{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T03:59:26Z","timestamp":1784001566614,"version":"3.55.0"},"reference-count":82,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:00:00Z","timestamp":1498089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Saarland Staatskanzlei","award":["WT\/2 - LFFP 14\/15"],"award-info":[{"award-number":["WT\/2 - LFFP 14\/15"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006406","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T17:47:26Z","timestamp":1498153646000},"page":"e1006406","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Identification of C\/EBP\u03b1 as a novel target of the HPV8 E6 protein regulating miR-203 in human keratinocytes"],"prefix":"10.1371","volume":"13","author":[{"given":"Anna M.","family":"Marthaler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Podgorska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Feld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0500-8103","authenticated-orcid":true,"given":"Alina","family":"Fingerle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Knerr-Rupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6234-5571","authenticated-orcid":true,"given":"Friedrich","family":"Gr\u00e4sser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8755-1598","authenticated-orcid":true,"given":"Hans","family":"Smola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Roemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Ebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6444-2938","authenticated-orcid":true,"given":"Yoo-Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer M.","family":"Bohle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia S. L.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Reichrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4495-9745","authenticated-orcid":true,"given":"Magdalena","family":"Malejczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6721-3743","authenticated-orcid":true,"given":"S\u0142awomir","family":"Majewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3289-6545","authenticated-orcid":true,"given":"Sigrun","family":"Smola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.virol.2010.02.002","article-title":"Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments","volume":"401","author":"HU Bernard","year":"2010","journal-title":"Virology"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/jnci\/92.9.690","article-title":"Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis","volume":"92","author":"H zur Hausen","year":"2000","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1073\/pnas.75.3.1537","article-title":"Characterization of two types of human papillomaviruses in lesions of epidermodysplasia verruciformis","volume":"75","author":"G Orth","year":"1978","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","first-page":"157","article-title":"Epidermodysplasia verruciformis: immunological and clinical aspects","volume":"186","author":"S Jablonska","year":"1994","journal-title":"Curr Top Microbiol Immunol"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"e1002833","DOI":"10.1371\/journal.ppat.1002833","article-title":"Human papillomavirus type 8 interferes with a novel C\/EBPbeta-mediated mechanism of keratinocyte CCL20 chemokine expression and Langerhans cell migration","volume":"8","author":"T Sperling","year":"2012","journal-title":"PLoS Pathog"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1006\/viro.1995.0028","article-title":"Differentiation-dependent transcription of the epidermodysplasia verruciformis-associated human papillomavirus type 5 in benign lesions","volume":"214","author":"K Haller","year":"1995","journal-title":"Virology"},{"issue":"31","key":"ref7","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/oxfordjournals.jncimonographs.a003483","article-title":"Chapter 8: Human papillomavirus and skin cancer","author":"H Pfister","year":"2003","journal-title":"J Natl Cancer Inst Monogr"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1158\/0008-5472.CAN-04-3263","article-title":"Development of skin tumors in mice transgenic for early genes of human papillomavirus type 8","volume":"65","author":"ID Schaper","year":"2005","journal-title":"Cancer Res"},{"issue":"Pt 12","key":"ref9","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1099\/vir.0.012872-0","article-title":"Spontaneous tumour