{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:56:09Z","timestamp":1781528169361,"version":"3.54.1"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006566","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000}}],"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T00:00:00Z","timestamp":1502928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI117303"],"award-info":[{"award-number":["AI117303"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI056172"],"award-info":[{"award-number":["AI056172"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["109799"],"award-info":[{"award-number":["109799"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI60555"],"award-info":[{"award-number":["AI60555"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005808","name":"Vietnam Education Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005808","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006566","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T18:16:54Z","timestamp":1502993814000},"page":"e1006566","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["T cell expression of IL-18R and DR3 is essential for non-cognate stimulation of Th1 cells and optimal clearance of intracellular bacteria"],"prefix":"10.1371","volume":"13","author":[{"given":"Oanh H.","family":"Pham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6460-9016","authenticated-orcid":true,"given":"Hope","family":"O\u2019Donnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0727-4189","authenticated-orcid":true,"given":"Aymen","family":"Al-Shamkhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8562-4151","authenticated-orcid":true,"given":"Tobias","family":"Kerrinnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9131-6657","authenticated-orcid":true,"given":"Ren\u00e9e M.","family":"Tsolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6363-3222","authenticated-orcid":true,"given":"Stephen J.","family":"McSorley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,8,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.immunol.19.1.23","article-title":"In vivo activation of antigen-specific CD4 T cells","volume":"19","author":"MK Jenkins","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev-immunol-030409-101212","article-title":"Differentiation of effector CD4 T cell populations (*)","volume":"28","author":"J Zhu","year":"2010","journal-title":"Annual Review of Immunology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev-immunol-031210-101400","article-title":"Follicular helper CD4 T cells (TFH)","volume":"29","author":"S Crotty","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1128\/CMR.00097-13","article-title":"CD4+ T Cells: guardians of the phagosome","volume":"27","author":"NJ Tubo","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/imr.12184","article-title":"Immunity to intestinal pathogens: lessons learned from Salmonella","volume":"260","author":"SJ McSorley","year":"2014","journal-title":"Immunol Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.immuni.2008.11.013","article-title":"Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin","volume":"30","author":"JB McLachlan","year":"2009","journal-title":"Immunity"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.immuni.2013.11.017","article-title":"Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues","volume":"40","author":"T Honda","year":"2014","journal-title":"Immunity"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.immuni.2012.05.015","article-title":"CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation","volume":"37","author":"AJ Muller","year":"2012","journal-title":"Immunity"},{"key":"ref9","first-page":"621","article-title":"Salmonella as a model for non-cognate Th1 cell stimulation","volume":"5","author":"H O'Donnell","year":"2014","journal-title":"Front Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.4049\/jimmunol.166.2.1097","article-title":"Bystander activation of CD8+ T cells contributes to the rapid production of IFN-gamma in response to bacterial pathogens","volume":"166","author":"G Lertmemongkolchai","year":"2001","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1084\/jem.20031051","article-title":"Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen","volume":"198","author":"RE Berg","year":"2003","journal-title":"J Exp Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"767","DOI":"10.4049\/jimmunol.174.2.767","article-title":"Dendritic cells and NK cells stimulate bystander T cell activation in response to TLR agonists through secretion of IFN-alpha beta and IFN-gamma","volume":"174","author":"AT Kamath","year":"2005","journal-title":"J Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1002\/1521-4141(2002010)32:10<2807::AID-IMMU2807>3.0.CO;2-0","article-title":"Contribution of CD8+ T cells to innate immunity: IFN-gamma secretion induced by IL-12 and IL-18","volume":"32","author":"RE Berg","year":"2002","journal-title":"Eur J Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.4049\/jimmunol.173.11.6873","article-title":"Activation of virus-specific CD8+ T cells by lipopolysaccharide-induced IL-12 and IL-18","volume":"173","author":"HP Raue","year":"2004","journal-title":"J Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1182\/blood-2004-07-2833","article-title":"Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines","volume":"105","author":"C Beadling","year":"2005","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"9971","DOI":"10.1073\/pnas.1203543109","article-title":"Regulation of innate CD8+ T-cell activation mediated by cytokines","volume":"109","author":"BE Freeman","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.it.2012.07.006","article-title":"Cytokine-induced cytokine production by conventional and innate lymphoid cells","volume":"33","author":"L Guo","year":"2012","journal-title":"Trends Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4603","DOI":"10.4049\/jimmunol.175.7.4603","article-title":"Expression of T-bet by CD4 T cells is essential for resistance to Salmonella infection","volume":"175","author":"R Ravindran","year":"2005","journal-title":"Journal of immunology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"6342","DOI":"10.4049\/jimmunol.178.10.6342","article-title":"Innate immune activation of CD4 T cells in salmonella-infected mice is dependent on IL-18","volume":"178","author":"A Srinivasan","year":"2007","journal-title":"Journal of immunology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.immuni.2013.12.013","article-title":"Toll-like Receptor and Inflammasome Signals