{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:09:41Z","timestamp":1793383781517,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006597","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000}}],"reference-count":78,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","award":["16fk0108315h0003"],"award-info":[{"award-number":["16fk0108315h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","award":["16cm0106315h0001, 17cm0106315h0002"],"award-info":[{"award-number":["16cm0106315h0001, 17cm0106315h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Japan Cancer Society"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006597","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T17:50:50Z","timestamp":1505411450000},"page":"e1006597","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":52,"title":["IL-10-mediated signals act as a switch for lymphoproliferation in Human T-cell leukemia virus type-1 infection by activating the STAT3 and IRF4 pathways"],"prefix":"10.1371","volume":"13","author":[{"given":"Leila","family":"Sawada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhiko","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikari","family":"Kanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Nogami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1992-8661","authenticated-orcid":true,"given":"Sayaka","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8439-3128","authenticated-orcid":true,"given":"Tomoo","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7527-0345","authenticated-orcid":true,"given":"Yoshihisa","family":"Yamano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuetsu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3433-2658","authenticated-orcid":true,"given":"Mari","family":"Kannagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3389\/fmicb.2012.00388","article-title":"Epidemiological Aspects and World Distribution of HTLV-1 Infection","volume":"3","author":"A Gessain","year":"2012","journal-title":"Frontiers in microbiology"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/ijc.2910430214","article-title":"Modelling the risk of adult T-cell leukemia\/lymphoma in persons infected with human T-lymphotropic virus type I","volume":"43","author":"EL Murphy","year":"1989","journal-title":"Int J Cancer"},{"issue":"11","key":"ref3","first-page":"1096","article-title":"The Risk of Development of Htlv-I-Associated Myelopathy Tropical Spastic Paraparesis among Persons Infected with Htlv-I","volume":"3","author":"JE Kaplan","year":"1990","journal-title":"J Acq Immun Def Synd"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00042560-199802010-00011","article-title":"Incidence of HTLV-I-associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) in Jamaica and Trinidad","volume":"17","author":"EM Maloney","year":"1998","journal-title":"J Acquir Immune Defic Syndr Hum Retrovirol"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1182\/blood.V50.3.481.481","article-title":"Adult T-cell leukemia: clinical and hematologic features of 16 cases","volume":"50","author":"T Uchiyama","year":"1977","journal-title":"Blood"},{"issue":"8452","key":"ref6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0140-6736(85)92734-5","article-title":"Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis","volume":"2","author":"A Gessain","year":"1985","journal-title":"Lancet"},{"issue":"8488","key":"ref7","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0140-6736(86)91298-5","article-title":"HTLV-I associated myelopathy, a new clinical entity","volume":"1","author":"M Osame","year":"1986","journal-title":"Lancet"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1128\/JVI.64.3.1278-1282.1990","article-title":"Sequence variants of human T-cell lymphotropic virus type I from patients with tropical spastic paraparesis and adult T-cell leukemia do not distinguish neurological from leukemic isolates","volume":"64","author":"S Daenke","year":"1990","journal-title":"J Virol"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/ijc.2910470403","article-title":"Sequence variations in LTR and env regions of HTLV-I do not discriminate between the virus from patients with HTLV-I-associated myelopathy and adult T-cell leukemia","volume":"47","author":"T Kinoshita","year":"1991","journal-title":"Int J Cancer"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00047753","article-title":"Malignant lymphomas in Japan: epidemiological analysis of adult T-cell leukemia\/lymphoma (ATL)","volume":"7","author":"K Tajima","year":"1988","journal-title":"Cancer Metastasis Rev"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"e517","DOI":"10.1016\/S1470-2045(14)70202-5","article-title":"Human T-cell leukaemia virus type I and adult T-cell leukaemia-lymphoma","volume":"15","author":"K Ishitsuka","year":"2014","journal-title":"Lancet