development in human papillomavirus type 8 E6 transgenic mice and rapid induction by UV-light exposure and wounding","volume":"90","author":"GP Marcuzzi","year":"2009","journal-title":"J Gen Virol"},{"issue":"21","key":"ref10","doi-asserted-by":"crossref","first-page":"10408","DOI":"10.1128\/JVI.00902-08","article-title":"E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation","volume":"82","author":"MP Underbrink","year":"2008","journal-title":"J Virol"},{"issue":"23","key":"ref11","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1101\/gad.182100","article-title":"Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins","volume":"14","author":"S Jackson","year":"2000","journal-title":"Genes Dev"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"e1002807","DOI":"10.1371\/journal.ppat.1002807","article-title":"HPV 5 and 8 E6 abrogate ATR activity resulting in increased persistence of UVB induced DNA damage","volume":"8","author":"NA Wallace","year":"2012","journal-title":"PLoS Pathog"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"6112","DOI":"10.1128\/JVI.03808-13","article-title":"Beta human papillomavirus E6 expression inhibits stabilization of p53 and increases tolerance of genomic instability","volume":"88","author":"NA Wallace","year":"2014","journal-title":"J Virol"},{"issue":"43","key":"ref14","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1038\/onc.2011.589","article-title":"Cutaneous papillomavirus E6 oncoproteins associate with MAML1 to repress transactivation and NOTCH signaling","volume":"31","author":"N Brimer","year":"2012","journal-title":"Oncogene"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.1128\/JVI.02527-12","article-title":"The human papillomavirus type 8 E6 protein interferes with NOTCH activation during keratinocyte differentiation","volume":"87","author":"JM Meyers","year":"2013","journal-title":"J Virol"},{"issue":"23","key":"ref16","doi-asserted-by":"crossref","first-page":"E1473","DOI":"10.1073\/pnas.1205991109","article-title":"Cutaneous beta-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling","volume":"109","author":"MJ Tan","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"e1006171","DOI":"10.1371\/journal.ppat.1006171","article-title":"Cutaneous HPV8 and MmuPV1 E6 Proteins Target the NOTCH and TGF-beta Tumor Suppressors to Inhibit Differentiation and Sustain Keratinocyte Proliferation","volume":"13","author":"JM Meyers","year":"2017","journal-title":"PLoS Pathog"},{"issue":"8","key":"ref18","doi-asserted-by":"crossref","first-page":"e1002211","DOI":"10.1371\/journal.ppat.1002211","article-title":"Beta-HPV 5 and 8 E6 promote p300 degradation by blocking AKT\/p300 association","volume":"7","author":"HL Howie","year":"2011","journal-title":"PLoS Pathog"},{"issue":"17","key":"ref19","doi-asserted-by":"crossref","first-page":"6913","DOI":"10.1158\/0008-5472.CAN-10-1307","article-title":"Cutaneous papillomavirus E6 proteins must interact with p300 and block p53-mediated apoptosis for cellular immortalization and tumorigenesis","volume":"70","author":"P Muench","year":"2010","journal-title":"Cancer Res"},{"issue":"7184","key":"ref20","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nature06642","article-title":"A skin microRNA promotes differentiation by repressing 'stemness'","volume":"452","author":"R Yi","year":"2008","journal-title":"Nature"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/cdd.2008.69","article-title":"miR-203 represses 'stemness' by repressing DeltaNp63","volume":"15","author":"AM Lena","year":"2008","journal-title":"Cell Death Differ"},{"issue":"9","key":"ref22","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1242\/dev.089649","article-title":"Rapid and widespread suppression of self-renewal by microRNA-203 during epidermal differentiation","volume":"140","author":"SJ Jackson","year":"2013","journal-title":"Development"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/jid.2009.294","article-title":"Protein kinase C-dependent upregulation of miR-203 induces the differentiation of human keratinocytes","volume":"130","author":"E Sonkoly","year":"2010","journal-title":"J Invest Dermatol"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S1097-2765(00)80275-0","article-title":"P63, a P53 Homolog at 3q27-29, Encodes Multiple Products with Transactivating, Death-Inducing, and Dominant-Negative Activities","volume":"2","author":"A