{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:36:19Z","timestamp":1792805779616,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006542","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000}}],"reference-count":86,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:00:00Z","timestamp":1501113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["#81620108021: Fetal Brain Maldevelopment Caused by Sox2 Downregulation during Congenital Cytomegalovirus Infection"],"award-info":[{"award-number":["#81620108021: Fetal Brain Maldevelopment Caused by Sox2 Downregulation during Congenital Cytomegalovirus Infection"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["#31600145: The mechanism of HCMV-IE1 regulating Hes1 expression and rhythm in neural progenitor cells."],"award-info":[{"award-number":["#31600145: The mechanism of HCMV-IE1 regulating Hes1 expression and rhythm in neural progenitor cells."]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571355"],"award-info":[{"award-number":["81571355"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["#81271850: The regulation mechanism of HCMV infection on Notch signaling pathway in NPCs."],"award-info":[{"award-number":["#81271850: The regulation mechanism of HCMV infection on Notch signaling pathway in NPCs."]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sino-Africa Joint Research Center, Chinese Academy of Sciences","award":["#SAJC201605: Geographical distribution and genetic variation of pathogens in Africa"],"award-info":[{"award-number":["#SAJC201605: Geographical distribution and genetic variation of pathogens in Africa"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006542","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T18:00:25Z","timestamp":1501178425000},"page":"e1006542","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase"],"prefix":"10.1371","volume":"13","author":[{"given":"Xi-Juan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Nan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong-Cong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0207-8018","authenticated-orcid":true,"given":"Xiao-Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9255-0453","authenticated-orcid":true,"given":"Shuang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Zi","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Nevels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Britt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8703-9140","authenticated-orcid":true,"given":"Simon","family":"Rayner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Bo","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9352-0643","authenticated-orcid":true,"given":"Min-Hua","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00006454-199202000-00007","article-title":"Symptomatic Congenital Cytomegalovirus-Infection\u2014Neonatal Morbidity and Mortality","volume":"11","author":"SB Boppana","year":"1992","journal-title":"Pediatr Infect Dis J"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1542\/peds.77.6.801","article-title":"Intellectual development in school-aged children with asymptomatic congenital cytomegalovirus infection","volume":"77","author":"TJ Conboy","year":"1986","journal-title":"Pediatrics"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/INF.0b013e318198c724","article-title":"Cytomegalovirus Shedding and Delayed Sensorineural Hearing Loss Results From Longitudinal Follow-up of Children With Congenital Infection","volume":"28","author":"LS Rosenthal","year":"2009","journal-title":"Pediatr Infect Dis J"},{"issue":"14","key":"ref4","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1001\/jama.1986.03380140074025","article-title":"Primary Cytomegalovirus-Infection in Pregnancy\u2014Incidence, Transmission to Fetus, and Clinical Outcome","volume":"256","author":"S Stagno","year":"1986","journal-title":"Jama-J Am Med Assoc"},{"issue":"13","key":"ref5","doi-asserted-by":"crossref","first-page":"6792","DOI":"10.1128\/JVI.00351-15","article-title":"Human Cytomegalovirus Infection Dysregulates the Localization and Stability of NICD1 and Jag1 in Neural Progenitor Cells","volume":"89","author":"XJ Li","year":"2015","journal-title":"Journal of virology"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1128\/JVI.02161-09","article-title":"Human cytomegalovirus infection causes premature and abnormal differentiation of human neural progenitor cells","volume":"84","author":"MH Luo","year":"2010","journal-title":"Journal of virology"},{"issue":"20","key":"ref7","doi-asserted-by":"crossref","first-page":"9994","DOI":"10.1128\/JVI.00943-08","article-title":"Neonatal neural progenitor cells and their neuronal and glial cell derivatives are fully permissive