{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:49:11Z","timestamp":1787730551520,"version":"build-2784847793"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006690","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000}}],"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T00:00:00Z","timestamp":1508716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5 U19 AI062629"],"award-info":[{"award-number":["5 U19 AI062629"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Oklahoma Center for the Advancement of Science and Technology (US)","award":["HR 13-0003"],"award-info":[{"award-number":["HR 13-0003"]}]},{"name":"Oklahoma Center for Adult Stem Cell Research"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006690","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T14:47:26Z","timestamp":1508770046000},"page":"e1006690","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling"],"prefix":"10.1371","volume":"13","author":[{"given":"Sudarshan","family":"Seshadri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S. J.","family":"Allan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Carlyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8787-5955","authenticated-orcid":true,"given":"Lauren A.","family":"Zenewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,10,23]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1056\/NEJM199909093411107","article-title":"Anthrax","volume":"341","author":"TC Dixon","year":"1999","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-micro-091014-104523","article-title":"Anthrax Pathogenesis","volume":"69","author":"M Moayeri","year":"2015","journal-title":"Annu Rev Microbiol"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/cmi.12445","article-title":"Modulation of the host innate immune and inflammatory response by translocated bacterial proteins","volume":"17","author":"S Asrat","year":"2015","journal-title":"Cell Microbiol"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nrmicro2539","article-title":"Modulation of NF-kappaB signalling by microbial pathogens","volume":"9","author":"MM Rahman","year":"2011","journal-title":"Nat Rev Microbiol"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3390\/toxins3060591","article-title":"The effects of anthrax lethal toxin on host barrier function","volume":"3","author":"T Xie","year":"2011","journal-title":"Toxins (Basel)"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.chom.2016.03.003","article-title":"Intrinsic Defense Mechanisms of the Intestinal Epithelium","volume":"19","author":"D Ramanan","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1084\/jem.20150318","article-title":"Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage","volume":"212","author":"P Aparicio-Domingo","year":"2015","journal-title":"J Exp Med"},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1084\/jem.20160525","article-title":"Emerging concepts and future challenges in innate lymphoid cell biology","volume":"213","author":"ED Tait Wojno","year":"2016","journal-title":"J Exp Med"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/ni.3489","article-title":"Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis","volume":"17","author":"CS Klose","year":"2016","journal-title":"Nat Immunol"},{"issue":"7534","key":"ref10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nature14189","article-title":"The biology of innate lymphoid cells","volume":"517","author":"D Artis","year":"2015","journal-title":"Nature"},{"issue":"7","key":"ref11","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nm.3892","article-title":"Innate lymphoid cells in the initiation, regulation and resolution of inflammation","volume":"21","author":"GF Sonnenberg","year":"2015","journal-title":"Nat Med"},{"issue":"7230","key":"ref12","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nature07537","article-title":"A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity","volume":"457","author":"M Cella","year":"2009","journal-title":"Nature"},{"issue":"24","key":"ref13","doi-asserted-by":"crossref","first-page":"10961","DOI":"10.1073\/pnas.1005641107","article-title":"Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity","volume":"107","author":"M Cella","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.immuni.2010.10.012","article-title":"Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells by Toll-like receptor 2","volume":"33","author":"NK Crellin","year":"2010","journal-title":"Immunity"},{"issue":"7612","key":"ref15","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nature18644","article-title":"Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence","volume":"535","author":"S Ibiza","year":"2016","journal-title":"Nature"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1146\/annurev-immunol-032414-112123","article-title":"Interleukin-22: immunobiology and pathology","volume":"33","author":"JA Dudakov","year":"2015","journal-title":"Annu Rev