Yang","year":"1998","journal-title":"Mol Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e514","DOI":"10.1038\/cddis.2013.37","article-title":"MiR203 mediates subversion of stem cell properties during mammary epithelial differentiation via repression of DeltaNP63alpha and promotes mesenchymal-to-epithelial transition","volume":"4","author":"AJ DeCastro","year":"2013","journal-title":"Cell Death Dis"},{"issue":"387","key":"ref26","doi-asserted-by":"crossref","first-page":"re9","DOI":"10.1126\/scisignal.aaa1033","article-title":"Maintaining epithelial stemness with p63","volume":"8","author":"G Melino","year":"2015","journal-title":"Sci Signal"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1158\/0008-5472.CAN-09-4063","article-title":"DeltaNp63alpha repression of the Notch1 gene supports the proliferative capacity of normal human keratinocytes and cervical cancer cells","volume":"70","author":"T Yugawa","year":"2010","journal-title":"Cancer Res"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/exd.12320","article-title":"Crosstalk among p53 family members in cutaneous carcinoma","volume":"23","author":"C Missero","year":"2014","journal-title":"Exp Dermatol"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.humpath.2004.12.003","article-title":"p63 overexpression associates with poor prognosis in head and neck squamous cell carcinoma","volume":"36","author":"L Lo Muzio","year":"2005","journal-title":"Hum Pathol"},{"issue":"10","key":"ref30","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1128\/JVI.00078-10","article-title":"Human papillomaviruses modulate expression of microRNA 203 upon epithelial differentiation to control levels of p63 proteins","volume":"84","author":"M Melar-New","year":"2010","journal-title":"J Virol"},{"issue":"20","key":"ref31","doi-asserted-by":"crossref","first-page":"10644","DOI":"10.1128\/JVI.00703-10","article-title":"MicroRNA 203 Expression in Keratinocytes Is Dependent on Regulation of p53 Levels by E6","volume":"84","author":"DJ McKenna","year":"2010","journal-title":"J Virol"},{"issue":"7","key":"ref32","doi-asserted-by":"crossref","first-page":"e21646","DOI":"10.1371\/journal.pone.0021646","article-title":"Human papillomavirus 16 E5 modulates the expression of host microRNAs","volume":"6","author":"D Greco","year":"2011","journal-title":"PLoS One"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.virol.2015.02.004","article-title":"Beta genus papillomaviruses and skin cancer","volume":"479\u2013480","author":"PM Howley","year":"2015","journal-title":"Virology"},{"issue":"10","key":"ref34","doi-asserted-by":"crossref","first-page":"6190","DOI":"10.1074\/jbc.274.10.6190","article-title":"CCAAT\/enhancer-binding proteins. A role in regulation of human involucrin promoter response to phorbol ester","volume":"274","author":"C Agarwal","year":"1999","journal-title":"J Biol Chem"},{"issue":"10","key":"ref35","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/ncb1960","article-title":"C\/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation","volume":"11","author":"RG Lopez","year":"2009","journal-title":"Nat Cell Biol"},{"issue":"7","key":"ref36","doi-asserted-by":"crossref","first-page":"e610","DOI":"10.1371\/journal.pone.0000610","article-title":"MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?","volume":"2","author":"E Sonkoly","year":"2007","journal-title":"PLoS One"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1083\/jcb.106.3.761","article-title":"Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line","volume":"106","author":"P Boukamp","year":"1988","journal-title":"J Cell Biol"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/jcp.1041430213","article-title":"Calcium regulation of growth and differentiation of normal human keratinocytes: modulation of differentiation competence by stages of growth and extracellular calcium","volume":"143","author":"S Pillai","year":"1990","journal-title":"J Cell Physiol"},{"issue":"22","key":"ref39","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1101\/gad.1463206","article-title":"p63 regulates proliferation and differentiation of developmentally mature keratinocytes","volume":"20","author":"AB Truong","year":"2006","journal-title":"Genes Dev"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0014-4827(82)90017-9","article-title":"The tumor promoter, 12-O-tetradecanoylphorbol-13-acetate