for human cytomegalovirus infection","volume":"82","author":"MH Luo","year":"2008","journal-title":"Journal of virology"},{"issue":"18","key":"ref8","doi-asserted-by":"crossref","first-page":"8929","DOI":"10.1128\/JVI.00676-06","article-title":"Human cytomegalovirus inhibits neuronal differentiation and induces apoptosis in human neural precursor cells","volume":"80","author":"J Odeberg","year":"2006","journal-title":"Journal of virology"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/jnr.21144","article-title":"Late human cytomegalovirus (HCMV) proteins inhibit differentiation of human neural precursor cells into astrocytes","volume":"85","author":"J Odeberg","year":"2007","journal-title":"J Neurosci Res"},{"issue":"20","key":"ref10","doi-asserted-by":"crossref","first-page":"10968","DOI":"10.1128\/JVI.01120-13","article-title":"Later passages of neural progenitor cells from neonatal brain are more permissive for human cytomegalovirus infection","volume":"87","author":"X Pan","year":"2013","journal-title":"Journal of virology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1146\/annurev.neuro.25.030702.130823","article-title":"The role of notch in promoting glial and neural stem cell fates","volume":"25","author":"N Gaiano","year":"2002","journal-title":"Annual review of neuroscience"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev.neuro.26.041002.131334","article-title":"Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration","volume":"26","author":"D Selkoe","year":"2003","journal-title":"Annual review of neuroscience"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neuron.2008.02.014","article-title":"Oscillations in notch signaling regulate maintenance of neural progenitors","volume":"58","author":"H Shimojo","year":"2008","journal-title":"Neuron"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/sj.cr.7290016","article-title":"The Notch-Hes pathway in mammalian neural development","volume":"9","author":"R Kageyama","year":"1999","journal-title":"Cell Res"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1007\/s00018-009-8668-7","article-title":"The Notch signaling pathway: transcriptional regulation at Notch target genes","volume":"66","author":"T Borggrefe","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1111\/j.1440-169X.2008.00993.x","article-title":"Roles of Hes genes in neural development","volume":"50","author":"R Kageyama","year":"2008","journal-title":"Dev Growth Differ"},{"issue":"32","key":"ref17","doi-asserted-by":"crossref","first-page":"30467","DOI":"10.1074\/jbc.M102420200","article-title":"Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain","volume":"276","author":"T Ohtsuka","year":"2001","journal-title":"The Journal of biological chemistry"},{"issue":"21","key":"ref18","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1007\/s00018-016-2277-z","article-title":"Hes1: the maestro in neurogenesis","volume":"73","author":"SB Dhanesh","year":"2016","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.ceb.2009.08.009","article-title":"Dynamic regulation of Notch signaling in neural progenitor cells","volume":"21","author":"R Kageyama","year":"2009","journal-title":"Current opinion in cell biology"},{"key":"ref20","first-page":"3","article-title":"Roles of Hes bHLH genes in neural development","volume":"98","author":"R Kageyama","year":"2006","journal-title":"J Neurochem"},{"issue":"22","key":"ref21","doi-asserted-by":"crossref","first-page":"5539","DOI":"10.1242\/dev.01436","article-title":"Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation","volume":"131","author":"J Hatakeyama","year":"2004","journal-title":"Development"},{"issue":"8","key":"ref22","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1093\/emboj\/18.8.2196","article-title":"Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation","volume":"18","author":"T Ohtsuka","year":"1999","journal-title":"Embo J"},{"issue":"24","key":"ref23","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1101\/gad.9.24.3136","article-title":"Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects","volume":"9","author":"M Ishibashi","year":"1995","journal-title":"Gene Dev"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1242\/dev.127.11.2323","article-title":"Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium","volume":"127","author":"E Cau","year":"2000","journal-title":"Development"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s12250-017-3956-0","article-title":"Human cytomegalovirus infection dysregulates neural progenitor cell fate by disrupting Hes1 rhythm and down-regulating its expression","volume":"32","author":"XJ Liu","year":"2017","journal-title":"Virologica