Oncol"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1073\/pnas.96.7.3848","article-title":"HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy","volume":"96","author":"KJ Jeffery","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Suppl","key":"ref13","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1002\/ana.410230733","article-title":"HLA haplotype-linked high immune responsiveness against HTLV-I in HTLV-I-associated myelopathy: comparison with adult T-cell leukemia\/lymphoma","volume":"23","author":"K Usuku","year":"1988","journal-title":"Ann Neurol"},{"issue":"39","key":"ref14","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1038\/sj.onc.1208970","article-title":"Cellular immune response to HTLV-1","volume":"24","author":"CR Bangham","year":"2005","journal-title":"Oncogene"},{"issue":"6298","key":"ref15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/348245a0","article-title":"Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease","volume":"348","author":"S Jacobson","year":"1990","journal-title":"Nature"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/sj.leu.2403176","article-title":"Loss of the ex vivo but not the reinducible CD8+ T-cell response to Tax in human T-cell leukemia virus type 1-infected patients with adult T-cell leukemia\/lymphoma","volume":"18","author":"B Arnulf","year":"2004","journal-title":"Leukemia"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1742-4690-8-100","article-title":"Functional impairment of Tax-specific but not cytomegalovirus-specific CD8+ T lymphocytes in a minor population of asymptomatic human T-cell leukemia virus type 1-carriers","volume":"8","author":"A Takamori","year":"2011","journal-title":"Retrovirology"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/ijc.20737","article-title":"Potential immunogenicity of adult T cell leukemia cells in vivo","volume":"114","author":"K Kurihara","year":"2005","journal-title":"Int J Cancer"},{"issue":"18","key":"ref19","doi-asserted-by":"crossref","first-page":"4855","DOI":"10.1182\/blood-2010-11-316463","article-title":"Kinetics and intracellular compartmentalization of HTLV-1 gene expression: nuclear retention of HBZ mRNAs","volume":"117","author":"F Rende","year":"2011","journal-title":"Blood"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1182\/blood.V99.1.88","article-title":"Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8(+) T cells, and disease severity in HTLV-1-associated myelopathy (HAM\/TSP)","volume":"99","author":"Y Yamano","year":"2002","journal-title":"Blood"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"6982","DOI":"10.1128\/JVI.71.9.6982-6989.1997","article-title":"Induction of tumor necrosis factor alpha in human neuronal cells by extracellular human T-cell lymphotropic virus type 1 Tax","volume":"71","author":"EP Cowan","year":"1997","journal-title":"J Virol"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1182\/blood.V88.3.1035.bloodjournal8831035","article-title":"Interleukin-10 gene expression in adult T-cell leukemia","volume":"88","author":"N Mori","year":"1996","journal-title":"Blood"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev.immunol.19.1.475","article-title":"Multiple viral strategies of HTLV-1 for dysregulation of cell growth control","volume":"19","author":"M Yoshida","year":"2001","journal-title":"Annu Rev Immunol"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/intimm\/3.8.761","article-title":"Predominant recognition of human T cell leukemia virus type I (HTLV-I) pX gene products by human CD8+ cytotoxic T cells directed against HTLV-I-infected cells","volume":"3","author":"M Kannagi","year":"1991","journal-title":"Int Immunol"},{"issue":"12","key":"ref25","doi-asserted-by":"crossref","first-page":"6490","DOI":"10.3390\/v7122952","article-title":"Roles of HTLV-1 basic Zip Factor (HBZ) in Viral Chronicity and Leukemic Transformation. Potential New Therapeutic Approaches to Prevent and Treat HTLV-1-Related Diseases","volume":"7","author":"JM Mesnard","year":"2015","journal-title":"Viruses"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1073\/pnas.0507631103","article-title":"HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells","volume":"103","author":"Y Satou","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1742-4690-6-19","article-title":"In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy\/tropical spastic paraparesis (HAM\/TSP)","volume":"6","author":"M Saito","year":"2009","journal-title":"Retrovirology"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1128\/JVI.02564-08","article-title":"Stromal cell-mediated suppression of human T-cell leukemia virus type 1 expression in vitro and in vivo by type I interferon","volume":"83","author":"S Kinpara","year":"2009","journal-title":"J Virol"},{"issue":"7","key":"ref29","first-page":"2360","article-title":"Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells","volume":"93","author":"N