{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:52:50Z","timestamp":1792093970694,"version":"4.4.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006777","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000}}],"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T00:00:00Z","timestamp":1513728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006777","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T21:56:20Z","timestamp":1513806980000},"page":"e1006777","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":45,"title":["Two classes of protective antibodies against Pseudorabies virus variant glycoprotein B: Implications for vaccine design"],"prefix":"10.1371","volume":"13","author":[{"given":"Xiangdong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xule","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxun","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George F.","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5362-1415","authenticated-orcid":true,"given":"Kegong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,12,20]]},"reference":[{"key":"ref1","unstructured":"Virus Taxonomy: Ninth Report of the International Committee on the Taxonomy of Viruses. 2012."},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1128\/MMBR.69.3.462-500.2005","article-title":"Molecular biology of Pseudorabies virus: impact on neurovirology and veterinary medicine","volume":"69","author":"LE Pomeranz","year":"2005","journal-title":"Microbiol Mol Biol Rev"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/0042-6822(86)90220-5","article-title":"Herpesvirus (Pseudorabies virus) latency in swine: occurrence and physical state of viral DNA in neural tissues","volume":"155","author":"HJ Rziha","year":"1986","journal-title":"Virology"},{"key":"ref4","article-title":"Diseases of Swine","year":"2012"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3201\/eid2001.130531","article-title":"Pathogenic Pseudorabies virus, China, 2012","volume":"20","author":"X Yu","year":"2014","journal-title":"Emerging infectious diseases"},{"key":"ref6","unstructured":"United States Department of Agriculture (USDA). Pseudorabies (Aujeszky&apos;s Disease) and its eradication: a report of the U.S. experience. 2008."},{"issue":"3\u20134","key":"ref7","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.vetmic.2015.09.021","article-title":"Emergence of a Pseudorabies virus variant with increased virulence to piglets","volume":"181","author":"W Tong","year":"2015","journal-title":"Vet Microbiol"},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.3201\/eid1911.130177","article-title":"Pseudorabies virus variant in Bartha-K61-vaccinated pigs, China, 2012","volume":"19","author":"TQ An","year":"2013","journal-title":"Emerging infectious diseases"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.4142\/jvs.2013.14.3.363","article-title":"Emergence of virulent Pseudorabies virus infection in northern China","volume":"14","author":"R Wu","year":"2013","journal-title":"J Vet Sci"},{"issue":"1\u20132","key":"ref10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.vetmic.2014.09.003","article-title":"Pathogenicity and genomic characterization of a Pseudorabies virus variant isolated from Bartha-K61-vaccinated swine population in China","volume":"174","author":"Y Luo","year":"2014","journal-title":"Vet Microbiol"},{"issue":"21","key":"ref11","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1016\/j.vaccine.2015.03.094","article-title":"Construction of a triple gene-deleted Chinese Pseudorabies virus variant and its efficacy study as a vaccine candidate on suckling piglets","volume":"33","author":"C Zhang","year":"2015","journal-title":"Vaccine"},{"key":"ref12","first-page":"684945","article-title":"Construction of a gE-deleted Pseudorabies virus and its efficacy to the new-emerging variant PRV challenge in the form of killed vaccine","volume":"2015","author":"T Wang","year":"2015","journal-title":"Biomed Res Int"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.virusres.2014.09.003","article-title":"A novel inactivated gE\/gI deleted Pseudorabies virus (PRV) vaccine completely protects pigs from an emerged variant PRV challenge","volume":"195","author":"Z Gu","year":"2015","journal-title":"Virus research"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1128\/JVI.78.1.424-440.2004","article-title":"Complete, annotated sequence of the Pseudorabies virus genome","volume":"78","author":"BG Klupp","year":"2004","journal-title":"Journal of virology"},{"issue":"5784","key":"ref15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.1126548","article-title":"Crystal structure of glycoprotein B from herpes simplex virus 1","volume":"313","author":"EE Heldwein","year":"2006","journal-title":"Science"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1073\/pnas.0810530106","article-title":"Structure of a trimeric variant of the Epstein-Barr virus glycoprotein B","volume":"106","author":"M Backovic","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"19","key":"ref17","doi-asserted-by":"crossref","first-page":"10179","DOI":"10.1128\/JVI.77.19.10179-10185.2003","article-title":"Herpesvirus entry: an update","volume":"77","author":"PG Spear","year":"2003","journal-title":"Journal of virology"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1128\/JVI.66.2.894-905.1992","article-title":"Pseudorabies virus envelope glycoproteins gp50 and gII are essential for virus penetration, but only gII is involved in membrane fusion","volume":"66","author":"B Peeters","year":"1992","journal-title":"Journal of virology"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1128\/JVI.72.1.873-875.1998","article-title":"Glycoproteins gB, gD, and gHgL of herpes simplex virus type 1 are necessary and sufficient to mediate membrane fusion in a Cos cell transfection system","volume":"72","author":"A Turner","year":"1998","journal-title":"Journal of virology"},{"issue":"12","key":"ref20","doi-asserted-by":"crossref","first-page":"6552","DOI":"10.3390\/v7122957","article-title":"Herpesvirus gB: A finely tuned fusion machine","volume":"7","author":"RS Cooper","year":"2015","journal-title":"Viruses"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/nsmb.1837","article-title":"Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL","volume":"17","author":"TK Chowdary","year":"2010","journal-title":"Nature structural & molecular biology"},{"issue":"23","key":"ref22","doi-asserted-by":"crossref","first-page":"4144","DOI":"10.1038\/sj.emboj.7600875","article-title":"Structure of unliganded HSV gD reveals a mechanism for receptor-mediated activation of virus entry","volume":"24","author":"C