{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:21:38Z","timestamp":1779250898493,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006401","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000}}],"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T00:00:00Z","timestamp":1495411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["RO1EY024649, RO1EY13615, and RO1EY026944"],"award-info":[{"award-number":["RO1EY024649, RO1EY13615, and RO1EY026944"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006401","type":"journal-article","created":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T18:35:24Z","timestamp":1495478124000},"page":"e1006401","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice"],"prefix":"10.1371","volume":"13","author":[{"given":"Dhong Hyun","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandana","family":"Zandian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5806-6940","authenticated-orcid":true,"given":"Jane","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin R.","family":"Mott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9042-2909","authenticated-orcid":true,"given":"Moshe","family":"Arditi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3291-1995","authenticated-orcid":true,"given":"Homayon","family":"Ghiasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1056\/NEJM200009283431307","article-title":"Multiple sclerosis","volume":"343","author":"JH Noseworthy","year":"2000","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1212\/WNL.50.3.708","article-title":"Optic neuritis: prognosis for multiple sclerosis from MRI, CSF, and HLA findings","volume":"50","author":"M Soderstrom","year":"1998","journal-title":"Neurology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1007\/s004150050453","article-title":"Long-term follow-up of isolated optic neuritis: the risk of developing multiple sclerosis, its outcome, and the prognostic role of paraclinical tests","volume":"246","author":"A Ghezzi","year":"1999","journal-title":"J Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1172\/JCI21357","article-title":"Multiple sclerosis","volume":"113","author":"DA Hafler","year":"2004","journal-title":"J Clin Invest"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/00019052-200206000-00001","article-title":"Pathogenesis of multiple sclerosis: an update on immunology","volume":"15","author":"B Hemmer","year":"2002","journal-title":"Curr Opin Neurol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1046\/j.1525-1594.2003.07304.x","article-title":"Retinal and optic nerve diseases","volume":"27","author":"E Margalit","year":"2003","journal-title":"Artif Organs"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1056\/NEJMcp053247","article-title":"Clinical practice. Optic neuritis","volume":"354","author":"LJ Balcer","year":"2006","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/eye.2011.81","article-title":"Optic neuritis","volume":"25","author":"D Pau","year":"2011","journal-title":"Eye (Lond)"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0022-510X(93)90032-T","article-title":"Interleukin-2 secreting cells in multiple sclerosis and controls","volume":"120","author":"CZ Lu","year":"1993","journal-title":"J Neurol Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/ana.410240618","article-title":"Interleukin-2 levels in serum and cerebrospinal fluid of multiple sclerosis patients","volume":"24","author":"P Gallo","year":"1988","journal-title":"Ann Neurol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/ana.410250211","article-title":"Correlation of immunological studies and disease progression in chronic progressive multiple sclerosis","volume":"25","author":"JL Trotter","year":"1989","journal-title":"Ann Neurol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0022-510X(89)90171-8","article-title":"Immune activation in multiple sclerosis: study of IL-2, sIL-2R, and gamma-IFN levels in serum and cerebrospinal fluid","volume":"92","author":"P Gallo","year":"1989","journal-title":"J Neurol Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1056\/NEJM198810133191518","article-title":"Elevated levels of soluble interleukin-2 receptors in multiple sclerosis","volume":"319","author":"SJ Greenberg","year":"1988","journal-title":"N Engl J Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1212\/WNL.40.2.215","article-title":"T cell activation in Guillain-Barre syndrome and in MS: elevated serum levels of soluble IL-2 receptors","volume":"40","author":"HP Hartung","year":"1990","journal-title":"Neurology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1600-0404.1991.tb04955.x","article-title":"Serum soluble interleukin-2 receptor levels in chronic progressive, stable and steroid-treated multiple sclerosis","volume":"84","author":"S Bansil","year":"1991","journal-title":"Acta Neurol Scand"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0165-5728(87)90082-8","article-title":"Multiple sclerosis: relevance of class I and class II MHC-expressing cells to lesion development","volume":"16","author":"U Traugott","year":"1987","journal-title":"J Neuroimmunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0140-6736(89)90103-7","article-title":"Interleukin-2 receptor levels indicating relapse in multiple sclerosis","volume":"1","author":"K Adachi","year":"1989","journal-title":"Lancet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/ana.410280209","article-title":"Soluble interleukin-2 receptors in cerebrospinal fluid from individuals with various neurological disorders","volume":"28","author":"SD Kittur","year":"1990","journal-title":"Ann Neurol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2004.12.004","article-title":"CD8+-dependent CNS demyelination following ocular infection of mice with a recombinant HSV-1 expressing murine IL-2","volume":"193","author":"Y Osorio","year":"2005","journal-title":"Exp Neurol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1167\/iovs.08-3211","article-title":"Optic neuritis in different strains of mice by a recombinant HSV-1 expressing murine interleukin-2","volume":"50","author":"M Zandian","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref21","first-page":"12102","article-title":"Role of IL-2 and HSV-1 in CNS demyelination in mice","volume":"87","author":"KR Mott","year":"2013","journal-title":"J Virol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1167\/iovs.10-6536","article-title":"Macrophage IL-12p70 signaling prevents HSV-1-induced CNS autoimmunity triggered by autoaggressive CD4+ Tregs","volume":"52","author":"KR Mott","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e16820","DOI":"10.1371\/journal.pone.0016820","article-title":"IL-2 suppression of IL-12p70 by a a recombinant HSV-1 expressing IL-2 induces T cells auto-reactivity and CNS demyelination","volume":"6","author":"M Zandian","year":"2011","journal-title":"PLoS ONE"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/gt.2011.32","article-title":"Use of cytokine immunotherapy to block CNS demyelination induced by a recombinant HSV-1 expressing murine interleukin-2","volume":"18","author":"M Zandian","year":"2011","journal-title":"Gene Ther"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nri3671","article-title":"Monocytes and macrophages: developmental pathways and tissue homeostasis","volume":"14","author":"F Ginhoux","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1128\/JVI.70.2.898-904.1996","article-title":"Neutrophil-mediated suppression of virus replication after herpes simplex virus type 1 infection of the murine cornea","volume":"70","author":"TM Tumpey","year":"1996","journal-title":"J Virol"},{"key":"ref27","first-page":"2990","article-title":"The role of macrophages in the pathogenesis of HSV-1 induced chorioretinitis in BALB\/c mice","volume":"35","author":"A Berra","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/S0264-410X(00)00298-X","article-title":"Corneal macrophage infiltrates following ocular herpes simplex virus type 1 challenge vary in BALB\/c mice vaccinated with different vaccines","volume":"19","author":"H Ghiasi","year":"2000","journal-title":"Vaccine"},{"key":"ref29","first-page":"1854","article-title":"Role of MIP-2 in neutrophil migration and tissue injury in the herpes simplex virus-1-infected cornea","volume":"39","author":"XT Yan","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1128\/JVI.72.5.3705-3710.1998","article-title":"Absence of macrophage inflammatory protein-1alpha prevents the development of blinding herpes stromal keratitis","volume":"72","author":"TM Tumpey","year":"1998","journal-title":"J Virol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0165-5728(95)00123-8","article-title":"Macrophages and microglia in HSV-1 infected mouse brain","volume":"62","author":"MM Esiri","year":"1995","journal-title":"J Neuroimmunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0166-3542(85)90025-7","article-title":"Enhancement of non-specific resistance to viral infection by muramyldipeptide and its analogs","volume":"5","author":"S Ikeda","year":"1985","journal-title":"Antiviral Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.2217\/fvl.15.85","article-title":"Cell entry mechanisms of HSV: what we have learned in recent years","volume":"10","author":"AM Agelidis","year":"2015","journal-title":"Future Virol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"DM Mosser","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1146\/annurev-immunol-032414-112220","article-title":"Macrophages: development and tissue specialization","volume":"33","author":"C Varol","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1084\/jem.176.5.1387","article-title":"Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells","volume":"176","author":"A D'Andrea","year":"1992","journal-title":"J Exp Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/0923-2494(96)83022-7","article-title":"Interleukin-12 and its role in cutaneous sensitization","volume":"146","author":"T Schwarz","year":"1995","journal-title":"Res Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1084\/jem.173.4.869","article-title":"Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers","volume":"173","author":"SH