accelerates keratinocyte differentiation and stimulates growth of an unidentified cell type in cultured human epidermis","volume":"137","author":"P Hawley-Nelson","year":"1982","journal-title":"Exp Cell Res"},{"issue":"6","key":"ref41","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1046\/j.1523-1747.1998.00199.x","article-title":"Expression of CCAAT\/enhancer binding proteins (C\/EBP) is associated with squamous differentiation in epidermis and isolated primary keratinocytes and is altered in skin neoplasms","volume":"110","author":"HS Oh","year":"1998","journal-title":"J Invest Dermatol"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1046\/j.1523-1747.1998.00123.x","article-title":"Transcription factors C\/EBP alpha, C\/EBP beta, and CHOP (Gadd153) expressed during the differentiation program of keratinocytes in vitro and in vivo","volume":"110","author":"EV Maytin","year":"1998","journal-title":"J Invest Dermatol"},{"issue":"1","key":"ref43","first-page":"88","article-title":"C\/EBPalpha: a tumour suppressor in multiple tissues?","volume":"1766","author":"MB Schuster","year":"2006","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1038\/jid.2011.31","article-title":"C\/EBPalpha expression is downregulated in human nonmelanoma skin cancers and inactivation of C\/EBPalpha confers susceptibility to UVB-induced skin squamous cell carcinomas","volume":"131","author":"EA Thompson","year":"2011","journal-title":"J Invest Dermatol"},{"issue":"6","key":"ref45","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/j.1460-2075.1990.tb08316.x","article-title":"A nuclear factor for IL-6 expression (NF-IL6) is a member of a C\/EBP family","volume":"9","author":"S Akira","year":"1990","journal-title":"EMBO J"},{"issue":"17","key":"ref46","doi-asserted-by":"crossref","first-page":"8718","DOI":"10.1128\/JVI.00250-06","article-title":"The E6 protein of the cutaneous human papillomavirus type 8 can stimulate the viral early and late promoters by distinct mechanisms","volume":"80","author":"A Muller-Schiffmann","year":"2006","journal-title":"J Virol"},{"issue":"6","key":"ref47","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/jnci\/djj093","article-title":"Epigenetic modulation of tumor suppressor CCAAT\/enhancer binding protein alpha activity in lung cancer","volume":"98","author":"Y Tada","year":"2006","journal-title":"J Natl Cancer Inst"},{"issue":"12","key":"ref48","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1016\/j.jid.2016.06.630","article-title":"MicroRNA-203 Inversely Correlates with Differentiation Grade, Targets c-MYC, and Functions as a Tumor Suppressor in cSCC","volume":"136","author":"W Lohcharoenkal","year":"2016","journal-title":"J Invest Dermatol"},{"issue":"9","key":"ref49","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/j.1600-0625.2010.01118.x","article-title":"The expression of microRNA-203 during human skin morphogenesis","volume":"19","author":"T Wei","year":"2010","journal-title":"Exp Dermatol"},{"key":"ref50","first-page":"66","article-title":"Interleukin-8 is regulated by miR-203 at the posttranscriptional level in primary human keratinocytes","volume":"23","author":"TL Wei","year":"2013","journal-title":"Eur J Dermatol"},{"issue":"12","key":"ref51","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/ncb1998","article-title":"The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs","volume":"11","author":"U Wellner","year":"2009","journal-title":"Nat Cell Biol"},{"issue":"Pt 4","key":"ref52","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1099\/vir.0.016527-0","article-title":"Human papillomavirus 5 and 8 E6 downregulate interleukin-8 secretion in primary human keratinocytes","volume":"91","author":"B Akgul","year":"2010","journal-title":"J Gen Virol"},{"issue":"13","key":"ref53","doi-asserted-by":"crossref","first-page":"7276","DOI":"10.1073\/pnas.96.13.7276","article-title":"Separation of C\/EBPalpha-mediated proliferation arrest and differentiation pathways","volume":"96","author":"C Muller","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"19","key":"ref54","doi-asserted-by":"crossref","first-page":"16348","DOI":"10.1074\/jbc.M100128200","article-title":"p300 coactivates the adipogenic transcription factor CCAAT\/enhancer-binding protein alpha","volume":"276","author":"RL Erickson","year":"2001","journal-title":"J Biol