Mori","year":"1999","journal-title":"Blood"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/IR:34:1:1","article-title":"Modulation of nuclear factor-varkappaB by human T cell leukemia virus type 1 tax protein: Implications for oncogenesis and inflammation","volume":"34","author":"JM Peloponese Jr.","year":"2006","journal-title":"Immunol Res"},{"issue":"11","key":"ref31","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/ng.3415","article-title":"Integrated molecular analysis of adult T cell leukemia\/lymphoma","volume":"47","author":"K Kataoka","year":"2015","journal-title":"Nature genetics"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/leu.2015.1","article-title":"Involvement of double-stranded RNA-dependent protein kinase and antisense viral RNA in the constitutive NFkappaB activation in adult T-cell leukemia\/lymphoma cells","volume":"29","author":"S Kinpara","year":"2015","journal-title":"Leukemia"},{"issue":"12","key":"ref33","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1002\/ijc.21688","article-title":"Clinical significance of serum Th1-, Th2- and regulatory T cells-associated cytokines in adult T-cell leukemia\/lymphoma: high interleukin-5 and -10 levels are significant unfavorable prognostic factors","volume":"118","author":"A Inagaki","year":"2006","journal-title":"Int J Cancer"},{"issue":"2A","key":"ref34","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1590\/S0004-282X2006000200009","article-title":"Association of cytokines, neurological disability, and disease duration in HAM\/TSP patients","volume":"64","author":"AL Muniz","year":"2006","journal-title":"Arq Neuropsiquiatr"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.actatropica.2012.09.012","article-title":"Proviral load and the balance of serum cytokines in HTLV-1-asymptomatic infection and in HTLV-1-associated myelopathy\/tropical spastic paraparesis (HAM\/TSP)","volume":"125","author":"AL Starling","year":"2013","journal-title":"Acta Trop"},{"key":"ref36","first-page":"129","article-title":"Regulation of adaptive immunity; the role of interleukin-10","volume":"4","author":"TH Ng","year":"2013","journal-title":"Front Immunol"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nri2711","article-title":"The regulation of IL-10 production by immune cells","volume":"10","author":"M Saraiva","year":"2010","journal-title":"Nature reviews Immunology"},{"issue":"37","key":"ref38","doi-asserted-by":"crossref","first-page":"25132","DOI":"10.1074\/jbc.M804770200","article-title":"Protein kinase R-dependent regulation of interleukin-10 in response to double-stranded RNA","volume":"283","author":"A Chakrabarti","year":"2008","journal-title":"J Biol Chem"},{"issue":"23","key":"ref39","first-page":"5315","article-title":"IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs","volume":"58","author":"I Tamm","year":"1998","journal-title":"Cancer Res"},{"issue":"5","key":"ref40","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1006\/bbrc.2001.4708","article-title":"Expression of survivin in HTLV-I-infected T-cell lines and primary ATL cells","volume":"282","author":"N Mori","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1046\/j.1365-2141.2001.02902.x","article-title":"Aberrant expression of caspase cascade regulatory genes in adult T-cell leukaemia: survivin is an important determinant for prognosis","volume":"114","author":"S Kamihira","year":"2001","journal-title":"Br J Haematol"},{"issue":"12","key":"ref42","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1182\/blood-2005-08-3423","article-title":"Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines","volume":"107","author":"XF Che","year":"2006","journal-title":"Blood"},{"issue":"25","key":"ref43","doi-asserted-by":"crossref","first-page":"13897","DOI":"10.1073\/pnas.94.25.13897","article-title":"Proliferation of adult T cell leukemia\/lymphoma cells is associated with the constitutive activation of JAK\/STAT proteins","volume":"94","author":"S Takemoto","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1089\/107999099313695","article-title":"The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes","volume":"19","author":"RP Donnelly","year":"1999","journal-title":"J Interferon Cytokine Res"},{"issue":"20","key":"ref45","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1182\/blood-2015-11-685032","article-title":"Constitutive activation of Pim1 kinase is a therapeutic target for adult T-cell leukemia","volume":"127","author":"M Bellon","year":"2016","journal-title":"Blood"},{"issue":"20","key":"ref46","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1056\/NEJMoa1114885","article-title":"Somatic STAT3 mutations in large granular lymphocytic leukemia","volume":"366","author":"HL Koskela","year":"2012","journal-title":"N Engl J Med"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.semcancer.2011.12.003","article-title":"Immunomodulating tellurium compounds as anti-cancer