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Zika virus transmission and risk 2016 [updated July 25, 2016August 1, 2016]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cdc.gov\/zika\/transmission\/index.html\" xlink:type=\"simple\">http:\/\/www.cdc.gov\/zika\/transmission\/index.html<\/ext-link>."},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.tim.2013.12.011","article-title":"Global spread of dengue virus types: mapping the 70 year history","volume":"22","author":"JP Messina","year":"2014","journal-title":"Trends in microbiology"},{"key":"ref5","unstructured":"Centers for Disease Control and Prevention. Geographic Distribution of Japanese Encephalitis Virus 2016 [updated August 5, 2015August 1, 2016]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cdc.gov\/japaneseencephalitis\/maps\/index.html\" xlink:type=\"simple\">http:\/\/www.cdc.gov\/japaneseencephalitis\/maps\/index.html<\/ext-link>."},{"key":"ref6","unstructured":"Centers for Disease Control and Prevention. Areas with Risk of Yellow Fever Virus Transmission in South America 2016 [updated July 12, 2016August 1, 2016]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.cdc.gov\/yellowfever\/maps\/south_america.html\" xlink:type=\"simple\">https:\/\/www.cdc.gov\/yellowfever\/maps\/south_america.html<\/ext-link>."},{"key":"ref7","unstructured":"World Health Organization. Zika virus, Microcephaly and Guillain-Barr\u00e9 syndrome 2016 [updated December 29, 2016]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/apps.who.int\/iris\/bitstream\/10665\/252672\/1\/zikasitrep29Dec16-eng.pdf\" xlink:type=\"simple\">http:\/\/apps.who.int\/iris\/bitstream\/10665\/252672\/1\/zikasitrep29Dec16-eng.pdf<\/ext-link>."},{"key":"ref8","unstructured":"Centers for Disease Control and Prevention. Florida investigation links four recent Zika cases to local mosquito-borne virus transmission 2016 [updated July 29, 2016July 29, 2016]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cdc.gov\/media\/releases\/2016\/p0729-florida-zika-cases.html\" xlink:type=\"simple\">http:\/\/www.cdc.gov\/media\/releases\/2016\/p0729-florida-zika-cases.html<\/ext-link>."},{"key":"ref9","article-title":"Zika Virus Disease in Colombia\u2014Preliminary Report","author":"O Pacheco","year":"2016","journal-title":"The New England journal of medicine"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJMp1605367","article-title":"Zika and the Risk of Microcephaly","volume":"375","author":"MA Johansson","year":"2016","journal-title":"The New England journal of 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