Immunol"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1002\/eji.200838655","article-title":"IL-22 and inflammation: leukin' through a glass onion","volume":"38","author":"LA Zenewicz","year":"2008","journal-title":"Eur J Immunol"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nm1710","article-title":"IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia","volume":"14","author":"SJ Aujla","year":"2008","journal-title":"Nat Med"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/infdis\/jiu106","article-title":"Activation of Type 3 innate lymphoid cells and interleukin 22 secretion in the lungs during Streptococcus pneumoniae infection","volume":"210","author":"L Van Maele","year":"2014","journal-title":"J Infect Dis"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.chom.2009.03.011","article-title":"Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine","volume":"5","author":"M Raffatellu","year":"2009","journal-title":"Cell Host Microbe"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.immuni.2014.09.010","article-title":"Interleukin-22 regulates the complement system to promote resistance against pathobionts after pathogen-induced intestinal damage","volume":"41","author":"M Hasegawa","year":"2014","journal-title":"Immunity"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1084\/jem.20082683","article-title":"STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing","volume":"206","author":"G Pickert","year":"2009","journal-title":"J Exp Med"},{"issue":"7583","key":"ref23","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/nature16460","article-title":"Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration","volume":"528","author":"CA Lindemans","year":"2015","journal-title":"Nature"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.immuni.2012.05.028","article-title":"Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease","volume":"37","author":"AM Hanash","year":"2012","journal-title":"Immunity"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nm1720","article-title":"Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens","volume":"14","author":"Y Zheng","year":"2008","journal-title":"Nat Med"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1002\/ibd.22929","article-title":"Healing of intestinal inflammation by IL-22","volume":"18","author":"A Mizoguchi","year":"2012","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.immuni.2013.10.021","article-title":"Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection","volume":"40","author":"X Guo","year":"2014","journal-title":"Immunity"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.immuni.2011.11.011","article-title":"The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells","volume":"36","author":"J Qiu","year":"2012","journal-title":"Immunity"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/ni.2187","article-title":"AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch","volume":"13","author":"JS Lee","year":"2011","journal-title":"Nat Immunol"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nri3707","article-title":"The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing","volume":"14","author":"SL Gaffen","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev.biochem.75.103004.142728","article-title":"Anthrax toxin: receptor binding, internalization, pore formation, and translocation","volume":"76","author":"JA Young","year":"2007","journal-title":"Annu Rev Biochem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.micro.091208.073255","article-title":"What sets Bacillus anthracis apart from other Bacillus species?","volume":"63","author":"AB Kolsto","year":"2009","journal-title":"Annu Rev Microbiol"},{"issue":"5364","key":"ref33","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.280.5364.734","article-title":"Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor","volume":"280","author":"NS Duesbery","year":"1998","journal-title":"Science"},{"issue":"6","key":"ref34","doi-asserted-by":"crossref","first-page":"e1003452","DOI":"10.1371\/journal.ppat.1003452","article-title":"Direct proteolytic cleavage of NLRP1B is necessary and sufficient for inflammasome activation by anthrax lethal factor","volume":"9","author":"J Chavarria-Smith","year":"2013","journal-title":"PLoS Pathog"},{"issue":"6946","key":"ref35","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature01794","article-title":"Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin","volume":"424","author":"A Agrawal","year":"2003","journal-title":"Nature"},{"issue":"8","key":"ref36","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.4049\/jimmunol.174.8.4966","article-title":"Anthrax lethal toxin blocks MAPK kinase-dependent IL-2 production in CD4+ T cells","volume":"174","author":"H Fang","year":"2005","journal-title":"J Immunol"},{"issue":"10","key":"ref37","doi-asserted-by":"crossref","first-page":"6155","DOI":"10.4049\/jimmunol.176.10.6155","article-title":"Anthrax lethal toxin has direct and potent inhibitory