Sinica"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s12250-014-3532-9","article-title":"Immediate-Early (IE) gene regulation of cytomegalovirus: IE1- and pp71-mediated viral strategies against cellular defenses","volume":"29","author":"L Torres","year":"2014","journal-title":"Virologica Sinica"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00430-007-0069-7","article-title":"Role of the cytomegalovirus major immediate early enhancer in acute infection and reactivation from latency","volume":"197","author":"MF Stinski","year":"2008","journal-title":"Medical microbiology and immunology"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.1128\/JVI.71.6.4599-4613.1997","article-title":"The major immediate-early proteins IE1 and IE2 of human cytomegalovirus colocalize with and disrupt PML-associated nuclear bodies at very early times in infected permissive cells","volume":"71","author":"JH Ahn","year":"1997","journal-title":"Journal of virology"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1128\/JVI.72.1.366-379.1998","article-title":"Defective growth correlates with reduced accumulation of a viral DNA replication protein after low-multiplicity infection by a human cytomegalovirus ie1 mutant","volume":"72","author":"RF Greaves","year":"1998","journal-title":"Journal of virology"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1128\/JVI.76.9.4441-4455.2002","article-title":"Absence of IE1 p72 protein function during low-multiplicity infection by human cytomegalovirus results in a broad block to viral delayed-early gene expression","volume":"76","author":"JM Gawn","year":"2002","journal-title":"Journal of virology"},{"issue":"9","key":"ref31","doi-asserted-by":"crossref","first-page":"6683","DOI":"10.1128\/JVI.71.9.6683-6691.1997","article-title":"Binding of SP1 to the immediate-early protein-responsive element of the human cytomegalovirus DNA polymerase promoter","volume":"71","author":"P Luu","year":"1997","journal-title":"Journal of virology"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1128\/JVI.64.4.1498-1506.1990","article-title":"Transactivation of a Human Cytomegalovirus Early Promoter by Gene-Products from the Immediate-Early Gene Ie2 and Augmentation by Ie1\u2014Mutational Analysis of the Viral-Proteins","volume":"64","author":"CL Malone","year":"1990","journal-title":"Journal of virology"},{"issue":"14","key":"ref33","doi-asserted-by":"crossref","first-page":"7185","DOI":"10.1128\/JVI.02231-09","article-title":"Human Cytomegalovirus IE72 Protein Interacts with the Transcriptional Repressor hDaxx To Regulate LUNA Gene Expression during Lytic Infection","volume":"84","author":"M Reeves","year":"2010","journal-title":"Journal of virology"},{"issue":"49","key":"ref34","doi-asserted-by":"crossref","first-page":"17234","DOI":"10.1073\/pnas.0407933101","article-title":"Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation","volume":"101","author":"M Nevels","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"14","key":"ref35","doi-asserted-by":"crossref","first-page":"7803","DOI":"10.1128\/JVI.78.14.7803-7812.2004","article-title":"SUMOylation of the human cytomegalovirus 72-kilodalton IE1 protein facilitates expression of the 86-kilodalton IE2 protein and promotes viral replication","volume":"78","author":"M Nevels","year":"2004","journal-title":"Journal of virology"},{"issue":"4","key":"ref36","doi-asserted-by":"crossref","first-page":"e1002016","DOI":"10.1371\/journal.ppat.1002016","article-title":"Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-gamma","volume":"7","author":"T Knoblach","year":"2011","journal-title":"PLoS pathogens"},{"issue":"23","key":"ref37","doi-asserted-by":"crossref","first-page":"12388","DOI":"10.1128\/JVI.00304-09","article-title":"Human cytomegalovirus IE1-72 protein interacts with p53 and inhibits p53-dependent transactivation by a mechanism different from that of IE2-86 protein","volume":"83","author":"ES Hwang","year":"2009","journal-title":"Journal of virology"},{"issue":"19","key":"ref38","doi-asserted-by":"crossref","first-page":"10763","DOI":"10.1128\/JVI.01197-13","article-title":"Human cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequestering STAT3 in the nucleus","volume":"87","author":"JM Reitsma","year":"2013","journal-title":"Journal of virology"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/glia.20179","article-title":"Downregulation of GFAP, TSP-1, and p53 in human glioblastoma cell line, U373MG, by IE1 protein from human cytomegalovirus","volume":"51","author":"K Lee","year":"2005","journal-title":"Glia"},{"issue":"Pt 4","key":"ref40","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1099\/vir.0.006486-0","article-title":"Human cytomegalovirus infection downregulates the expression of glial fibrillary