Converge to Amplify the Innate Bactericidal Capacity of T Helper 1 Cells","volume":"40","author":"H O'Donnell","year":"2014","journal-title":"Immunity"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1126\/science.274.5289.990","article-title":"Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95","volume":"274","author":"AM Chinnaiyan","year":"1996","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/384372a0","article-title":"A death-domain-containing receptor that mediates apoptosis","volume":"384","author":"J Kitson","year":"1996","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S1074-7613(00)80244-7","article-title":"TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1\/CD95)","volume":"6","author":"JL Bodmer","year":"1997","journal-title":"Immunity"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1073\/pnas.94.9.4615","article-title":"LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing","volume":"94","author":"GR Screaton","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"39251","DOI":"10.1074\/jbc.M305833200","article-title":"TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells","volume":"278","author":"L Wen","year":"2003","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1189\/jlb.3RI0315-095R","article-title":"The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator","volume":"98","author":"AC Richard","year":"2015","journal-title":"J Leukoc Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S1074-7613(02)00283-2","article-title":"TL1A is a TNF-like ligand for DR3 and TR6\/DcR3 and functions as a T cell costimulator","volume":"16","author":"TS Migone","year":"2002","journal-title":"Immunity"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.4049\/jimmunol.178.7.4033","article-title":"The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells","volume":"178","author":"JL Prehn","year":"2007","journal-title":"J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1002\/eji.200839087","article-title":"Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells","volume":"39","author":"DQ Shih","year":"2009","journal-title":"Eur J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/eji.201041950","article-title":"Death receptor 3 is essential for generating optimal protective CD4(+) T-cell immunity against Salmonella","volume":"42","author":"SL Buchan","year":"2012","journal-title":"Eur J Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"4868","DOI":"10.4049\/jimmunol.171.9.4868","article-title":"Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease","volume":"171","author":"G Bamias","year":"2003","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"7002","DOI":"10.4049\/jimmunol.172.11.7002","article-title":"TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells","volume":"172","author":"KA Papadakis","year":"2004","journal-title":"J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/mi.2012.124","article-title":"TL1A\/TNFSF15 directly induces proinflammatory cytokines, including TNFalpha, from CD3+CD161+ T cells to exacerbate gut inflammation","volume":"6","author":"S Jin","year":"2013","journal-title":"Mucosal Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/mi.2014.87","article-title":"A major population of mucosal memory CD4+ T cells, coexpressing IL-18Ralpha and DR3, display innate lymphocyte functionality","volume":"8","author":"P Holmkvist","year":"2015","journal-title":"Mucosal Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"8441","DOI":"10.1073\/pnas.0510903103","article-title":"Role of TL1A and its receptor DR3 in two models of chronic murine ileitis","volume":"103","author":"G Bamias","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4049\/jimmunol.1502466","article-title":"A Novel Role for TL1A\/DR3 in Protection against Intestinal Injury and Infection","volume":"197","author":"LG Jia","year":"2016","journal-title":"J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1096\/fj.11-200618","article-title":"The death receptor 3\/TL1A pathway is essential for efficient development of antiviral CD4(+) and CD8(+) T-cell immunity","volume":"26","author":"JP Twohig","year":"2012","journal-title":"FASEB J"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.it.2013.06.003","article-title":"Toll-like receptor regulation of effector T lymphocyte function","volume":"34","author":"JM Reynolds","year":"2013","journal-title":"Trends Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1126\/science.1224026","article-title":"Mycobacterial disease and impaired IFN-gamma immunity in humans with inherited ISG15 deficiency","volume":"337","author":"D Bogunovic","year":"2012","journal-title":"Science"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.4049\/jimmunol.1202183","article-title":"CD4+ T cell persistence and function after infection are maintained by low-level peptide:MHC class II presentation","volume":"190","author":"RW Nelson","year":"2013","journal-title":"J Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e0004027","DOI":"10.1371\/journal.pntd.0004027","article-title":"Transient Loss of Protection Afforded by a Live Attenuated Non-typhoidal Salmonella Vaccine in Mice Co-infected with Malaria","volume":"9","author":"JP Mooney","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"8739","DOI":"10.1073\/pnas.0401283101","article-title":"Antigen selection based on expression levels during infection facilitates vaccine development for an intracellular pathogen","volume":"101","author":"C Rollenhagen","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1073\/pnas.1111413109","article-title":"Identification of a common immune signature in murine and human systemic Salmonellosis","volume":"109","author":"SJ Lee","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref44","article-title":"Dual Immunization with SseB\/Flagellin Provides Enhanced Protection against Salmonella Infection Mediated by Circulating Memory Cells","author":"SJ Lee","year":"2017","journal-title":"J Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S1074-7613(02)00289-3","article-title":"Tracking Salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection","volume":"16","author":"SJ McSorley","year":"2002","journal-title":"Immunity"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.immuni.2013.11.010","article-title":"The interleukin-1 family: back to the future","volume":"39","author":"C Garlanda","year":"2013","journal-title":"Immunity"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1084\/jem.120.1.105","article-title":"The Immunological Basis of Acquired Cellular Resistance","volume":"120","author":"GB