effects on B cell proliferation and immunoglobulin production","volume":"176","author":"H Fang","year":"2006","journal-title":"J Immunol"},{"issue":"9","key":"ref38","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.it.2006.07.002","article-title":"Anthrax toxins: A paradigm of bacterial immune suppression","volume":"27","author":"CT Baldari","year":"2006","journal-title":"Trends Immunol"},{"issue":"9","key":"ref39","doi-asserted-by":"crossref","first-page":"e1000588","DOI":"10.1371\/journal.ppat.1000588","article-title":"Bacillus anthracis lethal toxin disrupts TCR signaling in CD1d-restricted NKT cells leading to functional anergy","volume":"5","author":"SK Joshi","year":"2009","journal-title":"PLoS Pathog"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.immuni.2010.12.009","article-title":"CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut","volume":"34","author":"GF Sonnenberg","year":"2011","journal-title":"Immunity"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.mib.2003.12.001","article-title":"The roles of anthrax toxin in pathogenesis","volume":"7","author":"M Moayeri","year":"2004","journal-title":"Curr Opin Microbiol"},{"issue":"31","key":"ref42","doi-asserted-by":"crossref","first-page":"12768","DOI":"10.1073\/pnas.1300318110","article-title":"IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis","volume":"110","author":"CL Zindl","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"ref43","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.4049\/jimmunol.1501541","article-title":"mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production","volume":"196","author":"F Chen","year":"2016","journal-title":"J Immunol"},{"issue":"11","key":"ref44","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.4049\/jimmunol.168.11.5699","article-title":"A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit","volume":"168","author":"C Parham","year":"2002","journal-title":"IL-23R. J Immunol"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/mi.2014.71","article-title":"An in vitro model of innate lymphoid cell function and differentiation","volume":"8","author":"DS Allan","year":"2015","journal-title":"Mucosal Immunol"},{"issue":"1\u20132","key":"ref46","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0014-5793(99)01502-1","article-title":"Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS\/IFNgamma-induced release of NO and TNFalpha","volume":"462","author":"R Pellizzari","year":"1999","journal-title":"FEBS Lett"},{"issue":"Pt 3","key":"ref47","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1042\/bj3520739","article-title":"Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor","volume":"352","author":"G Vitale","year":"2000","journal-title":"Biochem J"},{"issue":"9","key":"ref48","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri3495","article-title":"Mitogen-activated protein kinases in innate immunity","volume":"13","author":"JS Arthur","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"17","key":"ref49","doi-asserted-by":"crossref","first-page":"7686","DOI":"10.1073\/pnas.92.17.7686","article-title":"A synthetic inhibitor of the mitogen-activated protein kinase cascade","volume":"92","author":"DT Dudley","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0014-5793(95)00357-F","article-title":"SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1","volume":"364","author":"A Cuenda","year":"1995","journal-title":"FEBS Lett"},{"issue":"6178","key":"ref51","doi-asserted-by":"crossref","first-page":"1249288","DOI":"10.1126\/science.1249288","article-title":"Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis","volume":"343","author":"A Mortha","year":"2014","journal-title":"Science"},{"issue":"14","key":"ref52","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1038\/emboj.2011.201","article-title":"Identity, regulation and in vivo function of gut NKp46+RORgammat+ and NKp46+RORgammat- lymphoid cells","volume":"30","author":"A Reynders","year":"2011","journal-title":"EMBO J"},{"issue":"7","key":"ref53","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/35080089","article-title":"The bacterial toxin toolkit","volume":"2","author":"G Schiavo","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"ref54","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.4049\/jimmunol.0803851","article-title":"Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease","volume":"183","author":"CF Brereton","year":"2009","journal-title":"J Immunol"},{"issue":"3","key":"ref55","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cell.2016.03.017","article-title":"Innate Lymphocyte\/Ly6C(hi) Monocyte Crosstalk Promotes Klebsiella Pneumoniae Clearance","volume":"165","author":"H Xiong","year":"2016","journal-title":"Cell"},{"issue":"9","key":"ref56","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1093\/infdis\/jiu280","article-title":"Impaired colonic B-cell responses by gastrointestinal Bacillus anthracis infection","volume":"210","author":"B