acidic protein in human glioblastoma U373MG cells: identification of viral genes and protein domains involved","volume":"90","author":"K Koh","year":"2009","journal-title":"The Journal of general virology"},{"issue":"11","key":"ref41","doi-asserted-by":"crossref","first-page":"e1004512","DOI":"10.1371\/journal.ppat.1004512","article-title":"Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions","volume":"10","author":"M Scherer","year":"2014","journal-title":"PLoS pathogens"},{"issue":"6","key":"ref42","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/cr.2014.46","article-title":"Structural insights into the TRIM family of ubiquitin E3 ligases","volume":"24","author":"Y Li","year":"2014","journal-title":"Cell Res"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1128\/JVI.76.2.841-850.2002","article-title":"Herpes simplex virus type 1 immediate-early protein ICP0 and is isolated RING finger domain act as ubiquitin E3 ligases in vitro","volume":"76","author":"C Boutell","year":"2002","journal-title":"Journal of virology"},{"issue":"16","key":"ref44","doi-asserted-by":"crossref","first-page":"9335","DOI":"10.1128\/JVI.00873-14","article-title":"Kaposi&apos;s sarcoma-associated herpesvirus K3 and K5 ubiquitin E3 ligases have stage-specific immune evasion roles during lytic replication","volume":"88","author":"K Brulois","year":"2014","journal-title":"Journal of virology"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1073\/pnas.022531599","article-title":"Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes","volume":"99","author":"R Hagglund","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"12","key":"ref46","doi-asserted-by":"crossref","first-page":"7303","DOI":"10.1128\/JVI.66.12.7303-7308.1992","article-title":"Varicella-Zoster Virus Open Reading Frame 61 Protein Is Functionally Homologous to Herpes-Simplex Virus Type-1 Icpo","volume":"66","author":"H Moriuchi","year":"1992","journal-title":"Journal of virology"},{"issue":"13","key":"ref47","doi-asserted-by":"crossref","first-page":"6861","DOI":"10.1128\/JVI.00335-10","article-title":"The RING Finger Domain of Varicella-Zoster Virus ORF61p Has E3 Ubiquitin Ligase Activity That Is Essential for Efficient Autoubiquitination and Dispersion of Sp100-Containing Nuclear Bodies","volume":"84","author":"MS Walters","year":"2010","journal-title":"Journal of virology"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.immuni.2004.11.011","article-title":"The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradation","volume":"22","author":"Y Yu","year":"2005","journal-title":"Immunity"},{"issue":"24","key":"ref49","doi-asserted-by":"crossref","first-page":"12854","DOI":"10.1128\/JVI.01164-09","article-title":"Physical requirements and functional consequences of complex formation between the cytomegalovirus IE1 protein and human STAT2","volume":"83","author":"S Krauss","year":"2009","journal-title":"Journal of virology"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1128\/JVI.75.4.1870-1878.2001","article-title":"Human cytomegalovirus with IE-2 (UL122) deleted fails to express early lytic genes","volume":"75","author":"A Marchini","year":"2001","journal-title":"Journal of virology"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1128\/JVI.02606-13","article-title":"Human cytomegalovirus major immediate early 1 protein targets host chromosomes by docking to the acidic pocket on the nucleosome surface","volume":"88","author":"K Mucke","year":"2014","journal-title":"Journal of virology"},{"issue":"5594","key":"ref52","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1126\/science.1074560","article-title":"Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop","volume":"298","author":"H Hirata","year":"2002","journal-title":"Science"},{"issue":"21","key":"ref53","doi-asserted-by":"crossref","first-page":"10444","DOI":"10.1128\/JVI.00833-08","article-title":"Binding STAT2 by the acidic domain of human cytomegalovirus IE1 promotes viral growth and is negatively regulated by SUMO","volume":"82","author":"YH Huh","year":"2008","journal-title":"Journal of virology"},{"issue":"2","key":"ref54","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3390\/cells3020386","article-title":"The ubiquitin-conjugating system: multiple roles in viral replication and infection","volume":"3","author":"A Calistri","year":"2014","journal-title":"Cells"},{"issue":"15","key":"ref55","doi-asserted-by":"crossref","first-page":"8963","DOI":"10.1073\/pnas.1533420100","article-title":"The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5a","volume":"100","author":"H Gu","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1\u20133","key":"ref56","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbamcr.2004.09.019","article-title":"Ubiquitin: structures, functions, mechanisms","volume":"1695","author":"CM Pickart","year":"2004","journal-title":"Biochimica et biophysica acta"},{"issue":"1","key":"ref57","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1128\/JVI.02591-14","article-title":"Kaposi&apos;s sarcoma-associated herpesvirus-encoded replication and transcription activator impairs innate immunity via ubiquitin-mediated degradation of myeloid differentiation factor 88","volume":"89","author":"Q Zhao","year":"2015","journal-title":"Journal of virology"},{"issue":"22","key":"ref58","doi-asserted-by":"crossref","first-page":"11928","DOI":"10.1128\/JVI.00758-11","article-title":"Human cytomegalovirus infection causes degradation of Sp100 proteins that suppress viral gene expression","volume":"85","author":"YE Kim","year":"2011","journal-title":"Journal of virology"},{"issue":"18","key":"ref59","doi-asserted-by":"crossref","first-page":"9447","DOI":"10.1128\/JVI.00870-11","article-title":"Evidence for a dual antiviral role of the major nuclear domain 10 component Sp100 during the immediate-early and late phases of the human cytomegalovirus replication cycle","volume":"85","author":"N Tavalai","year":"2011","journal-title":"Journal of virology"},{"key":"ref60","first-page":"104","article-title":"Neuroinflammation and J2 prostaglandins: linking impairment of the ubiquitin-proteasome pathway and mitochondria to neurodegeneration","volume":"7","author":"ME Figueiredo-Pereira","year":"2014","journal-title":"Frontiers in molecular neuroscience"},{"issue":"1","key":"ref61","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1124\/pr.59.1.4","article-title":"Emerging roles for ubiquitin and protein degradation in neuronal function","volume":"59","author":"JJ Yi","year":"2007","journal-title":"Pharmacological reviews"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0065-2776(06)92006-9","article-title":"Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions","volume":"92","author":"J Loureiro","year":"2006","journal-title":"Advances in immunology"},{"issue":"2","key":"ref63","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.virol.2008.10.005","article-title":"Manipulation of the ubiquitin-proteasome pathway by small DNA tumor viruses","volume":"384","author":"P Blanchette","year":"2009","journal-title":"Virology"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"Artn S7","DOI":"10.1186\/1471-2091-9-S1-S7","article-title":"The ubiquitin system, disease, and drug discovery","volume":"9","author":"MD Petroski","year":"2008","journal-title":"Bmc Biochem"},{"issue":"7","key":"ref65","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1128\/JVI.02296-07","article-title":"Cellular proteasome activity facilitates herpes simplex virus entry at a postpenetration step","volume":"82","author":"MG Delboy","year":"2008","journal-title":"Journal of virology"},{"issue":"5","key":"ref66","doi-asserted-by":"crossref","first-page":"ARTN e1002703.","DOI":"10.1371\/journal.ppat.1002703","article-title":"The Ubiquitin\/Proteasome System Mediates Entry and Endosomal Trafficking of Kaposi&apos;s Sarcoma-Associated Herpesvirus in Endothelial Cells","volume":"8","author":"W Greene","year":"2012","journal-title":"PLoS pathogens"},{"issue":"6","key":"ref67","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1128\/JVI.02236-09","article-title":"Proteasome Subunits Relocalize during Human Cytomegalovirus Infection, and Proteasome Activity Is Necessary for Efficient Viral Gene Transcription","volume":"84","author":"K Tran","year":"2010","journal-title":"Journal of virology"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.biochem.67.1.425","article-title":"The ubiquitin system","volume":"67","author":"A Hershko","year":"1998","journal-title":"Annual review of biochemistry"},{"issue":"1","key":"ref69","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bbamcr.2013.05.026","article-title":"RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination","volume":"1843","author":"MB Metzger","year":"2014","journal-title":"Biochimica et biophysica acta"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.biochem.78.101807.093809","article-title":"RING domain E3 ubiquitin ligases","volume":"78","author":"RJ Deshaies","year":"2009","journal-title":"Annual review of biochemistry"},{"issue":"5","key":"ref71","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/ncb0509-527","article-title":"Viral avoidance and exploitation of the ubiquitin system","volume":"11","author":"F Randow","year":"2009","journal-title":"Nature cell biology"},{"issue":"8","key":"ref72","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1128\/MCB.18.8.4899","article-title":"Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML","volume":"18","author":"JH