{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:53:22Z","timestamp":1792652002725,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006637","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T00:00:00Z","timestamp":1506988800000}}],"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T00:00:00Z","timestamp":1505692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006637","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T19:27:43Z","timestamp":1505762863000},"page":"e1006637","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":53,"title":["Diminished neutrophil extracellular trap (NET) formation is a novel innate immune deficiency induced by acute ethanol exposure in polymicrobial sepsis, which can be rescued by CXCL1"],"prefix":"10.1371","volume":"13","author":[{"given":"Liliang","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Batra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1959-1328","authenticated-orcid":true,"given":"Samithamby","family":"Jeyaseelan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,9,18]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nri2402","article-title":"Harmful molecular mechanisms in sepsis","volume":"8","author":"D Rittirsch","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/alcalc\/agn051","article-title":"The effects of alcohol abuse on pulmonary alveolar-capillary barrier function in humans","volume":"44","author":"EL Burnham","year":"2009","journal-title":"Alcohol Alcohol"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"R312","DOI":"10.1186\/cc2911","article-title":"Altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock","volume":"8","author":"V von Dossow","year":"2004","journal-title":"Crit Care"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2334-7-13","article-title":"Obesity and smoking are factors associated with poor prognosis in patients with bacteraemia","volume":"7","author":"R Huttunen","year":"2007","journal-title":"BMC Infect Dis"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1097\/00005373-199506000-00019","article-title":"The impact of substance use on mortality and morbidity from thermal injury","volume":"38","author":"V McGill","year":"1995","journal-title":"J Trauma"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0741-8329(04)00102-8","article-title":"Ethanol suppresses cytokine responses induced through Toll-like receptors as well as innate resistance to Escherichia coli in a mouse model for binge drinking","volume":"33","author":"SB Pruett","year":"2004","journal-title":"Alcohol"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0039-6060(96)80245-5","article-title":"Actions of acute ethanol intoxication on cardiopulmonary function after an endotoxin challenge","volume":"120","author":"GE Woodman","year":"1996","journal-title":"Surgery"},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"6930","DOI":"10.4049\/jimmunol.1002300","article-title":"Early enhanced local neutrophil recruitment in peritonitis-induced sepsis improves bacterial clearance and survival","volume":"185","author":"FL Craciun","year":"2010","journal-title":"J Immunol"},{"issue":"5258","key":"ref9","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.272.5258.50","article-title":"The instructive role of innate immunity in the acquired immune response","volume":"272","author":"DT Fearon","year":"1996","journal-title":"Science"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"7846","DOI":"10.4049\/jimmunol.0803039","article-title":"IL-17 receptor signaling is required to control polymicrobial sepsis","volume":"182","author":"A Freitas","year":"2009","journal-title":"J Immunol"},{"issue":"7","key":"ref11","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.4049\/jimmunol.1401138","article-title":"CXCL1 contributes to host defense in polymicrobial sepsis via modulating T cell and neutrophil functions","volume":"193","author":"L Jin","year":"2014","journal-title":"J Immunol"},{"issue":"16","key":"ref12","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1182\/blood-2013-04-457671","article-title":"NETosis: how vital is it?","volume":"122","author":"BG Yipp","year":"2013","journal-title":"Blood"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.4049\/jimmunol.1201719","article-title":"Neutrophil extracellular traps: double-edged swords of innate immunity","volume":"189","author":"MJ Kaplan","year":"2012","journal-title":"J Immunol"},{"issue":"5663","key":"ref14","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"V Brinkmann","year":"2004","journal-title":"Science"},{"issue":"1","key":"ref15","first-page":"97","article-title":"Epigenetic targets for reversing immune defects caused by alcohol exposure","volume":"35","author":"BJ Curtis","year":"2013","journal-title":"Alcohol Res"},{"key":"ref16","first-page":"291","article-title":"Alcohol and infection","volume":"17","author":"RR MacGregor","year":"1997","journal-title":"Curr