Sahay","year":"2014","journal-title":"J Infect Dis"},{"issue":"1","key":"ref57","doi-asserted-by":"crossref","first-page":"e1002481","DOI":"10.1371\/journal.ppat.1002481","article-title":"Mechanisms of NK cell-macrophage Bacillus anthracis crosstalk: a balance between stimulation by spores and differential disruption by toxins","volume":"8","author":"M Klezovich-Benard","year":"2012","journal-title":"PLoS Pathog"},{"issue":"2","key":"ref58","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.immuni.2004.07.007","article-title":"IL-22 increases the innate immunity of tissues","volume":"21","author":"K Wolk","year":"2004","journal-title":"Immunity"},{"issue":"1","key":"ref59","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.immuni.2014.12.028","article-title":"Antimicrobial defense of the intestine","volume":"42","author":"S Mukherjee","year":"2015","journal-title":"Immunity"},{"issue":"2","key":"ref60","first-page":"534","article-title":"IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis","volume":"118","author":"K Sugimoto","year":"2008","journal-title":"J Clin Invest"},{"issue":"7524","key":"ref61","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nature13823","article-title":"Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness","volume":"514","author":"JM Pickard","year":"2014","journal-title":"Nature"},{"issue":"1","key":"ref62","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.chom.2015.06.011","article-title":"Innate Immune Defenses Mediated by Two ILC Subsets Are Critical for Protection against Acute Clostridium difficile Infection","volume":"18","author":"MC Abt","year":"2015","journal-title":"Cell Host Microbe"},{"issue":"11","key":"ref63","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1084\/jem.20151403","article-title":"Unique and redundant functions of NKp46+ ILC3s in models of intestinal inflammation","volume":"212","author":"C Song","year":"2015","journal-title":"J Exp Med"},{"issue":"6","key":"ref64","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/ni.2031","article-title":"The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF","volume":"12","author":"M El-Behi","year":"2011","journal-title":"Nat Immunol"},{"issue":"6","key":"ref65","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/ni.2027","article-title":"RORgammat drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation","volume":"12","author":"L Codarri","year":"2011","journal-title":"Nat Immunol"},{"issue":"4","key":"ref66","doi-asserted-by":"crossref","first-page":"476","DOI":"10.4161\/gmic.29964","article-title":"Role of GM-CSF in the inflammatory cytokine network that regulates neutrophil influx into the colonic mucosa during Clostridium difficile infection in mice","volume":"5","author":"AJ McDermott","year":"2014","journal-title":"Gut Microbes"},{"issue":"7128","key":"ref67","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nature05505","article-title":"Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis","volume":"445","author":"Y Zheng","year":"2007","journal-title":"Nature"},{"issue":"5","key":"ref68","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1084\/jem.20102149","article-title":"Memory\/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology","volume":"208","author":"M Kamanaka","year":"2011","journal-title":"J Exp Med"},{"issue":"5","key":"ref69","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0092-8674(92)90030-G","article-title":"RAG-1-deficient mice have no mature B and T lymphocytes","volume":"68","author":"P Mombaerts","year":"1992","journal-title":"Cell"},{"issue":"4","key":"ref70","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/ni1055","article-title":"Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro","volume":"5","author":"TM Schmitt","year":"2004","journal-title":"Nat Immunol"},{"issue":"1","key":"ref71","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cellimm.2005.12.006","article-title":"Blocking intrahepatic deletion of activated CD8+ T cells by an altered peptide ligand","volume":"238","author":"Y Kuniyasu","year":"2005","journal-title":"Cell Immunol"},{"issue":"3","key":"ref72","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.immuni.2014.01.011","article-title":"Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation","volume":"40","author":"TY Halim","year":"2014","journal-title":"Immunity"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006690","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006690","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T21:29:41Z","timestamp":1540243781000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006690"}},"subtitle":[],"editor":[{"given":"Steven R.","family":"Blanke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,23]]},"references-count":72,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006690","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1006690","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,23]]}}}