Chem"},{"issue":"24","key":"ref55","doi-asserted-by":"crossref","first-page":"13174","DOI":"10.1128\/JVI.02172-12","article-title":"Comprehensive analysis of host cellular interactions with human papillomavirus E6 proteins identifies new E6 binding partners and reflects viral diversity","volume":"86","author":"EA White","year":"2012","journal-title":"J Virol"},{"issue":"6","key":"ref56","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1046\/j.0022-202x.2001.01602.x","article-title":"Transduction of the E6 and E7 genes of epidermodysplasia-verruciformis-associated human papillomaviruses alters human keratinocyte growth and differentiation in organotypic cultures","volume":"117","author":"IL Boxman","year":"2001","journal-title":"J Invest Dermatol"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.virusres.2011.12.015","article-title":"Human papillomavirus 8 E6 disrupts terminal skin differentiation and prevents pro-Caspase-14 cleavage","volume":"163","author":"S Kazem","year":"2012","journal-title":"Virus Res"},{"issue":"5","key":"ref58","doi-asserted-by":"crossref","first-page":"689","DOI":"10.4161\/cc.4.5.1653","article-title":"Differential enhancement of a cutaneous HPV promoter by DeltaNP63alpha, Jun and mutant p53","volume":"4","author":"JW Fei","year":"2005","journal-title":"Cell Cycle"},{"issue":"7408","key":"ref59","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nature11288","article-title":"Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins","volume":"487","author":"O Rozenblatt-Rosen","year":"2012","journal-title":"Nature"},{"issue":"8","key":"ref60","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1101\/gad.1406006","article-title":"Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation","volume":"20","author":"BC Nguyen","year":"2006","journal-title":"Genes Dev"},{"issue":"21","key":"ref61","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1101\/gad.1477606","article-title":"Canonical notch signaling functions as a commitment switch in the epidermal lineage","volume":"20","author":"C Blanpain","year":"2006","journal-title":"Genes Dev"},{"issue":"9","key":"ref62","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1093\/nar\/gkp163","article-title":"The transcriptional coactivator MAML1 regulates p300 autoacetylation and HAT activity","volume":"37","author":"ML Hansson","year":"2009","journal-title":"Nucleic Acids Res"},{"issue":"24","key":"ref63","doi-asserted-by":"crossref","first-page":"10650","DOI":"10.1128\/MCB.24.24.10650-10660.2004","article-title":"C\/EBPalpha is a DNA damage-inducible p53-regulated mediator of the G1 checkpoint in keratinocytes","volume":"24","author":"K Yoon","year":"2004","journal-title":"Mol Cell Biol"},{"issue":"14","key":"ref64","doi-asserted-by":"crossref","first-page":"6768","DOI":"10.1158\/0008-5472.CAN-07-0139","article-title":"Genetic ablation of CCAAT\/enhancer binding protein alpha in epidermis reveals its role in suppression of epithelial tumorigenesis","volume":"67","author":"KD Loomis","year":"2007","journal-title":"Cancer Res"},{"issue":"9","key":"ref65","doi-asserted-by":"crossref","first-page":"e382","DOI":"10.1016\/S1470-2045(14)70008-7","article-title":"Translational implications of somatic genomics in acute myeloid leukaemia","volume":"15","author":"SC Meyer","year":"2014","journal-title":"Lancet Oncol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1186\/1471-2407-14-417","article-title":"Down-regulation of the expression of CCAAT\/enhancer binding protein alpha gene in cervical squamous cell carcinoma","volume":"14","author":"Z Pan","year":"2014","journal-title":"BMC Cancer"},{"issue":"10","key":"ref67","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1158\/0008-5472.CAN-06-4793","article-title":"Tumor suppressor activity of CCAAT\/enhancer binding protein alpha is epigenetically down-regulated in head and neck squamous cell carcinoma","volume":"67","author":"KL Bennett","year":"2007","journal-title":"Cancer Res"},{"issue":"3","key":"ref68","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1158\/0008-5472.861.65.3","article-title":"Diminished expression of C\/EBPalpha in skin carcinomas is linked to oncogenic Ras and reexpression of C\/EBPalpha in carcinoma cells inhibits proliferation","volume":"65","author":"M Shim","year":"2005","journal-title":"Cancer Res"},{"issue":"9","key":"ref69","doi-asserted-by":"crossref","first-page":"5253","DOI":"10.1128\/JVI.77.9.5253-5265.2003","article-title":"The