agents","volume":"22","author":"B Sredni","year":"2012","journal-title":"Semin Cancer Biol"},{"issue":"6","key":"ref48","first-page":"1270","article-title":"Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase\/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice","volume":"63","author":"MA Blaskovich","year":"2003","journal-title":"Cancer research"},{"issue":"12","key":"ref49","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1111\/j.1349-7006.2001.tb02151.x","article-title":"Possible involvement of interferon regulatory factor 4 (IRF4) in a clinical subtype of adult T-cell leukemia","volume":"92","author":"Y Imaizumi","year":"2001","journal-title":"Jpn J Cancer Res"},{"issue":"44","key":"ref50","doi-asserted-by":"crossref","first-page":"6751","DOI":"10.1038\/sj.onc.1205843","article-title":"Repression of IRF-4 target genes in human T cell leukemia virus-1 infection","volume":"21","author":"Y Mamane","year":"2002","journal-title":"Oncogene"},{"issue":"3\u20134","key":"ref51","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/10428199709051774","article-title":"Interleukin-10 in non-Hodgkin's lymphoma","volume":"26","author":"J Cortes","year":"1997","journal-title":"Leuk Lymphoma"},{"issue":"1","key":"ref52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/cyto.1995.1001","article-title":"Isolation of the human interleukin 10 promoter. Characterization of the promoter activity in Burkitt's lymphoma cell lines","volume":"7","author":"D Kube","year":"1995","journal-title":"Cytokine"},{"issue":"2","key":"ref53","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1378\/chest.117.2.365","article-title":"Serum interleukin-10 levels as a prognostic factor in advanced non-small cell lung cancer patients","volume":"117","author":"F De Vita","year":"2000","journal-title":"Chest"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3960\/jslrt.48.1","article-title":"Association of high proliferation in adult T-cell leukemia cells with apoptosis, and expression of p53 protein in acute type ATL","volume":"48","author":"J Wang","year":"2008","journal-title":"J Clin Exp Hematop"},{"issue":"8","key":"ref55","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nm0897-917","article-title":"A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma","volume":"3","author":"G Ambrosini","year":"1997","journal-title":"Nat Med"},{"issue":"4","key":"ref56","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1158\/1535-7163.MCT-14-0800","article-title":"Targeted Blockade of JAK\/STAT3 Signaling Inhibits Ovarian Carcinoma Growth","volume":"14","author":"G Gritsina","year":"2015","journal-title":"Mol Cancer Ther"},{"issue":"Pt 2","key":"ref57","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/bj3340297","article-title":"Interleukin-6-type cytokine signalling through the gp130\/Jak\/STAT pathway","volume":"334","author":"PC Heinrich","year":"1998","journal-title":"Biochem J"},{"issue":"10","key":"ref58","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.4049\/jimmunol.1402108","article-title":"At High Levels, Constitutively Activated STAT3 Induces Apoptosis of Chronic Lymphocytic Leukemia Cells","volume":"196","author":"U Rozovski","year":"2016","journal-title":"J Immunol"},{"issue":"2","key":"ref59","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ng1097-226","article-title":"Deregulation of MUM1\/IRF4 by chromosomal translocation in multiple myeloma","volume":"17","author":"S Iida","year":"1997","journal-title":"Nat Genet"},{"issue":"1","key":"ref60","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1182\/blood-2003-05-1545","article-title":"Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray","volume":"103","author":"CP Hans","year":"2004","journal-title":"Blood"},{"issue":"1","key":"ref61","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1046\/j.1365-2141.2000.02329.x","article-title":"Expression of MUM1\/IRF4 selectively clusters with primary effusion lymphoma among lymphomatous effusions: implications for disease histogenesis and pathogenesis","volume":"111","author":"A Carbone","year":"2000","journal-title":"Br J Haematol"},{"issue":"20","key":"ref62","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1182\/blood-2014-05-578575","article-title":"The oncogenic transcription factor IRF4 is regulated by a novel CD30\/NF-kappaB positive feedback loop in peripheral T-cell lymphoma","volume":"125","author":"RL Boddicker","year":"2015","journal-title":"Blood"},{"issue":"7201","key":"ref63","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature07064","article-title":"IRF4 addiction in multiple myeloma","volume":"454","author":"AL Shaffer","year":"2008","journal-title":"Nature"},{"issue":"6","key":"ref64","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.4049\/jimmunol.169.6.3120","article-title":"Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells","volume":"169","author":"S