Clin Top Infect Dis"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/mi.2015.80","article-title":"NLRP12 modulates host defense through IL-17A-CXCL1 axis","volume":"9","author":"S Cai","year":"2016","journal-title":"Mucosal Immunol"},{"key":"ref18","article-title":"IFN-gamma induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense","author":"S Cai","year":"2015","journal-title":"Mucosal Immunol"},{"issue":"11","key":"ref19","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.it.2009.07.011","article-title":"NETs: a new strategy for using old weapons","volume":"30","author":"V Papayannopoulos","year":"2009","journal-title":"Trends Immunol"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00281-013-0384-6","article-title":"Molecular mechanisms regulating NETosis in infection and disease","volume":"35","author":"N Branzk","year":"2013","journal-title":"Semin Immunopathol"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.4049\/jimmunol.1004201","article-title":"Innate immune collectin surfactant protein D simultaneously binds both neutrophil extracellular traps and carbohydrate ligands and promotes bacterial trapping","volume":"187","author":"DN Douda","year":"2011","journal-title":"J Immunol"},{"issue":"8","key":"ref22","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrmicro1710","article-title":"Beneficial suicide: why neutrophils die to make NETs","volume":"5","author":"V Brinkmann","year":"2007","journal-title":"Nat Rev Microbiol"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.4049\/jimmunol.173.5.3398","article-title":"Inhibition of myeloid dendritic cell accessory cell function and induction of T cell anergy by alcohol correlates with decreased IL-12 production","volume":"173","author":"P Mandrekar","year":"2004","journal-title":"J Immunol"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1093\/alcalc\/34.6.830","article-title":"Consequences of alcohol consumption on host defence","volume":"34","author":"G Szabo","year":"1999","journal-title":"Alcohol Alcohol"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1530-0277.1994.tb00921.x","article-title":"Effects of ethanol consumption on enriched natural killer cells from C57BL\/6 mice","volume":"18","author":"RM Gallucci","year":"1994","journal-title":"Alcohol Clin Exp Res"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nri744","article-title":"Alcohol, host defence and society","volume":"2","author":"S Nelson","year":"2002","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"ref27","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1086\/323661","article-title":"Acute ethanol intoxication suppresses lung chemokine production following infection with Streptococcus pneumoniae","volume":"184","author":"DM Boe","year":"2001","journal-title":"J Infect Dis"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/j.1530-0277.2001.tb02293.x","article-title":"Effect of alcohol consumption on host release of interleukin-17 during pulmonary infection with Klebsiella pneumoniae","volume":"25","author":"JE Shellito","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri1312","article-title":"NOX enzymes and the biology of reactive oxygen","volume":"4","author":"JD Lambeth","year":"2004","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"e95707","DOI":"10.1371\/journal.pone.0095707","article-title":"Alcohol enhances Acinetobacter baumannii-associated pneumonia and systemic dissemination by impairing neutrophil antimicrobial activity in a murine model of infection","volume":"9","author":"JA Gandhi","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"ref31","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.4049\/jimmunol.158.12.5581","article-title":"Mice lacking reduced nicotinamide adenine dinucleotide phosphate oxidase activity show increased susceptibility to early infection with Listeria monocytogenes","volume":"158","author":"MC Dinauer","year":"1997","journal-title":"J Immunol"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1074-7613(00)80004-7","article-title":"Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase","volume":"10","author":"MU Shiloh","year":"1999","journal-title":"Immunity"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1083\/jcb.200606027","article-title":"Novel cell death program leads to neutrophil extracellular traps","volume":"176","author":"TA Fuchs","year":"2007","journal-title":"J Cell Biol"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1189\/jlb.1010549","article-title":"Rac2 is required for the formation of neutrophil extracellular traps","volume":"90","author":"MB Lim","year":"2011","journal-title":"J Leukoc Biol"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"335","DOI":"10.4049\/jimmunol.154.1.335","article-title":"Functional characterization of the rat chemokine KC and its importance in neutrophil recruitment in a rat model of pulmonary