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National Institute of Health, ISCIII. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/vgripe.isciii.es\/gripe\/documentos\/20122013\/InformesAnuales\/Informe_Vigilancia_GRIPE_2012-13_18sep2013.pdf\" xlink:type=\"simple\">http:\/\/vgripe.isciii.es\/gripe\/documentos\/20122013\/InformesAnuales\/Informe_Vigilancia_GRIPE_2012-13_18sep2013.pdf<\/ext-link>."},{"key":"ref32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.virusres.2015.03.017","article-title":"Influenza virus polymerase: Functions on host range, inhibition of cellular response to infection and pathogenicity","volume":"209","author":"A Rodriguez-Frandsen","year":"2015","journal-title":"Virus Res"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1128\/JVI.54.1.151-160.1985","article-title":"Characterization of virulent and avirulent A\/chicken\/Pennsylvania\/83 influenza A viruses: potential role of defective interfering 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