Sharma","year":"2002","journal-title":"J Immunol"},{"issue":"7","key":"ref65","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1182\/blood-2006-07-036368","article-title":"IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia\/lymphoma","volume":"109","author":"JC Ramos","year":"2007","journal-title":"Blood"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1182\/blood.V126.23.2643.2643","article-title":"Prognostic Relevance of Integrated Genetic Profiling in Adult T-Cell Leukemia\/Lymphoma","volume":"126","author":"K Kataoka","year":"2015","journal-title":"Blood"},{"issue":"3","key":"ref67","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1053\/jhep.2001.22347","article-title":"Interleukin 10 polymorphisms as predictors of sustained response in antiviral therapy for chronic hepatitis C infection","volume":"33","author":"LJ Yee","year":"2001","journal-title":"Hepatology"},{"issue":"26","key":"ref68","doi-asserted-by":"crossref","first-page":"14467","DOI":"10.1073\/pnas.97.26.14467","article-title":"Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10","volume":"97","author":"HD Shin","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"ref69","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1086\/423942","article-title":"Polymorphism in the interleukin-10 promoter affects both provirus load and the risk of human T lymphotropic virus type I-associated myelopathy\/tropical spastic paraparesis","volume":"190","author":"AH Sabouri","year":"2004","journal-title":"J Infect Dis"},{"issue":"12","key":"ref70","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1002\/jmv.21341","article-title":"Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy\/tropical spastic paraparesis in Brazilian individuals","volume":"80","author":"SR Gadelha","year":"2008","journal-title":"J Med Virol"},{"issue":"3","key":"ref71","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1089\/aid.1998.14.261","article-title":"Expression of FAP-1 (Fas-associated phosphatase) and resistance to Fas-mediated apoptosis in T cell lines derived from human T cell leukemia virus type 1-associated myelopathy\/tropical spastic paraparesis patients","volume":"14","author":"M Arai","year":"1998","journal-title":"AIDS research and human retroviruses"},{"issue":"4561","key":"ref72","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1126\/science.6980467","article-title":"Transformation of human leukocytes by cocultivation with an adult T cell leukemia virus producer cell line","volume":"217","author":"N Yamamoto","year":"1982","journal-title":"Science"},{"issue":"2","key":"ref73","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/ijc.2910340213","article-title":"Cell surface phenotypes and expression of viral antigens of various human cell lines carrying human T-cell leukemia virus","volume":"34","author":"K Sugamura","year":"1984","journal-title":"International journal of cancer"},{"issue":"5","key":"ref74","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/ijc.2910190505","article-title":"Characterization of EBV-genome negative "null" and "T" cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphoma","volume":"19","author":"U Schneider","year":"1977","journal-title":"International journal of cancer"},{"issue":"3","key":"ref75","first-page":"891","article-title":"Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes","volume":"49","author":"J Minowada","year":"1972","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"ref76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1620\/tjem.157.1","article-title":"Monoclonal antibody defining tax protein of human T-cell leukemia virus type-I","volume":"157","author":"B Lee","year":"1989","journal-title":"Tohoku J Exp Med"},{"issue":"10","key":"ref77","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1182\/blood-2011-04-350579","article-title":"IRF4 mutations in chronic lymphocytic leukemia","volume":"118","author":"V Havelange","year":"2011","journal-title":"Blood"},{"issue":"2","key":"ref78","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1128\/JCM.02254-14","article-title":"Identification of TL-Om1, an adult T-cell leukemia (ATL) cell line, as reference material for quantitative PCR for human T-lymphotropic virus 1","volume":"53","author":"M Kuramitsu","year":"2015","journal-title":"J Clin Microbiol"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006597","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T17:52:24Z","timestamp":1602957144000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006597"}},"subtitle":[],"editor":[{"given":"Susan R.","family":"Ross","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,9,14]]},"references-count":78,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,9,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006597","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1006597","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,14]]}}}