inflammation","volume":"154","author":"CW Frevert","year":"1995","journal-title":"J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"13180","DOI":"10.1038\/ncomms13180","article-title":"Nlrp12 mutation causes C57BL\/6J strain-specific defect in neutrophil recruitment","volume":"7","author":"TK Ulland","year":"2016","journal-title":"Nat Commun"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/jlb.58.3.359","article-title":"Cloning, expression, and functional characterization of rat MIP-2: a neutrophil chemoattractant and epithelial cell mitogen","volume":"58","author":"KE Driscoll","year":"1995","journal-title":"J Leukoc Biol"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1073\/pnas.86.2.612","article-title":"Identification and characterization of macrophage inflammatory protein 2","volume":"86","author":"SD Wolpe","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"ref39","doi-asserted-by":"crossref","first-page":"7247","DOI":"10.1128\/IAI.72.12.7247-7256.2004","article-title":"Transcriptional profiling of lipopolysaccharide-induced acute lung injury","volume":"72","author":"S Jeyaseelan","year":"2004","journal-title":"Infect Immun"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1165\/rcmb.2005-0063OC","article-title":"Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium","volume":"32","author":"S Jeyaseelan","year":"2005","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"10","key":"ref41","doi-asserted-by":"crossref","first-page":"6214","DOI":"10.4049\/jimmunol.0903843","article-title":"CXCL1 regulates pulmonary host defense to Klebsiella Infection via CXCL2, CXCL5, NF-kappaB, and MAPKs","volume":"185","author":"S Cai","year":"2010","journal-title":"J Immunol"},{"issue":"7","key":"ref42","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.4049\/jimmunol.1101985","article-title":"Intrapulmonary administration of leukotriene B(4) augments neutrophil accumulation and responses in the lung to Klebsiella infection in CXCL1 knockout mice","volume":"188","author":"S Batra","year":"2012","journal-title":"J Immunol"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/00024382-199908000-00005","article-title":"Immunopathologic responses to non-lethal sepsis","volume":"12","author":"SJ Ebong","year":"1999","journal-title":"Shock"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"R685","DOI":"10.1152\/ajpregu.00678.2005","article-title":"Differential effect of imipenem treatment on wild-type and NK cell-deficient CD8 knockout mice during acute intra-abdominal injury","volume":"290","author":"VT Enoh","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/00024382-199808000-00005","article-title":"Antibiotic treatment influences outcome in murine sepsis: mediators of increased morbidity","volume":"10","author":"D Newcomb","year":"1998","journal-title":"Shock"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cyto.2003.10.006","article-title":"Sex steroid-mediated regulation of macrophage\/monocyte function in a two-hit model of trauma-hemorrhage and sepsis","volume":"25","author":"T Dienstknecht","year":"2004","journal-title":"Cytokine"},{"issue":"12","key":"ref47","doi-asserted-by":"crossref","first-page":"5748","DOI":"10.4049\/jimmunol.157.12.5748","article-title":"Prolactin administration following hemorrhagic shock improves macrophage cytokine release capacity and decreases mortality from subsequent sepsis","volume":"157","author":"R Zellweger","year":"1996","journal-title":"J Immunol"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"D Rittirsch","year":"2009","journal-title":"Nat Protoc"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1530-0277.1996.tb01055.x","article-title":"Development and characterization of a binge drinking model in mice for evaluation of the immunological effects of ethanol","volume":"20","author":"EJ Carson","year":"1996","journal-title":"Alcohol Clin Exp Res"},{"issue":"11","key":"ref50","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1128\/IAI.05641-11","article-title":"Receptor-interacting protein 2 controls pulmonary host defense to Escherichia coli infection via the regulation of interleukin-17A","volume":"79","author":"T Balamayooran","year":"2011","journal-title":"Infect Immun"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006637","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T00:00:00Z","timestamp":1506988800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T01:04:26Z","timestamp":1693011866000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006637"}},"subtitle":[],"editor":[{"given":"Andreas J","family":"Baumler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,9,18]]},"references-count":50,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,9,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006637","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1006637","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,18]]}}}