Krummenacher","year":"2005","journal-title":"Embo J"},{"issue":"8","key":"ref23","doi-asserted-by":"crossref","first-page":"e1002172","DOI":"10.1371\/journal.ppat.1002172","article-title":"B cell repertoire analysis identifies new antigenic domains on glycoprotein B of human cytomegalovirus which are target of neutralizing antibodies","volume":"7","author":"S Potzsch","year":"2011","journal-title":"PLoS Pathogens"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1128\/JVI.02710-06","article-title":"Antigenic and mutational analyses of herpes simplex virus glycoprotein B reveal four functional regions","volume":"81","author":"FC Bender","year":"2007","journal-title":"Journal of Virology"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"860","DOI":"10.2460\/ajvr.1988.49.06.860","article-title":"Protection of mice and swine from Pseudorabies virus-induced mortality by administration of Pseudorabies virus-specific mouse monoclonal antibodies","volume":"49","author":"C Marchioli","year":"1988","journal-title":"Am J Vet Res"},{"issue":"1\u20132","key":"ref26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0378-1135(93)90130-Y","article-title":"Role of Pseudorabies virus glycoprotein II in protection from lethal infection","volume":"36","author":"T Nakamura","year":"1993","journal-title":"Vet Microbiol"},{"issue":"9","key":"ref27","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1128\/JVI.61.9.2691-2701.1987","article-title":"The Pseudorabies virus gII gene is closely related to the gB glycoprotein gene of herpes simplex virus","volume":"61","author":"AK Robbins","year":"1987","journal-title":"Journal of Virology"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0923-2516(97)86898-7","article-title":"Glycoprotein B of Aujeszky&apos;s disease virus: topographical epitope mapping and epitope-specific antibody response","volume":"149","author":"MM Zaripov","year":"1998","journal-title":"Res Virol"},{"issue":"Pt 3","key":"ref29","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1099\/0022-1317-80-3-537","article-title":"Distribution of B-cell epitopes on the Pseudorabies virus glycoprotein B","volume":"80","author":"MM Zaripov","year":"1999","journal-title":"The Journal of General Virology"},{"key":"ref30","article-title":"Structure-function dissection of the Pseudorabies virus glycoprotein B fusion loops","author":"M Vallbracht","year":"2017","journal-title":"Journal of Virology"},{"issue":"5784","key":"ref31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1126\/science.1127683","article-title":"Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G","volume":"313","author":"S Roche","year":"2006","journal-title":"Science"},{"issue":"5813","key":"ref32","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1126\/science.1135710","article-title":"Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G","volume":"315","author":"S Roche","year":"2007","journal-title":"Science"},{"key":"ref33","article-title":"Antibody Engineering Volume 1","author":"Roland Konterman","year":"2010"},{"issue":"1","key":"ref34","first-page":"10102","article-title":"The macromolecular crystallography beamline of SSRF","volume":"26","author":"Q Wang","year":"2015","journal-title":"Nuclear Science and Techniques"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing of X-ray diffraction data collected in oscillation mode","volume":"276","author":"Z Otwinowski","year":"1997","journal-title":"Method Enzymol"},{"issue":"Pt 10","key":"ref36","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1107\/S0907444901012471","article-title":"Pushing the boundaries of molecular replacement with maximum likelihood","volume":"57","author":"RJ Read","year":"2001","journal-title":"Acta Crystallographica Section D, Biological Crystallography"},{"issue":"Pt 5","key":"ref37","first-page":"760","article-title":"The CCP4 suite: programs for protein crystallography","volume":"50","year":"1994","journal-title":"Acta Crystallographica Section D, Biological Crystallography"},{"issue":"Pt 2","key":"ref38","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"PD Adams","year":"2010","journal-title":"Acta Crystallographica Section D, Biological Crystallography"},{"issue":"Pt 12","key":"ref39","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"P Emsley","year":"2004","journal-title":"Acta Crystallographica Section D, Biological Crystallography"},{"issue":"Pt 1","key":"ref40","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1107\/S0907444909042073","article-title":"MolProbity: all-atom structure validation for macromolecular crystallography","volume":"66","author":"VB Chen","year":"2010","journal-title":"Acta Crystallographica Section D, Biological Crystallography"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jsb.2006.05.009","article-title":"EMAN2: an extensible image processing suite for electron microscopy","volume":"157","author":"G Tang","year":"2007","journal-title":"Journal of Structural Biology"},{"issue":"9","key":"ref42","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.ultramic.2008.03.004","article-title":"Restoration of weak phase-contrast images recorded with a high degree of defocus: the &quot;twin image&quot; problem associated with CTF correction","volume":"108","author":"KH Downing","year":"2008","journal-title":"Ultramicroscopy"},{"key":"ref43","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.18722","article-title":"Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2","volume":"5","author":"D Kimanius","year":"2016","journal-title":"eLife"},{"issue":"13","key":"ref44","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014a visualization system for exploratory research and analysis","volume":"25","author":"EF Pettersen","year":"2004","journal-title":"Journal of computational chemistry"},{"issue":"2\u20133","key":"ref45","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/jsbi.1998.4080","article-title":"Situs: A package for docking crystal structures into low-resolution maps from electron microscopy","volume":"125","author":"W Wriggers","year":"1999","journal-title":"Journal of Structural Biology"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006777","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T03:13:13Z","timestamp":1751166793000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006777"}},"subtitle":[],"editor":[{"given":"Thilo","family":"Stehle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,12,20]]},"references-count":45,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,12,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006777","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1006777","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,20]]}}}