Chan","year":"1991","journal-title":"J Exp Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/jlb.55.2.280","article-title":"Interleukin-12","volume":"55","author":"MJ Brunda","year":"1994","journal-title":"J Leukoc Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.4049\/jimmunol.152.6.2729","article-title":"IL-12 influences intrathymic T cell development","volume":"152","author":"DI Godfrey","year":"1994","journal-title":"J Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1126\/science.8097338","article-title":"Development of TH1 CD4+ T cells through IL-12 produced by Listeria- induced macrophages","volume":"260","author":"CS Hsieh","year":"1993","journal-title":"Science"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.4049\/jimmunol.154.10.5071","article-title":"Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells","volume":"154","author":"SE Macatonia","year":"1995","journal-title":"J Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1126\/science.271.5251.984","article-title":"Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development","volume":"271","author":"ML Guler","year":"1996","journal-title":"Science"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ni1263","article-title":"A function for interleukin 2 in Foxp3-expressing regulatory T cells","volume":"6","author":"JD Fontenot","year":"2005","journal-title":"Nat Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1017\/S0317167100041664","article-title":"The increased susceptibility of women to multiple sclerosis","volume":"19","author":"P Duquette","year":"1992","journal-title":"Can J Neurol Sci"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.4049\/jimmunol.162.9.5561","article-title":"Decreased IL-12 production underlies the decreased ability of male lymph node cells to induce experimental autoimmune encephalomyelitis","volume":"162","author":"S Kim","year":"1999","journal-title":"J Immunol"},{"key":"ref47","first-page":"409","article-title":"Macrophages, lymphocytes, and plasma cells in the perivascular compartment in chronic multiple sclerosis","volume":"38","author":"JW Prineas","year":"1978","journal-title":"Lab Invest"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/imm.12214","article-title":"Interleukin-12 (IL-12), but not IL-23, induces the expression of IL-7 in microglia and macrophages: implications for multiple sclerosis","volume":"141","author":"M Jana","year":"2014","journal-title":"Immunology"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0165-5728(99)00002-8","article-title":"IL-7 enhances Ag-specific human T cell response by increasing expression of IL-2R alpha and gamma chains","volume":"96","author":"YK Chou","year":"1999","journal-title":"J Neuroimmunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1006\/cyto.1999.0564","article-title":"Interleukin 7 is a potent co-stimulator of myelin specific T cells that enhances the adoptive transfer of experimental autoimmune encephalomyelitis","volume":"12","author":"BF Bebo Jr.","year":"2000","journal-title":"Cytokine"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1743-422X-6-56","article-title":"A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages","volume":"6","author":"KR Mott","year":"2009","journal-title":"Virol J"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1084\/jem.20030171","article-title":"CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses","volume":"198","author":"S Suvas","year":"2003","journal-title":"J Exp Med"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1084\/jem.20042307","article-title":"The macrophage F4\/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance","volume":"201","author":"HH Lin","year":"2005","journal-title":"J Exp Med"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.0906-6705.2004.00195.x","article-title":"Correlation of psoriasis activity with abundance of CD25+CD8+ T cells: conditions for cloning T cells from psoriatic plaques","volume":"13","author":"WM Kohlmann","year":"2004","journal-title":"Exp Dermatol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1084\/jem.20040298","article-title":"Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity","volume":"200","author":"S Mendez","year":"2004","journal-title":"J Exp Med"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1084\/jem.20052056","article-title":"Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens","volume":"203","author":"IJ Suffia","year":"2006","journal-title":"J Exp Med"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.4049\/jimmunol.178.5.2661","article-title":"Cutting Edge: Regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis","volume":"178","author":"M Kursar","year":"2007","journal-title":"J Immunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1084\/jem.20062105","article-title":"Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis","volume":"204","author":"JP Scott-Browne","year":"2007","journal-title":"J Exp Med"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1084\/jem.20082824","article-title":"In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression","volume":"206","author":"KE