Papillomavirus E2 protein binds to and synergizes with C\/EBP factors involved in keratinocyte differentiation","volume":"77","author":"D Hadaschik","year":"2003","journal-title":"J Virol"},{"issue":"1","key":"ref70","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1128\/JVI.00998-10","article-title":"Differential regulation of human papillomavirus type 8 by interferon regulatory factors 3 and 7","volume":"85","author":"M Oldak","year":"2011","journal-title":"J Virol"},{"issue":"2","key":"ref71","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1083\/jcb.122.2.417","article-title":"Mutual induction of growth factor gene expression by epidermal-dermal cell interaction","volume":"122","author":"H Smola","year":"1993","journal-title":"J Cell Biol"},{"issue":"3","key":"ref72","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1128\/JVI.01220-09","article-title":"Human papillomavirus type 8 E2 protein unravels JunB\/Fra-1 as an activator of the beta4-integrin gene in human keratinocytes","volume":"84","author":"M Oldak","year":"2010","journal-title":"J Virol"},{"issue":"3","key":"ref73","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/jid.2008.247","article-title":"Candidate housekeeping genes require evaluation before their selection for studies of human epidermal keratinocytes","volume":"129","author":"F Minner","year":"2009","journal-title":"J Invest Dermatol"},{"issue":"24","key":"ref74","doi-asserted-by":"crossref","first-page":"5248","DOI":"10.1158\/0008-5472.CAN-15-0732","article-title":"Stromal Fibroblasts Induce CCL20 through IL6\/C\/EBPbeta to Support the Recruitment of Th17 Cells during Cervical Cancer Progression","volume":"75","author":"B Walch-Ruckheim","year":"2015","journal-title":"Cancer Res"},{"issue":"1","key":"ref75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nprot.2009.153","article-title":"Quantification of beta-human papillomavirus DNA by real-time PCR","volume":"5","author":"SJ Weissenborn","year":"2010","journal-title":"Nat Protoc"},{"issue":"3","key":"ref76","first-page":"138","article-title":"Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue","volume":"8","author":"W Remmele","year":"1987","journal-title":"Pathologe"},{"issue":"11","key":"ref77","doi-asserted-by":"crossref","first-page":"8635","DOI":"10.18632\/oncotarget.3249","article-title":"RIPK3 expression in cervical cancer cells is required for PolyIC-induced necroptosis, IL-1alpha release, and efficient paracrine dendritic cell activation","volume":"6","author":"SV Schmidt","year":"2015","journal-title":"Oncotarget"},{"issue":"8","key":"ref78","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1101\/gad.8.8.869","article-title":"Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor","volume":"8","author":"R Eckner","year":"1994","journal-title":"Genes Dev"},{"issue":"3","key":"ref79","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4161\/rna.4.3.5206","article-title":"Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) induces the expression of the cellular microRNA miR-146a","volume":"4","author":"N Motsch","year":"2007","journal-title":"RNA Biol"},{"issue":"13","key":"ref80","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1093\/nar\/gkg605","article-title":"Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN","volume":"31","author":"D Farre","year":"2003","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"ref81","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/bioinformatics\/18.2.333","article-title":"PROMO: detection of known transcription regulatory elements using species-tailored searches","volume":"18","author":"X Messeguer","year":"2002","journal-title":"Bioinformatics"},{"issue":"15","key":"ref82","doi-asserted-by":"crossref","first-page":"6419","DOI":"10.1093\/nar\/17.15.6419","article-title":"Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells","volume":"17","author":"E Schreiber","year":"1989","journal-title":"Nucleic Acids Res"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T23:36:33Z","timestamp":1659137793000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006406"}},"subtitle":[],"editor":[{"given":"Robert F.","family":"Kalejta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,22]]},"references-count":82,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006406","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,22]]}}}