Mackaness","year":"1964","journal-title":"J Exp Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/nrmicro1004","article-title":"Antimicrobial reactive oxygen and nitrogen species: concepts and controversies","volume":"2","author":"FC Fang","year":"2004","journal-title":"Nat Rev Microbiol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/imr.12266","article-title":"Macrophage defense mechanisms against intracellular bacteria","volume":"264","author":"G Weiss","year":"2015","journal-title":"Immunol Rev"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.4049\/jimmunol.1301236","article-title":"Cutting edge: Direct recognition of infected cells by CD4 T cells is required for control of intracellular Mycobacterium tuberculosis in vivo","volume":"191","author":"S Srivastava","year":"2013","journal-title":"J Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1128\/IAI.62.8.3472-3478.1994","article-title":"Defective antigen presentation by Mycobacterium tuberculosis-infected monocytes","volume":"62","author":"J Gercken","year":"1994","journal-title":"Infect Immun"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.4049\/jimmunol.174.5.2892","article-title":"Intracellular Salmonella inhibit antigen presentation by dendritic cells","volume":"174","author":"C Cheminay","year":"2005","journal-title":"J Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"14052","DOI":"10.1073\/pnas.0906735106","article-title":"Salmonella regulates polyubiquitination and surface expression of MHC class II antigens","volume":"106","author":"N Lapaque","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref54","article-title":"Brucella abortus down-regulates MHC class II by the IL-6-dependent inhibition of CIITA through the downmodulation of IFN regulatory factor-1 (IRF-1)","author":"LN Velasquez","year":"2016","journal-title":"J Leukoc Biol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.chom.2016.10.007","article-title":"The Salmonella Effector SteD Mediates MARCH8-Dependent Ubiquitination of MHC II Molecules and Inhibits T Cell Activation","volume":"20","author":"E Bayer-Santos","year":"2016","journal-title":"Cell Host Microbe"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1128\/IAI.00949-07","article-title":"Brucella abortus inhibits major histocompatibility complex class II expression and antigen processing through interleukin-6 secretion via Toll-like receptor 2","volume":"76","author":"P Barrionuevo","year":"2008","journal-title":"Infect Immun"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2217\/fmb.14.98","article-title":"Protective host immune responses to Salmonella infection","volume":"10","author":"OH Pham","year":"2015","journal-title":"Future Microbiol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1128\/IAI.67.2.478-483.1999","article-title":"Interleukin 18 contributes to host resistance and gamma interferon production in mice infected with virulent Salmonella typhimurium","volume":"67","author":"P Mastroeni","year":"1999","journal-title":"Infect Immun"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1084\/jem.194.3.343","article-title":"A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production","volume":"194","author":"M Neighbors","year":"2001","journal-title":"J Exp Med"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.4049\/jimmunol.1202817","article-title":"Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection","volume":"190","author":"MT Gomes","year":"2013","journal-title":"J Immunol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.4049\/jimmunol.1301547","article-title":"CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infection","volume":"191","author":"LC Frazer","year":"2013","journal-title":"J Immunol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"5503","DOI":"10.4049\/jimmunol.1201413","article-title":"Cutting edge: B cells are essential for protective immunity against Salmonella independent of antibody secretion","volume":"189","author":"MR Nanton","year":"2012","journal-title":"J Immunol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.imlet.2012.10.009","article-title":"MHC class-I-restricted CD8 T cells play a protective role during primary Salmonella infection","volume":"148","author":"SJ Lee","year":"2012","journal-title":"Immunol Lett"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"e1002499","DOI":"10.1371\/journal.ppat.1002499","article-title":"Temporal expression of bacterial proteins instructs host CD4 T cell expansion and th17 development","volume":"8","author":"SJ Lee","year":"2012","journal-title":"PLoS Pathogens"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1128\/MCB.21.10.3451-3461.2001","article-title":"DR3 regulates negative selection during thymocyte development","volume":"21","author":"EC Wang","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.4049\/jimmunol.173.6.4091","article-title":"Low-dose Salmonella infection evades activation of flagellin-specific CD4 T cells","volume":"173","author":"A Srinivasan","year":"2004","journal-title":"Journal of immunology"},{"key":"ref67","first-page":"Unit 11A 11","article-title":"Cultivation and Laboratory Maintenance of Chlamydia trachomatis","volume":"11","author":"MA Scidmore","year":"2005","journal-title":"Curr Protoc Microbiol Chapter"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"e1003707","DOI":"10.1371\/journal.ppat.1003707","article-title":"B cells enhance antigen-specific CD4 T cell priming and prevent bacteria dissemination following Chlamydia muridarum genital tract infection","volume":"9","author":"LX Li","year":"2013","journal-title":"PLoS Pathog"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1073\/pnas.98.1.31","article-title":"Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection","volume":"98","author":"C Li","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref70","first-page":"RESEARCH0032","article-title":"Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application","volume":"2","author":"C Li","year":"2001","journal-title":"Genome Biol"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006566","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T15:58:35Z","timestamp":1602777515000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006566"}},"subtitle":[],"editor":[{"given":"Steven R.","family":"Blanke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,8,17]]},"references-count":70,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006566","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1006566","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,17]]}}}