Ahn","year":"1998","journal-title":"Molecular and cellular biology"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1042\/bse0410015","article-title":"E3 ubiquitin ligases","volume":"41","author":"HC Ardley","year":"2005","journal-title":"Essays in biochemistry"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"29232","DOI":"10.1038\/srep29232","article-title":"A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125","volume":"6","author":"MJ Bijlmakers","year":"2016","journal-title":"Sci Rep"},{"key":"ref75","article-title":"The ND10 component promyelocytic leukemia protein acts as an E3 ligase for SUMOylation of the major immediate-early protein IE1 of human cytomegalovirus","author":"N Reuter","year":"2017","journal-title":"Journal of virology"},{"issue":"6","key":"ref76","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.3390\/v7062751","article-title":"Contribution of the Major ND10 Proteins PML, hDaxx and Sp100 to the Regulation of Human Cytomegalovirus Latency and Lytic Replication in the Monocytic Cell Line THP-1","volume":"7","author":"N Wagenknecht","year":"2015","journal-title":"Viruses"},{"issue":"5","key":"ref77","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/jmv.24396","article-title":"Identification and BAC construction of Han, the first characterized HCMV clinical strain in China","volume":"88","author":"F Zhao","year":"2016","journal-title":"Journal of medical virology"},{"issue":"1\u20132","key":"ref78","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jviromet.2007.11.012","article-title":"A highly efficient protocol of generating and analyzing VZV ORF deletion mutants based on a newly developed luciferase VZV BAC system","volume":"148","author":"Z Zhang","year":"2008","journal-title":"Journal of virological methods"},{"issue":"17","key":"ref79","doi-asserted-by":"crossref","first-page":"8390","DOI":"10.1128\/JVI.00505-06","article-title":"Potential role for p53 in the permissive life cycle of human cytomegalovirus","volume":"80","author":"NC Casavant","year":"2006","journal-title":"Journal of virology"},{"issue":"2","key":"ref80","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1128\/JVI.01740-14","article-title":"MicroRNA miR-21 attenuates human cytomegalovirus replication in neural cells by targeting Cdc25a","volume":"89","author":"YR Fu","year":"2015","journal-title":"Journal of virology"},{"issue":"1","key":"ref81","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nprot.2006.37","article-title":"Production and purification of lentiviral vectors","volume":"1","author":"G Tiscornia","year":"2006","journal-title":"Nature protocols"},{"issue":"1","key":"ref82","doi-asserted-by":"crossref","first-page":"e02068","DOI":"10.1128\/mBio.02068-14","article-title":"E6^E7, a novel splice isoform protein of human papillomavirus 16, stabilizes viral E6 and E7 oncoproteins via HSP90 and GRP78","volume":"6","author":"M Ajiro","year":"2015","journal-title":"mBio"},{"issue":"7","key":"ref83","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/abbs\/gms041","article-title":"A faster immunofluorescence assay for tracking infection progress of human cytomegalovirus","volume":"44","author":"Y Duan","year":"2012","journal-title":"Acta biochimica et biophysica Sinica"},{"issue":"26","key":"ref84","doi-asserted-by":"crossref","first-page":"E2646","DOI":"10.1073\/pnas.1323107111","article-title":"RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage","volume":"111","author":"SR Ho","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"ref85","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bbrc.2013.02.012","article-title":"Characterization of TRIM62 as a RING finger E3 ubiquitin ligase and its subcellular localization","volume":"432","author":"F Huang","year":"2013","journal-title":"Biochemical and biophysical research communications"},{"issue":"2","key":"ref86","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0092-8674(02)01012-7","article-title":"The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson&apos;s disease susceptibility","volume":"111","author":"Y Liu","year":"2002","journal-title":"Cell"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006542","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T15:12:12Z","timestamp":1659280332000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006542"}},"subtitle":[],"editor":[{"given":"Eain Anthony","family":"Murphy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,27]]},"references-count":86,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006542","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1006542","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,27]]}}}