author":"PY Shu","year":"2003","journal-title":"Clin Diagn Lab Immunol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nprot.2015.133","article-title":"Integrated analysis of shotgun proteomic data with PatternLab for proteomics 4.0","volume":"11","author":"PC Carvalho","year":"2016","journal-title":"Nat Protoc"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/pmic.201200439","article-title":"Comet: an open-source MS\/MS sequence database search tool","volume":"13","author":"JK Eng","year":"2013","journal-title":"Proteomics"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"D76","DOI":"10.1093\/nar\/gkr1179","article-title":"neXtProt: a knowledge platform for human proteins","volume":"40","author":"L Lane","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/pmic.201100529","article-title":"Search engine processor: Filtering and organizing peptide spectrum matches","volume":"12","author":"PC Carvalho","year":"2012","journal-title":"Proteomics"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1021\/ac9023999","article-title":"Refinements to label free proteome quantitation: how to deal with peptides shared by multiple proteins","volume":"82","author":"Y Zhang","year":"2010","journal-title":"Anal Chem"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1093\/bioinformatics\/bts247","article-title":"Improving the TFold test for differential shotgun proteomics","volume":"28","author":"PC Carvalho","year":"2012","journal-title":"Bioinformatics"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"D808","DOI":"10.1093\/nar\/gks1094","article-title":"STRING v9.1: protein-protein interaction networks, with increased coverage and integration","volume":"41","author":"A Franceschini","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/1471-2105-15-129","article-title":"A web-based protein interaction network visualizer","volume":"15","author":"GA Salazar","year":"2014","journal-title":"BMC Bioinformatics"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jinf.2009.10.003","article-title":"Gene expression analysis during dengue virus infection in HepG2 cells reveals virus control of innate immune response","volume":"60","author":"TM Conceicao","year":"2010","journal-title":"J Infect"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006385","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T11:28:01Z","timestamp":1602156481000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006385"}},"subtitle":[],"editor":[{"given":"Richard J.","family":"Kuhn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,5,19]]},"references-count":72,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,5,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006385","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,19]]}}}