Webster","year":"2009","journal-title":"J Exp Med"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.it.2016.08.012","article-title":"Induced Regulatory T Cells: Their Development, Stability, and Applications","volume":"37","author":"M Kanamori","year":"2016","journal-title":"Trends Immunol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/353858a0","article-title":"Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis","volume":"353","author":"MJ Lenardo","year":"1991","journal-title":"Nature"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.immuni.2012.02.012","article-title":"Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation","volume":"36","author":"A Ballesteros-Tato","year":"2012","journal-title":"Immunity"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1006\/viro.1994.1679","article-title":"Down-regulation of glial fibrillary acidic protein expression during acute lytic varicella-zoster virus infection of cultured human astrocytes","volume":"205","author":"PG Kennedy","year":"1994","journal-title":"Virology"},{"key":"ref64","first-page":"307","article-title":"Early loss of astrocytes in herpes simplex virus-induced central nervous system demyelination","volume":"99","author":"Y Itoyama","year":"1991","journal-title":"Apmis"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"11511","DOI":"10.1523\/JNEUROSCI.1514-09.2009","article-title":"Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS","volume":"29","author":"RR Voskuhl","year":"2009","journal-title":"J Neurosci"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.neuroscience.2011.10.034","article-title":"Intravitreous interleukin-2 treatment and inflammation modulates glial cells activation and uncrossed retinotectal development","volume":"200","author":"S Espirito-Santo","year":"2012","journal-title":"Neuroscience"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/gt.2014.33","article-title":"A comparative study of experimental mouse models of central nervous system demyelination","volume":"21","author":"OM Dumitrascu","year":"2014","journal-title":"Gene Ther"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/83713","article-title":"The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3","volume":"27","author":"CL Bennett","year":"2001","journal-title":"Nat Genet"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"R75","DOI":"10.1172\/JCI11679","article-title":"JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome","volume":"106","author":"TA Chatila","year":"2000","journal-title":"J Clin Invest"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/83707","article-title":"X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy","volume":"27","author":"RS Wildin","year":"2001","journal-title":"Nat Genet"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"9069","DOI":"10.1128\/JVI.76.18.9069-9078.2002","article-title":"Overexpression of interleukin-2 by a recombinant herpes simplex virus type 1 attenuates pathogenicity and enhances antiviral immunity","volume":"76","author":"H Ghiasi","year":"2002","journal-title":"J Virol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"5774","DOI":"10.1128\/JVI.77.10.5774-5783.2003","article-title":"Comparison of adjuvant efficacy of herpes simplex virus type 1 recombinant viruses expressing TH1 and TH2 cytokine genes","volume":"77","author":"Y Osorio","year":"2003","journal-title":"J Virol"},{"key":"ref73","first-page":"1802","article-title":"The corneas of naive mice contain both CD4+ and CD8+ T cells","volume":"13","author":"KR Mott","year":"2007","journal-title":"Mol Vis"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1128\/JVI.69.1.334-340.1995","article-title":"Local expression of tumor necrosis factor alpha and interleukin-2 correlates with protection against corneal scarring after ocular challenge of vaccinated mice with herpes simplex virus type 1","volume":"69","author":"H Ghiasi","year":"1995","journal-title":"J Virol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ni1428","article-title":"Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice","volume":"8","author":"JM Kim","year":"2007","journal-title":"Nat Immunol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"12962","DOI":"10.1128\/JVI.01442-07","article-title":"A Recombinant Herpes Simplex Virus Type 1 Expressing Two Additional Copies of gK Is More Pathogenic than Wild-Type Virus in Two Different Strains of Mice","volume":"81","author":"KR Mott","year":"2007","journal-title":"J Virol"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006401","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T17:44:31Z","timestamp":1692812671000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006401"}},"subtitle":[],"editor":[{"given":"Pinghui","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,5,22]]},"references-count":76,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,5,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006401","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1006401","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,22]]}}}